Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0182 | 1 | 0.5 | |
Trypanosoma brucei | unspecified product | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.3216 | 0.3216 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3216 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3216 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0074 | 0.3216 | 0.3216 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3216 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1054 | 0.3276 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.3216 | 0.3216 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.3216 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3216 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.3216 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.3216 | 0.3216 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3216 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.2219 | 0.2219 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1054 | 0.1054 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.3216 | 0.3216 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.2219 | 0.2219 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.2219 | 0.2219 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1054 | 0.1054 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2219 | 0.2219 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.3216 | 0.3216 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.