Detailed information for compound 13628

Basic information

Technical information
  • TDR Targets ID: 13628
  • Name: 3-[[(6R,7S)-2-(2,2-dimethylpropanoyl)-7-metho xy-3-methyl-5,5,8-trioxo-5$l^{6}-thia-1-azabi cyclo[4.2.0]oct-2-en-4-yl]sulfanyl]-2-methyl- 1H-1,2,4-triazine-5,6-dione
  • MW: 458.509 | Formula: C17H22N4O7S2
  • H donors: 1 H acceptors: 6 LogP: 0.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@H]1C(=O)N2[C@@H]1S(=O)(=O)C(C(=C2C(=O)C(C)(C)C)C)Sc1nc(=O)c(=O)[nH]n1C
  • InChi: 1S/C17H22N4O7S2/c1-7-8(10(22)17(2,3)4)21-13(25)9(28-6)14(21)30(26,27)15(7)29-16-18-11(23)12(24)19-20(16)5/h9,14-15H,1-6H3,(H,19,24)/t9-,14+,15?/m0/s1
  • InChiKey: UQXPPXLTKHZSQJ-KHVYEAMJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[(6R,7S)-2-(2,2-dimethyl-1-oxopropyl)-7-methoxy-3-methyl-5,5,8-trioxo-5$l^{6}-thia-1-azabicyclo[4.2.0]oct-2-en-4-yl]thio]-2-methyl-1H-1,2,4-triazine-5,6-dione
  • 2-methyl-3-[[(6R,7S)-5,5,8-triketo-7-methoxy-3-methyl-2-pivaloyl-5$l^{6}-thia-1-azabicyclo[4.2.0]oct-2-en-4-yl]thio]-1H-1,2,4-triazine-5,6-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase eta 0.0034 0.001 0.001
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0057 0.0072 0.0122
Onchocerca volvulus 0.0033 0.001 0.0071
Leishmania major cathepsin L-like protease 0.0048 0.0048 0.0611
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Plasmodium falciparum metacaspase 1 0.0057 0.0072 0.092
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0004 0.0004
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Echinococcus multilocularis survival motor neuron protein 1 0.0147 0.0312 0.0312
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0218 0.05 0.05
Brugia malayi G-protein coupled receptor 0.0218 0.05 0.1141
Echinococcus multilocularis neurogenic locus notch protein 0.0032 0.0005 0.0005
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0057 0.0072 0.092
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0032 0.0005 0.001
Brugia malayi angiogenesis inhibito 0.0045 0.0039 0.0089
Brugia malayi hypothetical protein 0.0045 0.0039 0.0089
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.054 0.1355 0.1355
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0218 0.05 0.1141
Echinococcus multilocularis glycoprotein Antigen 5 0.0094 0.017 0.017
Trypanosoma brucei metacaspase MCA3 0.0057 0.0072 0.0256
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0084 0.0143 0.437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0218 0.05 0.05
Echinococcus granulosus G protein coupled receptor 139 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0004 0.0004
Trypanosoma cruzi subtilisin peptidase 0.0084 0.0143 0.1823
Schistosoma mansoni amine GPCR 0.0218 0.05 0.05
Echinococcus granulosus cyclin B 0.0272 0.0642 0.0642
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0037 0.002 0.002
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0084 0.0143 0.437
Brugia malayi Latrophilin receptor protein 2 0.0037 0.002 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0218 0.05 0.05
Echinococcus multilocularis neurogenic locus protein delta 0.0032 0.0005 0.0005
Echinococcus multilocularis thioredoxin glutathione reductase 0.003 0.0001 0.0001
Loa Loa (eye worm) glutathione reductase 0.003 0.0001 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0218 0.05 0.05
Toxoplasma gondii hypothetical protein 0.0033 0.001 0.0123
Schistosoma mansoni notch 0.0032 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0092 0.0165 0.0165
Brugia malayi celfurPC protein 0.1299 0.3374 0.7703
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0037 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0056 0.007 0.0159
Schistosoma mansoni notch 0.0032 0.0005 0.0005
Echinococcus multilocularis neurogenic locus notch protein 4 0.0032 0.0005 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Brugia malayi Protein kinase domain containing protein 0.0325 0.0785 0.1791
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0018 0.0018
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.004 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0092 0.0165 0.2561
Loa Loa (eye worm) melatonin receptor type 1A 0.0218 0.05 0.1141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Schistosoma mansoni hypothetical protein 0.0218 0.05 0.05
Trypanosoma cruzi metacaspase, putative 0.0057 0.0072 0.092
Brugia malayi notch-like transmembrane receptor 0.0032 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0037 0.0018 0.0018
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.051 0.1275 0.2156
Toxoplasma gondii EGF family domain-containing protein 0.0032 0.0005 0.0063
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0011
Brugia malayi larval opioid receptor 0.0218 0.05 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0004 0.0009
Trypanosoma cruzi cdc2-related kinase 3 0.0093 0.0167 0.2135
Leishmania major DNA polymerase eta, putative 0.0034 0.001 0.0127
Echinococcus multilocularis Furin 1 0.051 0.1275 0.1275
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0148 0.0314 0.0717
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0004 0.0004
Trypanosoma cruzi metacaspase, putative 0.0057 0.0072 0.092
Echinococcus granulosus peptide allatostatin:somatostatin 0.0218 0.05 0.05
Echinococcus granulosus mitogen activated protein kinase 0.0039 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus granulosus cyclins 0.0124 0.0249 0.0249
Loa Loa (eye worm) TK/EGFR protein kinase 0.0249 0.0583 0.1331
Brugia malayi Trypsin family protein 0.054 0.1355 0.3093
Loa Loa (eye worm) MH2 domain-containing protein 0.0076 0.0124 0.0283
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0084 0.0143 0.8176
Leishmania major DNA topoisomerase IB, large subunit 0.015 0.0321 0.4088
Giardia lamblia High cysteine membrane protein Group 2 0.0448 0.1112 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0143 0.0242
Schistosoma mansoni caspase-7 (C14 family) 0.0135 0.028 0.028
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.001 0.0022
Schistosoma mansoni hypothetical protein 0.0218 0.05 0.05
Brugia malayi Melatonin receptor type 1A 0.0218 0.05 0.1141
Schistosoma mansoni DNA topoisomerase type I 0.015 0.0321 0.0321
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0218 0.05 0.05
Echinococcus multilocularis g-protein coupled receptor 0.0218 0.05 0.05
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Brugia malayi Calcium binding EGF domain containing protein 0.0032 0.0005 0.0011
Entamoeba histolytica cell division protein kinase 2, putative 0.0093 0.0167 0.2607
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0004 0.0004
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.0159
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0094 0.017 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0004 0.0009
Brugia malayi Calcium binding EGF domain containing protein 0.0032 0.0005 0.0011
Brugia malayi GCC2 and GCC3 family protein 0.0032 0.0005 0.0011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0218 0.05 0.05
Brugia malayi Muscle positioning protein 4 0.0032 0.0005 0.0011
Echinococcus granulosus biogenic amine 5HT receptor 0.0218 0.05 0.05
Schistosoma mansoni neuropeptide receptor 0.0218 0.05 0.05
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0004 0.0004
Trichomonas vaginalis cyclins, putative 0.0272 0.0642 0.1086
Loa Loa (eye worm) hypothetical protein 0.0147 0.0312 0.0713
Giardia lamblia Kinase, CMGC CDK 0.0093 0.0167 0.1506
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0093 0.0167 0.0382
Echinococcus multilocularis neuropeptide s receptor 0.0218 0.05 0.05
Toxoplasma gondii microneme protein MIC4 0.0033 0.001 0.0123
Echinococcus granulosus microtubule associated protein 2 0.0887 0.2278 0.2278
Brugia malayi hypothetical protein 0.0218 0.05 0.1141
Toxoplasma gondii calcium binding egf domain-containing protein 0.0056 0.007 0.0889
Brugia malayi putative neuropeptide receptor NPR1 0.0218 0.05 0.1141
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0057 0.0072 0.0072
Echinococcus granulosus cyclins 0.0124 0.0249 0.0249
Brugia malayi hypothetical protein 0.0218 0.05 0.1141
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0143 0.0302 0.051
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0084 0.0143 0.0327
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0069 0.0104 0.3179
Onchocerca volvulus 0.0033 0.001 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0047 0.008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0004 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.002 0.0045
Brugia malayi PAN domain containing protein 0.0033 0.001 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0057 0.0072 0.0165
Echinococcus granulosus epidermal growth factor receptor 0.0249 0.0583 0.0583
Toxoplasma gondii microneme protein, putative 0.0033 0.001 0.0123
Brugia malayi Cell death protein 3 precursor 0.0057 0.0072 0.0165
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0272 0.0642 0.8188
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0009
Schistosoma mansoni site-1 peptidase (S08 family) 0.0084 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0175 0.0386 0.0882
Onchocerca volvulus 0.0218 0.05 0.3688
Echinococcus multilocularis DNA topoisomerase 1 0.0201 0.0455 0.0455
Brugia malayi hypothetical protein 0.0175 0.0386 0.0882
Plasmodium vivax metacaspase 1, putative 0.0057 0.0072 0.092
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Schistosoma mansoni hypothetical protein 0.0218 0.05 0.05
Plasmodium falciparum subtilisin-like protease 2 0.0084 0.0143 0.1823
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0032 0.0005 0.0037
Brugia malayi hypothetical protein 0.0094 0.017 0.0388
Trypanosoma cruzi cyclin 6, putative 0.0272 0.0642 0.8188
Trichomonas vaginalis AGC family protein kinase 0.0034 0.001 0.0017
Toxoplasma gondii subtilisin SUB10 0.0084 0.0143 0.1823
Entamoeba histolytica hypothetical protein 0.0092 0.0165 0.2561
Trypanosoma brucei cdc2-related kinase 1 0.0093 0.0167 0.0593
Schistosoma mansoni histamine h1 receptor 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0022
Brugia malayi glutathione reductase 0.003 0.0001 0.0003
Brugia malayi G-protein coupled receptor 0.0218 0.05 0.1141
Loa Loa (eye worm) hypothetical protein 0.0094 0.017 0.0388
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.015 0.0321 0.1135
Schistosoma mansoni neuropeptide receptor 0.0218 0.05 0.05
Onchocerca volvulus 0.0033 0.001 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus multilocularis protein jagged 1 0.0032 0.0005 0.0005
Brugia malayi Calcium binding EGF domain containing protein 0.0032 0.0005 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Loa Loa (eye worm) trypsin family protein 0.0094 0.017 0.0388
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0039 0.0026 0.0325
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0218 0.05 0.05
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0084 0.0143 0.0143
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0218 0.05 0.1141
Entamoeba histolytica protein kinase, putative 0.0034 0.001 0.0154
Trichomonas vaginalis AGC family protein kinase 0.0034 0.001 0.0017
Echinococcus multilocularis mitogen activated protein kinase 0.0039 0.0026 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0004 0.0004
Toxoplasma gondii hypothetical protein 0.0094 0.017 0.2165
Plasmodium falciparum subtilisin-like protease 3 0.0084 0.0143 0.1823
Echinococcus multilocularis rhodopsin orphan GPCR 0.0218 0.05 0.05
Onchocerca volvulus 0.0032 0.0005 0.0037
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.008 0.0134 0.0134
Leishmania major subtilisin-like serine peptidase 0.0084 0.0143 0.1823
Schistosoma mansoni biogenic amine receptor 0.0218 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Brugia malayi proprotein convertase 2 0.1277 0.3315 0.7569
Echinococcus granulosus rhodopsin orphan GPCR 0.0218 0.05 0.05
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0004 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0072 0.0122
Onchocerca volvulus 0.0033 0.001 0.0071
Toxoplasma gondii microneme protein MIC17B 0.0033 0.001 0.0123
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.001 0.0023
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0124 0.0249 0.0249
Trichomonas vaginalis cyclins, putative 0.0124 0.0249 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0004 0.0009
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0143 0.0302 0.4697
Echinococcus multilocularis Tolloid protein 1 0.0056 0.007 0.007
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.004 0.0028 0.0065
Mycobacterium ulcerans hypothetical protein 0.0094 0.017 1
Onchocerca volvulus 0.0218 0.05 0.3688
Echinococcus multilocularis 0.1299 0.3374 0.3374
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Schistosoma mansoni neuropeptide F-like receptor 0.0218 0.05 0.05
Schistosoma mansoni neuropeptide f receptor 76f 0.0218 0.05 0.05
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0018 0.0041
Schistosoma mansoni transcription factor LCR-F1 0.0092 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0005
Loa Loa (eye worm) DNA topoisomerase I 0.0201 0.0455 0.1039
Brugia malayi MH2 domain containing protein 0.0076 0.0124 0.0283
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0004 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0051 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0004 0.0009
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0084 0.0143 0.1823
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0094 0.017 0.017
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Brugia malayi photoreceptor-specific nuclear receptor 0.0285 0.0677 0.1546
Schistosoma mansoni notch 0.0032 0.0005 0.0005
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0084 0.0143 0.0143
Echinococcus multilocularis sex peptide receptor 0.0218 0.05 0.05
Echinococcus multilocularis notch 0.0032 0.0005 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.0134 0.0307
Echinococcus multilocularis GPCR, family 2 0.0037 0.002 0.002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0077 0.0125 0.3811
Brugia malayi Subtilase family protein 0.0084 0.0143 0.0327
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0218 0.05 0.05
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0218 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Brugia malayi ecdysteroid receptor 0.0031 0.0004 0.0009
Echinococcus multilocularis caspase 3 0.0078 0.0128 0.0128
Echinococcus granulosus caspase 3 0.0078 0.0128 0.0128
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Echinococcus multilocularis fibrillin 1 0.0058 0.0074 0.0074
Echinococcus granulosus protein jagged 2 0.0032 0.0005 0.0005
Brugia malayi ORL1-like opioid receptor 0.0218 0.05 0.1141
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0072 0.092
Echinococcus multilocularis protein jagged 2 0.0032 0.0005 0.0005
Toxoplasma gondii subtilisin SUB1 0.0084 0.0143 0.1823
Brugia malayi hypothetical protein 0.0218 0.05 0.1141
Schistosoma mansoni DNA polymerase eta 0.0034 0.001 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0077 0.0125 0.3811
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0426 0.1053 0.178
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0004 0.0004
Trichomonas vaginalis cyclin B, putative 0.0272 0.0642 0.1086
Toxoplasma gondii subtilisin SUB8 0.0084 0.0143 0.1823
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Brugia malayi Fibulin-1 precursor 0.0056 0.007 0.0159
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0004 0.0004
Echinococcus multilocularis neuropeptides capa receptor 0.0627 0.1587 0.1587
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0032 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Toxoplasma gondii PAN domain-containing protein 0.0301 0.072 0.9178
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0093 0.0167 0.2135
Echinococcus granulosus cyclins 0.0124 0.0249 0.0249
Onchocerca volvulus 0.0094 0.017 0.1253
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0118 0.0233 0.0533
Loa Loa (eye worm) hypothetical protein 0.0282 0.0671 0.1531
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0218 0.05 0.05
Plasmodium falciparum metacaspase-like protein 0.0057 0.0072 0.092
Echinococcus granulosus expressed protein 0.028 0.0665 0.0665
Schistosoma mansoni opsin-like receptor 0.0218 0.05 0.05
Echinococcus multilocularis dna polymerase eta 0.0034 0.001 0.001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0218 0.05 0.05
Brugia malayi ADAM-TS Spacer 1 family protein 0.0045 0.0039 0.0089
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0056 0.007 0.007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0004 0.0004
Brugia malayi Trypsin family protein 0.0094 0.017 0.0388
Echinococcus multilocularis cyclins 0.0124 0.0249 0.0249
Brugia malayi hypothetical protein 0.0218 0.05 0.1141
Echinococcus multilocularis g protein coupled receptor 0.0218 0.05 0.05
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.0159
Plasmodium falciparum subtilisin-like protease 1 0.0084 0.0143 0.1823
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Brugia malayi PAN domain containing protein 0.0033 0.001 0.0022
Entamoeba histolytica cyclin family protein 0.0124 0.0249 0.3877
Echinococcus granulosus neurogenic locus notch protein 4 0.0032 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Leishmania major trypanothione reductase 0.003 0.0001 0.0016
Schistosoma mansoni hypothetical protein 0.0037 0.002 0.002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0247 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0004 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0051 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.0167 0.0283
Trypanosoma brucei rac serine-threonine kinase, putative 0.0034 0.001 0.0035
Trypanosoma brucei subtilisin peptidase 0.0084 0.0143 0.0506
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.001 0.0022
Brugia malayi steroid hormone receptor 0.0031 0.0004 0.0009
Giardia lamblia G2/mitotic-specific cyclin B 0.0272 0.0642 0.5779
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Trypanosoma brucei RNA helicase, putative 0.1093 0.2825 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0218 0.05 0.05
Onchocerca volvulus 0.0218 0.05 0.3688
Echinococcus multilocularis cyclins 0.0124 0.0249 0.0249
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0202 0.0457 0.0457
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Toxoplasma gondii subtilisin SUB12 0.0117 0.0232 0.2956
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0084 0.0143 1
Brugia malayi hypothetical protein 0.0218 0.05 0.1141
Plasmodium vivax subtilisin-like protease 2, putative 0.0084 0.0143 0.1823
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0033 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Loa Loa (eye worm) G-protein coupled receptor 0.0218 0.05 0.1141
Toxoplasma gondii subtilisin SUB11 0.0084 0.0143 0.1823
Loa Loa (eye worm) hypothetical protein 0.0094 0.017 0.0388
Schistosoma mansoni hypothetical protein 0.0094 0.017 0.017
Echinococcus multilocularis cyclins 0.0124 0.0249 0.0249
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0069 0.0104 0.3179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0057 0.0072 0.0122
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0135 0.028 0.028
Onchocerca volvulus Neuropeptide F receptor homolog 0.0218 0.05 0.3688
Brugia malayi AKH receptor 0.0218 0.05 0.1141
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0218 0.05 0.05
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0218 0.05 0.05
Trichomonas vaginalis cyclin B, putative 0.0124 0.0249 0.0421
Plasmodium vivax glutathione reductase, putative 0.003 0.0001 0.0016
Echinococcus granulosus adam 0.0045 0.0039 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0026 0.0043
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0218 0.05 0.05
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0084 0.0143 0.437
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0004 0.0009
Trypanosoma brucei metacaspase 5, putative 0.0057 0.0072 0.0256
Schistosoma mansoni microtubule-associated protein tau 0.0887 0.2278 0.2278
Brugia malayi nuclear receptor NHR-88 0.0031 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Onchocerca volvulus 0.0218 0.05 0.3688
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0051 0.0055 0.0195
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0056 0.007 0.0159
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Onchocerca volvulus 0.0084 0.0143 0.1056
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus granulosus neuropeptide receptor A26 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0022
Trichomonas vaginalis cyclin B, putative 0.0272 0.0642 0.1086
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0218 0.05 0.3688
Schistosoma mansoni biogenic amine (5HT) receptor 0.0218 0.05 0.05
Echinococcus multilocularis caspase 2 0.0057 0.0072 0.0072
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0004 0.0004
Echinococcus multilocularis neuroendocrine convertase 2 0.1277 0.3315 0.3315
Echinococcus granulosus mitogen activated protein kinase 3 0.0039 0.0026 0.0026
Trichomonas vaginalis AGC family protein kinase 0.0034 0.001 0.0017
Echinococcus multilocularis neuropeptide receptor 0.0377 0.0924 0.0924
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0051 0.0051
Echinococcus multilocularis G protein coupled receptor 139 0.0377 0.0924 0.0924
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus multilocularis serotonin receptor 0.0218 0.05 0.05
Onchocerca volvulus Putative cubilin 0.0032 0.0005 0.0037
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Toxoplasma gondii subtilisin SUB6 0.0084 0.0143 0.1823
Brugia malayi Cyclin, N-terminal domain containing protein 0.0272 0.0642 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0004 0.0009
Echinococcus granulosus caspase 2 0.0057 0.0072 0.0072
Schistosoma mansoni neuropeptide F-like receptor 0.0218 0.05 0.05
Toxoplasma gondii kringle domain-containing protein 0.0325 0.0785 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0218 0.05 0.1141
Plasmodium vivax subtilisin-like protease 1 0.0084 0.0143 0.1823
Echinococcus multilocularis epidermal growth factor receptor 0.0249 0.0583 0.0583
Echinococcus granulosus notch 0.0032 0.0005 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0069 0.0104 0.3179
Loa Loa (eye worm) Notch2 0.0032 0.0005 0.0011
Echinococcus granulosus enteropeptidase 0.0094 0.017 0.017
Echinococcus granulosus serotonin receptor 0.0218 0.05 0.05
Echinococcus multilocularis protein jagged 1 0.0032 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Schistosoma mansoni biogenic amine receptor 0.0218 0.05 0.05
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0057 0.0072 0.0122
Brugia malayi putative neuropeptide receptor 0.0218 0.05 0.1141
Brugia malayi Trypsin family protein 0.0094 0.017 0.0388
Toxoplasma gondii PAN domain-containing protein 0.0033 0.001 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0072 0.0122
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Echinococcus granulosus GPCR family 2 0.0037 0.002 0.002
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0044 0.0037 0.047
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0056 0.007 0.0159
Onchocerca volvulus 0.003 0.0001 0.0005
Onchocerca volvulus 0.0077 0.0126 0.0929
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Schistosoma mansoni cyclin B3 0.0124 0.0249 0.0249
Trichomonas vaginalis AGC family protein kinase 0.0034 0.001 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0218 0.05 0.05
Echinococcus granulosus tm gpcr rhodopsin 0.1766 0.4613 0.4613
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Onchocerca volvulus 0.0218 0.05 0.3688
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0218 0.05 0.05
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.017 0.017
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0084 0.0143 0.8176
Onchocerca volvulus 0.0218 0.05 0.3688
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Brugia malayi Dopamine receptor protein 1 0.0218 0.05 0.1141
Echinococcus granulosus delta-like protein 1 0.0032 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0004 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0004 0.0009
Onchocerca volvulus Slit protein homolog 0.0032 0.0005 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0167 0.0167
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0143 0.0302 0.051
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0057 0.0072 0.0122
Schistosoma mansoni hypothetical protein 0.0214 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0218 0.05 0.1141
Echinococcus multilocularis geminin 0.0214 0.049 0.049
Leishmania major cathepsin L-like protease 0.0048 0.0048 0.0611
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0005
Loa Loa (eye worm) AGC/AKT protein kinase 0.0034 0.001 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0048 0.0611
Schistosoma mansoni hypothetical protein 0.1093 0.2825 0.2825
Schistosoma mansoni hypothetical protein 0.0037 0.002 0.002
Toxoplasma gondii microneme protein MIC17A 0.0033 0.001 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.051 0.1275 0.2156
Onchocerca volvulus 0.0094 0.017 0.1253
Trypanosoma cruzi cdc2-related kinase 3 0.0093 0.0167 0.2135
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0348 0.0845 0.193
Echinococcus multilocularis fmrfamide receptor 0.0218 0.05 0.05
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0045 0.0039 0.0039
Echinococcus granulosus sex peptide receptor 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1678 0.438 0.438
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.0072 0.0072
Brugia malayi p70 ribosomal S6 kinase beta 0.0032 0.0005 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0004 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0072 0.0122
Onchocerca volvulus 0.0033 0.001 0.0071
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.001 0.0127
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0039 0.0026 0.0325
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0218 0.05 0.05
Brugia malayi neuropeptide F receptor 0.0218 0.05 0.1141
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Loa Loa (eye worm) transcription factor SMAD2 0.0076 0.0124 0.0283
Echinococcus granulosus protein jagged 1 0.0032 0.0005 0.0005
Onchocerca volvulus 0.0048 0.0047 0.0349
Schistosoma mansoni amine GPCR 0.0218 0.05 0.05
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Brugia malayi Serotonin receptor 0.0218 0.05 0.1141
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0135 0.028 0.028
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0202 0.0457 0.0457
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.054 0.1355 0.1355
Schistosoma mansoni cyclin B 0.0272 0.0642 0.0642
Brugia malayi Protein kinase domain containing protein 0.0093 0.0167 0.0382
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0077 0.0125 0.3811
Echinococcus multilocularis cyclin B 0.0272 0.0642 0.0642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Schistosoma mansoni coup transcription factor 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus granulosus tm gpcr rhodopsin 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.0167 0.0283
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.002 0.002
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0004 0.0004
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Loa Loa (eye worm) hypothetical protein 0.0325 0.0785 0.1791
Echinococcus granulosus furin 0.1678 0.438 0.438
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0004 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0285 0.0677 0.1546
Echinococcus multilocularis rhodopsin orphan GPCR 0.0218 0.05 0.05
Schistosoma mansoni hypothetical protein 0.0218 0.05 0.05
Echinococcus granulosus g protein coupled receptor 0.0218 0.05 0.05
Mycobacterium leprae Possible secreted protease 0.0084 0.0143 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0143 0.0242
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0028 0.0332
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.051 0.1275 0.2156
Onchocerca volvulus 0.0218 0.05 0.3688
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0143 0.0302 0.051
Echinococcus granulosus neuropeptide receptor 0.0377 0.0924 0.0924
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Onchocerca volvulus 0.0218 0.05 0.3688
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0009
Loa Loa (eye worm) neuropeptide F receptor 0.0218 0.05 0.1141
Trypanosoma cruzi CYC2-like cyclin, putative 0.0272 0.0642 0.8188
Trypanosoma brucei cdc2-related kinase 3 0.0093 0.0167 0.0593
Onchocerca volvulus 0.0031 0.0004 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.051 0.1275 0.2156
Echinococcus granulosus caspase 8 0.0057 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.1596 0.4162 0.9503
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0218 0.05 0.1141
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1358 0.353 0.353
Entamoeba histolytica cyclin, putative 0.0272 0.0642 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0057 0.0072 0.092
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus multilocularis g protein coupled receptor 0.0218 0.05 0.05
Echinococcus multilocularis neuropeptide receptor A26 0.0218 0.05 0.05
Trypanosoma brucei protein kinase, putative 0.0039 0.0026 0.009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0004 0.0009
Giardia lamblia Kinase, CMGC CDK 0.0093 0.0167 0.1506
Brugia malayi PAN domain containing protein 0.0033 0.001 0.0022
Echinococcus granulosus geminin 0.0214 0.049 0.049
Brugia malayi PAN domain containing protein 0.0033 0.001 0.0022
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0028 0.0332
Echinococcus granulosus neuropeptide s receptor 0.0218 0.05 0.05
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0093 0.0167 0.0382
Schistosoma mansoni neuropeptide receptor 0.0218 0.05 0.05
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0034 0.001 0.0017
Onchocerca volvulus 0.0094 0.017 0.1253
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.017 0.017
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.004 0.0028 0.0834
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.001 0.0022
Trypanosoma cruzi cruzipain precursor, putative 0.0048 0.0048 0.0611
Onchocerca volvulus 0.0218 0.05 0.3688
Mycobacterium tuberculosis Probable reductase 0.0069 0.0104 0.3179
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0005
Plasmodium vivax topoisomerase I, putative 0.0201 0.0455 0.5799
Echinococcus granulosus Furin 1 0.051 0.1275 0.1275
Echinococcus multilocularis dro:myosuppressin receptor 0.0218 0.05 0.05
Echinococcus multilocularis microtubule associated protein 2 0.0887 0.2278 0.2278
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0249 0.0421
Trichomonas vaginalis cyclin D, putative 0.0124 0.0249 0.0421
Echinococcus granulosus g-protein coupled receptor 0.0218 0.05 0.05
Schistosoma mansoni tyrosine kinase 0.0249 0.0583 0.0583
Brugia malayi nuclear hormone receptor 0.0031 0.0004 0.0009
Trichomonas vaginalis cyclin B, putative 0.0272 0.0642 0.1086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0009
Brugia malayi Dopamine receptor protein 2 0.0218 0.05 0.1141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Toxoplasma gondii AGC kinase 0.0032 0.0005 0.0058
Trypanosoma cruzi cdc2-related kinase 1 0.0093 0.0167 0.2135
Brugia malayi Delta serrate ligand family protein 0.0032 0.0005 0.0011
Brugia malayi Cadherin domain containing protein 0.0032 0.0005 0.0011
Echinococcus multilocularis orexin receptor type 2 0.0218 0.05 0.05
Schistosoma mansoni hypothetical protein 0.0214 0.049 0.049
Echinococcus granulosus rhodopsin orphan GPCR 0.0218 0.05 0.05
Entamoeba histolytica cell division protein kinase 2, putative 0.0093 0.0167 0.2607
Loa Loa (eye worm) hypothetical protein 0.0094 0.017 0.0388
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0018 0.0018
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0091 0.0163 0.0373
Loa Loa (eye worm) endoprotease bli-4 0.1678 0.438 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0039 0.0026 0.0325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0218 0.05 0.05
Schistosoma mansoni alpha-1 adrenergic receptor 0.0218 0.05 0.05
Brugia malayi Dopamine receptor 0.0218 0.05 0.1141
Brugia malayi Calcium binding EGF domain containing protein 0.0056 0.007 0.0159
Schistosoma mansoni DNA topoisomerase type I 0.0201 0.0455 0.0455
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Echinococcus granulosus cyclin dependent kinase 1 0.0093 0.0167 0.0167
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.017 0.017
Brugia malayi neuropeptide F receptor 0.0218 0.05 0.1141
Echinococcus multilocularis mitogen activated protein kinase 3 0.0039 0.0026 0.0026
Schistosoma mansoni caspase-3 (C14 family) 0.0135 0.028 0.028
Loa Loa (eye worm) subtilase 0.0084 0.0143 0.0327
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0005
Brugia malayi PAN domain containing protein 0.0033 0.001 0.0022
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0379 0.0927 0.1567
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0093 0.0167 0.2135
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0004 0.0009
Brugia malayi hypothetical protein 0.0218 0.05 0.1141
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0026 0.0043
Echinococcus granulosus somatostatin receptor 0.0218 0.05 0.05
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0004 0.0004
Trypanosoma cruzi metacaspase 5, putative 0.0057 0.0072 0.092
Brugia malayi PAS domain containing protein 0.0052 0.006 0.0136
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.091 0.234 0.234
Echinococcus granulosus hypothetical protein 0.0218 0.05 0.05
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0051 0.0055 0.0701
Echinococcus multilocularis cyclins 0.0124 0.0249 0.0249
Brugia malayi GnHR receptor homolog 0.0218 0.05 0.1141
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0011
Trypanosoma cruzi metacaspase, putative 0.0057 0.0072 0.092
Onchocerca volvulus 0.0032 0.0005 0.0037
Brugia malayi sulfakinin receptor protein 0.0218 0.05 0.1141
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0039 0.0026 0.0325
Toxoplasma gondii PAN domain-containing protein 0.0033 0.001 0.0123
Schistosoma mansoni site-1 peptidase (S08 family) 0.0084 0.0143 0.0143
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.001 0.0022
Onchocerca volvulus 0.0218 0.05 0.3688
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Schistosoma mansoni slit 0.0032 0.0005 0.0005
Schistosoma mansoni notch 0.0032 0.0005 0.0005
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.015 0.0321 0.4088
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0143 0.0242
Echinococcus granulosus Mastin 0.0094 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0022
Brugia malayi hypothetical protein 0.0218 0.05 0.1141
Loa Loa (eye worm) neuropeptide F receptor 0.0218 0.05 0.1141
Giardia lamblia Furin precursor putative serine protease 0.0426 0.1053 0.9472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus granulosus neuropeptides capa receptor 0.0218 0.05 0.05
Echinococcus multilocularis fmrfamide receptor 0.0218 0.05 0.05
Echinococcus granulosus caspase 0.0135 0.028 0.028
Trichomonas vaginalis cyclins, putative 0.0178 0.0393 0.0665
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Schistosoma mansoni notch 0.0032 0.0005 0.0005
Echinococcus granulosus tissue type plasminogen activator 0.0325 0.0785 0.0785
Leishmania major cathepsin L-like protease 0.0048 0.0048 0.0611
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0004 0.0028
Trichomonas vaginalis cyclins, putative 0.0272 0.0642 0.1086
Echinococcus granulosus rhodopsin orphan GPCR 0.0218 0.05 0.05
Echinococcus granulosus neural cadherin 0.0032 0.0005 0.0005
Trypanosoma cruzi cyclin, putative 0.0272 0.0642 0.8188
Echinococcus granulosus cyclin dependent kinase 5 0.0093 0.0167 0.0167
Leishmania major hypothetical protein, conserved 0.0325 0.0785 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0004 0.0004
Brugia malayi Furin-like cysteine rich region family protein 0.0249 0.0583 0.1331
Echinococcus granulosus neuropeptides capa receptor 0.0627 0.1587 0.1587
Echinococcus granulosus cyclin B3 1 0.0124 0.0249 0.0249
Echinococcus granulosus fibropellin Ia 0.0032 0.0005 0.0005
Onchocerca volvulus Arrow homolog 0.0056 0.007 0.0515
Schistosoma mansoni amine GPCR 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.0159
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Echinococcus multilocularis neuropeptide Y receptor 0.0218 0.05 0.05
Echinococcus granulosus allatostatin A receptor 0.0218 0.05 0.05
Echinococcus granulosus cyclins 0.0124 0.0249 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Brugia malayi hypothetical protein 0.0092 0.0165 0.0376
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Onchocerca volvulus 0.0039 0.0023 0.0173
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0077 0.0125 0.5303
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0011
Onchocerca volvulus 0.0033 0.001 0.0071
Onchocerca volvulus 0.0033 0.001 0.0071
Onchocerca volvulus 0.0218 0.05 0.3688
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0023 0.0054
Schistosoma mansoni hypothetical protein 0.0037 0.002 0.002
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0093 0.0167 0.0382
Loa Loa (eye worm) G-protein coupled receptor 0.0218 0.05 0.1141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0004 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Echinococcus multilocularis neuropeptides capa receptor 0.0218 0.05 0.05
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0218 0.05 0.05
Trypanosoma cruzi cdc2-related kinase 1 0.0093 0.0167 0.2135
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus multilocularis slit 2 protein 0.0032 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Trypanosoma brucei metacaspase 0.0057 0.0072 0.0256
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0092 0.0165 0.0165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Onchocerca volvulus 0.0094 0.017 0.1253
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.091 0.234 0.234
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.004 0.0028 0.0028
Echinococcus multilocularis expressed protein 0.028 0.0665 0.0665
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0218 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Giardia lamblia NADPH oxidoreductase, putative 0.0143 0.0302 0.2714
Entamoeba histolytica protein kinase, putative 0.0032 0.0005 0.0071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.004 0.0028 0.0361
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0069 0.0104 0.3179
Toxoplasma gondii subtilisin SUB7 0.0084 0.0143 0.1823
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Entamoeba histolytica protein kinase, putative 0.0034 0.001 0.0154
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0004 0.0009
Plasmodium falciparum glutathione reductase 0.003 0.0001 0.0016
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0039 0.0026 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0084 0.0143 0.8176
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0218 0.05 0.05
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0057 0.0072 0.0122
Echinococcus granulosus neuropeptide Y receptor 0.0218 0.05 0.05
Trichomonas vaginalis cyclin D, putative 0.0124 0.0249 0.0421
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0218 0.05 0.1141
Echinococcus granulosus biogenic amine 5HT receptor 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.0159
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0218 0.05 0.1141
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0218 0.05 0.1141
Plasmodium vivax thioredoxin reductase, putative 0.003 0.0001 0.0016
Echinococcus granulosus survival motor neuron protein 1 0.0147 0.0312 0.0312
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0057 0.0072 0.0122
Echinococcus multilocularis cyclin dependent kinase 1 0.0093 0.0167 0.0167
Brugia malayi hypothetical protein 0.0218 0.05 0.1141
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0218 0.05 0.05
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.051 0.1275 0.2156
Onchocerca volvulus 0.0272 0.0642 0.4742
Trichomonas vaginalis AGC family protein kinase 0.0034 0.001 0.0017
Toxoplasma gondii microneme protein MIC17C 0.0033 0.001 0.0123
Giardia lamblia High cysteine protein 0.0032 0.0005 0.0045
Brugia malayi hypothetical protein 0.0218 0.05 0.1141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0118 0.0233 0.0533
Loa Loa (eye worm) TK/ROR protein kinase 0.0325 0.0785 0.1791
Echinococcus multilocularis G-protein coupled receptor, putative 0.0218 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0072 0.0122
Onchocerca volvulus 0.054 0.1355 1
Trypanosoma brucei trypanothione reductase 0.003 0.0001 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0026 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Echinococcus granulosus membrane bound transcription factor site 1 0.0084 0.0143 0.0143
Echinococcus multilocularis allatostatin A receptor 0.0218 0.05 0.05
Brugia malayi Cyclin, N-terminal domain containing protein 0.0272 0.0642 0.1467
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0004 0.0009
Giardia lamblia Hypothetical protein 0.0124 0.0249 0.224
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.0072 0.0533
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0282 0.0671 0.1531
Echinococcus granulosus neuropeptide receptor 0.0218 0.05 0.05
Schistosoma mansoni opsin-like receptor 0.0218 0.05 0.05
Echinococcus multilocularis rhodopsin orphan GPCR 0.0218 0.05 0.05
Echinococcus granulosus orexin receptor type 2 0.0218 0.05 0.05
Echinococcus multilocularis fat cadherin tumor suppressor 0.0032 0.0005 0.0005
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0039 0.0026 0.0325
Echinococcus multilocularis neurogenic locus notch protein 0.0032 0.0005 0.0005
Onchocerca volvulus 0.0218 0.05 0.3688
Schistosoma mansoni growth hormone secretagogue receptor 0.0218 0.05 0.05
Echinococcus granulosus cyclins 0.0124 0.0249 0.0249
Schistosoma mansoni cyclins 0.0124 0.0249 0.0249
Brugia malayi RE15519p 0.0218 0.05 0.1141
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0004 0.0004
Brugia malayi PAN domain containing protein 0.0033 0.001 0.0022
Plasmodium falciparum thioredoxin reductase 0.003 0.0001 0.0016
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.0249 0.0569
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0218 0.05 0.05
Entamoeba histolytica hypothetical protein 0.0092 0.0165 0.2561
Echinococcus granulosus Tolloid protein 1 0.0056 0.007 0.007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.017 0.017
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0218 0.05 0.05
Trichomonas vaginalis AGC family protein kinase 0.0034 0.001 0.0017
Onchocerca volvulus 0.0218 0.05 0.3688
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0039 0.0026 0.0325
Brugia malayi Trypsin family protein 0.0094 0.017 0.0388
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Echinococcus multilocularis somatostatin receptor 0.0218 0.05 0.05
Schistosoma mansoni cell polarity protein 0.0032 0.0005 0.0005
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0032 0.0005 0.0005
Onchocerca volvulus 0.0032 0.0005 0.0037
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.035 0.08
Toxoplasma gondii thioredoxin reductase 0.003 0.0001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0094 0.017 0.0388
Trypanosoma brucei mitotic cyclin 6 0.0272 0.0642 0.2274
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0218 0.05 0.05
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0218 0.05 0.05
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0124 0.0249 0.0249
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0084 0.0143 0.0327
Trypanosoma brucei Metacaspase-4 0.0057 0.0072 0.0256
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0051 0.0117
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0094 0.017 0.017
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0218 0.05 0.05
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0094 0.017 0.0388
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0218 0.05 0.05
Echinococcus multilocularis Mastin 0.0094 0.017 0.017
Echinococcus granulosus neurogenic locus notch protein 0.0032 0.0005 0.0005
Brugia malayi endoprotease bli-4 precursor 0.1678 0.438 1
Schistosoma mansoni notch 0.0032 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0005
Echinococcus multilocularis cyclins 0.0124 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0004 0.0028
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.004 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Echinococcus multilocularis cyclins 0.0124 0.0249 0.0249
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0093 0.0167 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Trypanosoma cruzi metacaspase, putative 0.0057 0.0072 0.092
Brugia malayi Serotonin receptor 0.0218 0.05 0.1141
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0009
Trypanosoma cruzi cyclin, putative 0.0272 0.0642 0.8188
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Loa Loa (eye worm) hypothetical protein 0.0045 0.0039 0.0089
Loa Loa (eye worm) cyclin domain-containing protein 0.0124 0.0249 0.0569
Onchocerca volvulus 0.0446 0.1106 0.8162
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0218 0.05 0.05
Onchocerca volvulus 0.0218 0.05 0.3688
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0004 0.0009
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.006 0.006
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0084 0.0143 0.1823
Trypanosoma brucei metacaspase MCA2 0.0057 0.0072 0.0256
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0033 0.001 0.0123
Echinococcus granulosus single minded 2 0.0039 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.2255 0.5915 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0218 0.05 0.05
Schistosoma mansoni furin-1 (S08 family) 0.0851 0.2183 0.2183
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus multilocularis neurogenic locus protein delta 0.0032 0.0005 0.0005
Schistosoma mansoni survival motor neuron protein 0.003 0.0001 0.0001
Echinococcus granulosus g protein coupled receptor 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.051 0.1275 0.2156
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0084 0.0143 0.0506
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0143 0.0302 0.4697
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0218 0.05 0.05
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0051 0.0051
Echinococcus granulosus 7tm_1 domain containing protein 0.0218 0.05 0.05
Echinococcus multilocularis neuropeptide Y receptor 0.0218 0.05 0.05
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0131 0.0269 0.0455
Echinococcus multilocularis adam 0.0045 0.0039 0.0039
Echinococcus granulosus glycoprotein Antigen 5 0.0094 0.017 0.017
Brugia malayi Cadherin domain containing protein 0.0032 0.0005 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Entamoeba histolytica hypothetical protein 0.0143 0.0302 0.4697
Echinococcus multilocularis caspase 0.0135 0.028 0.028
Brugia malayi Thioredoxin reductase 0.003 0.0001 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0131 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0009
Toxoplasma gondii DNA topoisomerase I, putative 0.0201 0.0455 0.5799
Plasmodium falciparum cyclin 0.0124 0.0249 0.3174
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Loa Loa (eye worm) hypothetical protein 0.1678 0.438 1
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0084 0.0143 0.437
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0057 0.0072 0.0122
Onchocerca volvulus 0.0218 0.05 0.3688
Trichomonas vaginalis cyclin B, putative 0.0272 0.0642 0.1086
Schistosoma mansoni hypothetical protein 0.0379 0.0927 0.0927
Toxoplasma gondii subtilisin SUB2 0.0084 0.0143 0.1823
Echinococcus multilocularis cyclin B3 1 0.0124 0.0249 0.0249
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0057 0.0072 0.0122
Loa Loa (eye worm) hypothetical protein 0.0815 0.2087 0.4765
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Loa Loa (eye worm) hypothetical protein 0.0084 0.0143 0.0327
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0018 0.0018
Brugia malayi MAP kinase sur-1 0.0039 0.0026 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0167 0.0167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1766 0.4613 0.4613
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0004 0.0009
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0143 0.0302 0.051
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.2255 0.5915 1
Trypanosoma cruzi metacaspase 5, putative 0.0057 0.0072 0.092
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.017 0.017
Onchocerca volvulus 0.0033 0.001 0.0071
Echinococcus multilocularis neuropeptide receptor 0.0218 0.05 0.05
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0218 0.05 0.05
Echinococcus granulosus neuroendocrine convertase 2 0.1277 0.3315 0.3315
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.0167 0.0283
Echinococcus multilocularis membrane bound transcription factor site 1 0.0084 0.0143 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Leishmania major cyclin 0.0272 0.0642 0.8188
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0018 0.0018
Brugia malayi hypothetical protein 0.0147 0.0312 0.0713
Brugia malayi jmjC domain containing protein 0.0037 0.0018 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.091 0.234 0.3956
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0057 0.0072 0.0165
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0001 0.0016
Giardia lamblia Kinase, CMGC MAPK 0.0039 0.0026 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.003 0.0001 0.0001
Toxoplasma gondii PAN/Apple domain-containing protein 0.0033 0.001 0.0123
Schistosoma mansoni adenoreceptor 0.0218 0.05 0.05
Schistosoma mansoni single-minded 0.0052 0.006 0.006
Echinococcus multilocularis neuropeptide FF receptor 2 0.1596 0.4162 0.4162
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0004 0.0004
Echinococcus multilocularis tissue type plasminogen activator 0.0325 0.0785 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Schistosoma mansoni laminin gamma-3 chain 0.0032 0.0005 0.0005
Echinococcus multilocularis neural cadherin 0.0032 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0218 0.05 0.05
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0057 0.0072 0.092
Brugia malayi G protein-coupled receptor F59B2.13 0.0218 0.05 0.1141
Plasmodium vivax subtilisin-like serine protease, putative 0.0084 0.0143 0.1823
Plasmodium vivax protein kinase Crk2 0.0093 0.0167 0.2135
Echinococcus granulosus cyclin b3 0.0124 0.0249 0.0249
Echinococcus granulosus cyclin dependent kinase 0.0093 0.0167 0.0167
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0011
Leishmania major DNA topoisomerase type IB small subunit 0.0051 0.0055 0.0701
Loa Loa (eye worm) proprotein convertase 2 0.051 0.1275 0.2912
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0218 0.05 0.05
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0218 0.05 0.1141
Plasmodium falciparum cysteine repeat modular protein 1 0.0325 0.0785 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0051 0.0117
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0272 0.0642 0.1467
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.051 0.1275 0.1275
Schistosoma mansoni hypothetical protein 0.0325 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0057 0.0072 0.0165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0004 0.0004
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0325 0.0785 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Trypanosoma cruzi major cysteine proteinase, putative 0.0038 0.0021 0.0264
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.165 0.4307 0.4307
Echinococcus multilocularis cyclin dependent kinase 5 0.0093 0.0167 0.0167
Toxoplasma gondii calcium binding egf domain-containing protein 0.0056 0.007 0.0889
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0056 0.007 0.0159
Leishmania major metacaspase, putative 0.0057 0.0072 0.092
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0048 0.0611
Trichomonas vaginalis cyclins, putative 0.0272 0.0642 0.1086
Echinococcus multilocularis serotonin receptor 0.0218 0.05 0.05
Onchocerca volvulus 0.0033 0.001 0.0071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Echinococcus granulosus rhodopsin orphan GPCR 0.0218 0.05 0.05
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0022
Schistosoma mansoni myosin xvIII 0.0218 0.05 0.05
Loa Loa (eye worm) TYRA-2 protein 0.0218 0.05 0.1141
Onchocerca volvulus 0.0032 0.0005 0.0037
Brugia malayi G protein-coupled receptor 0.0218 0.05 0.1141
Onchocerca volvulus 0.0094 0.017 0.1253
Brugia malayi Tachykinin-like peptides receptor 99D 0.1596 0.4162 0.9503
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0009
Brugia malayi PAN domain containing protein 0.0033 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Brugia malayi ADAMTS-like protease 0.0045 0.0039 0.0089
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0094 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Mycobacterium tuberculosis Probable dehydrogenase 0.0069 0.0104 0.3179
Echinococcus granulosus protein jagged 2 0.0032 0.0005 0.0005
Brugia malayi Kringle domain containing protein 0.0325 0.0785 0.1791
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Echinococcus multilocularis cyclin dependent kinase 1 0.0093 0.0167 0.0167
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0023 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Schistosoma mansoni DNA topoisomerase type I 0.015 0.0321 0.0321
Echinococcus granulosus tm gpcr rhodopsin 0.0218 0.05 0.05
Echinococcus multilocularis caspase 8 0.0057 0.0072 0.0072
Brugia malayi DNA topoisomerase I 0.0201 0.0455 0.1039
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0022
Giardia lamblia NADPH oxidoreductase, putative 0.0143 0.0302 0.2714
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0039 0.0026 0.0325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0218 0.05 0.05
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0009
Brugia malayi follicle stimulating hormone receptor 0.0218 0.05 0.1141
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0426 0.1053 0.178
Brugia malayi jmjC domain containing protein 0.0037 0.0018 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0094 0.017 0.017
Schistosoma mansoni amine GPCR 0.0218 0.05 0.05
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0004 0.0009
Brugia malayi PAN domain containing protein 0.0033 0.001 0.0022
Echinococcus granulosus fmrfamide receptor 0.0218 0.05 0.05
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Onchocerca volvulus 0.0033 0.001 0.0071
Trichomonas vaginalis cyclins, putative 0.0272 0.0642 0.1086
Trichomonas vaginalis cyclin B3, putative 0.0124 0.0249 0.0421
Onchocerca volvulus 0.0032 0.0005 0.0037
Echinococcus multilocularis cyclin dependent kinase 0.0093 0.0167 0.0167
Onchocerca volvulus 0.0218 0.05 0.3688
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0084 0.0143 1
Schistosoma mansoni hypothetical protein 0.3793 1 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0032 0.0005 0.0037
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0152 0.0326 1
Schistosoma mansoni egf-like domain protein 0.0056 0.007 0.007
Giardia lamblia NADPH oxidoreductase, putative 0.0143 0.0302 0.2714
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0143 0.0242
Entamoeba histolytica cyclin, putative 0.0124 0.0249 0.3877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0048 0.0611
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0084 0.0143 0.0143
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.091 0.234 0.3956
Brugia malayi Trypsin-like protease protein 5 0.0094 0.017 0.0388
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0004 0.0004
Echinococcus granulosus neurogenic locus protein delta 0.0032 0.0005 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0051 0.0051
Echinococcus multilocularis transmembrane protease serine 3 0.0094 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Echinococcus granulosus dro:myosuppressin receptor 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Loa Loa (eye worm) thioredoxin reductase 0.003 0.0001 0.0003
Schistosoma mansoni biogenic amine receptor 0.0218 0.05 0.05
Echinococcus multilocularis cyclins 0.0124 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.008 0.0134 0.0307
Brugia malayi hypothetical protein 0.0218 0.05 0.1141
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Schistosoma mansoni hypothetical protein 0.003 0.0001 0.0001
Brugia malayi cell division control protein 2 homolog 0.0093 0.0167 0.0382
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0218 0.05 0.05
Echinococcus granulosus g protein coupled receptor 0.0218 0.05 0.05
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0048 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0927 0.1567
Loa Loa (eye worm) hypothetical protein 0.054 0.1355 0.3093
Echinococcus granulosus thioredoxin glutathione reductase 0.003 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0377 0.0924 0.0924
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0022
Trichomonas vaginalis cyclin A, putative 0.0272 0.0642 0.1086
Echinococcus granulosus neuropeptide Y receptor 0.0218 0.05 0.05
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0035 0.0015 0.0034
Onchocerca volvulus 0.0218 0.05 0.3688
Toxoplasma gondii PAN domain-containing protein 0.0033 0.001 0.0123
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0218 0.05 0.1141
Echinococcus multilocularis g protein coupled receptor 0.0218 0.05 0.05
Loa Loa (eye worm) notch protein 0.0032 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Echinococcus multilocularis cyclin b3 0.0124 0.0249 0.0249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.054 0.1355 0.3093
Schistosoma mansoni amine GPCR 0.0218 0.05 0.05
Trypanosoma cruzi hypothetical protein, conserved 0.0325 0.0785 1
Schistosoma mansoni opsin-like receptor 0.0218 0.05 0.05
Brugia malayi Protein kinase domain containing protein 0.0034 0.001 0.0023
Brugia malayi neuroendocrine convertase 1 precursor 0.1578 0.4113 0.9392
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0143 0.0242
Echinococcus granulosus tachykinin peptides receptor 99D 0.0218 0.05 0.05
Echinococcus granulosus neuropeptide FF receptor 2 0.1596 0.4162 0.4162
Schistosoma mansoni hypothetical protein 0.0094 0.017 0.017
Echinococcus granulosus neurogenic locus notch protein 0.0032 0.0005 0.0005
Echinococcus granulosus protein jagged 1 0.0032 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0004 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.3793 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Giardia lamblia Cyclin A 0.0124 0.0249 0.224
Toxoplasma gondii subtilisin SUB5 0.0084 0.0143 0.1823
Toxoplasma gondii hypothetical protein 0.0033 0.001 0.0123
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0004 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.0218 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0072 0.0122
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0084 0.0143 0.1823
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0218 0.05 0.05
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0005
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0039 0.0026 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0272 0.0642 0.1467
Schistosoma mansoni septate junction protein 0.0032 0.0005 0.0005
Brugia malayi PAN domain containing protein 0.0033 0.001 0.0022
Echinococcus granulosus slit 2 protein 0.0032 0.0005 0.0005
Echinococcus granulosus alpha 1A adrenergic receptor 0.0218 0.05 0.05
Echinococcus granulosus laminin 0.0056 0.007 0.007
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Trichomonas vaginalis modulator of drug activity B, putative 0.0143 0.0302 0.051
Entamoeba histolytica cyclin family protein 0.0124 0.0249 0.3877
Onchocerca volvulus 0.0033 0.001 0.0071
Loa Loa (eye worm) hypothetical protein 0.0045 0.0039 0.0089
Plasmodium falciparum topoisomerase I 0.0201 0.0455 0.5799
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0143 0.0242
Echinococcus multilocularis laminin 0.0056 0.007 0.007
Echinococcus granulosus DNA topoisomerase 1 0.0201 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0037 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1141
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.017 0.017
Echinococcus granulosus transmembrane protease serine 3 0.0094 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.0045
Echinococcus multilocularis enteropeptidase 0.0094 0.017 0.017
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.001 0.0022
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0094 0.017 0.017
Echinococcus multilocularis fibropellin Ia 0.0032 0.0005 0.0005
Plasmodium falciparum protein kinase 5 0.0093 0.0167 0.2135
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0057 0.0072 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0072 0.0122
Brugia malayi hypoxia-induced factor 1 0.0162 0.035 0.08
Trichomonas vaginalis hypothetical protein 0.0379 0.0927 0.1567
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0092 0.0165 0.0165
Entamoeba histolytica hypothetical protein 0.0092 0.0165 0.2561
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0034 0.001 0.0023
Toxoplasma gondii subtilisin SUB4 0.0084 0.0143 0.1823
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0093 0.0167 0.2135
Toxoplasma gondii PAN domain-containing protein 0.0033 0.001 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0302 0.051
Toxoplasma gondii subtilisin SUB9 0.0084 0.0143 0.1823
Brugia malayi PAN domain containing protein 0.0033 0.001 0.0022
Toxoplasma gondii PAN domain-containing protein 0.0301 0.072 0.9178
Onchocerca volvulus 0.0325 0.0785 0.5791

Activities

Activity type Activity value Assay description Source Reference
Kon (binding) = 54000 M-1 s-1 Inhibition of human leukocyte elastase II (HLE-II) as second order rate constant ChEMBL. No reference
k_on (binding) = 54000 M-1 s-1 Inhibition of human leukocyte elastase II (HLE-II) as second order rate constant ChEMBL. No reference
pKa = 8.9 pKa value of the compound was determined ChEMBL. No reference
T1/2 = 16.3 hr Chemical half-life of the compound was evaluated at 37 degree C expressed as stability towards hydrolysis ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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