Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3074 | 0.3074 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.676 | 0.676 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3074 | 0.3074 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3074 | 0.509 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3074 | 0.3074 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3074 | 0.3074 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0146 | 0.8263 | 0.8263 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0126 | 0.676 | 0.676 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.8263 | 0.8263 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3074 | 0.509 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.017 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.8263 | 0.8263 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.6039 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.6039 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3074 | 0.3074 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.6039 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3074 | 0.509 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3074 | 0.3074 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3074 | 0.3074 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0126 | 0.676 | 0.676 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.