TDR Targets

Basic information

Technical information

TDR Targets ID: 1361147
Name: 1-(4-bromophenyl)-2-[[5-(4-ethoxyphenyl)-4-ph enyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
MW: 494.404 | Formula: C24H20BrN3O2S
H donors: 0 H acceptors: 3 LogP: 6.03 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)c1nnc(n1c1ccccc1)SCC(=O)c1ccc(cc1)Br
InChi: 1S/C24H20BrN3O2S/c1-2-30-21-14-10-18(11-15-21)23-26-27-24(28(23)20-6-4-3-5-7-20)31-16-22(29)17-8-12-19(25)13-9-17/h3-15H,2,16H2,1H3
InChiKey: GTRCURCHUHPIDY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

1-(4-bromophenyl)-2-[[5-(4-ethoxyphenyl)-4-phenyl-1,2,4-triazol-3-yl]thio]ethanone
NCGC00102354-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references
Homo sapiens	thyroid hormone receptor, beta	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	relaxin/insulin-like family peptide receptor 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	expressed protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	thyroid hormone receptor alpha	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, beta	461 aa	414 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Kinase, CMGC GSK	0.0462	0.3237	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.009	0.0276
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0165	0.1049	0.324
Echinococcus granulosus	nuclear receptor nhr 48	0.0048	0.0183	0.0566
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0133	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0165	0.1049	0.324
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0165	0.1049	0.324
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.009	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.1378	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0165	0.1049	0.1049
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0119	0.0119
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0165	0.1049	0.324
Echinococcus multilocularis	ecdysone induced protein 78C	0.0165	0.1049	0.324
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0117	0.0693	0.2142
Onchocerca volvulus		0.0462	0.3237	0.3235
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0334	0.1032
Brugia malayi	eukaryotic initiation factor 4A	0.0024	0.0004	0.0004
Entamoeba histolytica	protein kinase, putative	0.0462	0.3237	1
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0149	0.0459
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0035	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Leishmania major	hypothetical protein, conserved	0.0024	0.0008	0.0024
Mycobacterium tuberculosis	Conserved protein	0.0035	0.009	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0112	0.0345
Brugia malayi	intracellular kinase	0.0462	0.3237	0.3237
Brugia malayi	beta-lactamase family protein	0.0035	0.009	0.009
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0024	0.0004	0.0012
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0048	0.0183	0.0566
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0048	0.0183	0.0566
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0024	0.0004	0.0012
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0048	0.0183	0.0566
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0048	0.0183	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Echinococcus multilocularis	FTZ F1 alpha	0.0165	0.1049	0.324
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0462	0.3237	1
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0133	0.0411
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0024	0.0004	0.0012
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0024	0.0004	0.0012
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0462	0.3237	0.3237
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0165	0.1049	0.324
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.009	0.0265
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0165	0.1049	0.324
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0165	0.1049	0.324
Brugia malayi	nuclear receptor RXR	0.0117	0.0693	0.0693
Brugia malayi	nuclear hormone receptor	0.0165	0.1049	0.1049
Brugia malayi	beta-lactamase family protein	0.0035	0.009	0.009
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.009	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1049	0.1049
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0048	0.0183	0.0183
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0165	0.1049	0.1049
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0165	0.1049	0.1049
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0008	0.0024
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0063	0.029	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0035	0.009	0.009
Echinococcus granulosus	chromobox protein 1	0.0069	0.0334	0.1032
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0165	0.1049	0.324
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0008	0.0008
Mycobacterium ulcerans	hypothetical protein	0.0035	0.009	0.3082
Brugia malayi	hypothetical protein	0.0117	0.0693	0.0693
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0063	0.029	0.0897
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0117	0.0693	0.2142
Mycobacterium ulcerans	lipase LipD	0.0035	0.009	0.3082
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Brugia malayi	nuclear receptor NHR-88	0.0048	0.0183	0.0183
Echinococcus granulosus	thyroid hormone receptor alpha	0.0048	0.0183	0.0566
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0165	0.1049	0.324
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.009	0.0597
Leishmania major	eukaryotic initiation factor 4a, putative	0.0024	0.0004	0.0012
Onchocerca volvulus		0.003	0.005	0.0046
Brugia malayi	hypothetical protein	0.0048	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.009	0.3082
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0165	0.1049	0.1049
Onchocerca volvulus	Protein ultraspiracle homolog	0.0165	0.1049	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0035	0.009	0.009
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0149	0.0459
Schistosoma mansoni	thyroid hormone receptor	0.0317	0.2171	0.6707
Toxoplasma gondii	ABC1 family protein	0.0035	0.009	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0693	0.0693
Brugia malayi	Nuclear hormone receptor-like 1	0.0117	0.0693	0.0693
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0165	0.1049	0.1049
Loa Loa (eye worm)	steroid hormone receptor	0.0165	0.1049	0.1049
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0048	0.0183	0.0566
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.009	0.0276
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0165	0.1049	0.324
Echinococcus granulosus	protein kinase shaggy	0.0462	0.3237	1
Brugia malayi	hypothetical protein	0.0048	0.0183	0.0183
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0008	0.0012
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0024	0.0004	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0029	0.0089
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0165	0.1049	0.1049
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0048	0.0183	0.0179
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0063	0.029	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0119	0.0119
Plasmodium falciparum	glycogen synthase kinase 3	0.0462	0.3237	1
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0462	0.3237	0.3237
Giardia lamblia	Kinase, CMGC GSK	0.0462	0.3237	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0149	0.0459
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0165	0.1049	0.1049
Brugia malayi	nuclear receptor RXR	0.0048	0.0183	0.0183
Leishmania major	hypothetical protein, conserved	0.0035	0.009	0.0276
Onchocerca volvulus		0.0048	0.0183	0.0179
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.009	0.0276
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0254	0.0254
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0165	0.1049	0.324
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0112	0.0112
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.009	0.0597
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0334	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Entamoeba histolytica	hypothetical protein	0.0043	0.0149	0.0459
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0165	0.1049	0.1049
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0165	0.1049	0.324
Brugia malayi	hypothetical protein	0.0024	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0693	0.0693
Mycobacterium leprae	Probable lipase LipE	0.0035	0.009	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.029	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0165	0.1049	0.324
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.009	0.009
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0334	0.1032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0165	0.1049	0.1049
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.009	0.0597
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0334	0.0334
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0024	0.0004	0.0026
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0048	0.0183	0.0183
Brugia malayi	ecdysone receptor	0.0048	0.0183	0.0183
Brugia malayi	Steroid receptor seven-up type 2	0.0165	0.1049	0.1049
Brugia malayi	beta-lactamase	0.0035	0.009	0.009
Schistosoma mansoni	nuclear receptor nhr-48	0.0048	0.0183	0.0566
Brugia malayi	chromobox protein homolog 3	0.0038	0.0112	0.0112
Brugia malayi	steroid hormone receptor	0.0165	0.1049	0.1049
Treponema pallidum	ATP-dependent RNA helicase	0.0024	0.0004	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.009	0.0276
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0048	0.0183	0.0183
Loa Loa (eye worm)	nuclear hormone receptor	0.0048	0.0183	0.0183
Brugia malayi	nuclear hormone receptor family member odr-7	0.0048	0.0183	0.0183
Entamoeba histolytica	protein kinase domain containing protein	0.0462	0.3237	1
Brugia malayi	hypothetical protein	0.0117	0.0693	0.0693
Schistosoma mansoni	hypothetical protein	0.0039	0.0119	0.0368
Loa Loa (eye worm)	DR-78	0.0048	0.0183	0.0183
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0008	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1049	0.1049
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0024	0.0004	0.0012
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0462	0.3237	1
Trichomonas vaginalis	CMGC family protein kinase	0.0462	0.3237	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0112	0.0345
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0165	0.1049	0.324
Brugia malayi	photoreceptor-specific nuclear receptor	0.0165	0.1049	0.1049
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0462	0.3237	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Trichomonas vaginalis	esterase, putative	0.0035	0.009	0.0276
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0165	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1049	0.1049
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.009	0.0276
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0112	0.0108
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.009	0.0597
Schistosoma mansoni	chromobox protein	0.0069	0.0334	0.1032
Schistosoma mansoni	coup transcription factor	0.0165	0.1049	0.324
Brugia malayi	nuclear hormone receptor	0.0048	0.0183	0.0183
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0024	0.0004	0.0012
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0317	0.2171	0.6707
Loa Loa (eye worm)	hypothetical protein	0.0035	0.009	0.009
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.029	0.0897
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0165	0.1049	0.324
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0165	0.1049	0.1049
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0008	0.0012
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.009	0.0276
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0165	0.1049	0.1049
Mycobacterium ulcerans	beta-lactamase	0.0035	0.009	0.3082
Trichomonas vaginalis	CMGC family protein kinase	0.0462	0.3237	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.009	0.009
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0165	0.1049	0.1049
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0165	0.1049	0.1049
Echinococcus granulosus	ecdysone induced protein 78C	0.0165	0.1049	0.324
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0152	0.095	0.2936
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0029	0.0089
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0165	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0693	0.0693
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0048	0.0183	0.0566
Entamoeba histolytica	hypothetical protein	0.0043	0.0149	0.0459
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.009	0.0597
Schistosoma mansoni	nuclear hormone receptor	0.0165	0.1049	0.324
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Loa Loa (eye worm)	beta-lactamase	0.0035	0.009	0.009
Schistosoma mansoni	RAR-like nuclear receptor	0.0165	0.1049	0.324
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.009	0.0276
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0152	0.095	0.2936
Onchocerca volvulus		0.0035	0.009	0.0086
Schistosoma mansoni	nuclear hormone receptor	0.0048	0.0183	0.0566
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0024	0.0004	0.0012
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0048	0.0183	0.0566
Echinococcus granulosus	FTZ F1 alpha	0.0165	0.1049	0.324
Brugia malayi	tailless protein	0.0048	0.0183	0.0183
Brugia malayi	nuclear receptor NHR-88	0.0165	0.1049	0.1049
Onchocerca volvulus		0.0048	0.0183	0.0179
Schistosoma mansoni	nuclear receptor	0.0048	0.0183	0.0566
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0048	0.0183	0.0179
Loa Loa (eye worm)	hypothetical protein	0.003	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0693	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0693	0.0693
Brugia malayi	Nuclear hormone receptor-like 1	0.0165	0.1049	0.1049
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0024	0.0004	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Entamoeba histolytica	protein kinase domain containing protein	0.0462	0.3237	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0165	0.1049	0.1049
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0149	0.0459
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0165	0.1049	0.1049
Onchocerca volvulus		0.0035	0.009	0.0086
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0462	0.3237	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Brugia malayi	hypothetical protein	0.0043	0.0149	0.0149
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.009	0.0597
Trypanosoma brucei	protein kinase, putative	0.0462	0.3237	1
Schistosoma mansoni	nuclear receptor	0.0048	0.0183	0.0566
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.1499	1
Echinococcus multilocularis	protein kinase shaggy	0.0462	0.3237	1
Brugia malayi	conserved hypotetical protein	0.0048	0.0183	0.0183
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0165	0.1049	0.1045
Entamoeba histolytica	hypothetical protein	0.0043	0.0149	0.0459
Schistosoma mansoni	hypothetical protein	0.0152	0.095	0.2936
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0462	0.3237	1
Schistosoma mansoni	nuclear hormone receptor	0.0048	0.0183	0.0566
Toxoplasma gondii	aldehyde dehydrogenase	0.0063	0.029	0.0886
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0165	0.1049	0.324
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0048	0.0183	0.0566
Brugia malayi	orphan nuclear receptor NR2E1	0.0048	0.0183	0.0183
Brugia malayi	nuclear receptor NHR-67	0.0048	0.0183	0.0183
Schistosoma mansoni	zinc finger protein	0.0048	0.0183	0.0566
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0048	0.0183	0.0566
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0048	0.0183	0.0183
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0024	0.0004	0.0012
Leishmania major	eukaryotic initiation factor 4a, putative	0.0024	0.0004	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1049	0.1049
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0165	0.1049	0.1049
Onchocerca volvulus		0.0165	0.1049	0.1045
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.029	1
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0024	0.0004	0.0012
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0063	0.029	0.0897
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0334	0.1032
Schistosoma mansoni	retinoic acid receptor RXR	0.0165	0.1049	0.324
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.009	0.3082
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0117	0.0693	0.2142
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.009	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0165	0.1049	0.324
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0165	0.1049	0.324
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.029	0.0897
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0024	0.0004	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0165	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0254	0.0254
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0165	0.1049	0.1049
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0008	0.0012
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0165	0.1049	0.324
Mycobacterium tuberculosis	Conserved protein	0.0035	0.009	0.0597
Brugia malayi	Nuclear hormone receptor-like 1	0.0117	0.0693	0.0693
Echinococcus multilocularis	nuclear receptor nhr 48	0.0048	0.0183	0.0566
Echinococcus granulosus	chromobox protein 1	0.0069	0.0334	0.1032
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0165	0.1049	0.324
Brugia malayi	Nuclear hormone receptor E75	0.0048	0.0183	0.0183
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.009	0.0276
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0008	0.0024
Mycobacterium tuberculosis	Conserved protein	0.0035	0.009	0.0597
Schistosoma mansoni	thyroid hormone receptor	0.0317	0.2171	0.6707
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0048	0.0183	0.0566
Brugia malayi	Nuclear hormone receptor E75	0.0048	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0035	0.009	0.009
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.009	0.0597
Onchocerca volvulus	Bile acid receptor homolog	0.1378	1	1
Schistosoma mansoni	chromobox protein	0.0069	0.0334	0.1032
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0133	0.0411
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.009	0.0276
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0462	0.3237	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0254	0.0254
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0024	0.0004	0.0012
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0117	0.0693	0.0693
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0048	0.0183	0.0566
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0008	0.0012
Onchocerca volvulus		0.0035	0.009	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0035	0.009	0.009
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.009	0.0276
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0024	0.0004	0.0012
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.029	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1049	0.1049
Brugia malayi	Heterochromatin protein 1	0.0069	0.0334	0.0334
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0117	0.0693	0.2142
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0462	0.3237	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0149	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0004	0.0004

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.9093 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	= 3.5481 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	141.2538 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1473564

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1361147