Detailed information for compound 1360845

Basic information

Technical information
  • TDR Targets ID: 1360845
  • Name: 5-ethyl-N-[1-[(4-fluorophenyl)methyl]pyrazol- 4-yl]-1,2-oxazole-3-carboxamide
  • MW: 314.314 | Formula: C16H15FN4O2
  • H donors: 1 H acceptors: 3 LogP: 2.38 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1onc(c1)C(=O)Nc1cnn(c1)Cc1ccc(cc1)F
  • InChi: 1S/C16H15FN4O2/c1-2-14-7-15(20-23-14)16(22)19-13-8-18-21(10-13)9-11-3-5-12(17)6-4-11/h3-8,10H,2,9H2,1H3,(H,19,22)
  • InChiKey: WQYUWIANSXGDDU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-ethyl-N-[1-[(4-fluorophenyl)methyl]pyrazol-4-yl]isoxazole-3-carboxamide
  • 5-ethyl-N-[1-[(4-fluorophenyl)methyl]-4-pyrazolyl]-3-isoxazolecarboxamide
  • 5-ethyl-N-[1-(4-fluorobenzyl)pyrazol-4-yl]isoxazole-3-carboxamide
  • C226-2838
  • NCGC00105636-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Onchocerca volvulus 0.0064 0.7202 0.5
Onchocerca volvulus 0.0064 0.7202 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.7202 0.7202
Brugia malayi hypothetical protein 0.0064 0.7202 0.7202
Onchocerca volvulus 0.0064 0.7202 0.5
Toxoplasma gondii rhoptry neck protein RON1 0.0064 0.7202 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.7202 0.7202
Onchocerca volvulus 0.0064 0.7202 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.7202 0.7202
Plasmodium vivax apical sushi protein, putative 0.0064 0.7202 1
Echinococcus multilocularis tar DNA binding protein 0.0076 1 1
Onchocerca volvulus 0.0064 0.7202 0.5
Onchocerca volvulus 0.0064 0.7202 0.5
Brugia malayi TAR-binding protein 0.0076 1 1
Loa Loa (eye worm) TAR-binding protein 0.0076 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Leishmania major hypothetical protein, conserved 0.003 0 0.5
Brugia malayi Sushi domain 0.0064 0.7202 0.7202
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi pregnancy-associated plasma protein-A 0.0064 0.7202 0.7202
Brugia malayi hypothetical protein 0.0064 0.7202 0.7202
Onchocerca volvulus 0.0064 0.7202 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.7202 0.7202
Loa Loa (eye worm) hypothetical protein 0.0071 0.8752 0.8752
Brugia malayi GCC2 and GCC3 family protein 0.0064 0.7202 0.7202
Onchocerca volvulus 0.0064 0.7202 0.5
Brugia malayi hypothetical protein 0.0064 0.7202 0.7202
Brugia malayi RNA recognition motif domain containing protein 0.0076 1 1
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0064 0.7202 0.7202
Brugia malayi hypothetical protein 0.0064 0.7202 0.7202
Loa Loa (eye worm) RNA binding protein 0.0076 1 1
Echinococcus granulosus tar DNA binding protein 0.0076 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi hypothetical protein 0.0064 0.7202 0.7202
Onchocerca volvulus 0.0064 0.7202 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 1 1
Brugia malayi hypothetical protein 0.0064 0.7202 0.7202
Toxoplasma gondii rhoptry neck protein RON9 0.0064 0.7202 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.7202 0.7202
Plasmodium falciparum apical sushi protein 0.0064 0.7202 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.7202 0.7202
Onchocerca volvulus 0.0064 0.7202 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.7202 0.7202
Brugia malayi hypothetical protein 0.0064 0.7202 0.7202
Loa Loa (eye worm) hypothetical protein 0.0064 0.7202 0.7202

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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