Detailed information for compound 1362648

Basic information

Technical information
  • TDR Targets ID: 1362648
  • Name: N-[(3-fluorophenyl)methyl]-8-methyl-4,5-dihyd ro-1H-furo[5,4-g]indazole-7-carboxamide
  • MW: 325.337 | Formula: C18H16FN3O2
  • H donors: 2 H acceptors: 2 LogP: 2.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)CNC(=O)c1oc2c(c1C)c1[nH]ncc1CC2
  • InChi: 1S/C18H16FN3O2/c1-10-15-14(6-5-12-9-21-22-16(12)15)24-17(10)18(23)20-8-11-3-2-4-13(19)7-11/h2-4,7,9H,5-6,8H2,1H3,(H,20,23)(H,21,22)
  • InChiKey: JULWZFJUHWABNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-fluorobenzyl)-8-methyl-4,5-dihydro-1H-furo[5,4-g]indazole-7-carboxamide
  • E010-0302
  • NCGC00120112-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0013 0.0081 0.021
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0483 1 1
Echinococcus granulosus dual specificity 0.0098 0.1883 0.2717
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.087 0.1255
Trypanosoma brucei polo-like protein kinase 0.0104 0.2007 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0483 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0261 0.1162
Leishmania major trypanothione reductase 0.0062 0.1109 0.5454
Plasmodium vivax glutathione reductase, putative 0.0062 0.1109 1
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2357 0.2295
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0121 0.2357 0.2295
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0353 0.0274
Schistosoma mansoni kinase 0.0053 0.0933 0.1346
Schistosoma mansoni hypothetical protein 0.0338 0.6929 1
Loa Loa (eye worm) PWWP domain-containing protein 0.001 0.0032 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2007 0.1941
Brugia malayi hypothetical protein 0.0331 0.68 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0261 0.1162
Entamoeba histolytica hypothetical protein 0.0013 0.0081 0.021
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0261 0.0377
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0261 0.1162
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0121 0.2357 0.2295
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0261 0.213
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0479 0.2262
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0303 0.1371
Schistosoma mansoni flap endonuclease-1 0.0026 0.0356 0.0514
Echinococcus granulosus flap endonuclease 1 0.0029 0.0414 0.0598
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0261 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2357 0.2295
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0353 0.1623
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0261 0.5
Echinococcus multilocularis snurportin 1 0.0338 0.6929 1
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2007 0.1941
Brugia malayi Protein kinase domain containing protein 0.0098 0.1883 0.2769
Echinococcus granulosus geminin 0.0186 0.373 0.5383
Brugia malayi hypothetical protein 0.001 0.0032 0.0047
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0021 0.0261 0.5
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0261 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Schistosoma mansoni tsg101-related 0.0064 0.1151 0.1661
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0261 0.1162
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0012 0.0057 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0362 0.7455 0.7434
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.087 0.1255
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0728 0.105
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0261 0.1162
Leishmania major hypothetical protein, conserved 0.0024 0.0326 0.149
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0021 0.0261 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0098 0.1883 0.7958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0261 0.1162
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.1109 0.16
Echinococcus multilocularis dual specificity 0.0098 0.1883 0.2717
Brugia malayi glutathione reductase 0.0062 0.1109 0.1631
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0728 0.105
Brugia malayi Thioredoxin reductase 0.0062 0.1109 0.1631
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0076 0.142 0.2049
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0303 0.1371
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0021 0.0261 0.5
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0414 0.0598
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0261 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.1109 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0338 0.6929 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0142 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.2007 0.8492
Brugia malayi MH2 domain containing protein 0.0131 0.2572 0.3783
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2357 0.2295
Plasmodium falciparum flap endonuclease 1 0.0029 0.0414 0.1801
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2007 0.1941
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0036 0.057 0.0822
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0261 0.1162
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.2572 0.3712
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0081 0.0248
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0261 0.1162
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Entamoeba histolytica hypothetical protein 0.0013 0.0081 0.021
Entamoeba histolytica hypothetical protein 0.0043 0.0728 0.2993
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0483 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0414 0.1801
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0076 0.142 0.2049
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Entamoeba histolytica protein kinase, putative 0.0098 0.1883 0.7958
Schistosoma mansoni ran 0.0023 0.0303 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Schistosoma mansoni tsg101-related 0.0052 0.0906 0.1307
Plasmodium falciparum thioredoxin reductase 0.0062 0.1109 1
Schistosoma mansoni tsg101-related 0.0064 0.1151 0.1661
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0414 0.1935
Trichomonas vaginalis hypothetical protein 0.0037 0.0595 0.0518
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2007 0.1941
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.2007 0.2896
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1883 0.2717
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2007 0.1941
Trypanosoma brucei trypanothione reductase 0.0062 0.1109 0.5454
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0012 0.0057 0.0083
Brugia malayi hypothetical protein 0.001 0.0032 0.0047
Schistosoma mansoni hypothetical protein 0.0186 0.373 0.5383
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.2007 0.2918
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Schistosoma mansoni hypothetical protein 0.0186 0.373 0.5383
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Trichomonas vaginalis ran, putative 0.0023 0.0303 0.0224
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0303 0.0042
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0261 0.0377
Schistosoma mansoni hepatoma derived growth factor 0.001 0.0032 0.0046
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0303 0.0445
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.087 0.1255
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0261 0.0377
Echinococcus granulosus importin subunit beta 1 0.0032 0.0479 0.0691
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0303 0.1371
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2357 0.2295
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.1109 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.2007 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.142 0.2049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0261 0.1162
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0414 0.0598
Echinococcus granulosus snurportin 1 0.0338 0.6929 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0261 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Echinococcus multilocularis geminin 0.0186 0.373 0.5383
Onchocerca volvulus 0.0331 0.68 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0098 0.1883 0.9372
Echinococcus granulosus peregrin 0.001 0.0032 0.0046
Schistosoma mansoni importin beta-1 0.0032 0.0479 0.0691
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0024 0.0326 0.149
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0261 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2007 0.1941
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2357 0.2295
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Brugia malayi RNA, U transporter 1 0.009 0.1708 0.2512
Schistosoma mansoni ran 0.0023 0.0303 0.0437
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0024 0.0326 0.149
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0261 0.1162
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0728 0.105
Schistosoma mansoni SET domain protein 0.0012 0.0057 0.0083
Schistosoma mansoni hepatoma derived growth factor 0.001 0.0032 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.087 0.1255
Schistosoma mansoni hypothetical protein 0.001 0.0032 0.0046
Brugia malayi Importin beta-1 subunit 0.0032 0.0479 0.0704
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0353 0.0274
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.2007 0.2896
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0303 0.0437
Echinococcus multilocularis PWWP domain containing protein 2A 0.001 0.0032 0.0046
Entamoeba histolytica hypothetical protein 0.0013 0.0081 0.021
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0261 0.1162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.087 0.1255
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2357 0.2295
Plasmodium vivax importin-beta 2, putative 0.0032 0.0479 0.2563
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0904 0.083
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0414 0.1935
Entamoeba histolytica Ran family GTPase 0.0023 0.0303 0.1164
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.1109 0.5454
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0904 0.083
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.68 0.9813
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0479 0.4147
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0261 0.0182
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Loa Loa (eye worm) glutathione reductase 0.0062 0.1109 0.16
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.1883 0.9372
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0098 0.1883 0.2717
Entamoeba histolytica hypothetical protein 0.0043 0.0728 0.2993
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0052 0.0906 0.3757
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.1883 0.9372
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0414 0.0157
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0303 0.2513
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.2007 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2357 0.2295
Echinococcus granulosus PWWP domain containing protein 2A 0.001 0.0032 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0142 0.0209
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0261 0.1162
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.2007 0.2896
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0121 0.2357 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.087 0.1279
Brugia malayi PWWP domain containing protein 0.001 0.0032 0.0047
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Treponema pallidum NADH oxidase 0.0021 0.0261 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.2572 0.3712
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2007 0.1941
Plasmodium falciparum importin beta, putative 0.0032 0.0479 0.2563
Plasmodium falciparum glutathione reductase 0.0062 0.1109 1
Leishmania major GTP-binding protein, putative 0.0023 0.0303 0.1371
Entamoeba histolytica hypothetical protein 0.0098 0.1883 0.7958
Entamoeba histolytica hypothetical protein 0.0043 0.0728 0.2993
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0303 0.0437
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Echinococcus multilocularis peregrin 0.001 0.0032 0.0046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.087 0.1255
Brugia malayi hypothetical protein 0.0043 0.0728 0.107
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0098 0.1883 0.9372
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0303 0.0486
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0414 0.1643
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0021 0.0261 0.5
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0414 0.0336
Entamoeba histolytica hypothetical protein 0.0043 0.0728 0.2993
Echinococcus multilocularis PWWP domain containing protein 2A 0.001 0.0032 0.0046
Schistosoma mansoni hypothetical protein 0.001 0.0032 0.0046
Entamoeba histolytica hypothetical protein 0.0121 0.2357 1
Schistosoma mansoni phd finger protein 0.001 0.0032 0.0046
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0121 0.2357 0.2295
Loa Loa (eye worm) hypothetical protein 0.0097 0.1865 0.2691
Brugia malayi Flap endonuclease-1 0.0029 0.0414 0.0609
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0414 0.3548
Giardia lamblia NADPH oxidoreductase, putative 0.0483 1 1
Brugia malayi hypothetical protein 0.0076 0.142 0.2088
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0261 0.213
Echinococcus granulosus hepatoma derived growth factor protein 0.001 0.0032 0.0046
Giardia lamblia NADPH oxidoreductase, putative 0.0483 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0261 0.1162
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Schistosoma mansoni hypothetical protein 0.0043 0.0728 0.105
Entamoeba histolytica hypothetical protein 0.0026 0.0353 0.1379
Loa Loa (eye worm) hypothetical protein 0.0097 0.1865 0.2691
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0414 0.1935
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0036 0.057 0.0822
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0303 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2357 0.2295
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0121 0.2357 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.087 0.1255
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0353 0.0274
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.2007 0.2896
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0261 0.0182
Echinococcus multilocularis hepatoma derived growth factor protein 0.001 0.0032 0.0046
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.2007 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Entamoeba histolytica protein kinase, putative 0.0098 0.1883 0.7958
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0479 0.2262
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0021 0.0261 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2357 0.2295
Trichomonas vaginalis modulator of drug activity B, putative 0.0121 0.2357 0.2295
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Leishmania major importin beta-1 subunit, putative 0.0026 0.0353 0.1623
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.2007 0.2951
Schistosoma mansoni hypothetical protein 0.001 0.0032 0.0046
Giardia lamblia Kinase, PLK 0.0104 0.2007 0.1792
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0081 0.0248
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0081 0.0248
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0261 0.1162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0479 0.0691
Schistosoma mansoni SET domain protein 0.0036 0.057 0.0822
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.1109 0.16
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.087 0.1255
Toxoplasma gondii thioredoxin reductase 0.0062 0.1109 1
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0479 0.0691
Echinococcus granulosus PWWP domain containing protein 2A 0.001 0.0032 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0483 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.1109 0.16
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0303 0.0437

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.