Detailed information for compound 1364130

Basic information

Technical information
  • TDR Targets ID: 1364130
  • Name: 1-[bis(2-methylpropyl)sulfamoyl]-N-(3-ethoxyp ropyl)piperidine-4-carboxamide
  • MW: 405.596 | Formula: C19H39N3O4S
  • H donors: 1 H acceptors: 3 LogP: 2.43 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCCCNC(=O)C1CCN(CC1)S(=O)(=O)N(CC(C)C)CC(C)C
  • InChi: 1S/C19H39N3O4S/c1-6-26-13-7-10-20-19(23)18-8-11-21(12-9-18)27(24,25)22(14-16(2)3)15-17(4)5/h16-18H,6-15H2,1-5H3,(H,20,23)
  • InChiKey: GFNFCKXMBRCZGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(diisobutylsulfamoyl)-N-(3-ethoxypropyl)piperidine-4-carboxamide
  • 1-(diisobutylsulfamoyl)-N-(3-ethoxypropyl)-4-piperidinecarboxamide
  • 1-(diisobutylsulfamoyl)-N-(3-ethoxypropyl)isonipecotamide
  • SMR000032228
  • UNM000000893201
  • 1-[(diisobutylamino)sulfonyl]-N-(3-ethoxypropyl)piperidine-4-carboxamide
  • MLS000096279

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0622 0.1179
Brugia malayi hypothetical protein 0.0039 0.0622 0.1179
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0815 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.3181 0.6027
Brugia malayi ecdysone receptor 0.0049 0.0982 0.1861
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Brugia malayi hypothetical protein 0.0039 0.0622 0.1179
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0622 0.0381
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0982 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.119 0.0964
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0815 0.0579
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.2689 0.2501
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0105 0.2929 0.2747
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0622 0.0381
Echinococcus granulosus orexin receptor type 2 0.0039 0.0622 0.0381
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0982 0.075
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0712 0.0473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.2689 0.2501
Brugia malayi Thioredoxin reductase 0.0084 0.2216 0.4199
Brugia malayi nuclear receptor NHR-88 0.0105 0.2929 0.5551
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0105 0.2929 0.5551
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0105 0.2929 0.2747
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0622 0.0381
Leishmania major trypanothione reductase 0.0084 0.2216 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.1935 0.1727
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0622 0.0381
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.3181 0.6027
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0039 0.0622 0.0381
Brugia malayi nuclear receptor RXR 0.0049 0.0982 0.1861
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0982 0.1559
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0622 0.0381
Echinococcus granulosus hypothetical protein 0.0039 0.0622 0.0381
Schistosoma mansoni hypothetical protein 0.0076 0.1935 0.1727
Schistosoma mansoni hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0105 0.2929 0.2747
Leishmania major DNA polymerase eta, putative 0.0032 0.0369 0.1429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0049 0.0982 0.075
Echinococcus granulosus neuropeptide receptor A26 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0622 0.0381
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0273 0.0114
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0049 0.0982 0.075
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0622 0.0381
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0273 0.0023
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0273 0.0988
Schistosoma mansoni RAR-like nuclear receptor 0.0105 0.2929 0.2747
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0622 0.0381
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.119 0.0964
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0489 0.0244
Loa Loa (eye worm) hypothetical protein 0.0171 0.5277 0.5155
Brugia malayi hypothetical protein 0.0049 0.0982 0.1861
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0622 0.0381
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0622 0.0381
Brugia malayi AKH receptor 0.0039 0.0622 0.1179
Brugia malayi neuropeptide F receptor 0.0039 0.0622 0.1179
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0815 1
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0622 0.0381
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Brugia malayi hypothetical protein 0.0055 0.119 0.2256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.2689 0.2501
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0622 0.0381
Schistosoma mansoni amine GPCR 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus granulosus muscleblind protein 0.0171 0.5277 0.5155
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0273 0.0988
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0622 0.0381
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0105 0.2929 0.2747
Schistosoma mansoni adenoreceptor 0.0039 0.0622 0.0381
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0622 0.1179
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0273 0.0114
Echinococcus granulosus g protein coupled receptor 0.0039 0.0622 0.0381
Brugia malayi Muscleblind-like protein 0.0171 0.5277 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0622 0.0381
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0622 0.0381
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0712 0.1349
Brugia malayi nuclear hormone receptor family member odr-7 0.0049 0.0982 0.1861
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Onchocerca volvulus 0.0049 0.0982 0.1559
Brugia malayi putative neuropeptide receptor 0.0039 0.0622 0.1179
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0273 0.0988
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0273 0.0988
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0273 0.0114
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0273 0.5
Schistosoma mansoni hypothetical protein 0.0039 0.0622 0.0381
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0622 0.0381
Schistosoma mansoni neuropeptide receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) steroid hormone receptor 0.0105 0.2929 0.2747
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.065 0.0579
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0489 0.0244
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0622 0.1179
Brugia malayi hypothetical protein 0.0039 0.0622 0.1179
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0105 0.2929 0.5551
Schistosoma mansoni hypothetical protein 0.0205 0.6454 0.6363
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0273 0.0988
Schistosoma mansoni biogenic amine receptor 0.0039 0.0622 0.0381
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0273 0.2823
Mycobacterium tuberculosis Probable oxidoreductase 0.0214 0.6781 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.3181 0.3005
Brugia malayi RE15519p 0.0039 0.0622 0.1179
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0105 0.2929 0.5551
Echinococcus granulosus fmrfamide receptor 0.0039 0.0622 0.0381
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0622 0.0381
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0273 0.0988
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Schistosoma mansoni hypothetical protein 0.0035 0.0489 0.0244
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.119 0.0964
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0622 0.0381
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Schistosoma mansoni biogenic amine receptor 0.0039 0.0622 0.0381
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0982 0.075
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0622 0.0381
Echinococcus granulosus sex peptide receptor 0.0039 0.0622 0.0381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0105 0.2929 0.2747
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.119 0.0964
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0105 0.2929 0.5551
Loa Loa (eye worm) hypothetical protein 0.0035 0.0489 0.0244
Echinococcus multilocularis FTZ F1 alpha 0.0105 0.2929 0.2747
Echinococcus multilocularis serotonin receptor 0.0039 0.0622 0.0381
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0622 0.1179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0622 0.0381
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0622 0.0381
Brugia malayi orphan nuclear receptor NR2E1 0.0049 0.0982 0.1861
Brugia malayi MH2 domain containing protein 0.012 0.3477 0.6589
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0622 0.0381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.2689 0.2501
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0049 0.0982 0.075
Schistosoma mansoni nuclear hormone receptor 0.0105 0.2929 0.2747
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0815 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0273 0.0988
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) nuclear hormone receptor 0.0049 0.0982 0.075
Schistosoma mansoni amine GPCR 0.0039 0.0622 0.0381
Echinococcus multilocularis nuclear receptor nhr 48 0.0049 0.0982 0.075
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0982 0.075
Brugia malayi nuclear hormone receptor 0.0105 0.2929 0.5551
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0273 0.0988
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0982 0.075
Schistosoma mansoni nuclear receptor 0.0049 0.0982 0.075
Brugia malayi photoreceptor-specific nuclear receptor 0.0105 0.2929 0.5551
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0214 0.6781 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0844 0.0609
Schistosoma mansoni amine GPCR 0.0039 0.0622 0.0381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Schistosoma mansoni steroid hormone receptor ad4bp 0.0105 0.2929 0.2747
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.1935 0.3667
Echinococcus granulosus GPCR family 2 0.0035 0.0489 0.0244
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0622 0.0381
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0273 0.0988
Loa Loa (eye worm) hypothetical protein 0.0105 0.2929 0.2747
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0622 0.0381
Echinococcus multilocularis sex peptide receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0622 0.0381
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0712 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.2929 0.2747
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0622 0.0381
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0712 0.8635
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0622 0.0381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.119 0.2256
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Brugia malayi nuclear receptor RXR 0.0055 0.119 0.2256
Loa Loa (eye worm) DR-78 0.0049 0.0982 0.075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0273 0.2823
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0712 0.0473
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0105 0.2929 0.2747
Echinococcus multilocularis thioredoxin glutathione reductase 0.0085 0.2233 0.2033
Brugia malayi Dopamine receptor protein 1 0.0039 0.0622 0.1179
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.2216 0.2985
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0712 0.0473
Schistosoma mansoni neuropeptide receptor 0.0039 0.0622 0.0381
Echinococcus granulosus g protein coupled receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0105 0.2929 0.2747
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0815 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0815 0.3502
Echinococcus multilocularis GPCR, family 2 0.0035 0.0489 0.0244
Loa Loa (eye worm) hypothetical protein 0.0055 0.119 0.0964
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0982 0.1861
Brugia malayi Serotonin receptor 0.0039 0.0622 0.1179
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0712 0.0473
Echinococcus multilocularis serotonin receptor 0.0039 0.0622 0.0381
Schistosoma mansoni hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0622 0.0381
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0489 0.0244
Echinococcus multilocularis muscleblind protein 1 0.0171 0.5277 0.5155
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0712 0.2347
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0622 0.0381
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Brugia malayi nuclear receptor NHR-88 0.0049 0.0982 0.1861
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0815 0.3502
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.2689 0.2501
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0622 0.0381
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0622 0.0381
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0622 0.0381
Brugia malayi Dopamine receptor protein 2 0.0039 0.0622 0.1179
Brugia malayi hypothetical protein 0.0055 0.119 0.2256
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0192 0.6024 0.8766
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0622 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0105 0.2929 0.5551
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0622 0.0381
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0622 0.0381
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0815 0.2871
Echinococcus multilocularis thyroid hormone receptor alpha 0.0105 0.2929 0.2747
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0105 0.2929 0.2747
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0105 0.2929 0.2747
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0712 0.0473
Loa Loa (eye worm) hypothetical protein 0.0042 0.0712 0.0473
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0105 0.2929 0.2747
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0622 0.0381
Loa Loa (eye worm) nuclear receptor NHR-67 0.0049 0.0982 0.075
Brugia malayi nuclear receptor NHR-67 0.0049 0.0982 0.1861
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus multilocularis geminin 0.0205 0.6454 0.6363
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0273 0.0518
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.2929 0.5551
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0273 0.0988
Brugia malayi neuropeptide F receptor 0.0039 0.0622 0.1179
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0622 0.0381
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0982 0.075
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.119 0.2256
Schistosoma mansoni neuropeptide receptor 0.0039 0.0622 0.0381
Brugia malayi ecdysteroid receptor 0.0105 0.2929 0.5551
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0055 0.119 0.0964
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0622 0.0381
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0273 0.0023
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0273 0.0023
Echinococcus granulosus somatostatin receptor 0.0039 0.0622 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0105 0.2929 0.5551
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Loa Loa (eye worm) hypothetical protein 0.0171 0.5277 0.5155
Schistosoma mansoni hypothetical protein 0.0035 0.0489 0.0244
Schistosoma mansoni hypothetical protein 0.0205 0.6454 0.6363
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0105 0.2929 0.2747
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0982 0.1861
Echinococcus granulosus thyroid hormone receptor alpha 0.0049 0.0982 0.075
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0192 0.6024 0.8837
Brugia malayi Steroid receptor seven-up type 2 0.0105 0.2929 0.5551
Brugia malayi conserved hypotetical protein 0.0049 0.0982 0.1861
Schistosoma mansoni retinoic acid receptor RXR 0.0105 0.2929 0.2747
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0214 0.6781 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0105 0.2929 0.2747
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0622 0.0381
Schistosoma mansoni zinc finger protein 0.0049 0.0982 0.075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Brugia malayi Dopamine receptor 0.0039 0.0622 0.1179
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0815 1
Echinococcus granulosus FTZ F1 alpha 0.0105 0.2929 0.2747
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.2929 0.2747
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0622 0.0381
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0105 0.2929 1
Brugia malayi RNA, U transporter 1 0.0081 0.2109 0.3996
Brugia malayi hypothetical protein 0.0039 0.0622 0.1179
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0273 0.0114
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Echinococcus multilocularis somatostatin receptor 0.0039 0.0622 0.0381
Echinococcus granulosus ecdysone induced protein 78C 0.0105 0.2929 0.2747
Brugia malayi ORL1-like opioid receptor 0.0039 0.0622 0.1179
Echinococcus granulosus nuclear receptor nhr 48 0.0049 0.0982 0.075
Echinococcus multilocularis snurportin 1 0.0305 1 1
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0622 0.0381
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0489 0.0927
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0049 0.0982 0.075
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0489 0.0927
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0815 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0622 0.1179
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.3477 0.3309
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0982 0.075
Loa Loa (eye worm) glutathione reductase 0.0084 0.2216 0.2016
Onchocerca volvulus 0.0049 0.0982 0.1559
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.2929 0.2747
Schistosoma mansoni histamine h1 receptor 0.0039 0.0622 0.0381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.2689 0.2501
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0055 0.119 0.0964
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0105 0.2929 0.2747
Brugia malayi hypothetical protein 0.0039 0.0622 0.1179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0622 0.0381
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0622 0.0381
Schistosoma mansoni hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.3181 0.3005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.2689 0.2501
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.2216 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0622 0.0381
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0712 0.0473
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0712 0.3024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.119 0.0964
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0622 0.1179
Plasmodium vivax glutathione reductase, putative 0.0084 0.2216 1
Schistosoma mansoni hypothetical protein 0.0305 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0049 0.0982 0.075
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0712 0.0473
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0622 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0712 0.8635
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0214 0.6781 1
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0622 0.0381
Schistosoma mansoni inositol monophosphatase 0.0045 0.0815 0.0579
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0622 0.1179
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0982 0.1559
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Echinococcus multilocularis ecdysone induced protein 78C 0.0105 0.2929 0.2747
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0622 0.0381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0622 0.0381
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.119 0.0964
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0622 0.0381
Mycobacterium tuberculosis Probable reductase 0.0192 0.6024 0.8837
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0105 0.2929 0.2747
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0815 0.2871
Echinococcus granulosus neuropeptide receptor 0.0039 0.0622 0.0381
Echinococcus multilocularis neuropeptide s receptor 0.0039 0.0622 0.0381
Brugia malayi Melatonin receptor type 1A 0.0039 0.0622 0.1179
Loa Loa (eye worm) hypothetical protein 0.0105 0.2929 0.2747
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.3477 0.3309
Echinococcus granulosus dna polymerase eta 0.0045 0.0844 0.0609
Echinococcus granulosus neuropeptide receptor 0.0039 0.0622 0.0381
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0815 0.3502
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.2216 1
Brugia malayi steroid hormone receptor 0.0105 0.2929 0.5551
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0622 0.0381
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0622 0.0381
Onchocerca volvulus 0.0105 0.2929 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0982 0.075
Brugia malayi Inositol-1 0.0045 0.0815 0.1545
Brugia malayi follicle stimulating hormone receptor 0.0039 0.0622 0.1179
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0273 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0105 0.2929 0.2747
Brugia malayi nuclear hormone receptor family member nhr-6 0.0049 0.0982 0.1861
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.2929 0.2747
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0105 0.2929 0.5551
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0105 0.2929 0.2747
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0105 0.2929 0.5551
Brugia malayi GnHR receptor homolog 0.0039 0.0622 0.1179
Brugia malayi larval opioid receptor 0.0039 0.0622 0.1179
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0622 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0105 0.2929 0.5551
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0712 0.3024
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0844 0.302
Plasmodium falciparum thioredoxin reductase 0.0084 0.2216 1
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0622 0.0381
Schistosoma mansoni opsin-like receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Brugia malayi hypothetical protein 0.0039 0.0622 0.1179
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0622 0.0381
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0273 0.0988
Loa Loa (eye worm) hypothetical protein 0.0105 0.2929 0.2747
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0622 0.0381
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0622 0.0381
Schistosoma mansoni hypothetical protein 0.0035 0.0489 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0105 0.2929 0.5551
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0622 0.0381
Brugia malayi hypothetical protein 0.0039 0.0622 0.1179
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0815 0.0579
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0369 0.0598
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0489 0.0244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0105 0.2929 0.2747
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0622 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.2929 0.5551
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0049 0.0982 0.075
Brugia malayi nuclear hormone receptor 0.0049 0.0982 0.1861
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0712 0.8635
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0622 0.0381
Schistosoma mansoni myosin xvIII 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Schistosoma mansoni thyroid hormone receptor 0.0105 0.2929 0.2747
Brugia malayi sulfakinin receptor protein 0.0039 0.0622 0.1179
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Treponema pallidum NADH oxidase 0.0029 0.0273 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0622 0.0381
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0844 0.3638
Mycobacterium tuberculosis Probable dehydrogenase 0.0192 0.6024 0.8837
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0192 0.6024 0.8837
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0622 0.0381
Schistosoma mansoni opsin-like receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) hypothetical protein 0.0055 0.119 0.0964
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0105 0.2929 0.5551
Brugia malayi G-protein coupled receptor 0.0039 0.0622 0.1179
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0192 0.6024 0.8837
Brugia malayi hypothetical protein 0.0039 0.0622 0.1179
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.2689 0.5096
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0369 0.1429
Schistosoma mansoni thyroid hormone receptor 0.0105 0.2929 0.2747
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0712 0.3024
Schistosoma mansoni nuclear receptor 0.0049 0.0982 0.075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0105 0.2929 0.2747
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0105 0.2929 0.2747
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0273 0.0114
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0273 0.0988
Schistosoma mansoni amine GPCR 0.0039 0.0622 0.0381
Echinococcus granulosus neuropeptide s receptor 0.0039 0.0622 0.0381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0273 0.0114
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Toxoplasma gondii thioredoxin reductase 0.0084 0.2216 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0049 0.0982 0.1861
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0622 0.0381
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0712 0.8635
Schistosoma mansoni neuropeptide receptor 0.0039 0.0622 0.0381
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0105 0.2929 0.2747
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0844 0.16
Brugia malayi hypothetical protein 0.0049 0.0982 0.1861
Loa Loa (eye worm) hypothetical protein 0.0105 0.2929 0.2747
Echinococcus multilocularis dna polymerase eta 0.0045 0.0844 0.0609
Loa Loa (eye worm) hypothetical protein 0.0039 0.0622 0.0381
Schistosoma mansoni hypothetical protein 0.0035 0.0489 0.0244
Schistosoma mansoni opsin-like receptor 0.0039 0.0622 0.0381
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.2216 0.2016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0622 0.0381
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0622 0.0381
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0622 0.0381
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.2929 0.2747
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0489 0.0244
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0622 0.0381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0622 0.0381
Brugia malayi Importin beta-1 subunit 0.0029 0.0251 0.0476
Brugia malayi G-protein coupled receptor 0.0039 0.0622 0.1179
Plasmodium falciparum glutathione reductase 0.0029 0.0273 0.0114
Echinococcus granulosus g protein coupled receptor 0.0039 0.0622 0.0381
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0622 0.0381
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0622 0.0381
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0622 0.0381
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 1 1
Schistosoma mansoni amine GPCR 0.0039 0.0622 0.0381
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0105 0.2929 0.2747
Schistosoma mansoni inositol monophosphatase 0.0045 0.0815 0.0579
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0622 0.0381
Onchocerca volvulus Bile acid receptor homolog 0.0105 0.2929 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0105 0.2929 0.2747
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0622 0.0381
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0192 0.6024 0.8837
Onchocerca volvulus Protein ultraspiracle homolog 0.0105 0.2929 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0622 0.0381
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0273 0.0114
Brugia malayi hypothetical protein 0.0039 0.0622 0.1179
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0622 0.0381
Brugia malayi hypothetical protein 0.0039 0.0622 0.1179
Plasmodium falciparum thioredoxin reductase 0.0029 0.0273 0.0114
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0712 0.0473
Brugia malayi Serotonin receptor 0.0039 0.0622 0.1179
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0622 0.0381
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0273 0.0114
Brugia malayi glutathione reductase 0.0084 0.2216 0.4199
Echinococcus multilocularis muscleblind protein 0.0171 0.5277 0.5155
Brugia malayi tailless protein 0.0049 0.0982 0.1861
Loa Loa (eye worm) hypothetical protein 0.0105 0.2929 0.2747
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Brugia malayi G protein-coupled receptor 0.0039 0.0622 0.1179
Schistosoma mansoni biogenic amine receptor 0.0039 0.0622 0.0381
Schistosoma mansoni coup transcription factor 0.0105 0.2929 0.2747
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0622 0.0381
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0622 0.1179
Echinococcus granulosus geminin 0.0205 0.6454 0.6363
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0622 0.0381
Leishmania major DNA polymerase eta, putative 0.0045 0.0844 0.3638
Echinococcus multilocularis neuropeptide receptor A26 0.0039 0.0622 0.0381
Echinococcus granulosus serotonin receptor 0.0039 0.0622 0.0381
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0049 0.0982 0.075
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0622 0.0381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.2689 0.2501
Loa Loa (eye worm) inositol-1 0.0045 0.0815 0.0579
Trypanosoma brucei trypanothione reductase 0.0084 0.2216 1
Schistosoma mansoni DNA polymerase eta 0.0045 0.0844 0.0609
Echinococcus granulosus thioredoxin glutathione reductase 0.0085 0.2233 0.2033
Loa Loa (eye worm) hypothetical protein 0.0105 0.2929 0.2747
Echinococcus granulosus allatostatin A receptor 0.0039 0.0622 0.0381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0622 0.0381
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0622 0.0381
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0622 0.0381
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0105 0.2929 0.2747
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0273 0.0988
Plasmodium falciparum glutathione reductase 0.0084 0.2216 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0273 0.0114
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.075
Brugia malayi Nuclear hormone receptor-like 1 0.0105 0.2929 0.5551

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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