Detailed information for compound 1365030

Basic information

Technical information
  • TDR Targets ID: 1365030
  • Name: 3-(2,3-dimethylphenyl)-1-[9-(phenylmethyl)-9- azabicyclo[3.3.1]nonan-7-yl]thiourea
  • MW: 393.588 | Formula: C24H31N3S
  • H donors: 1 H acceptors: 0 LogP: 5.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: SC(=Nc1cccc(c1C)C)NC1CC2CCCC(C1)N2Cc1ccccc1
  • InChi: 1S/C24H31N3S/c1-17-8-6-13-23(18(17)2)26-24(28)25-20-14-21-11-7-12-22(15-20)27(21)16-19-9-4-3-5-10-19/h3-6,8-10,13,20-22H,7,11-12,14-16H2,1-2H3,(H2,25,26,28)
  • InChiKey: FQBNDSJMJYUEHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[9-(benzyl)-9-azabicyclo[3.3.1]nonan-7-yl]-3-(2,3-dimethylphenyl)thiourea
  • 1-(9-Benzyl-9-aza-bicyclo[3.3.1]non-3-yl)-3-(2,3-dimethyl-phenyl)-thiourea
  • ASN 06223651
  • MLS000709736
  • SMR000286603

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1307 0.1539
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0166 0.0303
Echinococcus granulosus dna polymerase kappa 0.0019 0.0166 0.0303
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0752 0.0886
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0121 0.0592
Trypanosoma cruzi cytochrome P450, putative 0.0229 0.2844 1
Leishmania major pyruvate kinase 0.0065 0.0752 0.2645
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0121 0.1608
Mycobacterium leprae putative cytochrome p450 0.0167 0.2043 1
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0752 0.5228
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2864 0.5706
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0166 0.0195
Trypanosoma brucei cytochrome P450, putative 0.0229 0.2844 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0585 0.2056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0549 0.2572
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0167 0.2043 0.7186
Echinococcus granulosus nuclear factor of activated T cells 5 0.0302 0.3768 0.7518
Leishmania major cytochrome p450-like protein 0.0167 0.2043 0.7186
Onchocerca volvulus 0.0014 0.0103 0.0715
Echinococcus multilocularis cpg binding protein 0.003 0.0303 0.0289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0628 0.1254
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0185 0.0763
Trypanosoma brucei acetyl-CoA synthetase, putative 0.002 0.0185 0.0649
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0014 0.0028
Loa Loa (eye worm) hypothetical protein 0.0119 0.1439 0.1694
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0121 0.0107
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0683 0.1363
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0121 0.0107
Schistosoma mansoni hypothetical protein 0.04 0.5007 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0628 0.0615
Brugia malayi isocitrate dehydrogenase 0.0015 0.0121 0.0142
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0301 0.0601
Brugia malayi pyruvate kinase 0.0014 0.01 0.0118
Loa Loa (eye worm) oxidoreductase 0.002 0.0185 0.0218
Entamoeba histolytica hypothetical protein 0.0035 0.0373 0.2107
Echinococcus granulosus expressed protein 0.0008 0.0031 0.0033
Mycobacterium ulcerans hypothetical protein 0.0069 0.0808 0.284
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0167 0.2043 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0167 0.2043 0.7186
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0301 0.0354
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0167 0.2043 1
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.087 0.1024
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0036 0.0043
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0166 0.0668
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0808 0.284
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.002 0.0185 0.0649
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0167 0.2043 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.002 0.0185 0.0341
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0319 0.2215
Entamoeba histolytica hypothetical protein 0.0035 0.0373 0.2107
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0602 0.2945
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0319 0.0609
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.002 0.0185 0.0649
Schistosoma mansoni hypothetical protein 0.0205 0.2528 0.5048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.0146
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0121 0.0425
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0808 0.0951
Brugia malayi nuclear hormone receptor 0.0014 0.0103 0.0121
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0628 0.074
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0167 0.2043 0.7186
Brugia malayi hypothetical protein 0.0016 0.0124 0.0146
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.0689
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0301 0.0354
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0301 0.0287
Echinococcus multilocularis pyruvate kinase 0.0065 0.0752 0.0739
Schistosoma mansoni pyruvate kinase 0.0033 0.035 0.0699
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0301 0.0354
Entamoeba histolytica acyl-CoA synthetase, putative 0.0069 0.0808 0.653
Brugia malayi Cytochrome P450 family protein 0.0674 0.8494 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0045 0.0502 0.0591
Echinococcus multilocularis pyruvate kinase 0.0033 0.035 0.0336
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0103 0.0088
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0301 0.0601
Toxoplasma gondii propionate-CoA ligase 0.002 0.0185 0.0904
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0051 0.0036
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0301 0.2092
Echinococcus multilocularis pyruvate kinase 0.0033 0.035 0.0336
Echinococcus multilocularis expressed conserved protein 0.009 0.1075 0.1062
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0069 0.0808 0.3859
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0124 0.022
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0167 0.2043 0.7186
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0354
Schistosoma mansoni hypothetical protein 0.0034 0.0363 0.0724
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0301 0.0601
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0121 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0185 0.0649
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0166 0.0195
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1307 0.1539
Brugia malayi Cytochrome P450 family protein 0.0229 0.2844 0.3348
Trypanosoma brucei pyruvate kinase 1, putative 0.0065 0.0752 0.2645
Schistosoma mansoni patched 1 0.0041 0.0451 0.09
Schistosoma mansoni DNA polymerase eta 0.0019 0.0166 0.033
Brugia malayi ecdysteroid receptor 0.003 0.0301 0.0354
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1674 0.1662
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.002 0.0185 0.0763
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0319 0.0305
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0302 0.3768 0.3759
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Echinococcus multilocularis protein patched 0.0041 0.0451 0.0437
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0752 1
Leishmania major cytochrome p450-like protein 0.0167 0.2043 0.7186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0301 0.0574
Schistosoma mansoni pyruvate kinase 0.0065 0.0752 0.1502
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0167 0.2043 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0301 0.0601
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0752 0.2645
Trypanosoma brucei unspecified product 0.0013 0.0091 0.032
Schistosoma mansoni ferritin light chain 0.0008 0.0031 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0185 0.0763
Loa Loa (eye worm) hypothetical protein 0.0041 0.0451 0.0531
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.0689
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0103 0.0177
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0167 0.2043 0.7186
Brugia malayi nuclear hormone receptor 0.003 0.0301 0.0354
Echinococcus granulosus geminin 0.0205 0.2528 0.5034
Entamoeba histolytica hypothetical protein 0.0035 0.0373 0.2107
Echinococcus granulosus smad 0.001 0.0051 0.0073
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0167 0.2043 0.7186
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0069 0.0808 0.3859
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0319 0.0375
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0124 0.0146
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0451 0.0531
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0301 0.0574
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0185 0.0649
Echinococcus multilocularis expressed protein 0.0008 0.0031 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0808 0.284
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.002 0.0185 0.0763
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0301 0.2092
Schistosoma mansoni nuclear receptor 0.0014 0.0103 0.0205
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0051 0.006
Echinococcus granulosus death domain containing protein 0.0031 0.0319 0.0609
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0166 0.0151
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0167 0.2043 0.7186
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0319 0.0375
Brugia malayi Death domain containing protein 0.0031 0.0319 0.0375
Onchocerca volvulus Huntingtin homolog 0.0119 0.1439 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0167 0.2043 1
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0185 0.0649
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0167 0.2043 0.7186
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0166 0.0581
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.002 0.0185 0.0763
Schistosoma mansoni hypothetical protein 0.004 0.0432 0.0862
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1759 0.2071
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0354
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0363 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0301 0.0354
Loa Loa (eye worm) hypothetical protein 0.0119 0.1439 0.1694
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0121 0.0107
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.002 0.0185 0.0763
Brugia malayi hypothetical protein 0.0035 0.0373 0.0439
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0752 0.5228
Brugia malayi STAT protein, DNA binding domain containing protein 0.0153 0.1875 0.2208
Echinococcus multilocularis protein dispatched 1 0.0047 0.0525 0.0511
Brugia malayi conserved hypotetical protein 0.0014 0.0103 0.0121
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.002 0.0185 0.0649
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0167 0.2043 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0301 0.0287
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0167 0.2043 1
Echinococcus granulosus FTZ F1 alpha 0.003 0.0301 0.0574
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0103 0.0088
Schistosoma mansoni netrin receptor unc5 0.0031 0.0319 0.0636
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0103 0.0121
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.032 0.0639
Brugia malayi AMP-binding enzyme family protein 0.002 0.0185 0.0218
Trypanosoma brucei unspecified product 0.0013 0.0091 0.032
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0103 0.0205
Schistosoma mansoni nuclear hormone receptor 0.003 0.0301 0.0601
Schistosoma mansoni hypothetical protein 0.0034 0.0363 0.0724
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0185 0.0649
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0301 0.0287
Loa Loa (eye worm) STAT protein 0.0153 0.1875 0.2208
Echinococcus granulosus pyruvate kinase 0.0033 0.035 0.0672
Trichomonas vaginalis antibiotic synthetase, putative 0.002 0.0185 0.2389
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0051 0.0101
Trichomonas vaginalis antibiotic synthetase, putative 0.002 0.0185 0.2389
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0167 0.2043 0.7186
Loa Loa (eye worm) hypothetical protein 0.0063 0.0726 0.0855
Loa Loa (eye worm) CYP4Cod1 0.0229 0.2844 0.3348
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0166 0.0581
Schistosoma mansoni ferritin 0.0008 0.0031 0.0062
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1149 0.2272
Toxoplasma gondii pyruvate kinase PyKII 0.0033 0.035 0.1713
Plasmodium falciparum pyruvate kinase 0.0065 0.0752 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0167 0.2043 1
Brugia malayi hypothetical protein 0.0231 0.2864 0.3371
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0229 0.2844 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0451 0.0437
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0283 0.0333
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0166 0.2131
Echinococcus multilocularis dna polymerase eta 0.0019 0.0166 0.0151
Brugia malayi Pyruvate kinase, M2 isozyme 0.0065 0.0752 0.0886
Schistosoma mansoni nuclear receptor 0.0014 0.0103 0.0205
Onchocerca volvulus 0.0047 0.0525 0.3648
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0065 0.0752 0.3584
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0808 0.0951
Giardia lamblia Pyruvate kinase 0.0033 0.035 0.4651
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0218
Echinococcus granulosus dna polymerase eta 0.0019 0.0166 0.0303
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0451 0.0874
Schistosoma mansoni smad1 5 8 and 0.001 0.0051 0.0101
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0167 0.2043 1
Schistosoma mansoni coup transcription factor 0.003 0.0301 0.0601
Brugia malayi MH2 domain containing protein 0.0144 0.1759 0.2071
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0103 0.0205
Toxoplasma gondii cytochrome p450 superfamily protein 0.0167 0.2043 1
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.01 0.0118
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0354
Onchocerca volvulus 0.002 0.0185 0.1284
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0124 0.0146
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Entamoeba histolytica acyl-coA synthetase, putative 0.0069 0.0808 0.653
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0301 0.0601
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.002 0.0185 0.0649
Brugia malayi nuclear receptor NHR-88 0.003 0.0301 0.0354
Loa Loa (eye worm) AMP-binding enzyme family protein 0.002 0.0185 0.0218
Brugia malayi CXXC zinc finger family protein 0.0028 0.0283 0.0333
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0121 0.0142
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0167 0.2043 0.7186
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0051 0.0036
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0363 0.0698
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0167 0.2043 0.7186
Plasmodium vivax acyl-CoA synthetase, putative 0.0052 0.0585 0.7774
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0301 0.0601
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0121 0.0142
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0167 0.2043 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.002 0.0185 0.0649
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0167 0.2043 0.7186
Schistosoma mansoni smad 0.001 0.0051 0.0101
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.002 0.0185 0.0649
Loa Loa (eye worm) cytochrome P450 family protein 0.0229 0.2844 0.3348
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0167 0.2043 0.7186
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.002 0.0185 0.0649
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0103 0.0177
Brugia malayi AMP-binding enzyme family protein 0.002 0.0185 0.0218
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0166 0.0581
Brugia malayi nuclear receptor RXR 0.0014 0.0103 0.0121
Echinococcus granulosus ferritin 0.0008 0.0031 0.0033
Brugia malayi AMP-binding enzyme family protein 0.002 0.0185 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Giardia lamblia DINP protein human, muc B family 0.0019 0.0166 0.2199
Loa Loa (eye worm) cytochrome P450 family protein 0.0674 0.8494 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0121 0.0425
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0451 0.0874
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1674 0.3323
Entamoeba histolytica acyl-CoA synthetase, putative 0.0069 0.0808 0.653
Loa Loa (eye worm) cytochrome P450 family protein 0.0229 0.2844 0.3348
Schistosoma mansoni zinc finger protein 0.0014 0.0103 0.0205
Schistosoma mansoni hypothetical protein 0.0047 0.0525 0.1048
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0167 0.2043 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0301 0.0354
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.002 0.0185 0.0171
Loa Loa (eye worm) pyruvate kinase 0.0014 0.01 0.0118
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.002 0.0185 0.0763
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0103 0.0715
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0091 0.032
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.002 0.0185 0.0195
Loa Loa (eye worm) hypothetical protein 0.0034 0.0363 0.0427
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.002 0.0185 0.0649
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.002 0.0185 0.0763
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0103 0.0088
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0036 0.0044
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0354
Entamoeba histolytica pyruvate kinase, putative 0.0045 0.0502 0.3423
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0166 0.0668
Trypanosoma brucei unspecified product 0.0019 0.0166 0.0581
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0301 0.0354
Echinococcus multilocularis pyruvate kinase 0.0051 0.0578 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0301 0.0354
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0051 0.0073
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.002 0.0185 0.0649
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0167 0.2043 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.002 0.0185 0.0649
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0185 0.0763
Loa Loa (eye worm) DR-78 0.0014 0.0103 0.0121
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2864 0.2853
Onchocerca volvulus 0.0069 0.0808 0.5613
Onchocerca volvulus 0.0014 0.0103 0.0715
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0301 0.0287
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0167 0.2043 0.7186
Brugia malayi tailless protein 0.0014 0.0103 0.0121
Echinococcus granulosus cytochrome P450 2K1 0.0167 0.2043 0.4064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0628 0.1229
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0 0.0003
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0069 0.0808 0.284
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1149 0.1353
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0051 0.0073
Schistosoma mansoni hypothetical protein 0.004 0.0432 0.0862
Brugia malayi MH1 domain containing protein 0.001 0.0051 0.006
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0373 0.0744
Loa Loa (eye worm) hypothetical protein 0.0069 0.0808 0.0951
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0301 0.0354
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1759 0.2071
Brugia malayi hypothetical protein 0.0119 0.1439 0.1694
Loa Loa (eye worm) hypothetical protein 0.0074 0.087 0.1024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0301 0.0574
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0166 0.0581
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0031 0.0109
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0301 0.0287
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0166 0.033
Brugia malayi Protein kinase domain containing protein 0.0031 0.0319 0.0375
Echinococcus multilocularis pyruvate kinase 0.0065 0.0752 0.0739
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0166 0.2131
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0363 0.0349
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.002 0.0185 0.0763
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0549 0.2572
Schistosoma mansoni apoferritin-2 0.0008 0.0031 0.0062
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0167 0.2043 0.7186
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0354
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0036 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0301 0.0287
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.002 0.0185 0.0763
Leishmania major pyruvate kinase 0.0065 0.0752 0.2645
Entamoeba histolytica hypothetical protein 0.0035 0.0373 0.2107
Loa Loa (eye worm) hypothetical protein 0.0045 0.0502 0.0591
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.0689
Brugia malayi Pyruvate kinase, muscle isozyme 0.0065 0.0752 0.0886
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0628 0.1229
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Onchocerca volvulus 0.002 0.0185 0.1284
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0628 0.074
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0167 0.2043 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0069 0.0808 0.284
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0167 0.2043 0.7186
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0069 0.0808 0.3859
Loa Loa (eye worm) cytochrome P450 0.0167 0.2043 0.2406
Schistosoma mansoni hypothetical protein 0.0034 0.0363 0.0724
Schistosoma mansoni hypothetical protein 0.0074 0.087 0.1737
Echinococcus granulosus cpg binding protein 0.003 0.0303 0.0578
Mycobacterium leprae Conserved hypothetical protein 0.0167 0.2043 1
Onchocerca volvulus 0.0028 0.0283 0.1964
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0301 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0301 0.0354
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0167 0.2043 0.7186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0301 0.0354
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0301 0.0601
Loa Loa (eye worm) hypothetical protein 0.0069 0.0808 0.0951
Echinococcus granulosus Smad4 0.001 0.0051 0.0073
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0808 0.284
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0166 0.0151
Echinococcus granulosus Ankyrin 0.0031 0.032 0.0613
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0166 0.0581
Brugia malayi steroid hormone receptor 0.003 0.0301 0.0354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0628 0.1254
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0103 0.0205
Brugia malayi nuclear receptor NHR-67 0.0014 0.0103 0.0121
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0103 0.0121
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0167 0.2043 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0301 0.0354
Brugia malayi hypothetical protein 0.0014 0.0103 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0301 0.0354
Leishmania major DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.0689
Echinococcus granulosus expressed conserved protein 0.009 0.1075 0.2124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0069 0.0808 0.284
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0121 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0091 0.032
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0319 0.0609
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.002 0.0185 0.0649
Brugia malayi Cytochrome P450 family protein 0.0229 0.2844 0.3348
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0121 0.1608
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0103 0.0121
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0808 0.284
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0091 0.032
Brugia malayi nuclear receptor RXR 0.0016 0.0124 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0218
Schistosoma mansoni ferritin 0.0008 0.0031 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.002 0.0185 0.0763
Leishmania major cytochrome p450-like protein 0.0229 0.2844 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0549 0.2572
Schistosoma mansoni hypothetical protein 0.004 0.0432 0.0862
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0301 0.0354
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0752 1
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0185 0.0649
Echinococcus multilocularis pyruvate kinase 0.0033 0.035 0.0336
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0031 0.5
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0052 0.0585 0.2751
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0 0.0001
Schistosoma mansoni smad1 5 8 and 0.001 0.0051 0.0101
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0752 0.5228
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.002 0.0185 0.0904
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0103 0.0177
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0103 0.0121
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0124 0.0247
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0103 0.0121
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0167 0.2043 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0121 0.0446
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0121 0.0425
Trypanosoma cruzi cytochrome P450, putative 0.0229 0.2844 1
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0185 0.0649
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0103 0.0121
Schistosoma mansoni thyroid hormone receptor 0.003 0.0301 0.0601
Echinococcus granulosus pyruvate kinase 0.0033 0.035 0.0672
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0176 0.0207
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0121 0.0592
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0167 0.2043 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0166 0.0581
Loa Loa (eye worm) hypothetical protein 0.0259 0.3217 0.3787
Trypanosoma brucei pyruvate kinase 1 0.0065 0.0752 0.2645
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0103 0.0205
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0103 0.0205
Brugia malayi acetyl-Coenzyme A synthetase 2 0.002 0.0185 0.0218
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0301 0.0354
Schistosoma mansoni hypothetical protein 0.0167 0.2043 0.4081
Leishmania major acetyl-CoA synthetase, putative 0.002 0.0185 0.0649
Echinococcus multilocularis ferritin 0.0008 0.0031 0.0017
Schistosoma mansoni thyroid hormone receptor 0.003 0.0301 0.0601
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0051 0.006
Brugia malayi cytochrome P450 0.0167 0.2043 0.2406
Mycobacterium ulcerans acetyl-CoA synthetase 0.002 0.0185 0.0649
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0301 0.0574
Brugia malayi Cytochrome P450 family protein 0.0167 0.2043 0.2406
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0149 0.0585
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0103 0.0715
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0031 0.0109
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.04 0.5007 0.5
Brugia malayi AMP-binding enzyme family protein 0.002 0.0185 0.0218
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0103 0.0177
Toxoplasma gondii pyruvate kinase PyK1 0.0065 0.0752 0.3681
Plasmodium vivax pyruvate kinase 2, putative 0.0033 0.035 0.4653
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0167 0.2043 0.7186
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0185 0.0649
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0167 0.2043 0.7186
Plasmodium vivax acetyl-CoA synthetase, putative 0.002 0.0185 0.2456
Brugia malayi hypothetical protein 0.0014 0.0103 0.0121
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1149 0.1136
Onchocerca volvulus 0.003 0.0301 0.2092
Loa Loa (eye worm) hypothetical protein 0.0031 0.032 0.0377
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0121 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0628 0.1254
Mycobacterium leprae Probable pyruvate kinase PykA 0.0065 0.0752 0.3584
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0103 0.0088
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.002 0.0185 0.0649
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0752 0.2645
Brugia malayi hypothetical protein 0.0016 0.0124 0.0146
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0319 0.0636
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0628 0.0615
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0166 0.0581
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.0146
Schistosoma mansoni cpg binding protein 0.003 0.0303 0.0605
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0124 0.011
Loa Loa (eye worm) hypothetical protein 0.0065 0.0752 0.0886
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0319 0.0305
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0549 0.2572
Loa Loa (eye worm) hypothetical protein 0.0051 0.0569 0.067
Schistosoma mansoni ferritin light chain 0.0008 0.0031 0.0062
Echinococcus multilocularis 0.0167 0.2043 0.2032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0166 0.0195
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0525 0.0618
Schistosoma mansoni hypothetical protein 0.0205 0.2528 0.5048
Loa Loa (eye worm) hypothetical protein 0.0096 0.1149 0.1353
Brugia malayi nuclear receptor NHR-88 0.0014 0.0103 0.0121
Leishmania major acetyl-CoA synthetase, putative 0.002 0.0185 0.0649
Giardia lamblia Pyruvate kinase 0.0065 0.0752 1
Onchocerca volvulus 0.002 0.0185 0.1284
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0167 0.2043 1
Schistosoma mansoni hypothetical protein 0.004 0.0432 0.0862
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0103 0.0121
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Schistosoma mansoni smad1 5 8 and 0.001 0.0051 0.0101
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0301 0.0354
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Echinococcus multilocularis smad 0.001 0.0051 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0301 0.0354
Schistosoma mansoni apoferritin-2 0.0008 0.0031 0.0062
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0103 0.0088
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0185 0.0218
Schistosoma mansoni cytochrome P450 0.0167 0.2043 0.4081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0301 0.0354
Mycobacterium ulcerans pyruvate kinase 0.0065 0.0752 0.2645
Schistosoma mansoni survival motor neuron protein 0.0047 0.0525 0.1048
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0167 0.2043 0.7186
Echinococcus granulosus dnaJ subfamily B 0.04 0.5007 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0103 0.0088
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0301 0.0354
Schistosoma mansoni hypothetical protein 0.0035 0.0373 0.0744
Plasmodium falciparum acetyl-CoA synthetase, putative 0.002 0.0185 0.2456
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0167 0.2043 1
Brugia malayi Uncoordinated protein 44 0.0031 0.0319 0.0375
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0121 0.0241
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0035 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0808 0.284
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0301 0.0574
Brugia malayi MH2 domain containing protein 0.001 0.0051 0.006
Loa Loa (eye worm) AMP-binding enzyme family protein 0.002 0.0185 0.0218
Echinococcus granulosus GPCR family 2 0.0034 0.0363 0.0698
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0185 0.0649
Leishmania major DNA polymerase eta, putative 0.0019 0.0166 0.0581
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0808 0.0951
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0808 0.3859
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0354
Echinococcus multilocularis GPCR, family 2 0.0034 0.0363 0.0349
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1307 0.1539
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0301 0.0287
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0301 0.0574
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0363 0.0427
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0167 0.2043 0.7186
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0031 0.5
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.002 0.0185 0.0904
Loa Loa (eye worm) hypothetical protein 0.0069 0.0808 0.0951
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0808 0.284
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0363 0.0698
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0301 0.0601
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0752 0.0886
Schistosoma mansoni ferritin 0.0008 0.0031 0.0062
Loa Loa (eye worm) Smad1 0.001 0.0051 0.006
Schistosoma mansoni Smad4 0.001 0.0051 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0319 0.0375
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0103 0.0121
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0185 0.0763
Brugia malayi CHE-14 protein 0.0041 0.0451 0.0531
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0121 0.0213
Schistosoma mansoni pyruvate kinase 0.0065 0.0752 0.1502
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.0689
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0363 0.0427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0301 0.0354
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0124 0.0247
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.002 0.0185 0.0649
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0167 0.2043 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0373 0.0718
Brugia malayi MH2 domain containing protein 0.001 0.0051 0.006
Brugia malayi MH1 domain containing protein 0.001 0.0051 0.006
Trichomonas vaginalis ferritin, putative 0.0008 0.0031 0.0328
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0301 0.0287
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0121 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1149 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0069 0.0808 0.284
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Loa Loa (eye worm) hypothetical protein 0.0231 0.2864 0.3371
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0167 0.2043 0.7186
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0124 0.0146
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0301 0.0601
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0301 0.0354
Echinococcus multilocularis Smad4 0.001 0.0051 0.0036
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.002 0.0185 0.0649
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0301 0.0574
Schistosoma mansoni hypothetical protein 0.0034 0.0363 0.0724
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0103 0.0177
Echinococcus multilocularis geminin 0.0205 0.2528 0.2517
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0301 0.0574
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0354
Echinococcus granulosus pyruvate kinase 0.0065 0.0752 0.1478
Echinococcus multilocularis Ankyrin 0.0031 0.032 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0451 0.5955
Brugia malayi photoreceptor-specific nuclear receptor 0.0259 0.3217 0.3787
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0121
Schistosoma mansoni cpg binding protein 0.0028 0.0283 0.0564
Onchocerca volvulus Huntingtin homolog 0.0119 0.1439 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0301 0.2092
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0752 0.0886
Echinococcus granulosus pyruvate kinase 0.0065 0.0752 0.1478
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0103 0.0121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0301 0.0354
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0166 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0301 0.0354
Plasmodium falciparum acyl-CoA synthetase 0.0052 0.0585 0.7774
Plasmodium vivax pyruvate kinase, putative 0.0065 0.0752 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0167 0.2043 0.7186
Loa Loa (eye worm) hypothetical protein 0.0109 0.1307 0.1539
Schistosoma mansoni acetyl-CoA synthetase 0.002 0.0185 0.0369
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0167 0.2043 0.7186
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0373 0.0359
Echinococcus granulosus pyruvate kinase 0.0033 0.035 0.0672
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0363 0.0349
Schistosoma mansoni hypothetical protein 0.0031 0.0319 0.0636
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0301 0.0354
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0167 0.2043 0.7186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0166 0.0581
Brugia malayi ecdysone receptor 0.0014 0.0103 0.0121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.0146
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0103 0.0177
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0166 0.0195
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0167 0.2043 1
Onchocerca volvulus 0.002 0.0185 0.1284
Brugia malayi Smad1 0.001 0.0051 0.006
Chlamydia trachomatis pyruvate kinase 0.0065 0.0752 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1168 0.2332
Schistosoma mansoni cpg binding protein 0.003 0.0303 0.0605
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0166 0.0581
Plasmodium falciparum pyruvate kinase 2 0.0033 0.035 0.4653
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0185 0.0763
Schistosoma mansoni ferritin 0.0008 0.0031 0.0062

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0026 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.5821 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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