Detailed information for compound 1361695

Basic information

Technical information
  • TDR Targets ID: 1361695
  • Name: N,N'-bis(3-phenylpropyl)hexanediamide
  • MW: 380.523 | Formula: C24H32N2O2
  • H donors: 2 H acceptors: 2 LogP: 4.06 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCCCc1ccccc1)CCCCC(=O)NCCCc1ccccc1
  • InChi: 1S/C24H32N2O2/c27-23(25-19-9-15-21-11-3-1-4-12-21)17-7-8-18-24(28)26-20-10-16-22-13-5-2-6-14-22/h1-6,11-14H,7-10,15-20H2,(H,25,27)(H,26,28)
  • InChiKey: AUQJAOVVVXCWCN-UHFFFAOYSA-N  

Network

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Synonyms

  • N,N'-bis(3-phenylpropyl)adipamide
  • SMR000497504
  • ZINC04894578
  • IVK/8197394
  • MLS001000900

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0232 0.8589
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0154 0.0046
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0121 0.2587
Onchocerca volvulus 0.003 0.0089 0.5875
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0044 0.0154 0.1236
Entamoeba histolytica hypothetical protein 0.0076 0.0304 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0152 0.0141
Schistosoma mansoni hypothetical protein 0.0076 0.0304 0.1199
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0843
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0075 0.0617
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0105 0.2216
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.0119
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0242 0.1085 0.8731
Echinococcus granulosus Smad4 0.0018 0.0034 0.0132
Schistosoma mansoni smad 0.0018 0.0034 0.0132
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.003 0.0119
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0244
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0011 0.0103
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0064 0.1297
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0022 0.0077
Giardia lamblia Hypothetical protein 0.0033 0.0105 0.076
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0281 0.111
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0034 0.0132
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2134 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0075 0.2789
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0275 0.1243 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0121 0.2587
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0152 0.0599
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0304 0.1199
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0033 0.0105 0.2216
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0061 0.0232 0.0835
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0127 0.1043
Trypanosoma brucei unspecified product 0.003 0.009 0.1872
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Trypanosoma cruzi DNA polymerase eta, putative 0.0073 0.029 0.6397
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0271 0.1222 0.1562
Loa Loa (eye worm) hypothetical protein 0.0043 0.0152 0.1221
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0105 0.2216
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0033 0.0105 0.0413
Loa Loa (eye worm) hypothetical protein 0.0043 0.0152 0.1221
Plasmodium falciparum glutathione reductase 0.0037 0.0121 0.2696
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0152 0.5612
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.003 0.0119
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0231 0.8539
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0207 0.1704
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1533 0.7166 1
Echinococcus granulosus dna polymerase eta 0.0073 0.029 0.1144
Trichomonas vaginalis C-MYB, putative 0.006 0.0231 0.8539
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Brugia malayi hypothetical protein 0.0025 0.0064 0.0527
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.2331
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0121 0.4481
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0105 0.2216
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0231 0.7601
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0231 0.7601
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0275 0.1243 0.4904
Schistosoma mansoni hypothetical protein 0.0549 0.2535 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0121 0.0893
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0152 0.0599
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0033 0.0105 0.2216
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0152 0.3377
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0105 0.2216
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0011 0.004
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0033 0.0105 0.2216
Toxoplasma gondii ABC1 family protein 0.0043 0.0152 0.0546
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0044 0.0154 0.0046
Loa Loa (eye worm) hypothetical protein 0.0073 0.029 0.2333
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.009 0.1872
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Loa Loa (eye worm) hypothetical protein 0.0119 0.0508 0.4087
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Entamoeba histolytica hypothetical protein 0.0011 0.000000000018973 0.00000000062421
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0011 0.0103
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0059 0.2163
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.2331
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0275 0.1243 0.4904
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0281 0.2313
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Mycobacterium tuberculosis Conserved protein 0.0043 0.0152 0.0043
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0271 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Toxoplasma gondii thioredoxin reductase 0.0107 0.045 0.1617
Trypanosoma brucei DNA polymerase eta, putative 0.0073 0.029 0.6397
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0154 0.568
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0152 0.0043
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0011 0.0103
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0243 0.1094 0.138
Echinococcus multilocularis chromobox protein 1 0.0069 0.0271 0.1067
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0128 0.4746
Leishmania major hypothetical protein, conserved 0.0043 0.0152 0.3278
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0121 0.2587
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0152 0.5612
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0121 0.2696
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0033 0.0105 0.2216
Brugia malayi polk-prov protein 0.0014 0.0011 0.0092
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.000000000018973 0.00000000015601
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.0119
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0231 0.7601
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0148 0.3181
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0121 0.0997
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0242 0.1085 0.4281
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0033 0.0105 0.0413
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0152 0.0043
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0231 0.8539
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0105 0.3874
Echinococcus multilocularis geminin 0.0549 0.2535 1
Loa Loa (eye worm) transcription factor SMAD2 0.0269 0.1216 0.9783
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0033 0.0105 0.2331
Echinococcus multilocularis smad 0.0018 0.0034 0.0132
Leishmania major DNA polymerase eta, putative 0.0043 0.0148 0.3181
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0007 0.0244
Plasmodium falciparum glutathione reductase 0.0107 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.1021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.003 0.0249
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Brugia malayi MH2 domain containing protein 0.0269 0.1216 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0152 0.1221
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Loa Loa (eye worm) glutathione reductase 0.0107 0.045 0.3617
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Loa Loa (eye worm) hypothetical protein 0.003 0.0089 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0121 0.4481
Echinococcus multilocularis chromobox protein 1 0.0069 0.0271 0.1067
Leishmania major DNA polymerase eta, putative 0.0073 0.029 0.6397
Mycobacterium tuberculosis Probable dehydrogenase 0.0243 0.1094 0.138
Plasmodium vivax phosphodiesterase gamma, putative 0.0033 0.0105 0.2331
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0121 0.0436
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.0011 0.004
Brugia malayi hypothetical protein 0.0076 0.0304 0.2499
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0011 0.0249
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000018973 0.000000000074839
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0121 0.2696
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0152 0.1249
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0033 0.0105 0.2216
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000018973 0.000000000074839
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0121 0.011
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0271 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0602 0.2781 0.3749
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0121 0.2696
Leishmania major cAMP-specific phosphodiesterase, putative 0.0033 0.0105 0.2216
Plasmodium falciparum DNA repair protein REV1, putative 0.0014 0.0011 0.0249
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0232 0.8589
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0034 0.0132
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0281 0.2263
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0152 0.1221
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0011 0.0103
Trypanosoma cruzi trypanothione reductase, putative 0.0107 0.045 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0281 0.111
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0152 0.5612
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Brugia malayi CHD4 protein 0.0011 0.000000000018973 0.00000000015601
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2134 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0034 0.0132
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0033 0.0105 0.0413
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0207 0.1667
Mycobacterium tuberculosis Conserved protein 0.0043 0.0152 0.0043
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0121 0.2587
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0152 0.0043
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0105 0.2216
Loa Loa (eye worm) RNA binding protein 0.0071 0.0281 0.2263
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0281 0.111
Giardia lamblia hypothetical protein 0.0033 0.0105 0.076
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Schistosoma mansoni smad1 5 8 and 0.0018 0.0034 0.0132
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0121 0.2587
Trichomonas vaginalis pc-MYB2, putative 0.006 0.0231 0.8539
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0602 0.2781 0.2773
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0121 0.2587
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0231 0.8539
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0011 0.0044
Trypanosoma brucei unspecified product 0.0044 0.0154 0.3319
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.000000000018973 0.00000000015601
Mycobacterium ulcerans hypothetical protein 0.0043 0.0152 0.0141
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0152 0.0043
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0128 0.4746
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0154 0.0606
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0011 0.0103
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0271 0.1222 0.1562
Echinococcus granulosus dna polymerase kappa 0.0044 0.0154 0.0606
Brugia malayi Heterochromatin protein 1 0.0069 0.0271 0.2225
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0121 0.2587
Plasmodium vivax glutathione reductase, putative 0.0107 0.045 1
Brugia malayi beta-lactamase 0.0043 0.0152 0.1249
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0075 0.0617
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0154 0.3319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0121 0.2587
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0281 0.111
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0033 0.0105 0.2216
Trichomonas vaginalis esterase, putative 0.0043 0.0152 0.5612
Echinococcus granulosus bloom syndrome protein 0.0024 0.0059 0.0231
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0207 0.0817
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0105 0.2216
Plasmodium falciparum thioredoxin reductase 0.0037 0.0121 0.2696
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.000000000018973 0.0000000004219
Trypanosoma brucei trypanothione reductase 0.0107 0.045 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0152 0.3278
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0121 0.2587
Plasmodium falciparum phosphodiesterase gamma, putative 0.0033 0.0105 0.2331
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.009 0.1872
Loa Loa (eye worm) hypothetical protein 0.0056 0.021 0.169
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.000000000018973 0.000000000068222
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0033 0.0105 0.0413
Loa Loa (eye worm) RecQ helicase 0.0024 0.0059 0.0471
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0281 0.111
Brugia malayi glutathione reductase 0.0107 0.045 0.3698
Echinococcus granulosus thioredoxin glutathione reductase 0.0107 0.045 0.1774
Echinococcus granulosus chromobox protein 1 0.0069 0.0271 0.1067
Schistosoma mansoni chromobox protein 0.0069 0.0271 0.1067
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0152 0.3278
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0231 0.8539
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Brugia malayi MH2 domain containing protein 0.0018 0.0034 0.0276
Brugia malayi MH1 domain containing protein 0.0018 0.0034 0.0276
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0105 0.2216
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0128 0.8456
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Brugia malayi hypothetical protein 0.0016 0.0023 0.0186
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2134 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.1425
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0033 0.0105 0.2216
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0033 0.0105 0.0862
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0242 0.1085 0.4281
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018973 0.00000000062421
Giardia lamblia Myb 1-like protein 0.0061 0.0232 0.1795
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.000000000018973 0.000000000074839
Plasmodium falciparum phosphodiesterase delta, putative 0.0033 0.0105 0.2331
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.0119
Brugia malayi MH1 domain containing protein 0.0018 0.0034 0.0276
Echinococcus multilocularis Smad4 0.0018 0.0034 0.0132
Leishmania major hypothetical protein, conserved 0.0033 0.0105 0.2216
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0121 0.2587
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0231 0.8539
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Onchocerca volvulus 0.0043 0.0152 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0152 0.5612
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0243 0.1094 0.138
Onchocerca volvulus 0.0043 0.0152 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0034 0.0132
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0022 0.0499
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0154 0.0143
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0121 0.0478
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0033 0.0105 0.3874
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.2331
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0121 0.2587
Schistosoma mansoni hypothetical protein 0.0011 0.000000000018973 0.000000000074839
Brugia malayi Thioredoxin reductase 0.0107 0.045 0.3698
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.1033
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0107 0.045 0.0466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0207 0.0817
Schistosoma mansoni chromobox protein 0.0069 0.0271 0.1067
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0275 0.1243 0.4904
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0275 0.1243 0.447
Entamoeba histolytica hypothetical protein 0.0076 0.0304 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0033 0.0105 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Leishmania major hypothetical protein, conserved 0.0033 0.0105 0.2216
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0602 0.2781 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0105 0.2216
Brugia malayi chromobox protein homolog 3 0.0038 0.0128 0.1056
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0231 0.8539
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0207 0.0817
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0034 0.0132
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0154 0.3319
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0011 0.0103
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.009 0.1872
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0154 0.568
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0271 0.2176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0121 0.2587
Onchocerca volvulus 0.0043 0.0152 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.021 0.169
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0105 0.0862
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0064 0.023
Loa Loa (eye worm) MH2 domain-containing protein 0.0269 0.1216 0.9783
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0105 0.2216
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0843
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0271 0.1222 0.1525
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0105 0.3874
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.1425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0207 0.0817
Echinococcus granulosus GPCR family 2 0.0018 0.003 0.0119
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0033 0.0105 0.0413
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0033 0.0105 0.0413
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0035 0.0138
Schistosoma mansoni DNA polymerase eta 0.0073 0.029 0.1144
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0105 0.2216
Brugia malayi Smad1 0.0018 0.0034 0.0276
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0121 0.2696
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0105 0.2216
Brugia malayi beta-lactamase family protein 0.0043 0.0152 0.1249
Plasmodium falciparum thioredoxin reductase 0.0107 0.045 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0033 0.0105 0.2216
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0034 0.027
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0154 0.3319
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.003 0.0244
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.000000000018973 0.000000000074839
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Mycobacterium tuberculosis Conserved protein 0.0043 0.0152 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0018 0.003 0.0249
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0033 0.0105 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0011 0.0103
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0105 0.0862
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0142 0.5254
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0033 0.0105 0.0413
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0843
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0243 0.1094 0.138
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018973 0.00000000062421
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.003 0.0119
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0033 0.0105 0.0862
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0033 0.0105 0.3874
Echinococcus multilocularis Chromo domain 0.0011 0.000000000018973 0.000000000074839
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0121 0.2587
Loa Loa (eye worm) hypothetical protein 0.0043 0.0152 0.1221
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.2216
Echinococcus multilocularis thioredoxin glutathione reductase 0.0107 0.045 0.1774
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0152 0.0043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.1297
Leishmania major DNA polymerase kappa, putative 0.0014 0.0011 0.0103
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0007 0.0217
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.021 0.1728
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.1297
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0152 0.0043
Echinococcus multilocularis GPCR, family 2 0.0018 0.003 0.0119
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.003 0.0119
Schistosoma mansoni smad1 5 8 and 0.0018 0.0034 0.0132
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0033 0.0105 0.0413
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0033 0.0105 0.0413
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Mycobacterium ulcerans lipase LipD 0.0043 0.0152 0.0141
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0044 0.0154 0.0606
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0152 0.0141
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0033 0.0105 0.2216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0207 0.0817
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0281 0.2263
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0033 0.0105 0.0862
Echinococcus granulosus chromobox protein 1 0.0069 0.0271 0.1067
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0033 0.0105 0.0413
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.2331
Echinococcus granulosus Chromo domain 0.0011 0.000000000018973 0.000000000074839
Leishmania major DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Loa Loa (eye worm) PDE1B protein 0.0033 0.0105 0.0843
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0033 0.0105 0.3874
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Echinococcus granulosus smad 0.0018 0.0034 0.0132
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0516
Echinococcus granulosus tar DNA binding protein 0.0071 0.0281 0.111
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.000000000018973 0.00000000015262
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0121 0.2587
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0033 0.0105 0.0413
Entamoeba histolytica deoxycytidyl transferase, putative 0.0044 0.0154 0.5056
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0033 0.0105 0.0413
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0033 0.0105 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0011 0.0103
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0602 0.2781 0.2693
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0231 0.7601
Loa Loa (eye worm) hypothetical protein 0.0043 0.0152 0.1221
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0121 0.0436
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0152 0.0599
Plasmodium vivax hypothetical protein, conserved 0.0011 0.000000000018973 0.0000000004219
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Giardia lamblia DINP protein human, muc B family 0.0044 0.0154 0.1157
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.2216
Trichomonas vaginalis MYB72, putative 0.006 0.0231 0.8539
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.029 0.2385
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Mycobacterium tuberculosis Probable reductase 0.0243 0.1094 0.138
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0152 0.3278
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0033 0.0105 0.2331
Trichomonas vaginalis MYB, putative 0.0061 0.0232 0.8589
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0121 0.011
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0148 0.0531
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0121 0.0478
Brugia malayi TAR-binding protein 0.0071 0.0281 0.2313
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.000000000018973 0.000000000074839
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0154 0.3319
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Trichomonas vaginalis pc-MYB2, putative 0.006 0.0231 0.8539
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0152 0.5612
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0075 0.2789
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0034 0.027
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0033 0.0105 0.0413
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0142 0.5254
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0304 0.1199
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.0119
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0243 0.1094 0.1343
Trypanosoma brucei unspecified product 0.003 0.009 0.1872
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0033 0.0105 0.0413
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0154 0.3319
Schistosoma mansoni Smad4 0.0018 0.0034 0.0132
Schistosoma mansoni hypothetical protein 0.0549 0.2535 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0304 0.1199
Leishmania major trypanothione reductase 0.0107 0.045 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Leishmania major hypothetical protein, conserved 0.0025 0.0064 0.1297
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0033 0.0105 0.0413
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0154 0.1264
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0044 0.0154 0.0606
Brugia malayi MH2 domain containing protein 0.0018 0.0034 0.0276
Schistosoma mansoni hypothetical protein 0.0038 0.0127 0.05
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1533 0.7166 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0033 0.0105 0.0843
Brugia malayi beta-lactamase family protein 0.0043 0.0152 0.1249
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0105 0.0862
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0231 0.7601
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0033 0.0105 0.0413
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0059 0.2163
Schistosoma mansoni terminal deoxycytidyl transferase 0.0044 0.0154 0.0606
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0105 0.0377
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0064 0.1425
Echinococcus multilocularis dna polymerase eta 0.0073 0.029 0.1144
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0242 0.1085 0.8925
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0281 0.111
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0105 0.3874
Plasmodium vivax thioredoxin reductase, putative 0.0107 0.045 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Loa Loa (eye worm) beta-lactamase 0.0043 0.0152 0.1221
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.021 0.1728
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.2331
Loa Loa (eye worm) Smad1 0.0018 0.0034 0.027
Schistosoma mansoni smad1 5 8 and 0.0018 0.0034 0.0132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0207 0.0817
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0243 0.1094 0.138
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0011 0.0103
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Loa Loa (eye worm) hypothetical protein 0.0043 0.0152 0.1221
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018973 0.00000000062421
Loa Loa (eye worm) thioredoxin reductase 0.0107 0.045 0.3617
Mycobacterium tuberculosis Probable oxidoreductase 0.0271 0.1222 0.1562
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0033 0.0105 0.0413
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0033 0.0105 0.0413
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0105 0.3874
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0059 0.0231
Loa Loa (eye worm) hypothetical protein 0.0011 0.000000000018973 0.00000000015262
Echinococcus granulosus geminin 0.0549 0.2535 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0105 0.3874
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0207 0.0817
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0142 0.9362
Trichomonas vaginalis MYB3r3, putative 0.006 0.0231 0.8539
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0059 0.0481
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0154 0.0143
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0121 0.011
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.000000000018973 0.000000000074839
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0121 0.2587
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0103
Loa Loa (eye worm) hypothetical protein 0.0275 0.1243 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0152 0.0043
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0152 0.0141
Entamoeba histolytica hypothetical protein 0.0076 0.0304 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1255 0.161
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0152 0.0599
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0275 0.1243 0.4904
Leishmania major DNA damage repair protein, putative 0.0014 0.0011 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Brugia malayi RNA binding protein 0.0071 0.0281 0.2313
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018973 0.00000000070125
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0275 0.1243 0.4904
Trichomonas vaginalis C-MYB, putative 0.006 0.0231 0.8539
Entamoeba histolytica hypothetical protein 0.0076 0.0304 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0121 0.2587
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0044 0.0154 0.0606
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0033 0.0105 0.0413
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0121 0.2587
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0121 0.0478
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0045 0.1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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