Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0076 | 0.1176 | 0.1767 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0126 | 0.2533 | 0.4955 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0066 | 0.0911 | 0.3126 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0076 | 0.1176 | 0.412 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0044 | 0.0313 | 0.0591 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0122 | 0.2404 | 0.9334 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.2486 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0214 | 0.4904 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0125 | 0.2486 | 0.9681 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0127 | 0.2561 | 1 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0076 | 0.1176 | 0.2398 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.0591 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0076 | 0.1176 | 0.4248 |
Leishmania major | trypanothione reductase | 0.0126 | 0.2533 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0122 | 0.2404 | 0.9334 |
Trypanosoma brucei | trypanothione reductase | 0.0126 | 0.2533 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0076 | 0.1176 | 0.4248 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0076 | 0.1176 | 0.0991 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0076 | 0.1176 | 0.1767 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0125 | 0.2486 | 0.3022 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0044 | 0.0313 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0205 | 0.0134 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0126 | 0.2533 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0085 | 0.142 | 0.1241 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0911 | 0.1503 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0066 | 0.0911 | 0.3033 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0044 | 0.0313 | 0.0463 |
Plasmodium falciparum | glutathione reductase | 0.0126 | 0.2533 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0044 | 0.0313 | 0.1109 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.011 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0288 | 0.6887 | 0.8854 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0044 | 0.0313 | 0.0143 |
Plasmodium falciparum | thioredoxin reductase | 0.0126 | 0.2533 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.032 | 0.7752 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.0591 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0086 | 0.144 | 0.2936 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0086 | 0.144 | 0.524 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0076 | 0.1176 | 0.1767 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0125 | 0.2486 | 0.2329 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.0591 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0076 | 0.1176 | 0.412 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.0463 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0127 | 0.2561 | 1 |
Onchocerca volvulus | 0.0244 | 0.5701 | 1 | |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.0457 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0126 | 0.2533 | 0.3085 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0214 | 0.4904 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0125 | 0.2486 | 0.2329 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0076 | 0.1176 | 0.0991 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.032 | 0.7752 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0044 | 0.0313 | 0.0591 |
Treponema pallidum | NADH oxidase | 0.0044 | 0.0313 | 0.5 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0076 | 0.1176 | 0.412 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0076 | 0.1176 | 0.4248 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0086 | 0.144 | 0.524 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0288 | 0.6887 | 0.8854 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0044 | 0.0313 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1176 | 0.2066 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0076 | 0.1176 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0122 | 0.2404 | 0.2245 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0044 | 0.0313 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0044 | 0.0313 | 0.0591 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0044 | 0.0313 | 0.0472 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.0457 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0205 | 0.0134 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.0591 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.0591 |
Leishmania major | DNA polymerase kappa, putative | 0.004 | 0.0205 | 0.0134 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0044 | 0.0313 | 0.0591 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.0463 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0044 | 0.0313 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0066 | 0.0911 | 0.2997 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.2486 | 1 |
Brugia malayi | glutathione reductase | 0.0126 | 0.2533 | 0.5166 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0066 | 0.0911 | 0.1858 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.0472 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.032 | 0.7752 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.144 | 0.2628 |
Toxoplasma gondii | thioredoxin reductase | 0.0126 | 0.2533 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0125 | 0.2486 | 0.9799 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0125 | 0.2486 | 0.9799 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0076 | 0.1176 | 0.417 |
Brugia malayi | Thioredoxin reductase | 0.0126 | 0.2533 | 0.5166 |
Plasmodium vivax | glutathione reductase, putative | 0.0126 | 0.2533 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0066 | 0.0911 | 0.3126 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.004 | 0.0205 | 0.0418 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0126 | 0.2533 | 1 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0076 | 0.1176 | 0.412 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0044 | 0.0313 | 0.0637 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0044 | 0.0313 | 0.0196 |
Schistosoma mansoni | DNA polymerase eta | 0.0066 | 0.0911 | 0.0721 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0044 | 0.0313 | 0.0591 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0044 | 0.0313 | 0.0591 |
Trichomonas vaginalis | set domain proteins, putative | 0.0244 | 0.5701 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0086 | 0.144 | 0.1261 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0076 | 0.1176 | 0.412 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0076 | 0.1176 | 0.412 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.0591 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.0591 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0205 | 0.0134 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.0591 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.2486 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0044 | 0.0313 | 0.0472 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0205 | 0.0134 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0288 | 0.6887 | 0.8854 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0288 | 0.6887 | 0.8854 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0288 | 0.6887 | 0.8854 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.032 | 0.7752 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0288 | 0.6887 | 0.8854 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0076 | 0.1176 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0044 | 0.0313 | 0.0463 |
Echinococcus granulosus | dna polymerase eta | 0.0066 | 0.0911 | 0.2997 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.004 | 0.0205 | 0.0134 |
Loa Loa (eye worm) | glutathione reductase | 0.0126 | 0.2533 | 0.4955 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0044 | 0.0313 | 0.0591 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0125 | 0.2486 | 0.9681 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta MST (functional) | C5/5 0 day | Mean survival time against trophozoite induced P. berghei in mice minus control was evaluated at a dose 640 mg/kg ; 5 survived out of 5 animals at 60 days postinjection. | ChEMBL. | 3881585 |
Delta MST (functional) | C10/10 0 day | Mean survival time against trophozoite induced P. berghei in mice minus control was evaluated at a dose 320 mg/kg ; 10 survived out of 10 animals at 60 days postinjection. | ChEMBL. | 3881585 |
Delta MST (functional) | C10/10 0 day | Mean survival time against trophozoite induced P. berghei in mice minus control was evaluated at a dose 160 mg/kg ; 10 survived out of 10 animals at 60 days postinjection. | ChEMBL. | 3881585 |
Delta MST (functional) | C10/10 0 day | Mean survival time against trophozoite induced P. berghei in mice minus control was evaluated at a dose 80 mg/kg ; 10 survived out of 10 animals at 60 days postinjection. | ChEMBL. | 3881585 |
Delta MST (functional) | C4/10 0 day | Mean survival time against trophozoite induced P. berghei in mice minus control was evaluated at a dose 40 mg/kg ; 4 survived out of 10 animals at 60 days postinjection. | ChEMBL. | 3881585 |
Delta MST (functional) | = 4.3 day | Mean survival time against trophozoite induced P. berghei in mice minus control was evaluated at a dose 10 mg/kg. | ChEMBL. | 3881585 |
Delta MST (functional) | = 4.3 day | Mean survival time against trophozoite induced P. berghei in mice minus control was evaluated at a dose 10 mg/kg. | ChEMBL. | 3881585 |
Delta MST (functional) | = 8.2 day | Mean survival time against trophozoite induced P. berghei in mice minus control was evaluated at a dose 20 mg/kg. | ChEMBL. | 3881585 |
Delta MST (functional) | = 8.2 day | Mean survival time against trophozoite induced P. berghei in mice minus control was evaluated at a dose 20 mg/kg. | ChEMBL. | 3881585 |
log(1/SD90) (functional) | = 5.24 | Antimalarial activity against Plasmodium berghei infected in po dosed mouse assessed as suppression of parasitemia | ChEMBL. | 319234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.