TDR Targets

Basic information

Technical information

TDR Targets ID: 1364119
Name: SMR000249875
MW: 380.42 | Formula: C19H16N4O3S
H donors: 1 H acceptors: 3 LogP: 2.71 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)sc(n2)NC(=O)C1=NN(C(=O)CC1)c1ccccc1
InChi: 1S/C19H16N4O3S/c1-26-13-7-8-14-16(11-13)27-19(20-14)21-18(25)15-9-10-17(24)23(22-15)12-5-3-2-4-6-12/h2-8,11H,9-10H2,1H3,(H,20,21,25)
InChiKey: JJRFMJXCZDFNLL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ZINC05859171
MLS000335117

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	runt-related transcription factor 1	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	core-binding factor, beta subunit		No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133916	All targets in OG5_133916
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133916	All targets in OG5_133916
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	hypothetical protein	Get druggable targets OG5_133916	All targets in OG5_133916
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Onchocerca volvulus		Get druggable targets OG5_133916	All targets in OG5_133916
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.0027	0.0028
Entamoeba histolytica	acetyl-coA carboxylase, putative	0.0681	0.1662	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0081	0.0084
Echinococcus granulosus	propionyl coenzyme A carboxylase alpha chain	0.152	0.3776	0.3776
Loa Loa (eye worm)	hypothetical protein	0.014	0.0299	0.031
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0081	0.0084
Mycobacterium tuberculosis	Probable dehydrogenase	0.0287	0.067	0.0737
Mycobacterium leprae	Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase)	0.0541	0.131	0.3368
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0024	0.0024
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0057	0.0057
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0164	0.036	0.036
Plasmodium falciparum	glutathione reductase	0.0126	0.0264	0.036
Treponema pallidum	NADH oxidase	0.0044	0.0057	0.0537
Echinococcus multilocularis	neuropeptide receptor A26	0.0492	0.1187	0.1187
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.152	0.3776	0.6117
Leishmania major	acetyl-CoA carboxylase, putative	0.3991	1	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0164	0.036	0.036
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E2	0.014	0.0299	0.0295
Leishmania major	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0541	0.131	0.1306
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.2888	0.7222	1
Brugia malayi	dihydrolipoamide S-acetyltransferase precursor, putative	0.014	0.0299	0.031
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0044	0.0057	0.0053
Trichomonas vaginalis	esterase, putative	0.0043	0.0057	0.0877
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0039	0.0575
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.002	0.0021
Leishmania major	dihydrolipoamide acetyltransferase precursor, putative	0.014	0.0299	0.0295
Echinococcus multilocularis	propionyl coenzyme A carboxylase beta chain	0.0541	0.131	0.131
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0117	0.0117
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0011	0.0009
Trichomonas vaginalis	CAMK family protein kinase	0.0195	0.044	0.7296
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0195	0.044	0.044
Schistosoma mansoni	kinase	0.0099	0.0197	0.0197
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0057	0.0057
Chlamydia trachomatis	dihydrolipoamide succinyltransferase	0.014	0.0299	0.072
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0117	0.0117
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0117	0.0117
Trypanosoma brucei	dihydrolipoamide acetyltransferase E2 subunit, putative	0.014	0.0299	0.0295
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0057	0.0877
Brugia malayi	Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor	0.014	0.0299	0.031
Mycobacterium tuberculosis	Probable pyruvate carboxylase Pca (pyruvic carboxylase)	0.152	0.3776	0.4178
Trypanosoma cruzi	dihydrolipoamide acetyltransferase precursor, putative	0.014	0.0299	0.0478
Leishmania major	methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein	0.152	0.3776	0.3774
Echinococcus multilocularis	cpg binding protein	0.003	0.0024	0.0024
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0287	0.067	0.0737
Schistosoma mansoni	aldehyde dehydrogenase	0.0126	0.0264	0.0264
Onchocerca volvulus		0.0043	0.0057	0.0439
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0057	0.0877
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0057	0.0058
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.0376	0.6231
Toxoplasma gondii	NADPH-glutathione reductase	0.0044	0.0057	0.0053
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0057	0.0877
Mycobacterium ulcerans	recombinase A	0.0115	0.0237	0.0615
Schistosoma mansoni	ankyrin 23/unc44	0.0032	0.0027	0.0027
Toxoplasma gondii	carbamoylphosphate synthetase	0.0344	0.0813	0.0809
Trypanosoma cruzi	dihydrolipoamide branched chain transacylase, putative	0.014	0.0299	0.0478
Echinococcus granulosus	propionyl coenzyme A carboxylase beta chain	0.0541	0.131	0.131
Leishmania major	propionyl-coa carboxylase beta chain, putative	0.0541	0.131	0.1306
Brugia malayi	glutathione reductase	0.0126	0.0264	0.0274
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.0601	1
Echinococcus multilocularis	netrin receptor unc 5	0.0032	0.0027	0.0027
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0057	0.0139
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.0601	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0039	0.0056
Schistosoma mansoni	hypothetical protein	0.0205	0.0463	0.0463
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0044	0.0057	0.0053
Brugia malayi	Thioredoxin reductase	0.0126	0.0264	0.0274
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0057	0.0085
Brugia malayi	beta-lactamase	0.0043	0.0057	0.0059
Chlamydia trachomatis	biotin carboxylase	0.1381	0.3424	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0126	0.0264	0.0264
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0044	0.0057	0.0317
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0164	0.036	0.0373
Trypanosoma brucei	unspecified product	0.1	0.2465	0.2461
Echinococcus multilocularis	dihydrolipoyllysine residue acetyltransferase	0.014	0.0299	0.0299
Echinococcus multilocularis	Protein lozenge	0.0067	0.0116	0.0116
Plasmodium falciparum	thioredoxin reductase	0.0044	0.0057	0.0073
Trypanosoma cruzi	trypanothione reductase, putative	0.0044	0.0057	0.0085
Toxoplasma gondii	ABC1 family protein	0.0043	0.0057	0.0052
Trypanosoma cruzi	trypanothione reductase, putative	0.0126	0.0264	0.0421
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0039	0.0207
Toxoplasma gondii	2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein	0.014	0.0299	0.0295
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.0601	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0399	0.6619
Trichomonas vaginalis	CAMK family protein kinase	0.0195	0.044	0.7296
Brugia malayi	CXXC zinc finger family protein	0.0029	0.002	0.0021
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0126	0.0264	0.0287
Trichomonas vaginalis	CAMK family protein kinase	0.0195	0.044	0.7296
Trypanosoma brucei	glucosidase, putative	0.0036	0.0039	0.0034
Plasmodium falciparum	dihydrolipoamide acyltransferase component E2	0.014	0.0299	0.0409
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 4 AccD4_2	0.0541	0.131	0.346
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0057	0.0052
Echinococcus multilocularis	neuropeptide s receptor	0.0492	0.1187	0.1187
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0044	0.0057	0.0073
Schistosoma mansoni	carbamoyl-phosphate synthetase	0.0344	0.0813	0.0813
Echinococcus multilocularis	X box binding protein 1	0.0289	0.0676	0.0676
Toxoplasma gondii	aldehyde dehydrogenase	0.0126	0.0264	0.0259
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0057	0.0085
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0044	0.0057	0.0053
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0057	0.0059
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0057	0.0877
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1	0.152	0.3776	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0005	0.0005
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0057	0.0085
Onchocerca volvulus		0.0239	0.0549	0.4238
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0287	0.067	0.0737
Trypanosoma cruzi	acetyl-CoA carboxylase	0.2471	0.6171	1
Trypanosoma cruzi	dihydrolipoamide acetyltransferase, putative	0.014	0.0299	0.0478
Trichomonas vaginalis	CAMK family protein kinase	0.0195	0.044	0.7296
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0024	0.0024
Mycobacterium leprae	Conserved hypothetical protein	0.1213	0.3002	0.7917
Echinococcus granulosus	neuropeptide receptor A26	0.0492	0.1187	0.1187
Onchocerca volvulus		0.0043	0.0057	0.0439
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0044	0.0057	0.0057
Brugia malayi	Death domain containing protein	0.0032	0.0027	0.0028
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0044	0.0057	0.0053
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0057	0.0058
Schistosoma mansoni	alpha glucosidase	0.0036	0.0039	0.0039
Brugia malayi	beta-lactamase family protein	0.0043	0.0057	0.0059
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0264	0.0687
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2	0.152	0.3776	1
Echinococcus multilocularis	Ankyrin	0.0032	0.0028	0.0028
Loa Loa (eye worm)	runx1	0.0067	0.0116	0.0121
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.0376	0.6231
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.0191	0.3127
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0032	0.0027	0.0028
Leishmania major	hypothetical protein, conserved	0.0043	0.0057	0.0052
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0126	0.0264	0.0259
Echinococcus granulosus	netrin receptor unc 5	0.0032	0.0027	0.0027
Brugia malayi	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta	0.014	0.0299	0.031
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0044	0.0057	0.0057
Mycobacterium tuberculosis	Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6	0.0541	0.131	0.1446
Echinococcus granulosus	death domain containing protein	0.0032	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0535	0.1294	0.1342
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0039	0.0575
Mycobacterium leprae	Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB	0.014	0.0299	0.0652
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0195	0.044	0.0435
Trypanosoma cruzi	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative	0.014	0.0299	0.0478
Toxoplasma gondii	thioredoxin reductase	0.0126	0.0264	0.026
Mycobacterium ulcerans	bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3	0.152	0.3776	1
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0057	0.0059
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0044	0.0057	0.0058
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0057	0.0057
Mycobacterium ulcerans	replicative DNA helicase DnaB	0.0411	0.0983	0.2595
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0057	0.0059
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0039	0.0034
Schistosoma mansoni	netrin receptor unc5	0.0032	0.0027	0.0027
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0024	0.0024
Schistosoma mansoni	cpg binding protein	0.003	0.0024	0.0024
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0127	0.0267	0.0267
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 4 AccD4	0.0541	0.131	0.346
Trypanosoma brucei	acetyl-CoA carboxylase	0.3991	1	1
Plasmodium falciparum	carbamoyl phosphate synthetase	0.0344	0.0813	0.112
Plasmodium falciparum	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex	0.014	0.0299	0.0409
Schistosoma mansoni	hypothetical protein	0.0205	0.0463	0.0463
Brugia malayi	Pre-SET motif family protein	0.0031	0.0024	0.0025
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0057	0.0085
Echinococcus granulosus	dnaJ subfamily B	0.0411	0.0982	0.0982
Leishmania major	hypothetical protein, conserved	0.0025	0.0011	0.0007
Mycobacterium ulcerans	acetyl/propionyl CoA carboxylase subunit beta	0.0541	0.131	0.346
Toxoplasma gondii	acyl-CoA carboxyltransferase beta chain, putative	0.0541	0.131	0.1306
Mycobacterium ulcerans	dihydrolipoamide acetyltransferase	0.014	0.0299	0.0782
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0024	0.0024
Brugia malayi	Pre-SET motif family protein	0.021	0.0476	0.0493
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide acyltransferase E2 component	0.014	0.0299	0.0782
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0039	0.0207
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0287	0.067	0.1648
Trichomonas vaginalis	CAMK family protein kinase	0.0195	0.044	0.7296
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0057	0.0058
Echinococcus granulosus	X box binding protein 1	0.0289	0.0676	0.0676
Trypanosoma cruzi	dihydrolipoamide branched chain transacylase, putative	0.014	0.0299	0.0478
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.0601	1
Treponema pallidum	recombinase A	0.0115	0.0237	0.2371
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0024	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0081	0.0084
Plasmodium vivax	SET domain protein, putative	0.0031	0.0024	0.0028
Wolbachia endosymbiont of Brugia malayi	carbamoyl phosphate synthase large subunit	0.0344	0.0813	0.2143
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0057	0.0072
Trypanosoma cruzi	glutamine dependent carbamoyl-phosphate synthase, putative	0.0344	0.0813	0.1311
Brugia malayi	Carboxyl transferase domain containing protein	0.3852	0.9648	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0057	0.0059
Onchocerca volvulus	Glucosylceramidase homolog	0.017	0.0376	0.2906
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.0376	0.6231
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0057	0.0059
Mycobacterium tuberculosis	Probable branched-chain keto acid dehydrogenase E2 component BkdC	0.014	0.0299	0.0327
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0044	0.0057	0.0139
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0005	0.0005
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0044	0.0057	0.0073
Echinococcus multilocularis	dihydrolipoyllysine residue succinyltransferase	0.014	0.0299	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0011	0.0012
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0024	0.0024
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0044	0.0057	0.0073
Trypanosoma cruzi	polo-like protein kinase, putative	0.0195	0.044	0.0705
Mycobacterium leprae	Probable biotinylated protein homolog TB7.3	0.014	0.0299	0.0652
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0044	0.0057	0.0139
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0311	0.073	0.073
Treponema pallidum	replicative DNA helicase (dnaB)	0.0411	0.0983	1
Loa Loa (eye worm)	hypothetical protein	0.0535	0.1294	0.1342
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 5 AccD5	0.0541	0.131	0.346
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0126	0.0264	0.0264
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0057	0.0085
Brugia malayi	beta-lactamase family protein	0.0043	0.0057	0.0059
Brugia malayi	MH2 domain containing protein	0.012	0.0249	0.0259
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0264	0.0687
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0039	0.0575
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0032	0.0028	0.0029
Brugia malayi	TAR-binding protein	0.0067	0.0117	0.0121
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0117	0.0117
Mycobacterium tuberculosis	RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].	0.3311	0.8285	0.9173
Trypanosoma cruzi	acetyl-CoA carboxylase, putative	0.0541	0.131	0.2116
Toxoplasma gondii	dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase	0.014	0.0299	0.0295
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0044	0.0057	0.0053
Leishmania major	dihydrolipoamide branched chain transacylase, putative	0.014	0.0299	0.0295
Echinococcus granulosus	dihydrolipoyllysine residue succinyltransferase	0.014	0.0299	0.0299
Echinococcus granulosus	dihydrolipoyllysine residue acetyltransferase	0.014	0.0299	0.0299
Schistosoma mansoni	hypothetical protein	0.0032	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0028	0.0029
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0319	0.0751	0.1865
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0011	0.0007
Echinococcus granulosus	Biotin lipoyl attachment	0.014	0.0299	0.0299
Onchocerca volvulus		0.0535	0.1294	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.014	0.0299	0.031
Onchocerca volvulus		0.0043	0.0057	0.0439
Schistosoma mansoni	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase	0.014	0.0299	0.0299
Schistosoma mansoni	acetyl-CoA carboxylase	0.3991	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0195	0.044	0.044
Echinococcus granulosus	microtubule associated protein 2	0.1428	0.3543	0.3543
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.152	0.3776	0.3776
Echinococcus granulosus	geminin	0.0205	0.0463	0.0463
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0287	0.067	0.0737
Echinococcus granulosus	thioredoxin glutathione reductase	0.0127	0.0267	0.0267
Loa Loa (eye worm)	thioredoxin reductase	0.0126	0.0264	0.0274
Onchocerca volvulus	Netrin receptor homolog	0.0032	0.0027	0.0211
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0057	0.0139
Schistosoma mansoni	Replicative DNA helicase	0.0411	0.0983	0.0983
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0088	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0057	0.0059
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0081	0.0084
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0195	0.044	0.3396
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0117	0.0121
Mycobacterium leprae	PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase	0.0411	0.0983	0.2491
Mycobacterium leprae	Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)	0.0541	0.131	0.3368
Trypanosoma cruzi	glutamine-dependent carbamoyl-phosphate synthetase, putative	0.0344	0.0813	0.1311
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0057	0.0058
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0044	0.0057	0.0057
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.152	0.3776	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0195	0.044	0.044
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.021	0.0476	0.0493
Mycobacterium tuberculosis	Probable oxidoreductase	0.0319	0.0751	0.0826
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.0601	1
Mycobacterium ulcerans	carbamoyl phosphate synthase large subunit	0.0344	0.0813	0.2143
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0057	0.0058
Echinococcus granulosus	cpg binding protein	0.003	0.0024	0.0024
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.002	0.002
Trichomonas vaginalis	mercuric reductase, putative	0.0044	0.0057	0.0882
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.0376	0.6231
Schistosoma mansoni	alpha-glucosidase	0.0141	0.0302	0.0302
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0011	0.0011
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0117	0.0121
Mycobacterium ulcerans	pyruvate carboxylase	0.152	0.3776	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0164	0.036	0.0373
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0264	0.0687
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0024	0.002
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0032	0.0028	0.0028
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0164	0.036	0.036
Schistosoma mansoni	hypothetical protein	0.0411	0.0982	0.0982
Trypanosoma brucei	2-oxoglutarate dehydrogenase E2 component, putative	0.014	0.0299	0.0295
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.152	0.3776	0.3776
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0005	0.0005
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.2888	0.7222	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0044	0.0057	0.0053
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.152	0.3776	0.3774
Trypanosoma brucei	pyruvate dehydrogenase complex E3 binding protein, putative	0.014	0.0299	0.0295
Trypanosoma cruzi	DNA repair protein, putative	0.0035	0.0036	0.0052
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0044	0.0057	0.0073
Toxoplasma gondii	acetyl-coA carboxylase ACC2	0.3991	1	1
Echinococcus multilocularis	dnaJ subfamily B	0.0411	0.0982	0.0982
Trypanosoma brucei	trypanothione reductase	0.0126	0.0264	0.026
Trypanosoma brucei	dihydrolipoamide branched chain transacylase, putative	0.014	0.0299	0.0295
Trypanosoma cruzi	polo-like protein kinase, putative	0.0195	0.044	0.0705
Wolbachia endosymbiont of Brugia malayi	Acetyl-CoA carboxylase, carboxyltransferase component	0.0541	0.131	0.346
Trypanosoma cruzi	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative	0.014	0.0299	0.0478
Trichomonas vaginalis	glutathione reductase, putative	0.0044	0.0057	0.0882
Mycobacterium tuberculosis	Probable reductase	0.0287	0.067	0.0737
Mycobacterium ulcerans	hypothetical protein	0.014	0.0299	0.0782
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0195	0.044	0.2625
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0057	0.0085
Trichomonas vaginalis	CAMK family protein kinase	0.0195	0.044	0.7296
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0057	0.0085
Schistosoma mansoni	ap endonuclease	0.0023	0.0005	0.0005
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.0249	0.0259
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0057	0.0058
Plasmodium vivax	glutathione reductase, putative	0.0126	0.0264	0.036
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	0.3991	1	1
Mycobacterium leprae	RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN].	0.0115	0.0237	0.0483
Mycobacterium tuberculosis	Biotinylated protein TB7.3	0.014	0.0299	0.0327
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.0601	1
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0032	0.0027	0.0027
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0039	0.0575
Echinococcus multilocularis	propionyl coenzyme A carboxylase alpha chain	0.152	0.3776	0.3776
Plasmodium falciparum	glutathione reductase	0.0044	0.0057	0.0073
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0126	0.0264	0.0288
Trichomonas vaginalis	set domain proteins, putative	0.0239	0.0548	0.9119
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0287	0.067	0.0737
Schistosoma mansoni	pyruvate carboxylase	0.152	0.3776	0.3776
Trypanosoma brucei	polo-like protein kinase	0.0195	0.044	0.0435
Schistosoma mansoni	cpg binding protein	0.0029	0.002	0.002
Trypanosoma cruzi	DNA repair protein, putative	0.0035	0.0036	0.0052
Schistosoma mansoni	ap endonuclease	0.0023	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0027	0.0028
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0044	0.0057	0.0139
Toxoplasma gondii	biotin-requiring enzyme domain-containing protein	0.014	0.0299	0.0295
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.152	0.3776	0.3774
Schistosoma mansoni	aldehyde dehydrogenase	0.0126	0.0264	0.0264
Leishmania major	dihydrolipoamide acetyltransferase precursorlike protein	0.014	0.0299	0.0295
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0044	0.0057	0.0085
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0057	0.0058
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.0647	0.0712
Chlamydia trachomatis	recombinase RecA	0.0115	0.0237	0.0533
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0011	0.0007
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0011	0.0011
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0011	0.0009
Schistosoma mansoni	dihydrolipoamide S-acetyltransferase	0.014	0.0299	0.0299
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0044	0.0057	0.0053
Brugia malayi	serine/threonine-protein kinase plk-2	0.0195	0.044	0.0456
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0044	0.0057	0.0085
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0039	0.0039
Mycobacterium leprae	ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6	0.0541	0.131	0.3368
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0039	0.004
Echinococcus granulosus	neuropeptide s receptor	0.0492	0.1187	0.1187
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0044	0.0057	0.0059
Plasmodium falciparum	thioredoxin reductase	0.0126	0.0264	0.036
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0117	0.0121
Chlamydia trachomatis	dihydrolipoamide succinyltransferase	0.014	0.0299	0.072
Toxoplasma gondii	pyruvate carboxylase	0.152	0.3776	0.3774
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0039	0.0575
Echinococcus multilocularis	Biotin lipoyl attachment	0.014	0.0299	0.0299
Onchocerca volvulus		0.0095	0.0186	0.1435
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0259	0.0601	0.0623
Echinococcus multilocularis	microtubule associated protein 2	0.1428	0.3543	0.3543
Treponema pallidum	pyruvate carboxylase subunit B	0.014	0.0299	0.3013
Schistosoma mansoni	aspartate carbamoyltransferase	0.0344	0.0813	0.0813
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0057	0.0139
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.0249	0.0259
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0032	0.0027	0.0027
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.0376	0.6231
Mycobacterium ulcerans	acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3	0.0541	0.131	0.346
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0039	0.004
Wolbachia endosymbiont of Brugia malayi	branched-chain alpha-keto acid dehydrogenase subunit E2	0.014	0.0299	0.0782
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.014	0.0299	0.031
Chlamydia trachomatis	replicative DNA helicase	0.0411	0.0983	0.275
Mycobacterium tuberculosis	Probable replicative DNA helicase DnaB	0.3607	0.9032	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0057	0.0058
Schistosoma mansoni	dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase	0.014	0.0299	0.0299
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0117	0.0117
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.152	0.3776	0.6117
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0057	0.0877
Plasmodium vivax	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative	0.014	0.0299	0.0409
Chlamydia trachomatis	acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	0.0541	0.131	0.372
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0057	0.0057
Mycobacterium ulcerans	lipase LipD	0.0043	0.0057	0.0139
Schistosoma mansoni	lozenge	0.0067	0.0116	0.0116
Trypanosoma cruzi	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0541	0.131	0.2116
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0259	0.0601	0.0623
Leishmania major	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative	0.014	0.0299	0.0295
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0399	0.6619
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0039	0.0039
Loa Loa (eye worm)	glutathione reductase	0.0126	0.0264	0.0274
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0039	0.0575
Mycobacterium leprae	Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP)	0.152	0.3776	1
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0311	0.073	0.073
Schistosoma mansoni	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase	0.014	0.0299	0.0299
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0195	0.044	0.0456
Trypanosoma brucei	recA bacterial DNA recombination protein, putative	0.0035	0.0036	0.0032
Chlamydia trachomatis	acetyl-CoA carboxylase biotin carboxyl carrier protein	0.014	0.0299	0.072
Plasmodium vivax	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative	0.014	0.0299	0.0409
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0032	0.0028	0.0029
Leishmania major	carbamoyl-phosphate synthase, putative	0.0344	0.0813	0.0809
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0104	0.0104
Brugia malayi	hypothetical protein	0.0025	0.0011	0.0012
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0117	0.0117
Mycobacterium tuberculosis	Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase)	0.0541	0.131	0.1446
Leishmania major	carboxylase, putative	0.152	0.3776	0.3774
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	0.3852	0.9648	1
Onchocerca volvulus		0.0029	0.002	0.0155
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0039	0.0575
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0057	0.0139
Plasmodium falciparum	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex	0.014	0.0299	0.0409
Schistosoma mansoni	propionyl-CoA carboxylase beta chain mitochondrial precursor	0.0541	0.131	0.131
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.0376	0.6231
Schistosoma mansoni	alpha-glucosidase	0.0141	0.0302	0.0302
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0044	0.0057	0.0139
Trichomonas vaginalis	CAMK family protein kinase	0.0195	0.044	0.7296
Giardia lamblia	Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative	0.0681	0.1662	1
Loa Loa (eye worm)	twinkle helicase	0.0118	0.0243	0.0252
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0039	0.004
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0044	0.0057	0.0053
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0319	0.0751	0.0826
Schistosoma mansoni	microtubule-associated protein tau	0.1428	0.3543	0.3543
Brugia malayi	Uncoordinated protein 44	0.0032	0.0027	0.0028
Leishmania major	trypanothione reductase	0.0126	0.0264	0.026
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.0376	0.6231
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0024	0.0024
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0057	0.0058
Schistosoma mansoni	carbamoyl-phosphate synthetase	0.0344	0.0813	0.0813
Schistosoma mansoni	hypothetical protein	0.0289	0.0676	0.0676
Toxoplasma gondii	dihydrolipoamide acyltransferase, putative	0.014	0.0299	0.0295
Schistosoma mansoni	cpg binding protein	0.003	0.0024	0.0024
Wolbachia endosymbiont of Brugia malayi	recombinase A	0.0115	0.0237	0.0615
Mycobacterium ulcerans	branched-chain alpha-keto acid dehydrogenase subunit E2	0.014	0.0299	0.0782
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0039	0.0034
Giardia lamblia	Kinase, PLK	0.0195	0.044	0.2625
Wolbachia endosymbiont of Brugia malayi	replicative DNA helicase	0.0411	0.0983	0.2595
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0039	0.004
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0057	0.0085
Chlamydia trachomatis	dihydrolipoamide acetyltransferase	0.014	0.0299	0.072
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.0191	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0057	0.0059
Trypanosoma brucei	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0541	0.131	0.1306
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0005	0.0005
Mycobacterium tuberculosis	DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase	0.014	0.0299	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0057	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0057	0.0059
Echinococcus multilocularis	geminin	0.0205	0.0463	0.0463
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0039	0.0056
Mycobacterium tuberculosis	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie	0.152	0.3776	0.4178
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0029	0.003
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0044	0.0057	0.0053
Trypanosoma cruzi	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0541	0.131	0.2116
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0057	0.0058
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0011	0.0009
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0117	0.0117
Brugia malayi	RNA binding protein	0.0067	0.0117	0.0121
Plasmodium vivax	carbamoyl phosphate synthetase, putative	0.0344	0.0813	0.112
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0319	0.0751	0.0826
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0117	0.0121
Mycobacterium ulcerans	acetyl-/propionyl-CoA carboxylase subunit beta	0.0541	0.131	0.346
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0039	0.0575
Brugia malayi	hypothetical protein	0.0535	0.1294	0.1342
Onchocerca volvulus		0.0031	0.0024	0.0189
Echinococcus granulosus	Ankyrin	0.0032	0.0028	0.0028
Trypanosoma cruzi	dihydrolipoamide acetyltransferase precursor, putative	0.014	0.0299	0.0478
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	0.3991	1	1
Plasmodium vivax	thioredoxin reductase, putative	0.0126	0.0264	0.036
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0039	0.0575
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0044	0.0057	0.0139
Trypanosoma brucei	glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative	0.0344	0.0813	0.0809

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.2944 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 3.5481 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (binding)	5.0119 uM	PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375]	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	11.5821 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	26.8545 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1497817

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1364119