Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0537 | 0.1287 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0537 | 0.1287 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1845 | 0.4427 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1845 | 0.4427 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.5663 | 0.5302 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2083 | 0.2083 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.2076 | 0.1417 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0247 | 0.0592 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.006 | 0.006 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.035 | 0.035 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.4517 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.035 | 0.0774 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0247 | 0.0592 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2314 | 0.2314 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5245 | 0.5245 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0537 | 0.1188 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4168 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4168 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2501 | 0.2501 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0247 | 0.0546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.