Detailed information for compound 1363229

Basic information

Technical information
  • TDR Targets ID: 1363229
  • Name: 4-methyl-N-[(E)-3-[(3-methylphenyl)amino]-1-( 4-methylsulfanylphenyl)-3-oxoprop-1-en-2-yl]b enzamide
  • MW: 416.535 | Formula: C25H24N2O2S
  • H donors: 2 H acceptors: 2 LogP: 5.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)/C=C(\C(=O)Nc1cccc(c1)C)/NC(=O)c1ccc(cc1)C
  • InChi: 1S/C25H24N2O2S/c1-17-7-11-20(12-8-17)24(28)27-23(16-19-9-13-22(30-3)14-10-19)25(29)26-21-6-4-5-18(2)15-21/h4-16H,1-3H3,(H,26,29)(H,27,28)/b23-16+
  • InChiKey: JCCANLTXZZMLLE-XQNSMLJCSA-N  


Substructure search Similarity search

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Synonyms

  • 4-methyl-N-[(E)-1-[(3-methylphenyl)carbamoyl]-2-(4-methylsulfanylphenyl)vinyl]benzamide
  • 4-methyl-N-[(E)-1-[[(3-methylphenyl)amino]-oxomethyl]-2-[4-(methylthio)phenyl]vinyl]benzamide
  • 4-methyl-N-[(E)-1-[(3-methylphenyl)carbamoyl]-2-[4-(methylthio)phenyl]vinyl]benzamide
  • 4-methyl-N-[(E)-3-[(3-methylphenyl)amino]-1-(4-methylsulfanylphenyl)-3-oxo-prop-1-en-2-yl]benzamide
  • STOCK1S-45052
  • BAS 01128341
  • 4-Methyl-N-[2-(4-methylsulfanyl-phenyl)-1-m-tolylcarbamoyl-vinyl]-benzamide
  • MLS000559802
  • SMR000176527

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0448 0.1305 0.1305
Leishmania major DNA polymerase eta, putative 0.0054 0.0107 0.0107
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0159 0.0159
Trypanosoma brucei unspecified product 0.0023 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0116 0.0295 0.0295
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0116 0.0295 0.0478
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0013 0.0013
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0448 0.1305 0.3436
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0448 0.1305 0.3436
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0116 0.0295 0.0478
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0013 0.0014
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0116 0.0295 0.0408
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0116 0.0295 0.0748
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0284 0.0808 0.2114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0116 0.0295 0.0478
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0052 0.0052
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0013 0.0116
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0284 0.0808 0.1476
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0013 0.0116
Echinococcus granulosus cathepsin l1 0.002 0.0004 0.0004
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0116 0.0295 0.0295
Leishmania major cathepsin L-like protease 0.0077 0.0177 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0052 0.0052
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0052 0.0052
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0159 0.0159
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1259 0.3774 0.3774
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0448 0.1305 0.3436
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1258 0.3773 0.3773
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.3304 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0177 0.0287
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0116 0.0295 0.0748
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0813 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0111 0.0115
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.1258 0.3773 1
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0448 0.1305 0.2116
Leishmania major carbamoyl-phosphate synthase, putative 0.0284 0.0808 0.0808
Toxoplasma gondii cathepsin CPL 0.002 0.0004 0.0004
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0159 0.0159
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0448 0.1305 0.2116
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0116 0.0295 0.0295
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0022
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0116 0.0295 0.0295
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.1258 0.3773 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0052 0.0052
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0448 0.1305 0.2905
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Plasmodium vivax vivapain-2 0.002 0.0004 0.0005
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0116 0.0295 0.0295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0004 0.0004
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0004 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0111 0.0111
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0004 0.0004
Chlamydia trachomatis biotin carboxylase 0.1143 0.3421 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0058 0.0058
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0058 0.0094
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0013 0.0013
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0116 0.0295 0.0748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0116 0.0295 0.0408
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0013 0.0013
Mycobacterium ulcerans hypothetical protein 0.0116 0.0295 0.0748
Echinococcus multilocularis Biotin lipoyl attachment 0.0116 0.0295 0.0295
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0004 0.0004
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0116 0.0295 0.0478
Echinococcus multilocularis muscleblind protein 1 0.018 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0116 0.0295 0.0305
Schistosoma mansoni DNA polymerase eta 0.0054 0.0107 0.0107
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0448 0.1305 0.2905
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0448 0.1305 0.2905
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0013 0.0013
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0004 0.0005
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0284 0.0808 0.131
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0448 0.1305 0.3436
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.018 0.0492 0.0509
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0116 0.0295 0.0295
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0448 0.1305 0.1305
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.2391 0.7221 1
Leishmania major cysteine peptidase A (CPA) 0.002 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0052 0.0052
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0159 0.0159
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0159 0.0164
Brugia malayi Carboxyl transferase domain containing protein 0.3188 0.9648 1
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0116 0.0295 0.0295
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0086 0.0442
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0177 0.0287
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0099 0.1176
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.1258 0.3773 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0013 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0013 0.0013
Echinococcus granulosus dna polymerase kappa 0.0023 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Leishmania major cathepsin L-like protease 0.002 0.0004 0.0004
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0159 0.0159
Leishmania major cathepsin L-like protease 0.0077 0.0177 0.0177
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1259 0.3774 0.3774
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0052 0.0052
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0116 0.0295 0.0408
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0116 0.0295 0.0748
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.1258 0.3773 1
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0284 0.0808 0.0808
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0448 0.1305 0.3436
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0048 0.0048
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0116 0.0295 0.0295
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0448 0.1305 0.3233
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Leishmania major acetyl-CoA carboxylase, putative 0.3304 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Brugia malayi Pre-SET motif family protein 0.0036 0.0052 0.0054
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0099 0.1176
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0284 0.0808 0.131
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0448 0.1305 0.3436
Brugia malayi Muscleblind-like protein 0.018 0.0492 0.0509
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.1258 0.3773 0.3773
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1258 0.3773 0.3773
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0052 0.0052
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.1258 0.3773 1
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0116 0.0295 0.0305
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0116 0.0295 0.0295
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0116 0.0295 0.0478
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0004 0.0004
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0004 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0116 0.0295 0.0295
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0099 0.0137
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0116 0.0295 0.0295
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0004 0.0005
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1258 0.3773 0.6117
Plasmodium vivax SET domain protein, putative 0.0036 0.0052 0.0072
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.3304 1 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0295 0.0305
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0004 0.0004
Plasmodium vivax vivapain-2 0.002 0.0004 0.0005
Leishmania major cathepsin L-like protease 0.002 0.0004 0.0004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0099 0.0099
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.1258 0.3773 0.3773
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0107 0.0111
Leishmania major cathepsin L-like protease 0.002 0.0004 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0013 0.0013
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0107 0.0107
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0563 0.1658 1
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0116 0.0295 0.0295
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0111 0.0115
Echinococcus multilocularis cysteine protease 0.002 0.0004 0.0004
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0116 0.0295 0.0408
Plasmodium falciparum carbamoyl phosphate synthetase 0.0284 0.0808 0.1119
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0284 0.0808 0.0808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.018 0.0492 0.0509
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0013 0.0013
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0116 0.0295 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Trypanosoma brucei unspecified product 0.0827 0.2461 0.2461
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0116 0.0295 0.0478
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0448 0.1305 0.3436
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0116 0.0295 0.0295
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0116 0.0295 0.0295
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.1258 0.3773 1
Loa Loa (eye worm) acetyltransferase 0.0175 0.0475 0.0493
Schistosoma mansoni aspartate carbamoyltransferase 0.0284 0.0808 0.0808
Leishmania major cathepsin L-like protease 0.002 0.0004 0.0004
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.0116 0.0295 0.0305
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.0111
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0107 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0111 0.0111
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0086 0.0496
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0116 0.0295 0.0305
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.3304 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0111 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0111 0.0111
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0284 0.0808 0.0808
Echinococcus granulosus dna polymerase eta 0.0054 0.0107 0.0107
Treponema pallidum pyruvate carboxylase subunit B 0.0116 0.0295 0.5
Trypanosoma cruzi acetyl-CoA carboxylase 0.2045 0.6169 1
Toxoplasma gondii pyruvate carboxylase 0.1258 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0036 0.0052 0.0054
Echinococcus multilocularis muscleblind protein 0.018 0.0492 0.0492
Brugia malayi jmjC domain containing protein 0.0071 0.0159 0.0164
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0159 0.0159
Mycobacterium ulcerans pyruvate carboxylase 0.1258 0.3773 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0052 0.0052
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0448 0.1305 0.1305
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0058 0.0058
Leishmania major cathepsin L-like protease 0.0077 0.0177 0.0177
Trypanosoma brucei acetyl-CoA carboxylase 0.3304 1 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Brugia malayi Pre-SET motif family protein 0.0251 0.0707 0.0733
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0086 0.0119
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.1258 0.3773 0.3773
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0116 0.0295 0.0295
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0116 0.0295 0.0295
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0116 0.0295 0.0295
Loa Loa (eye worm) fibroinase 0.002 0.0004 0.0004
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0177 0.0287
Brugia malayi jmjC domain containing protein 0.0071 0.0159 0.0164
Echinococcus granulosus muscleblind protein 0.018 0.0492 0.0492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Echinococcus multilocularis dna polymerase eta 0.0054 0.0107 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0111 0.0111
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0284 0.0808 0.1119
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0004 0.0004
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0127 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0563 0.1658 1
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0116 0.0295 0.0305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0448 0.1305 0.2116
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0004 0.0004
Echinococcus multilocularis cysteine protease 0.002 0.0004 0.0004
Onchocerca volvulus 0.0036 0.0052 0.0595
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0116 0.0295 0.0748
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.046 0.046
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0177 0.0287
Toxoplasma gondii carbamoylphosphate synthetase 0.0284 0.0808 0.0808
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0448 0.1305 0.3436
Loa Loa (eye worm) cysteine protease 0.002 0.0004 0.0004
Echinococcus granulosus Biotin lipoyl attachment 0.0116 0.0295 0.0295
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0475 0.0475
Loa Loa (eye worm) ctsf protein 0.002 0.0004 0.0004
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0116 0.0295 0.0408
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0013 0.0057
Schistosoma mansoni acetyl-CoA carboxylase 0.3304 1 1
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0013 0.0013
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0448 0.1305 0.1305
Schistosoma mansoni pyruvate carboxylase 0.1258 0.3773 0.3773
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0116 0.0295 0.0295
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0004 0.0006
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.1258 0.3773 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0111 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0022
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0448 0.1305 0.1305
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0116 0.0295 0.0478
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0004
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0448 0.1305 0.2905
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0159 0.0159
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0004 0.0004
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0475 0.0493
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.2391 0.7221 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0707 0.0733
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0099 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Onchocerca volvulus 0.0286 0.0813 1
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.3188 0.9648 1
Leishmania major carboxylase, putative 0.1258 0.3773 0.3773
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0448 0.1305 0.1305
Leishmania major cathepsin L-like protease 0.002 0.0004 0.0004
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0157 0.0254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0448 0.1305 0.1305
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0116 0.0295 0.0295
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1258 0.3773 0.6117
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0099 0.0099
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0177 0.0177
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0004 0.0004
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0116 0.0295 0.0295
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0111 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0022

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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