TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 230.309 | Formula: C13H18N4
H donors: 2 H acceptors: 2 LogP: 3.01 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1nc2[nH]nc(c2c2c1CCCC2)N)C
InChi: 1S/C13H18N4/c1-7(2)11-9-6-4-3-5-8(9)10-12(14)16-17-13(10)15-11/h7H,3-6H2,1-2H3,(H3,14,15,16,17)
InChiKey: FSLXKIINKXADSW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	protein tyrosine kinase 2 beta	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	glutaminase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	protein tyrosine kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130513	All targets in OG5_130513
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	TK/FAK protein kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Schistosoma japonicum	Protein tyrosine kinase 2 beta, putative	Get druggable targets OG5_130513	All targets in OG5_130513
Echinococcus multilocularis	protein tyrosine kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_130513	All targets in OG5_130513
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130513	All targets in OG5_130513
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0308	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0653	0.8545	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.018	0.2147	0.2147
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.004	0.0258	0.3561
Echinococcus granulosus	para nitrobenzyl esterase	0.011	0.1211	0.1211
Brugia malayi	beta-lactamase family protein	0.0043	0.0308	0.036
Loa Loa (eye worm)	glutaminase	0.033	0.4183	0.4895
Schistosoma mansoni	alpha-glucosidase	0.0155	0.1809	0.1809
Echinococcus multilocularis	acetylcholinesterase	0.0653	0.8545	0.8545
Onchocerca volvulus		0.0104	0.1124	0.9033
Brugia malayi	hypothetical protein	0.0074	0.0726	0.0849
Entamoeba histolytica	hypothetical protein	0.0074	0.0726	1
Onchocerca volvulus		0.011	0.1211	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.011	0.1211	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0308	0.036
Brugia malayi	beta-lactamase family protein	0.0043	0.0308	0.036
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0308	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0308	0.036
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0308	0.0735
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.3475	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.011	0.1211	0.1211
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0	0.5
Brugia malayi	hypothetical protein	0.0029	0.0115	0.0135
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0258	0.0618
Echinococcus multilocularis	tumor protein p63	0.0408	0.5236	0.5236
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.004	0.0258	0.84
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0115	0.3742
Loa Loa (eye worm)	carboxylesterase	0.011	0.1211	0.1417
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0467	0.0467
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0527	0.0527
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0308	0.0735
Echinococcus granulosus	acetylcholinesterase	0.0653	0.8545	0.8545
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.004	0.0258	0.3561
Onchocerca volvulus		0.011	0.1211	1
Trichomonas vaginalis	sucrase-isomaltase, putative	0.004	0.0258	0.0618
Brugia malayi	Carboxylesterase family protein	0.011	0.1211	0.1417
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0258	0.84
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0115	0.3742
Loa Loa (eye worm)	TK/FAK protein kinase	0.0309	0.3895	0.4558
Schistosoma mansoni	glutaminase	0.033	0.4183	0.4183
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0258	0.84
Echinococcus granulosus	carboxylesterase 5A	0.0653	0.8545	0.8545
Echinococcus granulosus	protein tyrosine kinase	0.0305	0.3846	0.3846
Loa Loa (eye worm)	hypothetical protein	0.011	0.1211	0.1417
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0467	0.0546
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0258	0.0618
Echinococcus granulosus	acetylcholinesterase	0.0653	0.8545	0.8545
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0308	0.0885
Loa Loa (eye worm)	hypothetical protein	0.011	0.1211	0.1417
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.011	0.1211	0.1211
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0308	0.0885
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0653	0.8545	0.8545
Loa Loa (eye worm)	hypothetical protein	0.011	0.1211	0.1417
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0726	0.0726
Leishmania major	hypothetical protein, conserved	0.0043	0.0308	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0534	0.0625
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0467	0.0467
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0258	0.0618
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.004	0.0258	0.0618
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0308	0.036
Echinococcus multilocularis	lysosomal alpha glucosidase	0.018	0.2147	0.2147
Brugia malayi	MH2 domain containing protein	0.0144	0.1669	0.1953
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0115	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.004	0.0258	0.0258
Brugia malayi	Glycosyl hydrolases family 31 protein	0.018	0.2147	0.2513
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0308	0.0735
Toxoplasma gondii	ABC1 family protein	0.0043	0.0308	1
Mycobacterium ulcerans	lipase LipD	0.0043	0.0308	0.0735
Mycobacterium ulcerans	glutaminase	0.033	0.4183	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0308	0.0735
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0308	0.0735
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0	0.5
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.011	0.1211	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0308	0.036
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0308	0.036
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0308	0.0885
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0308	0.036
Schistosoma mansoni	microtubule-associated protein tau	0.076	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0308	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1669	0.1953
Brugia malayi	glutaminase DH11.1	0.033	0.4183	0.4895
Entamoeba histolytica	hypothetical protein	0.0074	0.0726	1
Loa Loa (eye worm)	carboxylesterase	0.011	0.1211	0.1417
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0115	0.3742
Schistosoma mansoni	tyrosine kinase	0.0305	0.3846	0.3846
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0115	0.3742
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0467	0.0467
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0308	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0258	0.0618
Echinococcus multilocularis	lysosomal alpha glucosidase	0.018	0.2147	0.2147
Brugia malayi	beta-lactamase	0.0043	0.0308	0.036
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0308	0.0308
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0308	0.0735
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.004	0.0258	0.0618
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0308	0.0885
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0308	0.5
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0308	0.0885
Brugia malayi	Carboxylesterase family protein	0.011	0.1211	0.1417
Mycobacterium tuberculosis	Carboxylesterase LipT	0.011	0.1211	0.3484
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.011	0.1211	0.3484
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.004	0.0258	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0309	0.3895	0.4558
Echinococcus multilocularis	protein tyrosine kinase	0.0305	0.3846	0.3846
Schistosoma mansoni	BC026374 protein (S09 family)	0.011	0.1211	0.1211
Schistosoma mansoni	hypothetical protein	0.0041	0.0276	0.0276
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0308	0.0735
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.011	0.1211	0.2895
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0308	0.036
Entamoeba histolytica	hypothetical protein	0.0074	0.0726	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0308	0.0735
Trichomonas vaginalis	glutaminase, putative	0.033	0.4183	1
Trypanosoma brucei	glucosidase, putative	0.004	0.0258	0.84
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0308	0.0885
Loa Loa (eye worm)	carboxylesterase	0.0653	0.8545	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.1211	0.1417
Echinococcus multilocularis	neuroligin	0.011	0.1211	0.1211
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1669	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0653	0.8545	1
Onchocerca volvulus		0.011	0.1211	1
Leishmania major	hypothetical protein, conserved	0.0029	0.0115	0.3742
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.011	0.1211	0.1211
Brugia malayi	Carboxylesterase family protein	0.0653	0.8545	1
Loa Loa (eye worm)	glutaminase 2	0.033	0.4183	0.4895
Echinococcus multilocularis	BC026374 protein (S09 family)	0.011	0.1211	0.1211
Echinococcus multilocularis	microtubule associated protein 2	0.076	1	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.004	0.0258	0.0618
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0308	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.1211	0.1417
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0534	0.0625
Trichomonas vaginalis	esterase, putative	0.0043	0.0308	0.0735
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0	0.5
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0308	0.0308
Onchocerca volvulus		0.011	0.1211	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.011	0.1211	0.2895
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0308	0.0885
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0467	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0115	0.0135
Echinococcus multilocularis	acetylcholinesterase	0.0653	0.8545	0.8545
Echinococcus granulosus	tumor protein p63	0.0408	0.5236	0.5236
Echinococcus granulosus	neutral alpha glucosidase AB	0.004	0.0258	0.0258
Brugia malayi	Carboxylesterase family protein	0.011	0.1211	0.1417
Onchocerca volvulus		0.006	0.0527	0.2431
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0467	0.0467
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0308	0.036
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0115	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0467	0.0467
Brugia malayi	Carboxylesterase family protein	0.011	0.1211	0.1417
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0308	0.0885
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0308	0.0308
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0308	0.5
Schistosoma mansoni	alpha glucosidase	0.004	0.0258	0.0258
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0258	0.0618
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0726	0.0726
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.011	0.1211	0.3484
Brugia malayi	hypothetical protein	0.011	0.1211	0.1417
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0308	0.0885
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0308	0.036
Echinococcus granulosus	BC026374 protein S09 family	0.011	0.1211	0.1211
Schistosoma mansoni	alpha-glucosidase	0.0155	0.1809	0.1809
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0534	0.0625
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0467	0.0467
Entamoeba histolytica	hypothetical protein	0.0074	0.0726	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0276	0.0323
Brugia malayi	Glycosyl hydrolases family 31 protein	0.004	0.0258	0.0302
Echinococcus multilocularis	para nitrobenzyl esterase	0.011	0.1211	0.1211
Schistosoma mansoni	acetylcholinesterase	0.011	0.1211	0.1211
Mycobacterium ulcerans	carboxylesterase, LipT	0.011	0.1211	0.2895
Schistosoma mansoni	gliotactin	0.011	0.1211	0.1211
Loa Loa (eye worm)	hypothetical protein	0.011	0.1211	0.1417
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0726	0.0726
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0467	0.0546
Onchocerca volvulus		0.011	0.1211	1
Echinococcus granulosus	neuroligin	0.011	0.1211	0.1211
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0534	0.0625
Schistosoma mansoni	hypothetical protein	0.0074	0.0726	0.0726
Echinococcus multilocularis	carboxylesterase 5A	0.0653	0.8545	0.8545
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.011	0.1211	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0653	0.8545	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.018	0.2147	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0276	0.0323
Leishmania major	alpha glucosidase II subunit, putative	0.004	0.0258	0.84
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0308	0.0885
Brugia malayi	Carboxylesterase family protein	0.0653	0.8545	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0527	0.0617
Loa Loa (eye worm)	hypothetical protein	0.011	0.1211	0.1417
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0115	0.3742
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0308	0.0735

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 14.73 um	PUBCHEM_BIOASSAY: TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2). (Class of assay: confirmatory) [Related pubchem assays: 794, 727, 810 ]	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1491961

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1363957