Detailed information for compound 136056

Basic information

Technical information
  • TDR Targets ID: 136056
  • Name: [1-(6-aminopurin-9-yl)-3-hydroxypropan-2-yl]o xymethylphosphonic acid
  • MW: 303.212 | Formula: C9H14N5O5P
  • H donors: 4 H acceptors: 7 LogP: -2.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(Cn1cnc2c1ncnc2N)OCP(=O)(O)O
  • InChi: 1S/C9H14N5O5P/c10-8-7-9(12-3-11-8)14(4-13-7)1-6(2-15)19-5-20(16,17)18/h3-4,6,15H,1-2,5H2,(H2,10,11,12)(H2,16,17,18)
  • InChiKey: FRPXSOOHWNMLPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-[(6-aminopurin-9-yl)methyl]-2-hydroxy-ethoxy]methylphosphonic acid
  • [1-[(6-aminopurin-9-yl)methyl]-2-hydroxyethoxy]methylphosphonic acid
  • [1-(6-aminopurin-9-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid
  • [1-(adenin-9-ylmethyl)-2-hydroxy-ethoxy]methylphosphonic acid
  • 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine
  • [1-[(6-amino-9-purinyl)methyl]-2-hydroxyethoxy]methylphosphonic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Loa Loa (eye worm) hypothetical protein 0.008 0.1158 0.1203
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0138 0.1406
Onchocerca volvulus 0.0121 0.1852 0.5019
Loa Loa (eye worm) hypothetical protein 0.0121 0.1852 0.1926
Brugia malayi secreted modular calcium-binding protein 1 0.0083 0.1202 0.1247
Onchocerca volvulus Sepiapterin reductase homolog 0.0012 0.0012 0.0019
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0004 0.0022
Trypanosoma cruzi heat shock protein 85, putative 0.004 0.0484 0.2613
Toxoplasma gondii small ubiquitin family modifier, putative 0.0033 0.0358 0.123
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0012 0.0066
Onchocerca volvulus Matrix metalloproteinase homolog 0.0037 0.0436 0.117
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0012 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0012 0.0066
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0106 0.0272
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0381 0.0391
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0015 0.006 0.006
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0106 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.1239 0.1286
Plasmodium vivax SET domain protein, putative 0.0029 0.0292 0.0995
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0004 0.0002
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0015 0.006 0.0584
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0123 0.0111
Leishmania major short chain dehydrogenase, putative 0.0012 0.0012 0.0086
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Schistosoma mansoni hypothetical protein 0.0337 0.5522 0.5745
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.0007
Onchocerca volvulus 0.0018 0.0106 0.0272
Loa Loa (eye worm) hypothetical protein 0.0045 0.0562 0.0583
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.0012 0.0008
Leishmania major cathepsin L-like protease 0.0068 0.0957 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0106 0.0332
Loa Loa (eye worm) hypothetical protein 0.0083 0.1202 0.1249
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.001 0.0013
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.0012 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0106 0.0093
Leishmania major short chain dehydrogenase-like protein 0.0012 0.0012 0.0086
Trypanosoma cruzi multidrug resistance protein E, putative 0.0015 0.006 0.0322
Schistosoma mansoni hypothetical protein 0.0014 0.0038 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0085 0.1239 0.1288
Brugia malayi nuclear receptor NHR-88 0.004 0.048 0.0496
Echinococcus multilocularis multidrug resistance associated protein 1 0.0015 0.006 0.0081
Schistosoma mansoni ap endonuclease 0.0018 0.0111 0.011
Schistosoma mansoni hypothetical protein 0.0337 0.5522 0.5745
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0044 0.055 0.573
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.1239 0.1286
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0061 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0085 0.1239 0.1286
Brugia malayi hypothetical protein 0.0121 0.1852 0.1924
Brugia malayi nuclear receptor NHR-67 0.004 0.048 0.0496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0085 0.1239 0.1288
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0012 0.0012 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0083 0.1202 0.4236
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.1239 0.1286
Echinococcus granulosus Solute carrier organic anion transporter family 0.0121 0.1852 0.2511
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0038 0.0037
Entamoeba histolytica short chain dehydrogenase family protein 0.0012 0.0012 0.0115
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0111 0.183
Leishmania major cathepsin L-like protease 0.0018 0.0106 0.1065
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0232 0.0228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0106 0.0108
Schistosoma mansoni multidrug resistance protein 0.0015 0.006 0.0057
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0083 0.1202 0.1247
Echinococcus granulosus lamin 0.0054 0.0716 0.097
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0012 0.0012 0.0007
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0085 0.1239 0.1286
Giardia lamblia Sentrin 0.0033 0.0358 0.5888
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0106 0.0272
Trichomonas vaginalis set domain proteins, putative 0.0229 0.3682 0.3829
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0034 0.0313
Loa Loa (eye worm) hypothetical protein 0.0053 0.0699 0.0726
Schistosoma mansoni calcium-activated potassium channel 0.0159 0.2506 0.2604
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0085 0.1239 0.1286
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0012 0.0066
Schistosoma mansoni hypothetical protein 0.0015 0.0061 0.0058
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Trypanosoma brucei small ubiquitin-related modifier 0.0033 0.0358 0.3711
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0085 0.1239 0.1285
Loa Loa (eye worm) hypothetical protein 0.0121 0.1852 0.1926
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0077 0.0767
Toxoplasma gondii cathepsin CPL 0.0018 0.0106 0.0332
Loa Loa (eye worm) endoplasmin 0.0047 0.0599 0.0621
Brugia malayi Pre-SET motif family protein 0.0201 0.3211 0.3339
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0012 0.0007
Onchocerca volvulus 0.0121 0.1852 0.5019
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.048 0.0651
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0012 0.0017
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0138 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0292 0.0298
Schistosoma mansoni multidrug resistance protein 0.0015 0.006 0.0057
Trichomonas vaginalis glutaminase, putative 0.0578 0.9608 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0274 0.0371
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0106 0.057
Loa Loa (eye worm) glutaminase 0.0578 0.9608 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.001 0.0052
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0012 0.0012 0.0008
Onchocerca volvulus 0.0017 0.0088 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0358 0.0367
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0012 0.0008
Echinococcus granulosus GPCR family 2 0.0015 0.0061 0.0083
Mycobacterium ulcerans hydrolase 0.0021 0.015 0.0146
Schistosoma mansoni calcium-activated potassium channel 0.0152 0.2374 0.2467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Loa Loa (eye worm) hypothetical protein 0.0085 0.1239 0.1288
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Loa Loa (eye worm) hypothetical protein 0.0121 0.1852 0.1926
Schistosoma mansoni steroid hormone receptor ad4bp 0.0085 0.1239 0.1285
Brugia malayi Steroid receptor seven-up type 2 0.0085 0.1239 0.1286
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0012 0.0012 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Schistosoma mansoni carbonyl reductase 0.0012 0.0012 0.0007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0111 0.0099
Echinococcus multilocularis Small ubiquitin modifier 2 0.0033 0.0358 0.0485
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0111 0.0113
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.0007
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0106 0.1687
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.0012 0.0017
Entamoeba histolytica cysteine protease, putative 0.0018 0.0106 0.1687
Entamoeba histolytica hypothetical protein 0.0035 0.0402 0.6675
Onchocerca volvulus 0.0121 0.1852 0.5019
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0106 0.0332
Mycobacterium ulcerans short-chain type oxidoreductase 0.0012 0.0012 0.0008
Giardia lamblia ABC transporter, putative 0.0015 0.006 0.0809
Giardia lamblia MRP-like ABC transporter 0.0015 0.006 0.0809
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0019 0.0125 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0138 0.0138
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.0012 0.0017
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0011
Onchocerca volvulus 0.0047 0.0593 0.1596
Brugia malayi cathepsin L-like precursor 0.0012 0.0005 0.0001
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0138 0.0138
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0035 0.0402 0.0413
Echinococcus granulosus Ankyrin 0.0014 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0088 0.009
Onchocerca volvulus Matrilysin homolog 0.0037 0.0436 0.117
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0012 0.0012 0.0019
Trypanosoma brucei heat shock protein, putative 0.0047 0.0599 0.6243
Echinococcus granulosus cathepsin l1 0.0012 0.0005 0.0007
Leishmania major protein kinase, putative 0.0012 0.001 0.0059
Schistosoma mansoni hypothetical protein 0.0024 0.0207 0.021
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0243 0.033
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0138 0.0745
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0038 0.0035
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.0599 0.2089
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0012 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0085 0.1239 0.1288
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.0007
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0011
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0012 0.0012 0.0066
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.001 0.0004
Entamoeba histolytica ATP-binding cassette protein, putative 0.0015 0.006 0.0915
Brugia malayi conserved hypotetical protein 0.004 0.048 0.0496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Toxoplasma gondii heat shock protein HSP90 0.0047 0.0599 0.2089
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Onchocerca volvulus 0.0024 0.0207 0.0549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.0104
Brugia malayi glutaminase DH11.1 0.0578 0.9608 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0106 0.0093
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0012 0.0012 0.0086
Echinococcus multilocularis retinol dehydrogenase 13 0.0012 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Entamoeba histolytica ubiquitin like protein 0.0033 0.0358 0.5935
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0138 0.2234
Echinococcus granulosus geminin 0.0337 0.5522 0.7487
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Onchocerca volvulus 0.0229 0.3684 1
Onchocerca volvulus 0.0018 0.0106 0.0272
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.1009 0.1368
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0085 0.1239 0.1286
Leishmania major cathepsin L-like protease 0.0068 0.0957 1
Loa Loa (eye worm) RecQ helicase 0.0021 0.0152 0.0156
Trypanosoma cruzi MFS transporter, putative 0.0121 0.1852 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.066 0.3565
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Schistosoma mansoni nuclear hormone receptor 0.004 0.048 0.0495
Mycobacterium ulcerans dehydrogenase 0.0012 0.0012 0.0008
Echinococcus multilocularis FTZ F1 alpha 0.0085 0.1239 0.168
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.0007
Loa Loa (eye worm) nuclear hormone receptor 0.004 0.048 0.0498
Brugia malayi dehydrogenases, short chain protein 9 0.0012 0.0012 0.0008
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Echinococcus granulosus WW domain containing oxidoreductase 0.0012 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0085 0.1239 0.1288
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.1239 0.1286
Brugia malayi sodium-independent organic anion transporter family protein 0.0121 0.1852 0.1924
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0599 0.3234
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0012 0.0086
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.066 0.6888
Onchocerca volvulus Putative organic anion transporter 0.0121 0.1852 0.5019
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0038 0.0052
Leishmania major cathepsin L-like protease 0.0018 0.0106 0.1065
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0077 0.0231
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.1239 0.168
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0232 0.2388
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0716 0.0741
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0152 0.0153
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Trypanosoma brucei heat shock protein, putative 0.0047 0.0599 0.6243
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0123 0.0395
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0599 0.0619
Echinococcus multilocularis Ankyrin 0.0014 0.004 0.0054
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0004 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0138 0.1406
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0012 0.0017
Leishmania major protein kinase, putative 0.0012 0.001 0.0059
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0111 0.0107
Schistosoma mansoni hypothetical protein 0.0159 0.2506 0.2604
Plasmodium vivax small ubiquitin-related modifier, putative 0.0033 0.0358 0.123
Brugia malayi Matrixin family protein 0.0017 0.0088 0.0088
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0012 0.0086
Onchocerca volvulus 0.0025 0.0232 0.0615
Mycobacterium ulcerans ketoacyl reductase 0.0012 0.0012 0.0008
Mycobacterium ulcerans short chain dehydrogenase 0.0602 1 1
Brugia malayi Uncoordinated protein 44 0.0014 0.0038 0.0035
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0392 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0106 0.0104
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Mycobacterium ulcerans oxidoreductase 0.0012 0.0012 0.0008
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0187 0.0254
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0111 0.035
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0085 0.1239 0.1288
Echinococcus multilocularis endoplasmin 0.0044 0.055 0.0746
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0012 0.0012 0.0017
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0011
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0077 0.0767
Echinococcus multilocularis cysteine protease 0.0018 0.0106 0.0143
Giardia lamblia Multidrug resistance-associated protein 1 0.0015 0.006 0.0809
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0484 0.2613
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0012 0.0012 0.0086
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.0012 0.0066
Onchocerca volvulus 0.0012 0.001 0.0012
Brugia malayi Hsp90 protein 0.0031 0.0332 0.0341
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0106 0.0108
Brugia malayi Cathepsin L-like precursor 0.0012 0.0005 0.0001
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0332 0.1137
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0077 0.0105
Brugia malayi Matrixin family protein 0.0017 0.0088 0.0088
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0012 0.0086
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0033 0.0358 0.0367
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0085 0.1239 0.1285
Schistosoma mansoni lamin 0.0054 0.0716 0.074
Echinococcus granulosus small conductance calcium activated potassium 0.0159 0.2506 0.3398
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0012 0.0012 0.0066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0123 0.0126
Brugia malayi hypothetical protein 0.0045 0.0562 0.0581
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0106 0.0143
Loa Loa (eye worm) hypothetical protein 0.0072 0.1019 0.1059
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0012 0.0012 0.0008
Leishmania major pentamidine resistance protein 1 0.0015 0.006 0.0584
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0332 0.1791
Schistosoma mansoni single-minded 0.0047 0.0599 0.0619
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.004 0.0481 0.0495
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0106 0.1065
Mycobacterium ulcerans ketoacyl reductase 0.0012 0.0012 0.0008
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0332 0.3438
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.048 0.0496
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0106 0.0093
Plasmodium vivax vivapain-2 0.0018 0.0106 0.0332
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0044 0.055 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0012 0.0012 0.0066
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.001 0.0004
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0077 0.0075
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0012 0.0012 0.0066
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.0012 0.0017
Entamoeba histolytica short chain dehydrogenase family protein 0.0012 0.0012 0.0115
Schistosoma mansoni endoplasmin 0.0047 0.0599 0.0618
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0232 0.0228
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0332 0.5497
Schistosoma mansoni ap endonuclease 0.0018 0.0111 0.011
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0332 0.0343
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0038 0.0034
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Brugia malayi nuclear hormone receptor 0.004 0.048 0.0496
Echinococcus granulosus lamin dm0 0.0054 0.0716 0.097
Brugia malayi hypoxia-induced factor 1 0.0145 0.2268 0.2358
Loa Loa (eye worm) hypothetical protein 0.0085 0.1239 0.1288
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0034 0.0313
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0232 0.0228
Brugia malayi nuclear receptor NHR-88 0.0085 0.1239 0.1286
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0011
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0599 0.6243
Loa Loa (eye worm) hypothetical protein 0.0085 0.1239 0.1288
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0106
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0085 0.1239 0.1285
Leishmania major 3-keto-dihydrosphingosine reductase 0.0012 0.0012 0.0086
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.0562 0.0761
Brugia malayi steroid hormone receptor 0.0085 0.1239 0.1286
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0012 0.0012 0.0007
Entamoeba histolytica hypothetical protein 0.0035 0.0402 0.6675
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0232 0.4107
Brugia malayi ecdysone receptor 0.004 0.048 0.0496
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.0599 0.3234
Loa Loa (eye worm) hypothetical protein 0.0121 0.1852 0.1926
Trypanosoma brucei heat shock protein, putative 0.0047 0.0599 0.6243
Trypanosoma brucei oxidoreductase-like protein 0.0012 0.0012 0.0086
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0083 0.1202 0.1247
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0138 0.1406
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0012 0.0017
Brugia malayi Matrixin family protein 0.0041 0.0493 0.0509
Plasmodium falciparum endoplasmin, putative 0.0034 0.0381 0.1311
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0012 0.0012 0.0007
Onchocerca volvulus 0.0018 0.0106 0.0272
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0232 0.2388
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Loa Loa (eye worm) ctsf protein 0.0018 0.0106 0.0108
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Onchocerca volvulus 0.0121 0.1852 0.5019
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0292 0.0302
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0012 0.0066
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0083 0.1202 0.4236
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0012 0.0008
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0012 0.0007
Brugia malayi ABC transporter transmembrane region family protein 0.0015 0.006 0.0058
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0083 0.1202 0.1249
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0152 0.0206
Brugia malayi Endoplasmin precursor 0.0047 0.0599 0.0619
Trypanosoma brucei unspecified product 0.0014 0.0034 0.0313
Plasmodium vivax heat shock protein, putative 0.0178 0.282 1
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0012 0.0012 0.0066
Brugia malayi multidrug resistance related protein 1 0.0015 0.006 0.0058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0292 0.0395
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0111 0.1118
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.001 0.0013
Onchocerca volvulus Protein ultraspiracle homolog 0.0085 0.1239 0.3355
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0012 0.0012 0.0007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0243 0.033
Onchocerca volvulus Putative organic anion transporter 0.0121 0.1852 0.5019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Onchocerca volvulus Matrilysin homolog 0.0017 0.0088 0.0225
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.001 0.0052
Onchocerca volvulus Bile acid receptor homolog 0.0085 0.1239 0.3355
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0232 0.0237
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0138 0.0745
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0111 0.0597
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0402 0.0413
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0111 0.015
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0061 0.0083
Echinococcus granulosus agrin 0.0083 0.1202 0.1629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.048 0.0651
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0111 0.1677
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.7376 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.048 0.0651
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0012 0.0012 0.0066
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0138 0.0187
Brugia malayi Dehydrogenases, short chain protein 2 0.0012 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0048 0.0619 0.0642
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.004 0.048 0.0651
Trichomonas vaginalis heat shock protein, putative 0.004 0.0484 0.0498
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.0012 0.0115
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0106
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0012 0.0012 0.0115
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0012 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0111 0.1118
Schistosoma mansoni follistatin 0.0083 0.1202 0.1246
Echinococcus multilocularis cysteine protease 0.0018 0.0106 0.0143
Onchocerca volvulus 0.0012 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0015 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.0104
Onchocerca volvulus Putative organic anion transporter 0.0121 0.1852 0.5019
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0332 0.1137
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.7376 1
Brugia malayi hypothetical protein 0.0035 0.0402 0.0414
Loa Loa (eye worm) hypothetical protein 0.0025 0.0232 0.0239
Onchocerca volvulus 0.0012 0.0012 0.0019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0232 0.3811
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0361 0.0371
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0012 0.0012 0.0086
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0232 0.3811
Onchocerca volvulus 0.0012 0.0012 0.0019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0138 0.0141
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0332 0.045
Trichomonas vaginalis steroid dehydrogenase, putative 0.0012 0.0012 0.0007
Leishmania major hypothetical protein, conserved 0.0012 0.0012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0025 0.0227 0.0234
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0012 0.0012 0.0086
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.048 0.0496
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Schistosoma mansoni hypothetical protein 0.005 0.065 0.0671
Brugia malayi Ubiquitin-like protein SMT3 0.0033 0.0358 0.0368
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.0104
Schistosoma mansoni organic anion transporter 0.0121 0.1852 0.1923
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0599 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0044 0.055 1
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.0599 0.6243
Loa Loa (eye worm) hypothetical protein 0.0158 0.2476 0.2575
Schistosoma mansoni glutaminase 0.0578 0.9608 1
Echinococcus multilocularis lamin 0.0054 0.0716 0.097
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0012 0.0012 0.0066
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0121 0.1852 0.2511
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0015 0.006 0.0322
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0061 0.0841 0.114
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0121 0.1852 0.1926
Loa Loa (eye worm) DR-78 0.004 0.048 0.0498
Trypanosoma brucei unspecified product 0.0014 0.0034 0.0313
Echinococcus granulosus bloom syndrome protein 0.0021 0.0152 0.0206
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0012 0.0086
Trichomonas vaginalis heat shock protein, putative 0.0044 0.055 0.0567
Schistosoma mansoni coup transcription factor 0.0085 0.1239 0.1285
Onchocerca volvulus 0.0012 0.0012 0.0019
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0121 0.1852 0.2511
Trypanosoma cruzi short chain dehydrogenase, putative 0.0012 0.0012 0.0066
Echinococcus multilocularis expressed protein 0.0083 0.1202 0.1629
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0061 0.0059
Loa Loa (eye worm) dehydrogenase 0.0012 0.0012 0.0011
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0152 0.0153
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0106
Brugia malayi nuclear receptor RXR 0.0045 0.0562 0.0581
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0138 0.1406
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0012 0.0012 0.0066
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0011
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.001 0.0004
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0123 0.0395
Brugia malayi nuclear receptor RXR 0.004 0.048 0.0496
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Mycobacterium ulcerans glutaminase 0.0578 0.9608 0.9608
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0037
Echinococcus multilocularis dna polymerase kappa 0.002 0.0138 0.0187
Brugia malayi Retinol dehydrogenase 12 0.0012 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0123 0.0126
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Mycobacterium ulcerans carveol-like dehydrogenase 0.0012 0.0012 0.0008
Leishmania major p-glycoprotein e 0.0015 0.006 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0012 0.0086
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0138 0.0126
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0292 0.0395
Echinococcus granulosus intermediate filament protein 0.0054 0.0716 0.097
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0138 0.1406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Schistosoma mansoni retinoic acid receptor RXR 0.0085 0.1239 0.1285
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.0012 0.0008
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0392 0.0388
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0012 0.0007
Loa Loa (eye worm) matrix metalloproteinase 0.0017 0.0088 0.009
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.048 0.0496
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0012 0.0007
Echinococcus multilocularis heat shock protein 90 0.004 0.0484 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0138 0.1406
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0004 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0232 0.2388
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0138 0.0139
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0232 0.0239
Brugia malayi Protein kinase domain containing protein 0.0014 0.0038 0.0035
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0111 0.1773
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0012 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0232 0.0239
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0083 0.1202 0.1247
Onchocerca volvulus 0.0121 0.1852 0.5019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0232 0.0228
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0012 0.0066
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Schistosoma mansoni RAR-like nuclear receptor 0.0085 0.1239 0.1285
Loa Loa (eye worm) hypothetical protein 0.0015 0.0061 0.0061
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.048 0.0495
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0599 0.3234
Leishmania major hypothetical protein, conserved 0.0051 0.066 0.6888
Schistosoma mansoni hypothetical protein 0.0023 0.0187 0.0189
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Echinococcus granulosus FTZ F1 alpha 0.0085 0.1239 0.168
Brugia malayi Nuclear hormone receptor E75 0.004 0.048 0.0496
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0106 0.0143
Loa Loa (eye worm) hypothetical protein 0.0017 0.0088 0.009
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0012 0.0012 0.0066
Onchocerca volvulus 0.0029 0.0292 0.0778
Schistosoma mansoni nuclear hormone receptor 0.004 0.048 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0085 0.1239 0.1286
Brugia malayi sodium-independent organic anion transporter family protein 0.0121 0.1852 0.1924
Entamoeba histolytica ABC transporter, putative 0.0015 0.006 0.0915
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0138 0.1406
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0012 0.0012 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0085 0.1239 0.168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0085 0.1239 0.1288
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0012 0.0012 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.066 0.2308
Loa Loa (eye worm) hypothetical protein 0.0083 0.1202 0.1249
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0106 0.0104
Schistosoma mansoni organic anion transporter 0.0121 0.1852 0.1923
Leishmania major small ubiquitin protein, putative 0.0033 0.0358 0.3711
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0015 0.006 0.0584
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.1239 0.168
Schistosoma mansoni heat shock protein 0.0047 0.0599 0.0618
Schistosoma mansoni netrin receptor unc5 0.0014 0.0038 0.0034
Mycobacterium leprae PROBABLE HYDROLASE 0.0021 0.015 0.2604
Onchocerca volvulus 0.0085 0.1239 0.3355
Brugia malayi PAS domain containing protein 0.0047 0.0599 0.062
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0111 0.0597
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0265 0.0902
Mycobacterium ulcerans ketoacyl reductase 0.0012 0.0012 0.0008
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0003
Loa Loa (eye worm) agrin synaptic family protein 0.0083 0.1202 0.1249
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0138 0.0745
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0077 0.0231
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0138 0.0745
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.1009 0.1368
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0138 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0292 0.0298
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.048 0.0651
Plasmodium vivax heat shock protein 86, putative 0.0047 0.0599 0.2089
Mycobacterium leprae Probable oxidoreductase 0.0012 0.0012 0.0047
Loa Loa (eye worm) glutaminase 2 0.0578 0.9608 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0227 0.0234
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0138 0.0745
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0012 0.0012 0.0008
Leishmania major short chain dehydrogenase/reductase, putative 0.0012 0.0012 0.0086
Schistosoma mansoni DNA polymerase eta 0.002 0.0138 0.0138
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0077 0.0078
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0039 0.0095
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Entamoeba histolytica multidrug resistance protein, putative 0.0015 0.006 0.0915
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0138 0.1406
Brugia malayi SPARC precursor 0.0083 0.1202 0.1247
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0957 0.5166
Giardia lamblia Multidrug resistance-associated protein 1 0.0015 0.006 0.0809
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Loa Loa (eye worm) hypothetical protein 0.002 0.0138 0.0141
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0085 0.1239 0.168
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0011
Loa Loa (eye worm) cysteine protease 0.0018 0.0106 0.0108
Mycobacterium ulcerans heat shock protein 90 0.0044 0.055 0.0546
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0012 0.0012 0.0008
Trypanosoma brucei multidrug resistance protein E 0.0015 0.006 0.0584
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0061 0.0083
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0085 0.1239 0.1286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.1239 0.168
Schistosoma mansoni survival motor neuron protein 0.0047 0.0593 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Echinococcus granulosus heat shock protein 90 0.004 0.0484 0.0656
Trypanosoma brucei heat shock protein, putative 0.0047 0.0599 0.6243
Brugia malayi photoreceptor-specific nuclear receptor 0.0085 0.1239 0.1286
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0038 0.0052
Giardia lamblia Heat shock protein HSP 90-alpha 0.004 0.0484 0.8039
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0085 0.1239 0.1286
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.3211 0.3341
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.001 0.0052
Loa Loa (eye worm) hypothetical protein 0.0015 0.006 0.006
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0012 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Schistosoma mansoni lamin 0.0054 0.0716 0.074
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0044 0.055 0.0538
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0085 0.1239 0.1288
Brugia malayi heat shock protein 90 0.0047 0.0599 0.0619
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0292 0.0995
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0077 0.0417
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.048 0.0651
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0061 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0034 0.0313
Loa Loa (eye worm) hypothetical protein 0.0159 0.2506 0.2607
Schistosoma mansoni heat shock protein 0.0047 0.0599 0.0618
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0292 0.03
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0015 0.006 0.0584
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0038 0.0052
Leishmania major dehydrogenase-like protein 0.0012 0.0012 0.0086
Plasmodium falciparum heat shock protein 90 0.0047 0.0599 0.2089
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0111 0.011
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0012 0.0012 0.0066
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.015 0.0138
Brugia malayi tailless protein 0.004 0.048 0.0496
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.066 0.2308
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0083 0.1202 0.1249
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.048 0.0651
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0232 0.4107
Entamoeba histolytica ATP-binding cassette protein, putative 0.0015 0.006 0.0915
Leishmania major short chain dehydrogenase/reductase, putative 0.0012 0.0012 0.0086
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0077 0.0105
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0138 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0138 0.1406
Leishmania major DNA polymerase kappa, putative 0.002 0.0138 0.1406
Loa Loa (eye worm) heat shock protein 90 0.0047 0.0599 0.0621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Echinococcus multilocularis heat shock protein 0.0047 0.0599 0.0812
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0138 0.1406
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0083 0.1202 0.4236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.0104
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0106 0.0108
Giardia lamblia DINP protein human, muc B family 0.002 0.0138 0.2144
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0012 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0045 0.0562 0.0583
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0138 0.0126
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Onchocerca volvulus 0.004 0.048 0.1291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0178 0.282 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0085 0.1239 0.168
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0265 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0012 0.0012 0.0017
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0012 0.0086
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0106
Giardia lamblia Grp94/Hsp90 0.0044 0.055 0.9166
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.0012 0.0017
Echinococcus multilocularis ecdysone induced protein 78C 0.0085 0.1239 0.168
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0004 0.0002
Brugia malayi Hemopexin family protein 0.0024 0.0207 0.0212
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.001 0.0008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0619 0.0642
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Schistosoma mansoni retinal dehydrogenase 0.0012 0.0012 0.0007
Brugia malayi Matrixin family protein 0.0017 0.0088 0.0088
Brugia malayi Pre-SET motif family protein 0.0029 0.0292 0.0299
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0038 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Schistosoma mansoni heat shock protein 0.0031 0.0332 0.034
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.048 0.0496
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.1239 0.168
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0012 0.0086
Mycobacterium ulcerans dehydrogenase/reductase 0.0012 0.0012 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0085 0.1239 0.1288
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0021 0.015 0.0152
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.066 0.2308
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0152 0.0154
Brugia malayi Nuclear hormone receptor E75 0.004 0.048 0.0496
Brugia malayi sodium-independent organic anion transporter family protein 0.0121 0.1852 0.1924
Brugia malayi hypothetical protein 0.0158 0.2476 0.2573
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0392 0.0404
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.001 0.0004
Trypanosoma brucei p-glycoprotein 0.0015 0.006 0.0584
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.048 0.0651
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.0007
Leishmania major oxidoreductase-like protein 0.0012 0.0012 0.0086
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0138 0.0139
Leishmania major hypothetical protein, conserved 0.0012 0.0012 0.0086
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0136 0.0734
Loa Loa (eye worm) hypothetical protein 0.0019 0.0123 0.0126
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0088 0.009
Loa Loa (eye worm) hypothetical protein 0.0054 0.0716 0.0743
Plasmodium vivax vivapain-2 0.0018 0.0106 0.0332
Entamoeba histolytica hypothetical protein 0.0012 0.0012 0.0115
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.001 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0619 0.064
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.048 0.1291
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.0007
Onchocerca volvulus 0.0012 0.0012 0.0019
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0012 0.0012 0.0066
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.0007
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0106
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.048 0.0495
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.048 0.0498
Schistosoma mansoni hypothetical protein 0.0015 0.0061 0.0058
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0599 0.0618
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0085 0.1239 0.168
Brugia malayi hypothetical protein 0.0228 0.3675 0.3823
Schistosoma mansoni endoplasmin 0.0047 0.0599 0.0618
Echinococcus granulosus multidrug resistance associated protein 7 0.0015 0.006 0.0081
Echinococcus multilocularis geminin 0.0337 0.5522 0.7487
Brugia malayi prostaglandin transporter 0.0121 0.1852 0.1924
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0085 0.1239 0.168
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0106 0.0332
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0562 0.0581
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Schistosoma mansoni zinc finger protein 0.004 0.048 0.0495
Echinococcus granulosus heat shock protein 90 0.0047 0.0599 0.0812
Leishmania major heat shock protein, putative 0.0031 0.0332 0.3438
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.1239 0.1286
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0121 0.1852 0.2511
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.048 0.0498
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.001 0.0052
Brugia malayi Matrixin family protein 0.0017 0.0088 0.0088
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0017 0.0088 0.0086
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.0562 0.0583
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0077 0.0417
Loa Loa (eye worm) hypothetical protein 0.0033 0.0361 0.0373
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0619 0.064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Echinococcus multilocularis conserved hypothetical protein 0.0012 0.0012 0.0017
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.7376 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.1239 0.1286
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0085 0.1239 0.1285
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0012 0.0012 0.0019
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0232 0.022
Brugia malayi hypothetical protein 0.0012 0.0012 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0111 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0562 0.0581
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0012 0.0012 0.0019
Leishmania major hypothetical protein, conserved 0.0012 0.0012 0.0086
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.0562 0.0579
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0105
Leishmania major cathepsin L-like protease 0.0018 0.0106 0.1065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0085 0.1239 0.1288
Loa Loa (eye worm) matrixin family protein 0.0037 0.0436 0.0452
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0085 0.1239 0.168
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1877 0.1952
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0232 0.3811
Onchocerca volvulus 0.0083 0.1202 0.3252
Echinococcus granulosus dna polymerase kappa 0.002 0.0138 0.0187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0012 0.0086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0105
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Echinococcus granulosus endoplasmin 0.0044 0.055 0.0746
Schistosoma mansoni agrin 0.0083 0.1202 0.1246
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.066 0.2308
Trypanosoma cruzi short chain dehydrogenase, putative 0.0012 0.0012 0.0066
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Echinococcus granulosus oxidoreductase 0.0012 0.0012 0.0017
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.0012 0.0115
Entamoeba histolytica hypothetical protein 0.0015 0.006 0.0915
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0061 0.0083
Leishmania major hypothetical protein, conserved 0.0012 0.0012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0051 0.066 0.0685
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Echinococcus granulosus neuropeptide s receptor 0.0447 0.7376 1
Loa Loa (eye worm) matrixin family protein 0.0041 0.0493 0.0511
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0106 0.0143
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0957 0.5166
Brugia malayi nuclear hormone receptor 0.0085 0.1239 0.1286
Leishmania major cathepsin L-like protease 0.0018 0.0106 0.1065
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0123 0.0119
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Toxoplasma gondii transporter, major facilitator family protein 0.0121 0.1852 0.6551
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Plasmodium falciparum heat shock protein 90, putative 0.0178 0.282 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.001 0.0059
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Loa Loa (eye worm) dehydrogenase 0.0012 0.0012 0.0011
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0599 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0593 0.0613
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0012 0.0086
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.048 0.1291
Giardia lamblia Multidrug resistance-associated protein 1 0.0015 0.0058 0.0773
Onchocerca volvulus 0.004 0.048 0.1291
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0083 0.1202 0.1247
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.0498
Entamoeba histolytica hypothetical protein 0.0035 0.0402 0.6675
Echinococcus granulosus single minded 2 0.0035 0.0392 0.0532
Loa Loa (eye worm) fibroinase 0.0018 0.0106 0.0108
Entamoeba histolytica hypothetical protein 0.0035 0.0402 0.6675
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0085 0.1239 0.1285
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Schistosoma mansoni hypothetical protein 0.0015 0.0061 0.0058
Schistosoma mansoni nuclear receptor 0.004 0.048 0.0495
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0085 0.1239 0.1288
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0012 0.0017
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0012 0.0007
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0012 0.0012 0.0017
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0015 0.006 0.0584
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0012 0.0012 0.0086
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0292 0.0395
Echinococcus granulosus follistatin 0.0083 0.1202 0.1629
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.0104
Echinococcus granulosus multidrug resistance associated protein 1 0.0015 0.006 0.0081
Echinococcus multilocularis follistatin 0.0083 0.1202 0.1629
Echinococcus multilocularis agrin 0.0083 0.1202 0.1629
Echinococcus multilocularis GPCR, family 2 0.0015 0.0061 0.0083
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0232 0.0228
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0012 0.0012 0.0007
Echinococcus multilocularis small conductance calcium activated potassium 0.0159 0.2506 0.3398
Loa Loa (eye worm) steroid hormone receptor 0.0085 0.1239 0.1288
Trypanosoma cruzi small ubiquitin protein, putative 0.0033 0.0358 0.1931
Toxoplasma gondii exonuclease III APE 0.0018 0.0111 0.035
Schistosoma mansoni nuclear receptor 0.004 0.048 0.0495
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0106 0.0106
Onchocerca volvulus 0.0012 0.0012 0.0019
Brugia malayi intermediate filament protein 0.0054 0.0716 0.0741
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Onchocerca volvulus 0.0054 0.0716 0.1931
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.0012 0.0115
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.0012 0.0115
Onchocerca volvulus 0.0012 0.0012 0.0019
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.0012 0.0115
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0138 0.1406
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0036 0.0085
Echinococcus multilocularis transient receptor potential cation channel 0.0012 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0045 0.0562 0.0583
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0106
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.001 0.0004
Loa Loa (eye worm) SMO-1 protein 0.0033 0.0358 0.037
Trichomonas vaginalis endoplasmin, putative 0.0034 0.0381 0.0391
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0599 0.3234
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.048 0.0651
Loa Loa (eye worm) hypothetical protein 0.0029 0.0292 0.0301
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0857 0.4626
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0012 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0232 0.0237
Loa Loa (eye worm) hypothetical protein 0.0083 0.1202 0.1249
Loa Loa (eye worm) hypothetical protein 0.0121 0.1852 0.1926
Onchocerca volvulus 0.0035 0.0392 0.1052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0106 0.0093
Trypanosoma brucei heat shock protein, putative 0.0047 0.0599 0.6243
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0105
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0077 0.0065
Brugia malayi MH2 domain containing protein 0.0122 0.1877 0.195
Loa Loa (eye worm) hypothetical protein 0.0085 0.1239 0.1288
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0562 0.0579
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.001 0.0052
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.0562 0.0761
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0232 0.0228
Onchocerca volvulus 0.0012 0.0012 0.0019
Plasmodium falciparum small ubiquitin-related modifier 0.0033 0.0358 0.123
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.006 0.0169
Loa Loa (eye worm) hypothetical protein 0.0121 0.1852 0.1926
Onchocerca volvulus 0.0012 0.0012 0.0019
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Leishmania major cathepsin L-like protease 0.0018 0.0106 0.1065
Brugia malayi hypothetical protein 0.0012 0.0012 0.0008
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.001 0.0004
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0083 0.1202 0.4236
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0012 0.0007
Brugia malayi hypothetical protein 0.0121 0.1852 0.1924
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0232 0.022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0061 0.0059
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0012 0.0012 0.0115
Schistosoma mansoni hypothetical protein 0.0047 0.0593 0.0611
Trypanosoma brucei heat shock protein, putative 0.0047 0.0599 0.6243
Brugia malayi hypothetical protein 0.0051 0.066 0.0683
Onchocerca volvulus 0.0018 0.0106 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0012 0.0066
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0106 0.1687
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.1239 0.1286
Brugia malayi Cathepsin L-like precursor 0.0012 0.0005 0.0001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0106 0.0143
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.004 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0004
Trypanosoma brucei heat shock protein, putative 0.0047 0.0599 0.6243
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.0012 0.0008
Brugia malayi dehydrogenases, short chain protein 2 0.0012 0.0012 0.0008
Echinococcus granulosus cathepsin l1 0.0018 0.0106 0.0143
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.3675 0.4983
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.0012 0.0008
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0599 0.3234
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0012 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.0104
Onchocerca volvulus 0.0054 0.0716 0.1931
Echinococcus granulosus ecdysone induced protein 78C 0.0085 0.1239 0.168
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0004
Echinococcus multilocularis musashi 0.0054 0.0716 0.097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.0104
Brugia malayi oxidoreductase 0.0012 0.0012 0.0008
Trichomonas vaginalis heat shock protein, putative 0.0044 0.055 0.0567
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0012 0.0017
Plasmodium vivax endoplasmin, putative 0.0047 0.0599 0.2089
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.004 0.0484 0.0656
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0015 0.006 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Loa Loa (eye worm) hypothetical protein 0.0019 0.0123 0.0126
Treponema pallidum heat shock protein 90 0.0044 0.055 1
Leishmania major hypothetical protein, conserved 0.0012 0.0012 0.0086
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0012 0.0086
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1877 0.1952
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Schistosoma mansoni hypothetical protein 0.0015 0.0061 0.0058
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.004 0.048 0.0495
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0085 0.1239 0.168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0292 0.0298
Trypanosoma cruzi small ubiquitin protein, putative 0.0033 0.0358 0.1931
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0332 0.045
Leishmania major DNA polymerase eta, putative 0.002 0.0138 0.1406
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0015 0.006 0.0584
Loa Loa (eye worm) hypothetical protein 0.0045 0.0562 0.0583
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0012 0.0086
Echinococcus multilocularis oxidoreductase 0.0012 0.0012 0.0017
Entamoeba histolytica ATP-binding cassette protein, putative 0.0015 0.006 0.0915
Leishmania major short chain dehydrogenase, putative 0.0012 0.0012 0.0086
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0599 1
Echinococcus granulosus steroid dehydrogenase 0.0012 0.0012 0.0017
Brugia malayi Dehydrogenases, short chain protein 30 0.0012 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0243 0.0251
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0154
Toxoplasma gondii protease inhibitor PI2 0.0083 0.1202 0.4236
Onchocerca volvulus 0.0012 0.0012 0.0019
Brugia malayi Death domain containing protein 0.0014 0.0038 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0138 0.1406
Brugia malayi hypothetical protein 0.004 0.048 0.0496
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0012 0.0086
Schistosoma mansoni carbonyl reductase 0.0012 0.0012 0.0007
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0015 0.006 0.0584
Echinococcus multilocularis lamin dm0 0.0054 0.0716 0.097
Schistosoma mansoni thyroid hormone receptor 0.0085 0.1239 0.1285
Brugia malayi hypothetical protein 0.004 0.048 0.0496
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0232 0.0237
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0085 0.1239 0.1285
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0111 0.035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0123 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0138 0.1406
Mycobacterium ulcerans hypothetical protein 0.0025 0.0232 0.0228
Schistosoma mansoni nuclear hormone receptor 0.0085 0.1239 0.1285
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0012 0.0012 0.0008
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.001 0.0004
Loa Loa (eye worm) hypoxia-induced factor 1 0.0145 0.2268 0.2359
Trypanosoma brucei heat shock protein, putative 0.0047 0.0599 0.6243
Onchocerca volvulus 0.0012 0.0012 0.0019
Echinococcus granulosus heat shock protein 0.0047 0.0599 0.0812
Echinococcus multilocularis multidrug resistance associated protein 7 0.0015 0.006 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.0104
Loa Loa (eye worm) hypothetical protein 0.0085 0.1239 0.1288
Loa Loa (eye worm) hypothetical protein 0.0121 0.1852 0.1926
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0079 0.0076
Onchocerca volvulus 0.0012 0.0012 0.0019
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0085 0.1239 0.3355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.0104
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Schistosoma mansoni multidrug resistance protein 0.0015 0.006 0.0057
Leishmania major ABC-thiol transporter 0.0015 0.006 0.0584
Echinococcus multilocularis thyroid hormone receptor alpha 0.0085 0.1239 0.168
Loa Loa (eye worm) oxidoreductase 0.0012 0.0012 0.0011
Echinococcus granulosus dna polymerase eta 0.002 0.0138 0.0187
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0332 0.0887
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0077 0.0231
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0077 0.0231
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Brugia malayi ecdysteroid receptor 0.0085 0.1239 0.1286
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0716 0.0743
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0061 0.0841 0.114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0081 0.0083
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Brugia malayi isocitrate dehydrogenase 0.0016 0.0077 0.0076
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.001 0.0004
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0077 0.0767
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.048 0.0651
Echinococcus granulosus Small ubiquitin modifier 2 0.0033 0.0358 0.0485
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0085 0.1239 0.1285
Trypanosoma brucei unspecified product 0.002 0.0138 0.1406
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0106 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0957 1
Brugia malayi hypothetical protein 0.0045 0.0562 0.0581
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.0012 0.0017
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0038 0.0089
Onchocerca volvulus 0.0018 0.0106 0.0272
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.001 0.0013
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0106 0.0272
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0105
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0402 0.0544
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0111 0.015
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0012 0.0012 0.0011
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0957 0.5166
Leishmania major cathepsin L-like protease 0.0068 0.0957 1
Schistosoma mansoni hypothetical protein 0.0033 0.0361 0.037
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.048 0.0651
Loa Loa (eye worm) hypothetical protein 0.0228 0.3675 0.3824
Onchocerca volvulus 0.002 0.0138 0.0361
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0012 0.0012 0.0066
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0187 0.0254
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0232 0.0228
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0012 0.0017
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0005 0.0001
Schistosoma mansoni carbonyl reductase 0.0012 0.0012 0.0007
Echinococcus granulosus death domain containing protein 0.0014 0.0038 0.0052
Brugia malayi hypothetical protein 0.0033 0.0356 0.0367
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.0012 0.0017
Entamoeba histolytica ATP-binding cassette protein, putative 0.0015 0.006 0.0915
Echinococcus granulosus hypothetical protein 0.0012 0.0012 0.0017
Leishmania major heat shock protein 83-1 0.0047 0.0599 0.6243
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0292 0.0298
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0957 0.5166
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.3675 0.4983
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0077 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Mycobacterium ulcerans oxidoreductase 0.0012 0.0012 0.0008
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.048 0.0651
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0138 0.1406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0047
Echinococcus multilocularis heat shock protein 90 0.0047 0.0599 0.0812
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0012 0.0012 0.0047
Leishmania major pteridine reductase 1 0.0012 0.0012 0.0086
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.0012 0.0017
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.0012 0.0066
Schistosoma mansoni intermediate filament proteins 0.0054 0.0716 0.074
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0106 0.0143
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0599 0.6243
Echinococcus multilocularis dna polymerase eta 0.002 0.0138 0.0187
Onchocerca volvulus 0.0018 0.0106 0.0272
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0012 0.0012 0.0066
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0008
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0012 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.0562 0.0583
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0402 0.0544
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.071 0.3833
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0085 0.1239 0.168
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0138 0.0134
Echinococcus granulosus hypothetical protein 0.0012 0.0012 0.0017
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0012 0.0012 0.0017
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0106 0.0143
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.011 0.0347
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.066 0.3565
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0012 0.0012 0.0047
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0111 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0138 0.1406
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0085 0.1239 0.168
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0012 0.0008
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0716 0.0743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.0104
Schistosoma mansoni multidrug resistance protein 0.0015 0.006 0.0057
Onchocerca volvulus 0.0018 0.0106 0.0272

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) 0 Antiviral activity against HIV-1 was determined; No inhibition ChEMBL. 2391689
Inhibition (functional) 0 Antiviral activity against HCMV was determined; No inhibition ChEMBL. 2391689
MCC (functional) > 400 ug ml-1 Tested for the minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology in human embryonic skin muscle (E6SM) fibroblast cell cultures. ChEMBL. 7877148
MIC (functional) = 0.01 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce VZV TK-(YS/R) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 0.03 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce VZV TK+(OKA) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 0.04 mg ml-1 Minimum inhibitory concentration required to reduce VZV TK-(07-1) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 0.05 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce VZV TK+(YS) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 0.1 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce HSV-1 TK-(B2006) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 0.1 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce HSV-2(G) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 0.15 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce CMV(AD-169) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 0.2 mg ml-1 Compound was tested in vitro for minimum inhibitory concentration required to reduce HSV-1(KOS) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 0.2 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce CMV(Davis) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 0.7 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce VV induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 3.7 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce MSV induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) > 20 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce HSV-1(IIIb) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) > 20 mg ml-1 Compound was tested in vitro for Minimum inhibitory concentration required to reduce HSV-2(ROD) induced cytopathicity in Human MT-4 cells ChEMBL. 8765509
MIC (functional) = 0.02 ug ml-1 Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-2) strain G induced cytopathogenicity by 50%. ChEMBL. 7877148
MIC (functional) = 0.07 ug ml-1 Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-2) strain 196 induced cytopathogenicity by 50%. ChEMBL. 7877148
MIC (functional) = 0.1 ug ml-1 Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-2) strain Lyons induced cytopathogenicity by 50%. ChEMBL. 7877148
MIC (functional) = 0.2 ug ml-1 Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-1) strain KOS induced cytopathogenicity by 50%. ChEMBL. 7877148
MIC (functional) = 0.2 ug ml-1 Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-1) strain F induced cytopathogenicity by 50%. ChEMBL. 7877148
MIC (functional) = 0.7 ug ml-1 Tested for the minimum inhibitory concentration required to reduce vaccinia virus(VV) induced cytopathogenicity by 50%. ChEMBL. 7877148
MIC (functional) = 1 ug ml-1 Tested for the minimum inhibitory concentration required to reduce thymidine kinase deficient herpes simplex virus type 1 (TK- HSV-1) strain B2006 induced cytopathogenicity by 50%. ChEMBL. 7877148
MIC (functional) = 1 ug ml-1 Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (TK- / TK+ HSV-1) strain VMW-1837 induced cytopathogenicity by 50%. ChEMBL. 7877148
MIC (functional) = 2 ug ml-1 Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-1) strain McIntyre induced cytopathogenicity by 50%. ChEMBL. 7877148
MIC (functional) > 400 ug ml-1 Tested for the minimum inhibitory concentration required to reduce vesicular stomatitis virus(VSV) induced cytopathogenicity by 50% ChEMBL. 7877148

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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