Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Schistosoma mansoni | Thioredoxin glutathione reductase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | glutathione reductase | 0.0046 | 0.2529 | 0.2569 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.2574 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.6874 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0016 | 0.0312 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.2529 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0016 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.6874 | 0.8837 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.9842 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0312 | 0.0317 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.6874 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0312 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.2529 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.7738 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.9842 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.7738 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.7738 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.7738 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0312 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.2529 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.6874 | 0.8837 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0016 | 0.0312 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0312 | 0.5 |
Leishmania major | trypanothione reductase | 0.0046 | 0.2529 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.2529 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.2529 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.2529 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0016 | 0.0312 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.2529 | 0.2569 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.2529 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0312 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0016 | 0.0312 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.2529 | 0.2985 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.9842 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.2574 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.