Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0333 | 0.7772 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.0895 | 0.195 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0248 | 0.5208 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0271 | 0.5884 | 0.7254 |
Brugia malayi | Matrixin family protein | 0.0271 | 0.5884 | 0.7254 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1091 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7772 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0248 | 0.5208 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0216 | 0.4226 | 0.4844 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1091 | 0.0286 |
Brugia malayi | Matrixin family protein | 0.0112 | 0.1091 | 0.0286 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0333 | 0.7772 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.0895 | 0.195 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0112 | 0.1091 | 0.2378 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.4589 | 0.5371 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.0895 | 0.195 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0136 | 0.1828 | 0.1357 |
Loa Loa (eye worm) | matrixin family protein | 0.0248 | 0.5208 | 0.6271 |
Schistosoma mansoni | hypothetical protein | 0.0159 | 0.2504 | 0.5456 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0333 | 0.7772 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0228 | 0.4589 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0216 | 0.4226 | 0.4844 |
Schistosoma mansoni | tar DNA-binding protein | 0.0216 | 0.4226 | 0.9209 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1828 | 0.1357 |
Schistosoma mansoni | tar DNA-binding protein | 0.0216 | 0.4226 | 0.9209 |
Schistosoma mansoni | tar DNA-binding protein | 0.0216 | 0.4226 | 0.9209 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.0895 | 0.195 |
Brugia malayi | Matrixin family protein | 0.0112 | 0.1091 | 0.0286 |
Brugia malayi | Matrixin family protein | 0.0112 | 0.1091 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1091 | 0.0286 |
Onchocerca volvulus | 0.0159 | 0.2504 | 0.3431 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0216 | 0.4226 | 0.9209 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0407 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0216 | 0.4226 | 0.3659 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0216 | 0.4226 | 0.4844 |
Brugia malayi | Hemopexin family protein | 0.0159 | 0.2504 | 0.234 |
Brugia malayi | RNA binding protein | 0.0216 | 0.4226 | 0.4844 |
Schistosoma mansoni | tar DNA-binding protein | 0.0216 | 0.4226 | 0.9209 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0112 | 0.1091 | 0.0286 |
Echinococcus granulosus | tar DNA binding protein | 0.0216 | 0.4226 | 0.3659 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0216 | 0.4226 | 0.4844 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0136 | 0.1828 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0136 | 0.1828 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0228 | 0.4589 | 0.5371 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0136 | 0.1828 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0216 | 0.4226 | 0.4844 |
Brugia malayi | Matrixin family protein | 0.0112 | 0.1091 | 0.0286 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.