Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.6517 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1678 | 0.2574 |
Echinococcus multilocularis | musashi | 0.0033 | 0.6517 | 0.6517 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.6517 | 0.6517 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0933 | 0.1432 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.6517 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.6517 | 0.6517 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.1124 | 0.1124 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.6517 | 0.6517 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.6517 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0933 | 0.1432 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.1124 | 0.1124 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.6517 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.6517 | 0.6517 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.6517 | 0.6517 |
Onchocerca volvulus | 0.0033 | 0.6517 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.6327 | 0.9707 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1124 | 0.1725 |
Echinococcus granulosus | lamin | 0.0033 | 0.6517 | 0.6517 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.6517 | 0.6517 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.6517 | 0.6517 |
Schistosoma mansoni | lamin | 0.0033 | 0.6517 | 0.6517 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.1678 | 0.1678 |
Echinococcus multilocularis | lamin | 0.0033 | 0.6517 | 0.6517 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) [Related pubchem assays: 1487 ] | ChEMBL. | No reference |
Potency (binding) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 11.5821 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.