Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.1422 | 0.1422 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.1422 | 0.1422 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0024 | 0.1422 | 0.1422 |
Trypanosoma brucei | cytochrome P450, putative | 0.0024 | 0.1422 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0024 | 0.1422 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 0.1422 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 0.1422 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0024 | 0.1422 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.