Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0134 | 0.9256 | 0.9256 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0023 | 0.0956 | 0.1033 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.9256 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 0.9256 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0023 | 0.0956 | 0.1033 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0956 | 0.0956 |
Schistosoma mansoni | acetylcholinesterase | 0.0023 | 0.0956 | 0.1033 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0956 | 0.1033 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0956 | 0.0956 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0956 | 0.0956 |
Onchocerca volvulus | 0.0023 | 0.0956 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.9256 | 0.9256 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.9256 | 0.9256 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0.0956 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0134 | 0.9256 | 0.9256 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.9256 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.9256 | 0.9256 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0956 | 0.0956 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0134 | 0.9256 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.0956 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.9256 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0023 | 0.0956 | 0.1033 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0956 | 0.1033 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.9256 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0956 | 0.0956 |
Echinococcus granulosus | neuroligin | 0.0023 | 0.0956 | 0.1033 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0956 | 0.0956 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0956 | 0.0956 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0023 | 0.0956 | 0.5 |
Onchocerca volvulus | 0.0023 | 0.0956 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0023 | 0.0956 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.0956 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0.0956 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0023 | 0.0956 | 0.1033 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.9256 | 0.9256 |
Onchocerca volvulus | 0.0023 | 0.0956 | 0.5 | |
Schistosoma mansoni | gliotactin | 0.0023 | 0.0956 | 0.1033 |
Echinococcus granulosus | carboxylesterase 5A | 0.0134 | 0.9256 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0956 | 0.0956 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0956 | 0.0956 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0956 | 0.0956 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0956 | 0.1033 |
Echinococcus multilocularis | neuroligin | 0.0023 | 0.0956 | 0.1033 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0956 | 0.0956 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0023 | 0.0956 | 0.1033 |
Onchocerca volvulus | 0.0023 | 0.0956 | 0.5 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0023 | 0.0956 | 0.1033 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0023 | 0.0956 | 0.1033 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0023 | 0.0956 | 0.1033 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0956 | 0.0956 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0956 | 0.0956 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0956 | 0.0956 |
Onchocerca volvulus | 0.0023 | 0.0956 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1259 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.