Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0033 | 0.0407 | 0.5 | |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0191 | 1 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0184 | 0.9595 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0191 | 1 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0184 | 0.9595 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0138 | 0.6803 | 0.5 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0191 | 1 | 1 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0033 | 0.0405 | 0.5 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0191 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0407 | 0.0407 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0073 | 0.2839 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0407 | 0.0407 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0138 | 0.6803 | 0.5 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0191 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0073 | 0.2839 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0118 | 0.5594 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.0407 | 0.0407 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0407 | 0.0407 |
Trypanosoma brucei | unspecified product | 0.0048 | 0.1329 | 0.1329 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0407 | 0.0407 |
Chlamydia trachomatis | biotin carboxylase | 0.0066 | 0.2433 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0073 | 0.2839 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0073 | 0.2839 | 0.2839 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0073 | 0.2839 | 0.2839 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0073 | 0.2839 | 0.2839 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0073 | 0.2839 | 0.2839 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0191 | 1 | 1 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0033 | 0.0405 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0407 | 0.0407 |
Schistosoma mansoni | pyruvate carboxylase | 0.0073 | 0.2839 | 0.2839 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0407 | 0.0039 |
Toxoplasma gondii | pyruvate carboxylase | 0.0073 | 0.2839 | 0.2839 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0073 | 0.2839 | 0.2839 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0073 | 0.2839 | 0.2839 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0407 | 0.0039 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0073 | 0.2839 | 1 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0073 | 0.2839 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0407 | 0.0039 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0073 | 0.2839 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0073 | 0.2839 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0073 | 0.2839 | 0.5074 |
Onchocerca volvulus | 0.0033 | 0.0407 | 0.5 | |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0407 | 0.0407 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0073 | 0.2839 | 0.5074 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0073 | 0.2839 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0407 | 0.0407 |
Leishmania major | carboxylase, putative | 0.0073 | 0.2839 | 0.2839 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0073 | 0.2839 | 0.2839 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 630.9573 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.