Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0218 | 0.4803 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0268 | 0.6688 | 0.6688 |
Toxoplasma gondii | kringle domain-containing protein | 0.0268 | 0.6688 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0356 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0268 | 0.6688 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0356 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0218 | 0.4803 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0218 | 0.4803 | 0.6646 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.6688 | 0.6688 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.5125 | 0.5125 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0268 | 0.6688 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0218 | 0.4803 | 0.4182 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0227 | 0.5125 | 0.4543 |
Mycobacterium ulcerans | proteasome PrcB | 0.0218 | 0.4803 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0268 | 0.6688 | 0.6688 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0268 | 0.6688 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0218 | 0.4803 | 0.6646 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0268 | 0.6688 | 0.6293 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0218 | 0.4803 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0227 | 0.5125 | 0.4543 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.5125 | 0.5125 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0218 | 0.4803 | 0.4803 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0218 | 0.4803 | 0.6646 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0218 | 0.4803 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0218 | 0.4803 | 0.4182 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0356 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0268 | 0.6688 | 0.6293 |
Brugia malayi | Protein kinase domain containing protein | 0.0268 | 0.6688 | 0.6688 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0218 | 0.4803 | 0.4803 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0218 | 0.4803 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0356 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0268 | 0.6688 | 0.6293 |
Onchocerca volvulus | 0.0227 | 0.5125 | 0.2964 | |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0218 | 0.4803 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0356 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0218 | 0.4803 | 0.6646 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0268 | 0.6688 | 1 |
Onchocerca volvulus | 0.0268 | 0.6688 | 0.5221 | |
Brugia malayi | prolyl oligopeptidase family protein | 0.012 | 0.1067 | 0.1067 |
Brugia malayi | Trypsin family protein | 0.0227 | 0.5125 | 0.5125 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0218 | 0.4803 | 0.4182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.