Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | EGF-like domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | Animal haem peroxidase family protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Schistosoma mansoni | peroxidasin | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | notch-like transmembrane receptor | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | animal heme peroxidase | 0.027 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | notch protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | EGF-like domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Echinococcus multilocularis | peroxidasin | 0.027 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0058 | 0.1134 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Onchocerca volvulus | 0.027 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | Animal haem peroxidase family protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | animal heme peroxidase | 0.027 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Schistosoma mansoni | peroxidasin | 0.027 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.027 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.027 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | Muscle positioning protein 4 | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | EGF-like domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Onchocerca volvulus | 0.027 | 1 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.027 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | Peroxidasin | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | animal heme peroxidase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | EGF-like domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Onchocerca volvulus | 0.027 | 1 | 1 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.027 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.027 | 1 | 1 |
Loa Loa (eye worm) | Notch2 | 0.0058 | 0.1134 | 0.1134 |
Brugia malayi | Animal haem peroxidase family protein | 0.027 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.027 | 1 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0058 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1134 | 0.1134 |
Onchocerca volvulus | Peroxidase homolog | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.027 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0058 | 0.1134 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0058 | 0.1134 | 0.1134 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0052 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.0928 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.