Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.049 | 0.0166 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0148 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.3599 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.0335 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.3599 | 1 |
Brugia malayi | hypothetical protein | 0.0079 | 0.3599 | 0.3545 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.0335 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.049 | 0.0409 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0079 | 0.3599 | 0.3269 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.3599 | 1 |
Brugia malayi | hypothetical protein | 0.0121 | 0.7562 | 0.7542 |
Onchocerca volvulus | Huntingtin homolog | 0.0121 | 0.7562 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.7562 | 0.7542 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.7562 | 0.7542 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0143 | 0.9616 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0148 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0121 | 0.7562 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1831 | 0.1762 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.049 | 0.0409 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.3599 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.049 | 0.0409 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.0335 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.0335 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.0335 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0148 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0079 | 0.3599 | 0.3516 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.049 | 0.0166 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1831 | 0.1762 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0079 | 0.3599 | 0.3545 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1831 | 0.1762 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1831 | 0.1762 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.049 | 0.0409 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.3599 | 0.3545 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.049 | 0.0409 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 1000 uM | Agonist effect for Ionotropic glutamate receptor AMPA was determined from in vitro electrophysiology studies using rat cortical wedge preparation. | ChEMBL. | 9651156 |
EC50 (functional) | > 1000 uM | Agonist effect for Ionotropic glutamate receptor AMPA was determined from in vitro electrophysiology studies using rat cortical wedge preparation. | ChEMBL. | 9651156 |
IC50 (binding) | = 100 uM | Ability to inhibit the binding of [3H]-AMPA radioligand to Ionotropic glutamate receptor AMPA in rat brain membranes. | ChEMBL. | 9651156 |
IC50 (binding) | > 100 uM | Ability to inhibit the binding of [3H]-kainic acid radioligand to Ionotropic glutamate receptor kainate in rat brain membranes. | ChEMBL. | 9651156 |
IC50 (binding) | > 100 uM | Ability to inhibit the binding of [3H]-CPP radioligand to N-methyl-D-aspartate glutamate receptor in rat brain membranes. | ChEMBL. | 9651156 |
IC50 (binding) | = 100 uM | Ability to inhibit the binding of [3H]-AMPA radioligand to Ionotropic glutamate receptor AMPA in rat brain membranes. | ChEMBL. | 9651156 |
IC50 (binding) | > 100 uM | Ability to inhibit the binding of [3H]-kainic acid radioligand to Ionotropic glutamate receptor kainate in rat brain membranes. | ChEMBL. | 9651156 |
IC50 (binding) | > 100 uM | Ability to inhibit the binding of [3H]-CPP radioligand to N-methyl-D-aspartate glutamate receptor in rat brain membranes. | ChEMBL. | 9651156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.