Detailed information for compound 1364919

Basic information

Technical information
  • TDR Targets ID: 1364919
  • Name: N-(2-diethylaminoethyl)-1-[[5-[(E)-2-(2-fluor ophenyl)ethenyl]-3-methyl-1,2-oxazol-4-yl]sul fonyl]piperidine-4-carboxamide
  • MW: 492.607 | Formula: C24H33FN4O4S
  • H donors: 1 H acceptors: 4 LogP: 2.86 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)C1CCN(CC1)S(=O)(=O)c1c(onc1C)/C=C/c1ccccc1F)CC
  • InChi: 1S/C24H33FN4O4S/c1-4-28(5-2)17-14-26-24(30)20-12-15-29(16-13-20)34(31,32)23-18(3)27-33-22(23)11-10-19-8-6-7-9-21(19)25/h6-11,20H,4-5,12-17H2,1-3H3,(H,26,30)/b11-10+
  • InChiKey: HNKWCTYGBJTFKG-ZHACJKMWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-diethylaminoethyl)-1-[5-[(E)-2-(2-fluorophenyl)vinyl]-3-methyl-isoxazol-4-yl]sulfonyl-piperidine-4-carboxamide
  • N-(2-diethylaminoethyl)-1-[[5-[(E)-2-(2-fluorophenyl)vinyl]-3-methyl-4-isoxazolyl]sulfonyl]-4-piperidinecarboxamide
  • N-(2-diethylaminoethyl)-1-[5-[(E)-2-(2-fluorophenyl)vinyl]-3-methyl-isoxazol-4-yl]sulfonyl-isonipecotamide
  • G637-0952
  • NCGC00132648-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Schistosoma mansoni myosin xvIII 0.0029 0.0208 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0208 0.0279
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0208 0.0279
Echinococcus multilocularis serotonin receptor 0.0029 0.0208 0.0279
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0467 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0125 0.0237
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Brugia malayi hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0125 0.0237
Brugia malayi hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Onchocerca volvulus 0.0033 0.0271 0.0453
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.5279 1
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0125 0.0111
Echinococcus granulosus neuropeptide receptor 0.0029 0.0208 0.0279
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0467 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0125 0.0237
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0467 0.0454
Brugia malayi sulfakinin receptor protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.0208 0.0395
Brugia malayi STAT protein, DNA binding domain containing protein 0.0152 0.2421 0.4586
Schistosoma mansoni hypothetical protein 0.0152 0.2413 0.2403
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0411 0.0755
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0467 0.7008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Schistosoma mansoni hypothetical protein 0.0029 0.0208 0.0195
Brugia malayi G-protein coupled receptor 0.0029 0.0208 0.0395
Echinococcus multilocularis muscleblind protein 1 0.018 0.2921 0.416
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.0208 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0319 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0411 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0411 0.0755
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0043 0.0467 0.0884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.066 0.1228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.0043 0.0467 0.0884
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0125 0.0159
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0237
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0208 0.0279
Brugia malayi ecdysteroid receptor 0.0024 0.0125 0.0237
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0467 0.0861
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0467 0.7008
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0467 0.0861
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0208 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0269 0.0484
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0125 0.0237
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.0208 0.0395
Onchocerca volvulus 0.0029 0.0208 0.0259
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0467 0.5
Loa Loa (eye worm) hypothetical protein 0.018 0.2921 0.5534
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0125 0.0237
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.4667 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0233 0.3393
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0029 0.0054
Brugia malayi Protein kinase domain containing protein 0.0203 0.3322 0.6293
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0213 0.0378
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.0208 0.0279
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0125 0.0159
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.5279 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0466 0.0648
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Onchocerca volvulus 0.0029 0.0208 0.0259
Echinococcus granulosus lamin 0.0033 0.0271 0.0369
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.066 1
Onchocerca volvulus 0.0029 0.0208 0.0259
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.0208 0.0195
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.3356 0.6348
Onchocerca volvulus 0.0029 0.0208 0.0259
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0208 0.0195
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0208 0.0279
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0125 0.0111
Schistosoma mansoni lamin 0.0033 0.0271 0.0258
Schistosoma mansoni biogenic amine receptor 0.0029 0.0208 0.0195
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0125 0.0237
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0208 0.0279
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0462 0.6934
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0208 0.0195
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0237
Schistosoma mansoni lamin 0.0033 0.0271 0.0258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0208 0.0195
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.3356 0.6348
Schistosoma mansoni biogenic amine receptor 0.0029 0.0208 0.0195
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0208 0.0279
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.0208 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Echinococcus multilocularis tumor protein p63 0.0408 0.7003 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0467 0.0884
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.0208 0.0279
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.0208 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0125 0.0237
Echinococcus granulosus sex peptide receptor 0.0029 0.0208 0.0279
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.0208 0.0279
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0125 0.0159
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.0208 0.0195
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.3356 0.6348
Onchocerca volvulus 0.0029 0.0208 0.0259
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0425 0.0805
Echinococcus multilocularis GPCR, family 2 0.0019 0.0029 0.0022
Loa Loa (eye worm) beta-lactamase 0.0043 0.0467 0.0884
Schistosoma mansoni thyroid hormone receptor 0.0176 0.2851 0.2841
Onchocerca volvulus 0.0033 0.0271 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0125 0.0237
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0237
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Brugia malayi G-protein coupled receptor 0.0029 0.0208 0.0395
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0208 0.0279
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0208 0.0279
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0125 0.0237
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0125 0.0159
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.0208 0.0279
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.0208 0.0195
Trichomonas vaginalis esterase, putative 0.0043 0.0467 0.0861
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0125 0.0159
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Schistosoma mansoni hypothetical protein 0.0029 0.0208 0.0195
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0208 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.066 0.1228
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0208 0.0279
Brugia malayi beta-lactamase family protein 0.0043 0.0467 0.0884
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0015
Brugia malayi intermediate filament protein 0.0033 0.0271 0.0514
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0125 0.0111
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.0208 0.0395
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0125 0.0111
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0125 0.0237
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Onchocerca volvulus 0.0029 0.0208 0.0259
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Echinococcus multilocularis muscleblind protein 0.018 0.2921 0.416
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0029 0.0054
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0208 0.0195
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0237
Loa Loa (eye worm) STAT protein 0.0152 0.2421 0.4586
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Onchocerca volvulus 0.0043 0.0467 0.1058
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0208 0.0279
Brugia malayi hypothetical protein 0.002 0.004 0.0075
Leishmania major hypothetical protein, conserved 0.003 0.0233 0.3393
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0462 0.6934
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.0208 0.0395
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0208 0.0395
Echinococcus multilocularis sex peptide receptor 0.0029 0.0208 0.0279
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0467 0.0648
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.5279 1
Echinococcus granulosus allatostatin A receptor 0.0029 0.0208 0.0279
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.066 0.0648
Schistosoma mansoni opsin-like receptor 0.0029 0.0208 0.0195
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0029 0.0208 0.0259
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0208 0.0395
Echinococcus granulosus muscleblind protein 0.018 0.2921 0.416
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.0208 0.0395
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.0208 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0212 0.0377
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.0208 0.0395
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.0041 0.0425 0.0805
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0767 0.1452
Onchocerca volvulus 0.0029 0.0208 0.0259
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0125 0.0111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.066 0.0925
Schistosoma mansoni opsin-like receptor 0.0029 0.0208 0.0195
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0208 0.0279
Brugia malayi beta-lactamase 0.0043 0.0467 0.0884
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.3356 0.6348
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0125 0.0111
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0271 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0269 0.0484
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0208 0.0279
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0125 0.0159
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0208 0.0279
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.0208 0.0279
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.0208 0.0279
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0467 0.0884
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0125 0.0237
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0208 0.0279
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.0208 0.0279
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.3356 0.6348
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0125 0.0237
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.5279 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0237
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0125 0.0237
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.066 0.0925
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0029 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0125 0.0237
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.066 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0263 0.0474
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.0208 0.0279
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0208 0.0195
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.0208 0.0395
Echinococcus multilocularis orexin receptor type 2 0.0029 0.0208 0.0279
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0466 0.0648
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.0208 0.0195
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0029 0.0054
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.2413 0.3433
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0208 0.0279
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.0208 0.0395
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.0208 0.0279
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2272 0.4304
Echinococcus multilocularis lamin 0.0033 0.0271 0.0369
Echinococcus granulosus somatostatin receptor 0.0029 0.0208 0.0279
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0125 0.0159
Onchocerca volvulus 0.0029 0.0208 0.0259
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0125 0.0159
Schistosoma mansoni histamine h1 receptor 0.0029 0.0208 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0269 0.0484
Brugia malayi RE15519p 0.0029 0.0208 0.0395
Brugia malayi beta-lactamase family protein 0.0043 0.0467 0.0884
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0467 1
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0015
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0208 0.0279
Echinococcus multilocularis lamin dm0 0.0033 0.0271 0.0369
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0467 0.0861
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0015
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.0208 0.0395
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0208 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.066 0.1228
Schistosoma mansoni coup transcription factor 0.0024 0.0125 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0125 0.0237
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0208 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0212 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0125 0.0237
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.0208 0.0395
Echinococcus granulosus hypothetical protein 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0208 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0125 0.0237
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.0208 0.0195
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.066 0.1251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0208 0.0195
Brugia malayi Dopamine receptor 0.0029 0.0208 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0411 0.0755
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0208 0.0279
Schistosoma mansoni thyroid hormone receptor 0.0176 0.2851 0.2841
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0125 0.0237
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.0208 0.0279
Onchocerca volvulus 0.0043 0.0467 0.1058
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.0208 0.0279
Onchocerca volvulus 0.006 0.0758 0.196
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.0208 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0518 0.0958
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Schistosoma mansoni hypothetical protein 0.0043 0.0466 0.0453
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.5279 1
Echinococcus multilocularis serotonin receptor 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.0043 0.0467 0.0884
Schistosoma mansoni opsin-like receptor 0.0029 0.0208 0.0195
Echinococcus granulosus g protein coupled receptor 0.0029 0.0208 0.0279
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0208 0.0279
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0208 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.3356 0.6348
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Onchocerca volvulus 0.0029 0.0208 0.0259
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.0208 0.0279
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0758 0.0745
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0233 0.3393
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0208 0.0195
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.0208 0.0395
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0467 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0029 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0467 0.0861
Brugia malayi AKH receptor 0.0029 0.0208 0.0395
Echinococcus granulosus g protein coupled receptor 0.0029 0.0208 0.0279
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.066 0.1251
Schistosoma mansoni amine GPCR 0.0029 0.0208 0.0195
Brugia malayi hypothetical protein 0.0029 0.0208 0.0395
Echinococcus granulosus serotonin receptor 0.0029 0.0208 0.0279
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.0208 0.0279
Brugia malayi nuclear receptor NHR-88 0.0024 0.0125 0.0237
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.3356 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.5279 1
Brugia malayi hypothetical protein 0.003 0.0233 0.0441
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.3553 0.6723
Onchocerca volvulus 0.0029 0.0208 0.0259
Loa Loa (eye worm) hypothetical protein 0.006 0.0758 0.1436
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0014 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0213 0.0378
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0091 0.1204
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0125 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.034 0.062
Loa Loa (eye worm) hypothetical protein 0.0033 0.0271 0.0514
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.066 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.0208 0.0279
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0125 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Brugia malayi ORL1-like opioid receptor 0.0029 0.0208 0.0395
Echinococcus multilocularis thyroid hormone receptor alpha 0.0176 0.2851 0.4059
Onchocerca volvulus 0.0029 0.0208 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0208 0.0195
Onchocerca volvulus 0.0029 0.0208 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0461 0.085
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0208 0.0395
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0208 0.0195
Brugia malayi Serotonin receptor 0.0029 0.0208 0.0395
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.018 0.2921 0.5534
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0125 0.0237
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Schistosoma mansoni amine GPCR 0.0029 0.0208 0.0195
Toxoplasma gondii ABC1 family protein 0.0043 0.0467 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Giardia lamblia GTOR 0.0054 0.066 0.5
Brugia malayi neuropeptide F receptor 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0493
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.0208 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0213 0.0378
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0043 0.0467 0.0884
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0208 0.0279
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.066 1
Echinococcus multilocularis somatostatin receptor 0.0029 0.0208 0.0279
Schistosoma mansoni hypothetical protein 0.0041 0.0425 0.0412
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.0208 0.0279
Brugia malayi larval opioid receptor 0.0029 0.0208 0.0395
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0029 0.0022
Brugia malayi hypothetical protein 0.0029 0.0208 0.0395
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.2413 0.3433
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0411 0.0755
Schistosoma mansoni neuropeptide receptor 0.0029 0.0208 0.0195
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0208 0.0279
Schistosoma mansoni neuropeptide receptor 0.0029 0.0208 0.0195
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0233 0.3393
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2272 0.4304
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0125 0.0111
Echinococcus granulosus GPCR family 2 0.0019 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Schistosoma mansoni hypothetical protein 0.0029 0.0208 0.0195
Onchocerca volvulus 0.0029 0.0208 0.0259
Loa Loa (eye worm) hypothetical protein 0.0043 0.0467 0.0884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0263 0.0474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0208 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0208 0.0195
Echinococcus multilocularis allatostatin A receptor 0.0029 0.0208 0.0279
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0208 0.0279
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.066 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0271 0.0369
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Schistosoma mansoni intermediate filament proteins 0.0033 0.0271 0.0258
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0125 0.0237
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0237
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0014 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0461 0.085
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.0208 0.0279
Schistosoma mansoni biogenic amine receptor 0.0029 0.0208 0.0195
Brugia malayi neuropeptide F receptor 0.0029 0.0208 0.0395
Schistosoma mansoni amine GPCR 0.0029 0.0208 0.0195
Mycobacterium ulcerans hypothetical protein 0.0043 0.0467 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0467 0.7008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0208 0.0195
Brugia malayi hypothetical protein 0.0029 0.0208 0.0395
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0125 0.0159
Brugia malayi Serotonin receptor 0.0029 0.0208 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.3553 0.6723
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.0208 0.0279
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0271 0.0514
Echinococcus granulosus g-protein coupled receptor 0.0029 0.0208 0.0279
Loa Loa (eye worm) WEE protein kinase 0.0203 0.3322 0.6293
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0125 0.0159
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0125 0.0159
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0208 0.0195
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0411 0.7611
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0467 0.0861
Schistosoma mansoni neuropeptide receptor 0.0029 0.0208 0.0195
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0208 0.0195
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.0208 0.0195
Brugia malayi MH2 domain containing protein 0.0144 0.2272 0.4304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0125 0.0159
Mycobacterium ulcerans beta-lactamase 0.0043 0.0467 0.5
Schistosoma mansoni amine GPCR 0.0029 0.0208 0.0195
Brugia malayi hypothetical protein 0.0029 0.0208 0.0395
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0208 0.0279
Echinococcus granulosus orexin receptor type 2 0.0029 0.0208 0.0279
Brugia malayi Muscleblind-like protein 0.018 0.2921 0.5534
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0029 0.0022
Brugia malayi hypothetical protein 0.0029 0.0208 0.0395
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.0208 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0212 0.0377
Loa Loa (eye worm) hypothetical protein 0.003 0.0233 0.0441
Brugia malayi follicle stimulating hormone receptor 0.0029 0.0208 0.0395
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0208 0.0279
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.0208 0.0279
Loa Loa (eye worm) hypothetical protein 0.006 0.0767 0.1452
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.0208 0.0279
Mycobacterium leprae Probable lipase LipE 0.0043 0.0467 0.5
Echinococcus granulosus fmrfamide receptor 0.0029 0.0208 0.0279
Onchocerca volvulus 0.0029 0.0208 0.0259
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0125 0.0159
Echinococcus multilocularis musashi 0.0033 0.0271 0.0369
Onchocerca volvulus 0.0029 0.0208 0.0259
Schistosoma mansoni hypothetical protein 0.0029 0.0208 0.0195
Brugia malayi Dopamine receptor protein 2 0.0029 0.0208 0.0395
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0467 0.0454
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.0208 0.0395
Brugia malayi Dopamine receptor protein 1 0.0029 0.0208 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.3356 0.6348
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0147 0.207
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0125 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0125 0.0237
Brugia malayi hypothetical protein 0.0029 0.0208 0.0395
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0125 0.0111
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0208 0.0279
Brugia malayi G protein-coupled receptor 0.0029 0.0208 0.0395
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0208 0.0279
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0462 0.6934
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0237
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Echinococcus granulosus tumor protein p63 0.0408 0.7003 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.066 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0411 0.0755
Echinococcus granulosus neuropeptide s receptor 0.0029 0.0208 0.0279
Brugia malayi hypothetical protein 0.0029 0.0208 0.0395
Leishmania major hypothetical protein, conserved 0.0043 0.0467 0.7008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0125 0.0159
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.066 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.066 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0125 0.0159
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0125 0.0159
Echinococcus granulosus lamin dm0 0.0033 0.0271 0.0369
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.0208 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0461 0.085
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0208 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0411 0.0755
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Echinococcus granulosus g protein coupled receptor 0.0029 0.0208 0.0279
Onchocerca volvulus 0.0043 0.0467 0.1058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0125 0.0237
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0466 0.0453
Brugia malayi Melatonin receptor type 1A 0.0029 0.0208 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0461 0.085
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.0208 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0125 0.0237
Onchocerca volvulus 0.0029 0.0208 0.0259
Schistosoma mansoni adenoreceptor 0.0029 0.0208 0.0195
Brugia malayi steroid hormone receptor 0.0024 0.0125 0.0237
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0125 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0461 0.085
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.5279 1
Brugia malayi hypothetical protein 0.0029 0.0208 0.0395
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0233 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0233 0.5
Brugia malayi putative neuropeptide receptor 0.0029 0.0208 0.0395
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0271 0.0514
Onchocerca volvulus 0.0029 0.0208 0.0259
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Schistosoma mansoni neuropeptide receptor 0.0029 0.0208 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Brugia malayi nuclear hormone receptor 0.0024 0.0125 0.0237
Echinococcus granulosus neuropeptide receptor 0.0029 0.0208 0.0279
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0208 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.0208 0.0279
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0208 0.0279
Brugia malayi hypothetical protein 0.0043 0.0466 0.0883
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0467 0.0884
Mycobacterium ulcerans lipase LipD 0.0043 0.0467 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0767 0.1452
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.0208 0.0395
Brugia malayi GnHR receptor homolog 0.0029 0.0208 0.0395
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.5279 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0767 0.1452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0213 0.0378
Onchocerca volvulus Neuropeptide F receptor homolog 0.0029 0.0208 0.0259
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0395

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 28.849 uM PUBCHEM_BIOASSAY: MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 30.447 uM PUBCHEM_BIOASSAY: MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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