Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.117 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.117 | 1 |
Onchocerca volvulus | 0.0033 | 0.117 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.117 | 0.1236 |
Onchocerca volvulus | 0.0033 | 0.117 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0033 | 0.117 | 0.1135 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.9182 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0156 | 0.1333 |
Echinococcus granulosus | lamin | 0.0033 | 0.117 | 0.1236 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.9182 | 0.9178 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.117 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.113 | 0.9658 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.004 | 0.0342 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.117 | 0.1236 |
Echinococcus multilocularis | lamin | 0.0033 | 0.117 | 0.1135 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.117 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.117 | 0.1135 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.9182 | 0.9073 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.117 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0028 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (binding) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.