Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS3 protease/helicase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0052 | 0.1804 | 0.2352 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0031 | 0.0612 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.003 | 0.0528 | 0.2147 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0028 | 0.0442 | 0.1301 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1631 | 0.4805 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0464 | 0.0581 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1797 | 0.2341 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0031 | 0.0612 | 0.0684 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.1797 | 0.2341 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.1797 | 0.2341 |
Mycobacterium leprae | Probable lipase LipE | 0.0031 | 0.0612 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.003 | 0.0528 | 0.0568 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0031 | 0.0612 | 0.0088 |
Brugia malayi | eukaryotic initiation factor 4A | 0.003 | 0.0528 | 0.0771 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0612 | 0.1802 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0232 | 0.0684 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0312 | 0.0266 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.003 | 0.0528 | 0.7588 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.1797 | 0.5292 |
Echinococcus multilocularis | geminin | 0.015 | 0.7273 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3395 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0072 | 0.2919 | 0.3911 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0068 | 0.269 | 0.3591 |
Mycobacterium tuberculosis | Conserved protein | 0.0031 | 0.0612 | 0.0088 |
Toxoplasma gondii | ABC1 family protein | 0.0031 | 0.0612 | 0.283 |
Loa Loa (eye worm) | beta-lactamase | 0.0031 | 0.0612 | 0.1802 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0031 | 0.0612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0612 | 0.1802 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0052 | 0.1804 | 0.5314 |
Trichomonas vaginalis | esterase, putative | 0.0031 | 0.0612 | 1 |
Onchocerca volvulus | 0.0052 | 0.1804 | 1 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0031 | 0.0612 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0757 | 0.1444 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.1797 | 0.2341 |
Plasmodium vivax | RNA helicase-1, putative | 0.003 | 0.0528 | 0.7588 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0612 | 0.1802 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0047 | 0.1488 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0031 | 0.0612 | 0.1016 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0612 | 0.1802 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0031 | 0.0612 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1631 | 0.4805 |
Echinococcus multilocularis | musashi | 0.0052 | 0.1804 | 0.2352 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0031 | 0.0612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0266 | 0.0783 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0047 | 0.1488 | 0.191 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0031 | 0.0612 | 0.0088 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.1797 | 0.2341 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0047 | 0.1488 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0085 | 0.3669 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.003 | 0.0528 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1325 | 0.3902 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0047 | 0.1488 | 0.191 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1631 | 0.4012 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.1169 | 0.1464 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.132 | 0.3099 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0312 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0612 | 0.1802 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1804 | 0.5314 |
Brugia malayi | intermediate filament protein | 0.0052 | 0.1804 | 0.452 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.1797 | 0.4498 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.003 | 0.0528 | 0.2147 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0028 | 0.0442 | 0.0516 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1797 | 0.2341 |
Echinococcus granulosus | geminin | 0.015 | 0.7273 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0031 | 0.0612 | 0.1016 |
Echinococcus multilocularis | lamin | 0.0052 | 0.1804 | 0.2352 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0031 | 0.0612 | 0.1016 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0052 | 0.1804 | 0.452 |
Onchocerca volvulus | 0.0031 | 0.0612 | 0.0654 | |
Mycobacterium tuberculosis | Conserved protein | 0.0031 | 0.0612 | 0.0088 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1797 | 0.2341 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0612 | 0.1802 |
Loa Loa (eye worm) | intermediate filament protein | 0.0052 | 0.1804 | 0.5314 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0031 | 0.0612 | 0.0088 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0025 | 0.0286 | 0.0229 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0031 | 0.0612 | 0.1802 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.7273 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.019 | 0.0559 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0047 | 0.1488 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1631 | 0.4012 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.003 | 0.0528 | 0.0568 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0031 | 0.0612 | 0.0684 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.003 | 0.0528 | 0.0568 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.003 | 0.0528 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.0612 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0031 | 0.0612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0528 | 0.1556 |
Mycobacterium tuberculosis | Conserved protein | 0.0031 | 0.0612 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1599 | 0.4709 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0286 | 0.0842 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.003 | 0.0528 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0068 | 0.269 | 0.3591 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0757 | 0.0888 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.003 | 0.0528 | 0.7588 |
Echinococcus granulosus | intermediate filament protein | 0.0052 | 0.1804 | 0.2352 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0031 | 0.0612 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.003 | 0.0528 | 0.0568 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0031 | 0.0612 | 1 |
Brugia malayi | beta-lactamase | 0.0031 | 0.0612 | 0.1016 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0047 | 0.1488 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.1169 | 0.1464 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0757 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1476 | 0.4348 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.175 | 0.5156 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.003 | 0.0528 | 0.0568 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0031 | 0.0612 | 0.0684 |
Echinococcus multilocularis | lamin dm0 | 0.0052 | 0.1804 | 0.2352 |
Schistosoma mansoni | lamin | 0.0052 | 0.1804 | 0.2352 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.003 | 0.0528 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0232 | 0.0684 |
Leishmania major | hypothetical protein, conserved | 0.0031 | 0.0612 | 0.283 |
Onchocerca volvulus | 0.0031 | 0.0612 | 0.0654 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0047 | 0.1488 | 0.191 |
Onchocerca volvulus | 0.0052 | 0.1804 | 1 | |
Echinococcus granulosus | lamin | 0.0052 | 0.1804 | 0.2352 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0312 | 0.0266 |
Schistosoma mansoni | intermediate filament proteins | 0.0052 | 0.1804 | 0.2352 |
Mycobacterium leprae | conserved hypothetical protein | 0.0031 | 0.0612 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0031 | 0.0612 | 0.0088 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.003 | 0.0528 | 0.7588 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0031 | 0.0612 | 1 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.7273 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0047 | 0.1488 | 1 |
Onchocerca volvulus | 0.0031 | 0.0612 | 0.0654 | |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0025 | 0.0286 | 0.0229 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.003 | 0.0528 | 0.2147 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0031 | 0.0612 | 0.0088 |
Echinococcus granulosus | lamin dm0 | 0.0052 | 0.1804 | 0.2352 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0031 | 0.0612 | 0.0088 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.019 | 0.0095 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0031 | 0.0612 | 0.0684 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0047 | 0.1488 | 0.1013 |
Treponema pallidum | ATP-dependent RNA helicase | 0.003 | 0.0528 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0047 | 0.1488 | 0.191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.