Detailed information for compound 136302

Basic information

Technical information
  • TDR Targets ID: 136302
  • Name: 2-[(4-hexoxyphenyl)sulfonyl-(2-methylpropyl)a mino]-N-hydroxyacetamide
  • MW: 386.506 | Formula: C18H30N2O5S
  • H donors: 2 H acceptors: 4 LogP: 3.56 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCOc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(C)C
  • InChi: 1S/C18H30N2O5S/c1-4-5-6-7-12-25-16-8-10-17(11-9-16)26(23,24)20(13-15(2)3)14-18(21)19-22/h8-11,15,22H,4-7,12-14H2,1-3H3,(H,19,21)
  • InChiKey: MEGRMEXCUOBMOZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(4-hexoxyphenyl)sulfonyl-isobutyl-amino]ethanehydroxamic acid
  • 2-[(4-hexoxyphenyl)sulfonyl-isobutylamino]ethanehydroxamic acid
  • 2-[(4-hexoxyphenyl)sulfonyl-(2-methylpropyl)amino]-N-hydroxy-ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 3 (stromelysin 1, progelatinase) 477 aa 431 aa 34.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0369 0.225
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.1175 0.3814
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1402 0.455
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0039
Onchocerca volvulus 0.0028 0.0782 0.0175
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0701 0.1037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1393 0.4521
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0039 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1641 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.1402 0.9694
Loa Loa (eye worm) matrix metalloproteinase 0.0026 0.0718 0.1062
Schistosoma mansoni hypothetical protein 0.0064 0.2016 0.4145
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0369 0.5
Trichomonas vaginalis chaperonin, putative 0.0048 0.1447 0.1447
Loa Loa (eye worm) hypothetical protein 0.0082 0.2627 0.3888
Loa Loa (eye worm) hypothetical protein 0.0038 0.1124 0.1663
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0782 0.1156
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0048 0.1447 0.4694
Giardia lamblia TCP-1 chaperonin subunit beta 0.0048 0.1447 0.1447
Trichomonas vaginalis helicase, putative 0.0006 0.0039 0.0039
Mycobacterium tuberculosis Probable reductase 0.0106 0.3428 0.6914
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0701 0.4847
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1402 0.2075
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0048 0.1447 0.2974
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.2627 0.3888
Plasmodium falciparum thioredoxin reductase 0.0016 0.0369 0.2551
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0369 0.2551
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.2016 0.6541
Loa Loa (eye worm) matrixin family protein 0.0058 0.181 0.2679
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0048 0.1447 1
Leishmania major trypanothione reductase 0.0046 0.1402 0.9694
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0039
Schistosoma mansoni lamin 0.0082 0.2627 0.5402
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.2016 0.6541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1393 0.2865
Loa Loa (eye worm) hypothetical protein 0.0064 0.2016 0.2983
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0039
Echinococcus multilocularis lamin dm0 0.0082 0.2627 0.8524
Schistosoma mansoni intermediate filament proteins 0.0082 0.2627 0.5402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 1 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0048 0.1447 0.2974
Treponema pallidum fructose-bisphosphate aldolase 0.0299 1 1
Plasmodium falciparum T-complex protein 1 subunit beta 0.0048 0.1447 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.3831 0.7824
Brugia malayi Matrixin family protein 0.0026 0.0718 0.1062
Loa Loa (eye worm) hypothetical protein 0.004 0.1175 0.1739
Echinococcus granulosus flap endonuclease 1 0.0026 0.0701 0.2275
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0114 0.0169
Onchocerca volvulus 0.0082 0.2627 0.5274
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0369 0.2551
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0369 0.2551
Plasmodium falciparum flap endonuclease 1 0.0026 0.0701 0.4847
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0369 0.1198
Onchocerca volvulus Huntingtin homolog 0.0133 0.4338 1
Onchocerca volvulus Huntingtin homolog 0.0133 0.4338 1
Echinococcus granulosus lamin dm0 0.0082 0.2627 0.8524
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0039
Brugia malayi Matrixin family protein 0.0026 0.0718 0.1062
Plasmodium falciparum glutathione reductase 0.0046 0.1402 0.9694
Brugia malayi intermediate filament protein 0.0082 0.2627 0.3888
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0039
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.006 0.0194
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.1324 0.196
Brugia malayi T-complex protein 1, beta subunit 0.0048 0.1447 0.2141
Loa Loa (eye worm) hypothetical protein 0.0133 0.4338 0.6419
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1393 0.2062
Schistosoma mansoni cpg binding protein 0.003 0.0836 0.1719
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0369 0.0369
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.6758 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0026 0.0718 0.1476
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.2016 0.6541
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0096 0.3082 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.006 0.0123
Brugia malayi Latrophilin receptor protein 2 0.0064 0.2016 0.2983
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0369 0.2551
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 1 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0058 0.181 0.3018
Loa Loa (eye worm) intermediate filament protein 0.0082 0.2627 0.3888
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 1 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.4563 0.6752
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.2016 0.2983
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0039 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 1 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.006 0.0194
Brugia malayi Flap endonuclease-1 0.0026 0.0701 0.1037
Echinococcus granulosus intermediate filament protein 0.0082 0.2627 0.8524
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0048 0.1447 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0118 0.0175
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0701 0.0701
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0701 0.0701
Schistosoma mansoni hypothetical protein 0.0064 0.2016 0.4145
Onchocerca volvulus 0.0082 0.2627 0.5274
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0701 0.4847
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0384
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0369 0.2551
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0369 0.2551
Loa Loa (eye worm) glutathione reductase 0.0046 0.1402 0.2075
Loa Loa (eye worm) hypothetical protein 0.0204 0.6758 1
Schistosoma mansoni cpg binding protein 0.003 0.0836 0.1719
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0369 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.006 0.0194
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.4794 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0048 0.1447 0.4694
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0048 0.1447 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.1402 0.8548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0039
Brugia malayi Thioredoxin reductase 0.0046 0.1402 0.2075
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0096 0.3082 1
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0369 0.2551
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.3428 0.6914
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0701 0.2275
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0032 0.0914 0.1352
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.4563 0.6752
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0369 0.2551
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0039
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0369 0.2551
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1393 0.2865
Echinococcus multilocularis lamin 0.0082 0.2627 0.8524
Plasmodium vivax glutathione reductase, putative 0.0046 0.1402 0.9694
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0032 0.0914 0.1231
Schistosoma mansoni cpg binding protein 0.0028 0.0782 0.1607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1393 0.4521
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.1175 0.3814
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1402 0.2335
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 1 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0224 0.0331
Schistosoma mansoni hypothetical protein 0.0139 0.4563 0.9382
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.3428 0.6481
Brugia malayi T-complex protein 1, beta subunit 0.0048 0.1447 0.2141
Loa Loa (eye worm) matrixin family protein 0.0064 0.199 0.2944
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0369 0.2551
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1393 0.2062
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0369 0.2551
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.3831 0.7824
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1402 0.9694
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0369 0.225
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.3428 0.6914
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1393 0.2865
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0369 0.1198
Brugia malayi Matrixin family protein 0.0026 0.0718 0.1062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1393 0.4521
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0369 0.5
Mycobacterium ulcerans hydrolase 0.0032 0.0914 0.1231
Echinococcus multilocularis cpg binding protein 0.003 0.0836 0.2713
Echinococcus granulosus cpg binding protein 0.003 0.0836 0.2713
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.2016 0.6541
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.006 0.0194
Echinococcus multilocularis GPCR, family 2 0.0064 0.2016 0.6541
Schistosoma mansoni hypothetical protein 0.0064 0.2016 0.4145
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.6758 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.3428 0.6914
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0701 0.4847
Plasmodium falciparum glutathione reductase 0.0016 0.0369 0.2551
Loa Loa (eye worm) hypothetical protein 0.0038 0.1124 0.1663
Schistosoma mansoni lamin 0.0082 0.2627 0.5402
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.4794 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.3428 0.6914
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0039
Brugia malayi glutathione reductase 0.0046 0.1402 0.2075
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0048 0.1447 0.2974
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0037 0.1093 0.2247
Schistosoma mansoni hypothetical protein 0.0064 0.2016 0.4145
Leishmania major T-complex protein 1, beta subunit, putative 0.0048 0.1447 1
Echinococcus granulosus GPCR family 2 0.0064 0.2016 0.6541
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0048 0.1447 0.1447
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.3831 0.7824
Loa Loa (eye worm) hypothetical protein 0.0026 0.0718 0.1062
Onchocerca volvulus 0.0037 0.1093 0.1035
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.1324 0.196
Brugia malayi Hemopexin family protein 0.0037 0.1093 0.1617
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0369 0.2551
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.2627 0.3888
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0369 0.0759
Schistosoma mansoni flap endonuclease-1 0.0023 0.0617 0.1268
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0369 0.2551
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0369 0.2551
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.4794 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.2576 0.3812
Trypanosoma brucei trypanothione reductase 0.0046 0.1402 0.9694
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0048 0.1447 0.1447
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0369 0.2551
Loa Loa (eye worm) hypothetical protein 0.0026 0.0718 0.1062
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.2016 0.2983
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0369 0.2551
Loa Loa (eye worm) hypothetical protein 0.0032 0.0914 0.1352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 1 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0369 0.0546
Brugia malayi Matrixin family protein 0.0064 0.199 0.2944
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0701 0.4847
Loa Loa (eye worm) hypothetical protein 0.0133 0.4338 0.6419
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0039
Brugia malayi hypothetical protein 0.0133 0.4338 0.6419
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0369 0.0369
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0369 0.0369
Onchocerca volvulus Matrilysin homolog 0.0058 0.181 0.3018
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1402 0.9694
Loa Loa (eye worm) hypothetical protein 0.0026 0.0718 0.1062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.3831 0.7519
Brugia malayi Matrixin family protein 0.0026 0.0718 0.1062
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.6758 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0369 0.2551
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0369 0.2551
Brugia malayi CXXC zinc finger family protein 0.0028 0.0782 0.1156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0039
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1858 0.382
Toxoplasma gondii t-complex protein beta subunit 0.0048 0.1447 0.8818
Echinococcus granulosus lamin 0.0082 0.2627 0.8524
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0224 0.0331
Echinococcus multilocularis musashi 0.0082 0.2627 0.8524
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1402 0.455
Loa Loa (eye worm) T-complex protein 1 0.0048 0.1447 0.2141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1393 0.4521
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0369 0.2551
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0369 0.2551
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0701 0.4274
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0701 0.0701
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0369 0.2551
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.3428 0.6914

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 7.2 Inhibition of human recombinant MMP3 ChEMBL. 17275314
Ki (binding) = 0.063 uM Inhibition activity against recombinant human stromelysin (Matrix metalloproteinase-3) ChEMBL. 9258358
Ki (binding) = 0.063 uM Inhibition activity against recombinant human stromelysin (Matrix metalloproteinase-3) ChEMBL. 9258358
log(1/Ki) (binding) = 7.2 Inhibition of human recombinant MMP3 ChEMBL. 17275314

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.