Detailed information for compound 1365775

Basic information

Technical information
  • TDR Targets ID: 1365775
  • Name: 3-ethylsulfanyl-4-methyl-5-(4-pyrrolidin-1-yl sulfonylphenyl)-1,2,4-triazole
  • MW: 352.475 | Formula: C15H20N4O2S2
  • H donors: 0 H acceptors: 4 LogP: 1.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1nnc(n1C)c1ccc(cc1)S(=O)(=O)N1CCCC1
  • InChi: 1S/C15H20N4O2S2/c1-3-22-15-17-16-14(18(15)2)12-6-8-13(9-7-12)23(20,21)19-10-4-5-11-19/h6-9H,3-5,10-11H2,1-2H3
  • InChiKey: XHCSDINFVFGFJY-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-(ethylthio)-4-methyl-5-(4-1-pyrrolidinylsulfonylphenyl)-1,2,4-triazole
  • 3-(ethylthio)-4-methyl-5-(4-pyrrolidin-1-ylsulfonylphenyl)-1,2,4-triazole
  • ASN 04446122
  • Oprea1_346710
  • Oprea1_460319
  • ZINC00930777
  • 3-Ethylsulfanyl-4-methyl-5-[4-(pyrrolidine-1-sulfonyl)-phenyl]-4H-[1,2,4]triazole
  • MLS000032122
  • SMR000003410

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli O157:H7 Shiga toxin Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni katanin P80 subunit Shiga toxin   89 aa 72 aa 23.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Schistosoma japonicum Katanin p80 WD40-containing subunit B1, putative Shiga toxin   89 aa 72 aa 23.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Echinococcus granulosus imidazolonepropionase Shiga toxin   89 aa 94 aa 25.5 %
Trichomonas vaginalis coatomer beta subunit, putative Shiga toxin   89 aa 87 aa 27.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Echinococcus multilocularis imidazolonepropionase Shiga toxin   89 aa 94 aa 26.6 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni retinal dehydrogenase 0.0073 0.3141 0.3141
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0073 0.3141 0.4101
Giardia lamblia Reductase, putative 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Leishmania major short chain dehydrogenase-like protein 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0073 0.3141 1
Brugia malayi hypothetical protein 0.0073 0.3141 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0073 0.3141 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.7659 1
Leishmania major pteridine reductase 1 0.0073 0.3141 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0073 0.3141 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0073 0.3141 1
Mycobacterium tuberculosis Probable reductase 0.013 0.6747 0.8809
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Loa Loa (eye worm) oxidoreductase 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Trypanosoma brucei short-chain dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.6747 0.8809
Trypanosoma cruzi short chain dehydrogenase, putative 0.0073 0.3141 1
Brugia malayi dehydrogenases, short chain protein 9 0.0073 0.3141 1
Onchocerca volvulus 0.0073 0.3141 0.5
Onchocerca volvulus 0.0073 0.3141 0.5
Schistosoma mansoni steroid dehydrogenase 0.0073 0.3141 0.3141
Leishmania major hypothetical protein, conserved 0.0073 0.3141 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Brugia malayi hypothetical protein 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Trypanosoma brucei oxidoreductase-like protein 0.0073 0.3141 1
Leishmania major hypothetical protein, conserved 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0073 0.3141 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0073 0.3141 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0073 0.3141 0.4101
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1157 0.3683
Mycobacterium ulcerans short-chain dehydrogenase 0.0073 0.3141 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0073 0.3141 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0073 0.3141 1
Schistosoma mansoni steroid dehydrogenase 0.0073 0.3141 0.3141
Leishmania major trypanothione reductase 0.0057 0.2158 0.6869
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0073 0.3141 1
Schistosoma mansoni carbonyl reductase 0.0073 0.3141 0.3141
Leishmania major short chain dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0073 0.3141 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0073 0.3141 0.4101
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.6747 0.7982
Schistosoma mansoni steroid dehydrogenase 0.0073 0.3141 0.3141
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.3141 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0073 0.3141 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0073 0.3141 0.4101
Leishmania major oxidoreductase-like protein 0.0073 0.3141 1
Leishmania major quinonoid dihydropteridine reductase 0.0073 0.3141 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0073 0.3141 0.4101
Mycobacterium ulcerans dehydrogenase/reductase 0.0073 0.3141 1
Onchocerca volvulus 0.0073 0.3141 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0073 0.3141 0.4101
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.2158 0.2817
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0073 0.3141 0.4101
Loa Loa (eye worm) oxidoreductase 0.0073 0.3141 1
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.2158 0.6869
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.7659 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0073 0.3141 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0073 0.3141 0.3141
Brugia malayi glutathione reductase 0.0057 0.2158 0.6869
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0073 0.3141 1
Echinococcus multilocularis transient receptor potential cation channel 0.0073 0.3141 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.0073 0.3141 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0073 0.3141 1
Entamoeba histolytica hypothetical protein, conserved 0.0073 0.3141 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0073 0.3141 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium ulcerans short-chain type oxidoreductase 0.0073 0.3141 1
Loa Loa (eye worm) glutathione reductase 0.0057 0.2158 0.6869
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Mycobacterium tuberculosis Probable oxidoreductase 0.0073 0.3141 0.4101
Mycobacterium tuberculosis Possible oxidoreductase 0.0073 0.3141 0.4101
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0073 0.3141 0.4101
Echinococcus multilocularis steroid dehydrogenase 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.3141 1
Leishmania major short chain dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Plasmodium vivax glutathione reductase, putative 0.0057 0.2158 0.6869
Echinococcus granulosus hypothetical protein 0.0073 0.3141 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0073 0.3141 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0073 0.3141 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.7659 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Toxoplasma gondii oxidoreductase, putative 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Echinococcus multilocularis oxidoreductase 0.0073 0.3141 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0073 0.3141 0.4101
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2352 0.7488
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0073 0.3141 1
Loa Loa (eye worm) oxidoreductase 0.0073 0.3141 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0073 0.3141 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0073 0.3141 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0073 0.3141 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Leishmania major quinonoid dihydropteridine reductase 0.0073 0.3141 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.6747 0.8809
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0073 0.3141 0.4101
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Schistosoma mansoni steroid dehydrogenase 0.0073 0.3141 0.3141
Schistosoma mansoni carbonyl reductase 0.0073 0.3141 0.3141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0073 0.3141 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0073 0.3141 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0073 0.3141 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0073 0.3141 1
Echinococcus multilocularis carbonyl reductase 1 0.0073 0.3141 1
Loa Loa (eye worm) dehydrogenase 0.0073 0.3141 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0073 0.3141 0.4101
Schistosoma mansoni hypothetical protein 0.0041 0.1157 0.1157
Loa Loa (eye worm) oxidoreductase 0.0073 0.3141 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0073 0.3141 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0073 0.3141 1
Mycobacterium ulcerans oxidoreductase 0.0073 0.3141 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Loa Loa (eye worm) dehydrogenase 0.0073 0.3141 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0073 0.3141 1
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Loa Loa (eye worm) oxidoreductase 0.0073 0.3141 1
Plasmodium vivax steroid dehydrogenase, putative 0.0073 0.3141 1
Schistosoma mansoni steroid dehydrogenase 0.0073 0.3141 0.3141
Echinococcus granulosus hypothetical protein 0.0073 0.3141 1
Onchocerca volvulus 0.0073 0.3141 0.5
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0073 0.3141 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Onchocerca volvulus 0.0073 0.3141 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0073 0.3141 0.4101
Onchocerca volvulus 0.0073 0.3141 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0073 0.3141 1
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0073 0.3141 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0073 0.3141 1
Schistosoma mansoni steroid dehydrogenase 0.0073 0.3141 0.3141
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium ulcerans ketoacyl reductase 0.0073 0.3141 1
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.2158 0.6869
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0073 0.3141 1
Brugia malayi oxidoreductase 0.0073 0.3141 1
Echinococcus multilocularis carbonyl reductase 1 0.0073 0.3141 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2352 0.7488
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.2158 0.6869
Echinococcus granulosus steroid dehydrogenase 0.0073 0.3141 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Leishmania major hypothetical protein, conserved 0.0073 0.3141 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0073 0.3141 1
Leishmania major quinonoid dihydropteridine reductase 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0073 0.3141 1
Onchocerca volvulus 0.0073 0.3141 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0073 0.3141 1
Loa Loa (eye worm) oxidoreductase 0.0073 0.3141 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0073 0.3141 0.4101
Onchocerca volvulus 0.0073 0.3141 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0073 0.3141 1
Echinococcus granulosus WW domain containing oxidoreductase 0.0073 0.3141 1
Mycobacterium ulcerans dehydrogenase 0.0073 0.3141 1
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0073 0.3141 0.4101
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0073 0.3141 0.4101
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0073 0.3141 1
Plasmodium falciparum steroid dehydrogenase, putative 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Echinococcus multilocularis carbonyl reductase 1 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Onchocerca volvulus 0.0073 0.3141 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0073 0.3141 0.4101
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Leishmania major dehydrogenase-like protein 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0073 0.3141 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0073 0.3141 1
Toxoplasma gondii thioredoxin reductase 0.0057 0.2158 0.6869
Giardia lamblia Hypothetical protein 0.0073 0.3141 1
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0073 0.3141 1
Echinococcus multilocularis carbonyl reductase 1 0.0073 0.3141 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0073 0.3141 0.4101
Mycobacterium tuberculosis Probable oxidoreductase 0.0073 0.3141 0.4101
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.3141 1
Brugia malayi Thioredoxin reductase 0.0057 0.2158 0.6869
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0073 0.3141 1
Schistosoma mansoni steroid dehydrogenase 0.0073 0.3141 0.3141
Loa Loa (eye worm) oxidoreductase 0.0073 0.3141 1
Loa Loa (eye worm) oxidoreductase 0.0073 0.3141 1
Schistosoma mansoni carbonyl reductase 0.0073 0.3141 0.3141
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.6747 0.8809
Entamoeba histolytica hypothetical protein, conserved 0.0073 0.3141 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0073 0.3141 1
Echinococcus granulosus retinol dehydrogenase 11 0.0073 0.3141 1
Plasmodium vivax hypothetical protein, conserved 0.0073 0.3141 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Trypanosoma brucei short-chain dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0073 0.3141 0.4101
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Leishmania major hypothetical protein, conserved 0.0073 0.3141 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0073 0.3141 1
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0073 0.3141 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0073 0.3141 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0073 0.3141 1
Echinococcus granulosus oxidoreductase 0.0073 0.3141 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0073 0.3141 1
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0073 0.3141 1
Onchocerca volvulus 0.0073 0.3141 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0073 0.3141 1
Toxoplasma gondii carbonyl reductase 1, putative 0.0073 0.3141 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0073 0.3141 0.4101
Loa Loa (eye worm) hypothetical protein 0.0073 0.3141 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.6747 0.8809
Echinococcus granulosus carbonyl reductase 1 0.0073 0.3141 1
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.2158 0.6869
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Plasmodium falciparum glutathione reductase 0.0057 0.2158 0.6869
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0073 0.3141 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.3141 1
Schistosoma mansoni steroid dehydrogenase 0.0073 0.3141 0.3141
Entamoeba histolytica hypothetical protein 0.0073 0.3141 1
Schistosoma mansoni steroid dehydrogenase 0.0073 0.3141 0.3141
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0073 0.3141 1
Leishmania major quinonoid dihydropteridine reductase 0.0073 0.3141 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0073 0.3141 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0073 0.3141 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0073 0.3141 0.4101
Trypanosoma cruzi short chain dehydrogenase, putative 0.0073 0.3141 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Toxoplasma gondii oxidoreductase, putative 0.0073 0.3141 1
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.6747 0.8809
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Onchocerca volvulus 0.0073 0.3141 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Leishmania major quinonoid dihydropteridine reductase 0.0073 0.3141 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0073 0.3141 0.4101
Leishmania major 3-keto-dihydrosphingosine reductase 0.0073 0.3141 1
Loa Loa (eye worm) hypothetical protein 0.006 0.2352 0.7488
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Echinococcus multilocularis steroid dehydrogenase 0.0073 0.3141 1
Brugia malayi Retinol dehydrogenase 12 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Onchocerca volvulus Sepiapterin reductase homolog 0.0073 0.3141 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Onchocerca volvulus 0.0073 0.3141 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0073 0.3141 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0073 0.3141 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0073 0.3141 1
Mycobacterium ulcerans oxidoreductase 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Plasmodium falciparum thioredoxin reductase 0.0057 0.2158 0.6869
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0073 0.3141 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0073 0.3141 0.3141
Trichomonas vaginalis steroid dehydrogenase, putative 0.0073 0.3141 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2352 0.7488
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Brugia malayi dehydrogenases, short chain protein 2 0.0073 0.3141 1
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0073 0.3141 1
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0073 0.3141 1
Mycobacterium ulcerans ketoacyl reductase 0.0073 0.3141 1
Echinococcus granulosus carbonyl reductase 1 0.0073 0.3141 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.7659 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0073 0.3141 0.4101
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Echinococcus granulosus carbonyl reductase 1 0.0073 0.3141 1
Trypanosoma brucei trypanothione reductase 0.0057 0.2158 0.6869
Leishmania major hypothetical protein, conserved 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Leishmania major short chain dehydrogenase/reductase, putative 0.0073 0.3141 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0073 0.3141 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0073 0.3141 0.4101
Echinococcus granulosus carbonyl reductase 1 0.0073 0.3141 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0073 0.3141 0.4101
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Schistosoma mansoni steroid dehydrogenase 0.0073 0.3141 0.3141
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.3141 1
Loa Loa (eye worm) oxidoreductase 0.0073 0.3141 1
Onchocerca volvulus 0.0073 0.3141 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0073 0.3141 0.4101
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0073 0.3141 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0073 0.3141 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Mycobacterium ulcerans short chain dehydrogenase 0.0073 0.3141 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.3141 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.2158 0.6869
Echinococcus granulosus retinol dehydrogenase 11 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Echinococcus multilocularis retinol dehydrogenase 13 0.0073 0.3141 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1157 0.3683
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0073 0.3141 1
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0073 0.3141 0.3141
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0073 0.3141 0.3141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.3141 1
Echinococcus multilocularis conserved hypothetical protein 0.0073 0.3141 1
Schistosoma mansoni short chain dehydrogenase 0.0073 0.3141 0.3141
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0073 0.3141 1
Leishmania major quinonoid dihydropteridine reductase 0.0073 0.3141 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0026 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.1592 um PUBCHEM_BIOASSAY: A qHTS for Small Molecule Inhibitors of Shiga Toxin (Confirmatory). (Class of assay: confirmatory) [Related pubchem assays: 2314, 2318, 2315 ] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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