Detailed information for compound 1365614

Basic information

Technical information
  • TDR Targets ID: 1365614
  • Name: N-(4,5-dihydro-1,3-thiazol-2-yl)-2-(6-methyl- 5-propan-2-yl-1-benzofuran-3-yl)acetamide
  • MW: 316.418 | Formula: C17H20N2O2S
  • H donors: 1 H acceptors: 1 LogP: 3.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1coc2c1cc(C(C)C)c(c2)C)NC1=NCCS1
  • InChi: 1S/C17H20N2O2S/c1-10(2)13-8-14-12(9-21-15(14)6-11(13)3)7-16(20)19-17-18-4-5-22-17/h6,8-10H,4-5,7H2,1-3H3,(H,18,19,20)
  • InChiKey: BRWWRJWXDGKBFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4,5-dihydrothiazol-2-yl)-2-(5-isopropyl-6-methyl-benzofuran-3-yl)acetamide
  • N-(4,5-dihydrothiazol-2-yl)-2-(5-isopropyl-6-methyl-3-benzofuranyl)acetamide
  • N-(4,5-dihydro-1,3-thiazol-2-yl)-2-(6-methyl-5-propan-2-yl-1-benzofuran-3-yl)ethanamide
  • ZINC02651382
  • MLS000053855
  • SMR000064280

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0022 0.0165 0.044
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0165 0.0196
Mycobacterium tuberculosis Conserved protein 0.0043 0.0766 0.0835
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0522 0.0363
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.2681 0.2681
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.5077 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0751 0.089
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0766 0.0835
Trichomonas vaginalis esterase, putative 0.0043 0.0766 0.0907
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0771 0.0913
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2867 0.2867
Echinococcus multilocularis acetylcholinesterase 0.0131 0.3227 0.3113
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0766 0.0835
Loa Loa (eye worm) RNA binding protein 0.0076 0.1695 0.1695
Brugia malayi Importin beta-1 subunit 0.0035 0.0522 0.1028
Brugia malayi MH2 domain containing protein 0.0118 0.2867 0.5646
Schistosoma mansoni hypothetical protein 0.0076 0.1688 0.1548
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0766 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.844 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0585 0.0427
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0766 0.0611
Brugia malayi Carboxylesterase family protein 0.0131 0.3227 0.6356
Mycobacterium ulcerans beta-lactamase 0.0043 0.0766 0.1613
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0766 0.0907
Loa Loa (eye worm) carboxylesterase 0.0131 0.3227 0.3227
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0264 0.01
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0585 0.0427
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0751 0.974
Leishmania major basic transcription factor 3a, putative 0.0042 0.073 0.9476
Brugia malayi beta-lactamase family protein 0.0043 0.0766 0.1508
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0868 0.0715
Echinococcus granulosus geminin 0.0342 0.9171 0.9157
Brugia malayi Carboxylesterase family protein 0.0022 0.0165 0.0325
Schistosoma mansoni alpha-glucosidase 0.0169 0.4307 0.4211
Onchocerca volvulus 0.0022 0.0165 0.044
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0766 0.0907
Echinococcus multilocularis acetylcholinesterase 0.0131 0.3227 0.3113
Loa Loa (eye worm) hypothetical protein 0.0112 0.2681 0.2681
Schistosoma mansoni alpha-glucosidase 0.0169 0.4307 0.4211
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.073 0.0865
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1695 0.3337
Loa Loa (eye worm) hypothetical protein 0.0043 0.0766 0.0766
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0751 0.974
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0165 0.0196
Mycobacterium tuberculosis Conserved protein 0.0043 0.0766 0.0835
Loa Loa (eye worm) hypothetical protein 0.0043 0.0766 0.0766
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0585 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0868 0.0715
Schistosoma mansoni inositol monophosphatase 0.0043 0.0751 0.0595
Onchocerca volvulus 0.0043 0.0766 0.2042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.844 1
Echinococcus granulosus GPCR family 2 0.0035 0.0535 0.0377
Echinococcus granulosus importin subunit beta 1 0.0035 0.0522 0.0363
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0771 1
Echinococcus multilocularis carboxylesterase 5A 0.0131 0.3227 0.3113
Mycobacterium leprae Probable lipase LipE 0.0043 0.0766 0.0434
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0244 0.3172
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.073 0.9476
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0766 0.0835
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0766 0.1613
Onchocerca volvulus 0.0043 0.0766 0.2042
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0771 0.0913
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0337 0.0399
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0337 0.0399
Loa Loa (eye worm) carboxylesterase 0.0022 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0035 0.0535 0.0377
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0751 0.5
Brugia malayi hypothetical protein 0.015 0.375 0.7386
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0771 0.0913
Leishmania major hypothetical protein, conserved 0.0025 0.0244 0.3172
Loa Loa (eye worm) hypothetical protein 0.0022 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.073 0.0865
Brugia malayi Inositol-1 0.0043 0.0751 0.1479
Echinococcus granulosus acetylcholinesterase 0.0131 0.3227 0.3113
Schistosoma mansoni ran 0.0026 0.0264 0.01
Trypanosoma brucei glucosidase, putative 0.0044 0.0771 1
Trichomonas vaginalis ran, putative 0.0026 0.0264 0.0312
Plasmodium vivax importin-beta 2, putative 0.0035 0.0522 0.5327
Echinococcus multilocularis transcription factor btf3 0.0042 0.073 0.0575
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0751 0.0595
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.073 1
Schistosoma mansoni hypothetical protein 0.0342 0.9171 0.9157
Giardia lamblia Fructose-bisphosphate aldolase 0.0316 0.844 1
Entamoeba histolytica hypothetical protein 0.0037 0.0585 0.0693
Schistosoma mansoni importin beta-1 0.0035 0.0522 0.0363
Brugia malayi TAR-binding protein 0.0076 0.1695 0.3337
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0337 0.4371
Brugia malayi Carboxylesterase family protein 0.0022 0.0165 0.0325
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0522 0.5276
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0316 0.844 1
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0766 0.0835
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0751 0.1573
Entamoeba histolytica hypothetical protein 0.0037 0.0585 0.0693
Mycobacterium tuberculosis Conserved protein 0.0043 0.0766 0.0835
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0766 0.0766
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0766 0.0835
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0264 0.0362
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0766 0.0611
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0766 0.0434
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1695 0.1695
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0771 0.0913
Loa Loa (eye worm) beta-lactamase 0.0043 0.0766 0.0766
Plasmodium falciparum importin beta, putative 0.0035 0.0522 0.5715
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0751 0.962
Schistosoma mansoni hypothetical protein 0.0035 0.0535 0.0377
Leishmania major GTP-binding protein, putative 0.0026 0.0264 0.3419
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.073 0.9321
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.5077 0.5077
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0771 0.0913
Onchocerca volvulus 0.0043 0.0766 0.2042
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.5077 0.4995
Treponema pallidum fructose-bisphosphate aldolase 0.0316 0.844 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0535 0.0377
Loa Loa (eye worm) hypothetical protein 0.0035 0.0522 0.0522
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0522 0.6774
Schistosoma mansoni hypothetical protein 0.0035 0.0535 0.0377
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0751 0.974
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0766 0.0611
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1695 0.1555
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0751 0.089
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1695 0.1555
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0771 0.0913
Loa Loa (eye worm) carboxylesterase 0.0022 0.0165 0.0165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.844 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.844 1
Loa Loa (eye worm) inositol-1 0.0043 0.0751 0.0751
Schistosoma mansoni hypothetical protein 0.0372 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0535 0.0377
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0771 0.0913
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0751 0.089
Schistosoma mansoni transcription factor btf3 0.0042 0.073 0.0575
Schistosoma mansoni alpha glucosidase 0.0044 0.0771 0.0616
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.844 1
Entamoeba histolytica hypothetical protein 0.0028 0.0337 0.0399
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0751 0.974
Onchocerca volvulus 0.0114 0.2744 0.7316
Loa Loa (eye worm) hypothetical protein 0.0022 0.0165 0.0165
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0766 0.0907
Loa Loa (eye worm) hypothetical protein 0.0076 0.1688 0.1688
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0771 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.073 0.0865
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0624 0.0638
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0771 0.0913
Brugia malayi Carboxylesterase family protein 0.0022 0.0165 0.0325
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0771 0.0616
Brugia malayi Carboxylesterase family protein 0.0022 0.0165 0.0325
Brugia malayi RNA binding protein 0.0076 0.1695 0.3337
Brugia malayi beta-lactamase 0.0043 0.0766 0.1508
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.3889 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0771 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0766 0.1613
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0337 0.0399
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0244 0.3172
Echinococcus granulosus carboxylesterase 5A 0.0131 0.3227 0.3113
Echinococcus granulosus tar DNA binding protein 0.0076 0.1695 0.1555
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0264 0.0264
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0766 0.0835
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0771 0.0771
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.5077 0.4995
Onchocerca volvulus 0.015 0.375 1
Toxoplasma gondii NAC domain-containing protein 0.0042 0.073 0.9232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0868 0.0715
Entamoeba histolytica hypothetical protein 0.0037 0.0585 0.0693
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0868 0.0715
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0751 0.0595
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0316 0.844 1
Entamoeba histolytica hypothetical protein 0.0037 0.0585 0.0693
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0868 0.0715
Loa Loa (eye worm) hypothetical protein 0.0043 0.0766 0.0766
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1695 0.1555
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0264 0.3419
Schistosoma mansoni hypothetical protein 0.0342 0.9171 0.9157
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0771 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0535 0.0377
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.3889 0.5178
Loa Loa (eye worm) hypothetical protein 0.0131 0.3227 0.3227
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.844 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0165 0.0165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.2681 0.5279
Entamoeba histolytica hypothetical protein 0.0042 0.073 0.0865
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.073 0.9476
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0771 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0264 0.0519
Schistosoma mansoni hypothetical protein 0.0035 0.0535 0.0377
Loa Loa (eye worm) hypothetical protein 0.0043 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.0131 0.3227 0.3227
Loa Loa (eye worm) acetylcholinesterase 1 0.0131 0.3227 0.3227
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0771 0.1518
Schistosoma mansoni inositol monophosphatase 0.0043 0.0751 0.0595
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0766 0.1508
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0244 0.3172
Onchocerca volvulus 0.0022 0.0165 0.044
Onchocerca volvulus 0.0022 0.0165 0.044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0165 0.0165
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0766 0.9935
Loa Loa (eye worm) hypothetical protein 0.0022 0.0165 0.0165
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0535 0.1055
Echinococcus multilocularis geminin 0.0342 0.9171 0.9157
Schistosoma mansoni ran 0.0026 0.0264 0.01
Loa Loa (eye worm) ICD-1 protein 0.0042 0.073 0.073
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0868 0.0868
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.073 0.9476
Brugia malayi beta-lactamase family protein 0.0043 0.0766 0.1508
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1695 0.1555
Brugia malayi Carboxylesterase family protein 0.0131 0.3227 0.6356
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0766 0.0907
Leishmania major importin beta-1 subunit, putative 0.0028 0.0337 0.4371
Loa Loa (eye worm) hypothetical protein 0.0043 0.0766 0.0766
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.2681 0.5279
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.844 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0165 0.0165
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0264 0.01
Brugia malayi hypothetical protein 0.0025 0.0244 0.0481
Onchocerca volvulus 0.0022 0.0165 0.044
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2867 0.2867
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1695 0.1555
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1695 0.1555
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0771 0.0913
Loa Loa (eye worm) hypothetical protein 0.015 0.375 0.375
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0868 0.171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0868 0.0715
Echinococcus multilocularis GPCR, family 2 0.0035 0.0535 0.0377
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0766 0.1613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.844 1
Echinococcus granulosus transcription factor btf3 0.0042 0.073 0.0575
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0868 0.0715
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.073 0.0865
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0766 0.0835
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0264 0.3419
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.5077 0.4995
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0766 0.0907
Toxoplasma gondii ABC1 family protein 0.0043 0.0766 0.9904
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0771 0.0616
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0535 0.1055
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.1688 0.3324
Brugia malayi hypothetical protein 0.0022 0.0165 0.0325
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.3889 1
Brugia malayi hypothetical protein 0.0037 0.0585 0.1152
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0766 0.9935
Echinococcus granulosus acetylcholinesterase 0.0131 0.3227 0.3113
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0751 0.089
Loa Loa (eye worm) hypothetical protein 0.0035 0.0535 0.0535
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0264 0.3419
Brugia malayi beta-NAC-like protein 0.0042 0.073 0.1438
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0535 0.0377
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1695 0.1695
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.7357 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0535 0.0535
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0522 0.6774
Mycobacterium ulcerans hypothetical protein 0.0043 0.0766 0.1613
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0766 0.0611
Loa Loa (eye worm) hypothetical protein 0.0025 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.0037 0.0585 0.0427
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0264 0.0392
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0771 0.0913
Leishmania major hypothetical protein, conserved 0.0043 0.0766 0.9935
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0131 0.3227 0.3113
Brugia malayi RNA, U transporter 1 0.0099 0.2328 0.4585
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0264 0.0366
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0766 0.9935
Echinococcus multilocularis snurportin 1 0.0372 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0165 0.0165
Entamoeba histolytica Ran family GTPase 0.0026 0.0264 0.0312
Loa Loa (eye worm) hypothetical protein 0.0043 0.0766 0.0766

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 4.348 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.7308 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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