Detailed information for compound 1364459

Basic information

Technical information
  • TDR Targets ID: 1364459
  • Name: 2-(2-chlorophenyl)-N-(3-morpholin-4-ylsulfony lphenyl)acetamide
  • MW: 394.872 | Formula: C18H19ClN2O4S
  • H donors: 1 H acceptors: 3 LogP: 2.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccccc1Cl)Nc1cccc(c1)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C18H19ClN2O4S/c19-17-7-2-1-4-14(17)12-18(22)20-15-5-3-6-16(13-15)26(23,24)21-8-10-25-11-9-21/h1-7,13H,8-12H2,(H,20,22)
  • InChiKey: HOKPBLXAKXCWJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-chlorophenyl)-N-(3-morpholinosulfonylphenyl)acetamide
  • 2-(2-chlorophenyl)-N-(3-morpholin-4-ylsulfonylphenyl)ethanamide
  • MLS000394356
  • SMR000248331
  • T5399959
  • ZINC05633223

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TAR-binding protein 0.0651 0.5967 0.5967
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0042
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0076 0.0476 0.0476
Echinococcus multilocularis smad 0.0059 0.031 0.052
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0042 0.0063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0042 0.0071
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0042 0.0063
Loa Loa (eye worm) isocitrate dehydrogenase 0.0129 0.0978 0.0978
Loa Loa (eye worm) hypothetical protein 0.0274 0.2365 0.2365
Brugia malayi ecdysteroid receptor 0.0031 0.0042 0.0042
Brugia malayi RNA binding protein 0.0651 0.5967 0.5967
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0042 0.0071
Loa Loa (eye worm) Smad1 0.0059 0.031 0.031
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0129 0.0978 0.1447
Loa Loa (eye worm) hypothetical protein 0.1074 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0042 0.0063
Brugia malayi steroid hormone receptor 0.0031 0.0042 0.0042
Brugia malayi Tyrosine-protein kinase abl-1 0.0249 0.2128 0.2128
Schistosoma mansoni smad1 5 8 and 0.0059 0.031 0.0459
Brugia malayi Tyrosine-protein kinase abl-1 0.0168 0.1349 0.1349
Schistosoma mansoni hypothetical protein 0.0734 0.6757 1
Loa Loa (eye worm) RNA binding protein 0.0651 0.5967 0.5967
Toxoplasma gondii isocitrate dehydrogenase 0.0129 0.0978 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.0978 0.1639
Loa Loa (eye worm) latrophilin receptor protein 2 0.034 0.2993 0.2993
Loa Loa (eye worm) hypothetical protein 0.0734 0.6757 0.6757
Toxoplasma gondii isocitrate dehydrogenase 0.0129 0.0978 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0042 0.0071
Brugia malayi Smad1 0.0059 0.031 0.031
Brugia malayi hypothetical protein 0.0074 0.0453 0.0453
Loa Loa (eye worm) nuclear factor I 0.0033 0.006 0.006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0651 0.5967 0.5967
Brugia malayi nuclear hormone receptor 0.0031 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0042
Echinococcus multilocularis tar DNA binding protein 0.0651 0.5967 1
Brugia malayi Steroid receptor seven-up type 2 0.0211 0.1766 0.1766
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.006 0.006
Mycobacterium ulcerans glutaminase 0.0275 0.237 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0042 0.0063
Echinococcus granulosus tyrosine protein kinase ABL1 0.0411 0.3673 0.6155
Schistosoma mansoni tyrosine kinase 0.0405 0.3616 0.5352
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0042 0.0071
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0042 0.0063
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.034 0.2993 0.5015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0042 0.0042
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0042 0.0071
Brugia malayi latrophilin 2 splice variant baaae 0.0734 0.6757 0.6757
Brugia malayi MH2 domain containing protein 0.0059 0.031 0.031
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0211 0.1766 0.2959
Brugia malayi MH2 domain containing protein 0.0059 0.031 0.031
Loa Loa (eye worm) glutaminase 2 0.0275 0.237 0.237
Loa Loa (eye worm) MH2 domain-containing protein 0.0863 0.7984 0.7984
Brugia malayi TAR-binding protein 0.0651 0.5967 0.5967
Schistosoma mansoni glutaminase 0.0275 0.237 0.3508
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.0978 0.1639
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0074 0.0453 0.076
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.0978 1
Brugia malayi MH1 domain containing protein 0.0059 0.031 0.031
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.0978 1
Brugia malayi glutaminase DH11.1 0.0275 0.237 0.237
Schistosoma mansoni Smad4 0.0059 0.031 0.0459
Loa Loa (eye worm) MH1 domain-containing protein 0.0059 0.031 0.031
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0074 0.0453 0.076
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0042 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0156 0.1238 0.1238
Loa Loa (eye worm) hypothetical protein 0.0197 0.1627 0.1627
Echinococcus granulosus Glycosyl transferase family 8 0.0076 0.0476 0.0798
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0042 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.034 0.2993 0.2993
Echinococcus granulosus GPCR family 2 0.034 0.2993 0.5015
Schistosoma mansoni smad1 5 8 and 0.0059 0.031 0.0459
Echinococcus multilocularis conserved hypothetical protein 0.0057 0.0289 0.0484
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0042 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0074 0.0453 0.0453
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0129 0.0978 1
Echinococcus granulosus smad 0.0059 0.031 0.052
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0042 0.0071
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0042 0.0042
Brugia malayi MH1 domain containing protein 0.0059 0.031 0.031
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0129 0.0978 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0042 0.0063
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0042 0.0042
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0042 0.0063
Echinococcus multilocularis GPCR, family 2 0.034 0.2993 0.5015
Echinococcus multilocularis mothers against decapentaplegic 5 0.0059 0.031 0.052
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0057 0.0289 0.0484
Loa Loa (eye worm) MH2 domain-containing protein 0.0059 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0651 0.5967 0.8832
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0042 0.0042
Loa Loa (eye worm) nuclear hormone receptor 0.0195 0.1611 0.1611
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0211 0.1766 0.2959
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0042 0.0042
Brugia malayi Isocitrate dehydrogenase 0.0129 0.0978 0.0978
Loa Loa (eye worm) transcription factor SMAD2 0.0863 0.7984 0.7984
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0074 0.0453 0.076
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0411 0.3673 0.6155
Loa Loa (eye worm) TK/ABL protein kinase 0.0411 0.3673 0.3673
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0042 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0651 0.5967 0.8832
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.034 0.2993 0.5015
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0129 0.0978 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0042 0.0042
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0059 0.031 0.0459
Echinococcus multilocularis tyrosine protein kinase Abl 0.0168 0.1349 0.226
Echinococcus granulosus mothers against decapentaplegic 5 0.0059 0.031 0.052
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0059 0.031 0.052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1074 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0042 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0042 0.0042
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.0978 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0042 0.0042
Brugia malayi nuclear receptor NHR-88 0.0031 0.0042 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0042 0.0071
Brugia malayi isocitrate dehydrogenase 0.0129 0.0978 0.0978
Loa Loa (eye worm) glutaminase 0.0275 0.237 0.237
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0042 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0651 0.5967 0.8832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0042 0.0042
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0042 0.0063
Brugia malayi Glycosyl transferase family 8 protein 0.0076 0.0476 0.0476
Echinococcus multilocularis Glycosyl transferase, family 8 0.0076 0.0476 0.0798
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0129 0.0978 0.1639
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0042 0.0071
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.0978 0.1639
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0042 0.0063
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0042 0.0071
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0065 0.0108
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0042 1
Schistosoma mansoni hypothetical protein 0.034 0.2993 0.4429
Echinococcus granulosus TGF beta signal transducer SmadC 0.0059 0.031 0.052
Schistosoma mansoni hypothetical protein 0.034 0.2993 0.4429
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0042 0.0071
Schistosoma mansoni tar DNA-binding protein 0.0651 0.5967 0.8832
Trichomonas vaginalis glutaminase, putative 0.0275 0.237 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0042 0.0042
Brugia malayi RNA recognition motif domain containing protein 0.0651 0.5967 0.5967
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.034 0.2993 0.5015
Brugia malayi MH2 domain containing protein 0.0863 0.7984 0.7984
Schistosoma mansoni glycosyltransferase-related 0.0076 0.0476 0.0705
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0042 0.0071
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0042 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0042 0.0071
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0129 0.0978 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0129 0.0978 0.5
Echinococcus multilocularis isocitrate dehydrogenase 0.0129 0.0978 0.1639
Echinococcus granulosus Smad4 0.0059 0.031 0.052
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0042 0.0063
Schistosoma mansoni hypothetical protein 0.0033 0.0065 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0042 0.0042
Brugia malayi hypothetical protein 0.0048 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.034 0.2993 0.2993
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0074 0.0453 0.076
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0129 0.0978 0.1639
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.034 0.2993 0.5015
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0042 0.0071
Schistosoma mansoni coup transcription factor 0.0031 0.0042 0.0063
Schistosoma mansoni smad 0.0059 0.031 0.0459
Brugia malayi MH1 domain containing protein 0.0033 0.006 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.1074 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0042 1
Brugia malayi Latrophilin receptor protein 2 0.034 0.2993 0.2993
Schistosoma mansoni tar DNA-binding protein 0.0651 0.5967 0.8832
Onchocerca volvulus 0.0031 0.0042 1
Brugia malayi MH1 domain containing protein 0.0033 0.006 0.006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0042 0.0071
Brugia malayi photoreceptor-specific nuclear receptor 0.0274 0.2365 0.2365
Echinococcus multilocularis Smad4 0.0059 0.031 0.052
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0057 0.0289 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.034 0.2993 0.4429
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0042 0.0071
Schistosoma mansoni hypothetical protein 0.034 0.2993 0.4429
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0042 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0042 0.0042
Schistosoma mansoni smad1 5 8 and 0.0059 0.031 0.0459
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0065 0.0108
Echinococcus granulosus tar DNA binding protein 0.0651 0.5967 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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