Detailed information for compound 1365076

Basic information

Technical information
  • TDR Targets ID: 1365076
  • Name: (4-methyl-3-piperidin-1-ylsulfonylphenyl)-pyr rolidin-1-ylmethanone
  • MW: 336.449 | Formula: C17H24N2O3S
  • H donors: 0 H acceptors: 3 LogP: 2.23 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1S(=O)(=O)N1CCCCC1)C(=O)N1CCCC1
  • InChi: 1S/C17H24N2O3S/c1-14-7-8-15(17(20)18-9-5-6-10-18)13-16(14)23(21,22)19-11-3-2-4-12-19/h7-8,13H,2-6,9-12H2,1H3
  • InChiKey: DOEVZRCJEATUDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-methyl-3-(1-piperidylsulfonyl)phenyl]-pyrrolidin-1-yl-methanone
  • [4-methyl-3-(1-piperidylsulfonyl)phenyl]-1-pyrrolidinylmethanone
  • (4-methyl-3-piperidinosulfonyl-phenyl)-pyrrolidin-1-yl-methanone
  • (4-methyl-3-piperidin-1-ylsulfonyl-phenyl)-pyrrolidin-1-yl-methanone
  • Oprea1_434779
  • ZINC03216210
  • STK213605

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide receptor 0.0014 0.011 0.0114
Brugia malayi follicle stimulating hormone receptor 0.0014 0.011 0.011
Echinococcus granulosus serotonin receptor 0.0014 0.011 0.0114
Echinococcus multilocularis fmrfamide receptor 0.0014 0.011 0.011
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.099 0.099
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.011 0.011
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.099 0.099
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.011 0.011
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.011 0.011
Schistosoma mansoni amine GPCR 0.0014 0.011 0.011
Trypanosoma brucei unspecified product 0.0015 0.022 0.0516
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Echinococcus multilocularis neuropeptide receptor 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.099 0.2321
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.011 0.011
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.003 0.1888 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.011 0.011
Brugia malayi sulfakinin receptor protein 0.0014 0.011 0.011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.011 0.011
Echinococcus granulosus g protein coupled receptor 0.0014 0.011 0.0114
Onchocerca volvulus 0.0014 0.011 0.5
Echinococcus granulosus neuropeptide s receptor 0.0014 0.011 0.0114
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.011 0.0114
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.011 0.011
Echinococcus multilocularis fmrfamide receptor 0.0014 0.011 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.011 0.011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.011 0.011
Brugia malayi hypothetical protein 0.0014 0.011 0.011
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0102 1 1
Brugia malayi hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Brugia malayi Serotonin receptor 0.0014 0.011 0.011
Trichomonas vaginalis bromodomain-containing protein, putative 0.003 0.1888 1
Brugia malayi GnHR receptor homolog 0.0014 0.011 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Plasmodium falciparum histone acetyltransferase GCN5 0.0028 0.1607 1
Brugia malayi putative neuropeptide receptor 0.0014 0.011 0.011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.011 0.011
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus dna polymerase kappa 0.0022 0.099 0.1023
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.4265 1
Leishmania major DNA polymerase eta, putative 0.0036 0.2554 0.5988
Echinococcus granulosus sex peptide receptor 0.0014 0.011 0.0114
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.011 0.011
Echinococcus granulosus g protein coupled receptor 0.0014 0.011 0.0114
Onchocerca volvulus 0.0014 0.011 0.5
Brugia malayi hypothetical protein 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase eta, putative 0.0051 0.4265 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.011 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.099 0.2321
Brugia malayi Serotonin receptor 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Echinococcus multilocularis neuropeptide receptor 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Schistosoma mansoni histamine h1 receptor 0.0014 0.011 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.011 0.011
Echinococcus granulosus orexin receptor type 2 0.0014 0.011 0.0114
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.099 0.2321
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.099 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.011 0.011
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.011 0.011
Onchocerca volvulus Neuropeptide F receptor homolog 0.0014 0.011 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.011 0.0114
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.011 0.0114
Trypanosoma brucei unspecified product 0.0015 0.022 0.0516
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.099 0.2321
Schistosoma mansoni amine GPCR 0.0014 0.011 0.011
Echinococcus multilocularis g protein coupled receptor 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.011 0.011
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus g protein coupled receptor 0.0014 0.011 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0102 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.011 0.011
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.011 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.099 0.2321
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.022 0.0516
Schistosoma mansoni biogenic amine receptor 0.0014 0.011 0.011
Echinococcus granulosus histone acetyltransferase KAT2B 0.01 0.9678 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.099 0.099
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.011 0.0114
Schistosoma mansoni hypothetical protein 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.099 0.2321
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.011 0.0114
Echinococcus multilocularis allatostatin A receptor 0.0014 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus hypothetical protein 0.0014 0.011 0.0114
Echinococcus granulosus fmrfamide receptor 0.0014 0.011 0.0114
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0013 0 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.022 0.0516
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.011 0.011
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.099 0.2321
Brugia malayi Dopamine receptor protein 2 0.0014 0.011 0.011
Schistosoma mansoni opsin-like receptor 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.099 0.2321
Brugia malayi Melatonin receptor type 1A 0.0014 0.011 0.011
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.011 0.011
Brugia malayi hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.011 0.0114
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.099 0.2321
Echinococcus granulosus histone acetyltransferase KAT2B 0.003 0.1888 0.1951
Loa Loa (eye worm) hypothetical protein 0.0051 0.4265 0.4265
Schistosoma mansoni neuropeptide receptor 0.0014 0.011 0.011
Leishmania major DNA polymerase kappa, putative 0.0022 0.099 0.2321
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.011 0.011
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.011 0.011
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.011 0.0114
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.011 0.011
Brugia malayi AKH receptor 0.0014 0.011 0.011
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0014 0.011 0.5
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.2554 1
Echinococcus multilocularis orexin receptor type 2 0.0014 0.011 0.011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.099 0.2321
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.011 0.0114
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.011 0.011
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.099 0.6162
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.011 0.0114
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.011 0.011
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.099 0.5243
Schistosoma mansoni neuropeptide receptor 0.0014 0.011 0.011
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.011 0.011
Brugia malayi hypothetical protein 0.0014 0.011 0.011
Echinococcus multilocularis g protein coupled receptor 0.0014 0.011 0.011
Giardia lamblia DINP protein human, muc B family 0.0022 0.099 0.6162
Schistosoma mansoni hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus multilocularis dna polymerase eta 0.0051 0.4265 0.4265
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.011 0.0114
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Brugia malayi ORL1-like opioid receptor 0.0014 0.011 0.011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.011 0.011
Echinococcus granulosus g-protein coupled receptor 0.0014 0.011 0.0114
Brugia malayi G-protein coupled receptor 0.0014 0.011 0.011
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.011 0.011
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.011 0.011
Brugia malayi G protein-coupled receptor 0.0014 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.011 0.011
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.022 0.0516
Brugia malayi neuropeptide F receptor 0.0014 0.011 0.011
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.011 0.0114
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.099 0.2321
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.011 0.011
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.011 0.0114
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.011 0.0114
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.099 0.5243
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.011 0.011
Schistosoma mansoni amine GPCR 0.0014 0.011 0.011
Brugia malayi hypothetical protein 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.099 0.2321
Schistosoma mansoni opsin-like receptor 0.0014 0.011 0.011
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.099 1
Brugia malayi G-protein coupled receptor 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Brugia malayi neuropeptide F receptor 0.0014 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.099 0.2321
Brugia malayi hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.011 0.0114
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.011 0.0114
Schistosoma mansoni neuropeptide receptor 0.0014 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.011 0.011
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.099 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.003 0.1888 0.7394
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.4265 0.4265
Echinococcus granulosus dna polymerase eta 0.0051 0.4265 0.4407
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus multilocularis dna polymerase kappa 0.0022 0.099 0.099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0014 0.011 0.011
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.011 0.011
Schistosoma mansoni myosin xvIII 0.0014 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.099 0.2321
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.011 0.0114
Echinococcus multilocularis g protein coupled receptor 0.0014 0.011 0.011
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.011 0.011
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.099 0.099
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.011 0.0114
Plasmodium vivax histone acetyltransferase GCN5, putative 0.003 0.1888 1
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.011 0.011
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.011 0.0114
Onchocerca volvulus 0.0014 0.011 0.5
Trypanosoma brucei unspecified product 0.0022 0.099 0.2321
Echinococcus multilocularis sex peptide receptor 0.0014 0.011 0.011
Schistosoma mansoni neuropeptide receptor 0.0014 0.011 0.011
Brugia malayi Dopamine receptor protein 1 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Brugia malayi RE15519p 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.099 1
Brugia malayi Dopamine receptor 0.0014 0.011 0.011
Brugia malayi hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.011 0.0114
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.011 0.0114
Leishmania major DNA polymerase eta, putative 0.0051 0.4265 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.099 0.1023
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.011 0.011
Schistosoma mansoni DNA polymerase eta 0.0051 0.4265 0.4265
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.011 0.011
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.011 0.011
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.011 0.0114
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.011 0.011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.011 0.0114
Schistosoma mansoni adenoreceptor 0.0014 0.011 0.011
Echinococcus multilocularis serotonin receptor 0.0014 0.011 0.011
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.011 0.011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0013 0 0.5
Onchocerca volvulus 0.0014 0.011 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.011 0.011
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.011 0.011
Brugia malayi larval opioid receptor 0.0014 0.011 0.011
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus granulosus neuropeptide receptor 0.0014 0.011 0.0114
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.099 0.2321
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.099 0.2321
Echinococcus multilocularis serotonin receptor 0.0014 0.011 0.011
Brugia malayi hypothetical protein 0.0014 0.011 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.099 0.2321
Loa Loa (eye worm) acetyltransferase 0.0102 1 1
Schistosoma mansoni biogenic amine receptor 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.099 0.2321
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.011 0.011
Schistosoma mansoni amine GPCR 0.0014 0.011 0.011
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.011 0.011
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.003 0.1888 0.7394
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.011 0.011
Giardia lamblia Histone acetyltransferase GCN5 0.0028 0.1607 1
Echinococcus granulosus allatostatin A receptor 0.0014 0.011 0.0114
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.011 0.011
Echinococcus granulosus somatostatin receptor 0.0014 0.011 0.0114
Brugia malayi hypothetical protein 0.0014 0.011 0.011
Schistosoma mansoni biogenic amine receptor 0.0014 0.011 0.011
Schistosoma mansoni opsin-like receptor 0.0014 0.011 0.011
Entamoeba histolytica acetyltransferase, GNAT family 0.0028 0.1607 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.011 0.011
Onchocerca volvulus 0.0014 0.011 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.2554 0.5988
Schistosoma mansoni amine GPCR 0.0014 0.011 0.011
Echinococcus multilocularis somatostatin receptor 0.0014 0.011 0.011
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0014 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.011 0.011

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.