Detailed information for compound 1365864

Basic information

Technical information
  • TDR Targets ID: 1365864
  • Name: 5-oxo-1-(1-phenylethyl)-N-(1,3-thiazol-2-yl)p yrrolidine-3-carboxamide
  • MW: 315.39 | Formula: C16H17N3O2S
  • H donors: 1 H acceptors: 3 LogP: 1.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CC(=O)N(C1)C(c1ccccc1)C)Nc1nccs1
  • InChi: 1S/C16H17N3O2S/c1-11(12-5-3-2-4-6-12)19-10-13(9-14(19)20)15(21)18-16-17-7-8-22-16/h2-8,11,13H,9-10H2,1H3,(H,17,18,21)
  • InChiKey: ZZOVQFLAYXWPGP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-oxo-1-(1-phenylethyl)-N-thiazol-2-yl-pyrrolidine-3-carboxamide
  • 5-oxo-1-(1-phenylethyl)-N-(2-thiazolyl)-3-pyrrolidinecarboxamide
  • 5-keto-1-(1-phenylethyl)-N-thiazol-2-yl-pyrrolidine-3-carboxamide
  • 5-Oxo-1-(1-phenyl-ethyl)-pyrrolidine-3-carboxylic acid thiazol-2-ylamide
  • ST063981
  • BAS 10427891

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Onchocerca volvulus 0.0072 0.0405 0.2126
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0022 0.0014
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0098 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-31 0.006 0.0298 0.029
Echinococcus granulosus ecdysone induced protein 78C 0.006 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0134 0.0941 0.0941
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.0235 0.0235
Loa Loa (eye worm) ACC-1 protein 0.0072 0.0405 0.0405
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0024 0.0024
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0024 0.0024
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0098 0.0442
Onchocerca volvulus 0.0242 0.1878 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0082 0.0074
Echinococcus granulosus glycine receptor subunit alpha 1 0.0072 0.0405 0.0405
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0051 0.0222 0.0914
Echinococcus granulosus heat shock protein 90 0.0064 0.0336 0.0336
Schistosoma mansoni zinc finger protein 0.006 0.03 0.0293
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0098 0.1116
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0082 0.0358
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0592 0.0592
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0022 0.0059
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0104 0.0556
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.118 1 1
Brugia malayi Pre-SET motif family protein 0.0213 0.1624 0.1618
Toxoplasma gondii heat shock protein HSP90 0.0064 0.0336 0.4054
Echinococcus multilocularis Niemann Pick C1 protein 0.0427 0.3482 0.3482
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.0298 0.029
Trypanosoma brucei heat shock protein, putative 0.0064 0.0336 0.1396
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0024 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0298 0.029
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.026 0.1606
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.006 0.0298 0.0298
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.006 0.0298 0.0298
Schistosoma mansoni hypothetical protein 0.006 0.03 0.0293
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0022 0.036
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Brugia malayi TAR-binding protein 0.0127 0.0876 0.0869
Trichomonas vaginalis esterase, putative 0.0035 0.0082 0.0364
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0051 0.0222 0.3456
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0054 0.0054
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0044 0.0157 0.0149
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0104 0.0472
Onchocerca volvulus 0.0048 0.0194 0.0995
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0022 0.0059
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0022 0.0022
Echinococcus multilocularis muscleblind protein 1 0.015 0.1082 0.1082
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0592 0.0592
Brugia malayi hypothetical protein 0.0029 0.0029 0.0021
Loa Loa (eye worm) bromodomain containing protein 0.0069 0.0381 0.0381
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.006 0.0298 0.029
Brugia malayi photoreceptor-specific nuclear receptor 0.006 0.0298 0.029
Brugia malayi intermediate filament protein 0.0053 0.0235 0.0228
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0024 0.0016
Echinococcus multilocularis nuclear receptor nhr 48 0.0028 0.0024 0.0024
Trypanosoma brucei heat shock protein 90, putative 0.0064 0.0336 0.1396
Schistosoma mansoni hypothetical protein 0.0134 0.0941 0.0933
Echinococcus granulosus muscleblind protein 0.015 0.1082 0.1082
Mycobacterium leprae Probable lipase LipE 0.0035 0.0082 0.1041
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0157
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0024 0.0024
Schistosoma mansoni nuclear hormone receptor 0.006 0.0298 0.029
Schistosoma mansoni patched 1 0.0128 0.0892 0.0885
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.006 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0062 0.0317 0.0317
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0082 0.0074
Echinococcus granulosus Protein patched homolog 1 0.0128 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.006 0.0298 0.0298
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.012 0.012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0999 0.4222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0361 0.2012
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0121 0.0554
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus granulosus fetal alzheimer antigen falz 0.0092 0.0575 0.0575
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2355 1
Loa Loa (eye worm) hypothetical protein 0.015 0.1082 0.1082
Echinococcus granulosus expressed conserved protein 0.0281 0.2214 0.2214
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0592 0.2863
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0071 0.0395 0.221
Plasmodium falciparum heat shock protein 90 0.0064 0.0336 0.8471
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0082
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0592 0.0585
Trypanosoma cruzi ISWI complex protein 0.006 0.03 0.1247
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Schistosoma mansoni importin beta-1 0.0028 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Brugia malayi Steroid receptor seven-up type 2 0.006 0.0298 0.029
Loa Loa (eye worm) hypothetical protein 0.0196 0.1478 0.1478
Echinococcus granulosus jumonji domain containing protein 0.0039 0.012 0.012
Echinococcus multilocularis thyroid hormone receptor alpha 0.006 0.0298 0.0298
Echinococcus multilocularis heat shock protein 90 0.0051 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.118 1 1
Brugia malayi nuclear hormone receptor 0.006 0.0298 0.029
Schistosoma mansoni cpg binding protein 0.0068 0.0373 0.0365
Schistosoma mansoni survival motor neuron protein 0.0048 0.0194 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0098 0.0442
Trypanosoma brucei glucosidase, putative 0.0037 0.0098 0.0384
Loa Loa (eye worm) LGC-31 protein 0.0072 0.0405 0.0405
Schistosoma mansoni alpha glucosidase 0.0037 0.0098 0.009
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0311 0.0304
Schistosoma mansoni bromodomain containing protein 0.0252 0.196 0.1954
Schistosoma mansoni nuclear receptor nhr-48 0.0028 0.0024 0.0016
Onchocerca volvulus 0.0035 0.0082 0.0398
Trypanosoma brucei heat shock protein, putative 0.0064 0.0336 0.1396
Brugia malayi Niemann-Pick C1 protein precursor 0.0299 0.2371 0.2365
Onchocerca volvulus 0.0028 0.0022 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-14 0.006 0.0298 0.029
Trichomonas vaginalis endoplasmin, putative 0.0039 0.0121 0.0554
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0179 0.0179
Schistosoma mansoni acetylcholinesterase 0.0199 0.1507 0.15
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0072 0.0405 0.0405
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0072 0.0405 0.0398
Onchocerca volvulus 0.0072 0.0405 0.2126
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.2355 1
Brugia malayi Bromodomain containing protein 0.0298 0.2358 0.2352
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.127 0.6178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.136 0.1353
Trypanosoma brucei polo-like protein kinase 0.0094 0.0592 0.2491
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0072 0.0405 0.0405
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0082 0.0317
Schistosoma mansoni nAChR subunit 0.0072 0.0405 0.0398
Echinococcus multilocularis Niemann Pick C1 protein 0.0299 0.2371 0.2371
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1212 0.1212
Schistosoma mansoni lamin 0.0053 0.0235 0.0228
Echinococcus multilocularis nAChR subunit 0.0044 0.0157 0.0157
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.127 0.6178
Schistosoma mansoni nAChR subunit 0.0072 0.0405 0.0398
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0999 0.4222
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0876 0.0876
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0876 0.0869
Schistosoma mansoni nuclear receptor 0.0028 0.0024 0.0016
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0128 0.0892 0.0892
Loa Loa (eye worm) carboxylesterase 0.0199 0.1507 0.1507
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0071 0.0395 0.0395
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1212 0.1212
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0024 0.0425
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0311 0.1293
Schistosoma mansoni ap endonuclease 0.0037 0.0104 0.0097
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0024 0.0016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0124 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0299 0.2371 0.2371
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.0222 0.0914
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0179 0.0179
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0028 0.0024 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0022 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0603 0.0595
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0082
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Brugia malayi beta-lactamase 0.0035 0.0082 0.0074
Trypanosoma brucei heat shock protein, putative 0.0064 0.0336 0.1396
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0603 0.391
Onchocerca volvulus 0.0029 0.0029 0.0111
Echinococcus multilocularis muscleblind protein 0.015 0.1082 0.1082
Mycobacterium tuberculosis Conserved protein 0.0035 0.0082 0.0358
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0028 0.0024 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.0816 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0051 0.0222 1
Onchocerca volvulus 0.0072 0.0405 0.2126
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0072 0.0405 0.0405
Trypanosoma brucei heat shock protein, putative 0.0064 0.0336 0.1396
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0222 0.1051
Schistosoma mansoni hypothetical protein 0.0062 0.0317 0.031
Plasmodium vivax importin-beta 2, putative 0.0028 0.0024 0.0421
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Onchocerca volvulus 0.0199 0.1507 0.8019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.136 0.136
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0082 0.0364
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0054
Onchocerca volvulus 0.0028 0.0022 0.0074
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0024 0.0088
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0143 0.1022 0.1022
Schistosoma mansoni zinc finger protein 0.008 0.0474 0.0467
Loa Loa (eye worm) beta-lactamase 0.0035 0.0082 0.0082
Brugia malayi Endoplasmin precursor 0.0064 0.0336 0.0328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.006 0.0298 0.0298
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0051 0.0222 0.119
Schistosoma mansoni hypothetical protein 0.0062 0.0317 0.031
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0179 0.0179
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0108 0.0427
Brugia malayi hypothetical protein 0.0124 0.0852 0.0845
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0797 0.668 0.668
Brugia malayi Nuclear hormone receptor family member nhr-1 0.006 0.0298 0.029
Toxoplasma gondii ABC1 family protein 0.0035 0.0082 0.092
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0098 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-3 0.006 0.0298 0.029
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1212 0.1212
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.025 0.025
Schistosoma mansoni nAChR subunit 0.0072 0.0405 0.0398
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0054 0.0573
Loa Loa (eye worm) nuclear receptor NHR-67 0.0028 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0603 0.0595
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Trypanosoma cruzi ISWI complex protein 0.006 0.03 0.1247
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0317 0.0317
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0029 0.0021
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.1418 0.1418
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0311 0.3755
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1212 0.1212
Echinococcus multilocularis dnaJ subfamily B 0.0821 0.689 0.689
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0046 0.0179 0.0179
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0592 0.2863
Echinococcus granulosus transcription factor btf3 0.0034 0.0078 0.0078
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0082 0.0358
Schistosoma mansoni lipoxygenase 0.0054 0.025 0.0242
Loa Loa (eye worm) hypothetical protein 0.0071 0.0395 0.0395
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0317 0.0317
Loa Loa (eye worm) RNA binding protein 0.0127 0.0876 0.0876
Brugia malayi Nuclear hormone receptor family member nhr-41 0.006 0.0298 0.029
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0072 0.0405 0.0405
Brugia malayi nuclear hormone receptor family member odr-7 0.0028 0.0024 0.0016
Leishmania major hypothetical protein, conserved 0.0035 0.0082 0.0317
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0054
Brugia malayi nuclear receptor NHR-88 0.006 0.0298 0.029
Echinococcus granulosus sterol regulatory element binding protein 0.0128 0.0892 0.0892
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0072 0.0405 0.0405
Mycobacterium ulcerans hypothetical protein 0.0035 0.0082 0.0407
Schistosoma mansoni nAChR subunit 0.0029 0.0029 0.0021
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0092 0.0575 0.0568
Echinococcus granulosus GPCR family 2 0.0062 0.0317 0.0317
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0028 0.0024 0.0024
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0072 0.0405 0.0405
Brugia malayi Carboxylesterase family protein 0.0199 0.1507 0.15
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0098 0.0384
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0028 0.0024 0.0024
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.006 0.0298 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.0298 0.029
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0098 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0603 0.391
Schistosoma mansoni hypothetical protein 0.03 0.2383 0.2377
Loa Loa (eye worm) hypothetical protein 0.006 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Schistosoma mansoni methyl-cpg binding protein mbd 0.0067 0.036 0.0353
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0603 0.0595
Onchocerca volvulus 0.0032 0.0054 0.0248
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0092 0.0575 0.0575
Entamoeba histolytica hypothetical protein 0.0143 0.1022 0.4293
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0072 0.0405 0.0405
Schistosoma mansoni hypothetical protein 0.0836 0.7021 0.7019
Echinococcus multilocularis heat shock protein 90 0.0064 0.0336 0.0336
Mycobacterium ulcerans hypothetical protein 0.0157 0.1137 0.7505
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0142 0.0573
Schistosoma mansoni hypothetical protein 0.0062 0.0317 0.031
Echinococcus granulosus retinoic acid receptor rxr beta a 0.006 0.0298 0.0298
Echinococcus granulosus lamin dm0 0.0053 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Echinococcus multilocularis endoplasmin 0.0051 0.0222 0.0222
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.1418 0.1418
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0022
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0082 0.0358
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0052 0.0235 0.0235
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0072 0.0405 0.0398
Schistosoma mansoni hypothetical protein 0.0288 0.2272 0.2266
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0311 0.195
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0098 0.0442
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0142 0.0573
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0072 0.0405 0.0405
Brugia malayi PHD-finger family protein 0.0028 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.006 0.0298 0.0298
Plasmodium falciparum acyl-CoA synthetase 0.0071 0.0395 1
Loa Loa (eye worm) nuclear hormone receptor 0.0028 0.0024 0.0024
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0029 0.0029 0.0021
Loa Loa (eye worm) hypothetical protein 0.0053 0.0235 0.0235
Brugia malayi hypothetical protein 0.0234 0.1808 0.1801
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0603 0.391
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus granulosus thyroid hormone receptor alpha 0.0028 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0024 0.0024
Giardia lamblia Heat shock protein HSP 90-alpha 0.0064 0.0336 0.5478
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0022 0.0022
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0876 0.0876
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0098 0.0384
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.015 0.1079 0.1079
Echinococcus multilocularis ecdysone induced protein 78C 0.006 0.0298 0.0298
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0634 0.0627
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0072 0.0405 0.0405
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0082 0.0082
Giardia lamblia Kinase, PLK 0.0094 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0082 0.0364
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.015 0.1082 0.1082
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0054
Onchocerca volvulus 0.0072 0.0405 0.2126
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0199 0.1507 0.8804
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0024 0.0016
Echinococcus granulosus lamin 0.0053 0.0235 0.0235
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0361 0.2012
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0078 0.1824
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0022 0.0068
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0022 0.0059
Echinococcus granulosus glycine receptor subunit alpha 1 0.0072 0.0405 0.0405
Giardia lamblia Heat shock protein HSP 90-alpha 0.0051 0.0222 0.3488
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0592 0.2863
Schistosoma mansoni endoplasmin 0.0064 0.0336 0.0328
Loa Loa (eye worm) DR-78 0.0028 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0098 0.0382
Trichomonas vaginalis heat shock protein, putative 0.0064 0.0336 0.1605
Brugia malayi nuclear hormone receptor family member nhr-6 0.0028 0.0024 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0022 0.0014
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.1808 0.1808
Entamoeba histolytica heat shock protein 90, putative 0.0064 0.0336 0.1387
Schistosoma mansoni nuclear receptor 0.0028 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.006 0.0298 0.0298
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0029 0.0029 0.0029
Schistosoma mansoni retinoic acid receptor RXR 0.006 0.0298 0.029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.006 0.0298 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0592 0.2863
Onchocerca volvulus 0.0028 0.0022 0.0074
Loa Loa (eye worm) hypothetical protein 0.0095 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Echinococcus granulosus para nitrobenzyl esterase 0.0199 0.1507 0.1507
Schistosoma mansoni gliotactin 0.0199 0.1507 0.15
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.205 0.2044
Brugia malayi hypothetical protein 0.0029 0.0029 0.0021
Loa Loa (eye worm) hypothetical protein 0.0095 0.0603 0.0603
Brugia malayi Cation transporter family protein 0.0072 0.0405 0.0398
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0157
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0024 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.205 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.0029 0.0029 0.0021
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0072 0.0405 0.0398
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0029 0.0029 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.006 0.0298 0.029
Brugia malayi beta-NAC-like protein 0.0034 0.0078 0.0071
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0072 0.0405 0.0405
Loa Loa (eye worm) steroid hormone receptor 0.006 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0157
Onchocerca volvulus 0.0199 0.1507 0.8019
Loa Loa (eye worm) acetylcholinesterase 1 0.118 1 1
Echinococcus granulosus glycine receptor subunit beta 0.0072 0.0405 0.0405
Schistosoma mansoni thyroid hormone receptor 0.006 0.0298 0.029
Schistosoma mansoni hypothetical protein 0.0143 0.1022 0.1015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0143 0.1022 0.1022
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Plasmodium vivax SET domain protein, putative 0.0032 0.0054 0.1198
Onchocerca volvulus 0.015 0.1079 0.5732
Brugia malayi nuclear receptor NHR-88 0.0028 0.0024 0.0016
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0072 0.0405 0.0398
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0876 0.0876
Plasmodium vivax heat shock protein 86, putative 0.0064 0.0336 0.8471
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0082 0.0364
Brugia malayi excitatory GABA receptor EXP-1A 0.0072 0.0405 0.0398
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.026 0.1076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0361 0.2012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0095 0.0603 0.391
Brugia malayi Carboxylesterase family protein 0.118 1 1
Schistosoma mansoni alpha-glucosidase 0.0142 0.1013 0.1006
Loa Loa (eye worm) hypothetical protein 0.0124 0.0852 0.0852
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.205 1
Onchocerca volvulus 0.0046 0.0179 0.0918
Echinococcus multilocularis FTZ F1 alpha 0.006 0.0298 0.0298
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0052 0.0235 0.0227
Onchocerca volvulus 0.006 0.0298 0.1549
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0022 0.036
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1212 0.1205
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0054 0.0046
Schistosoma mansoni zinc finger protein 0.0028 0.0024 0.0016
Echinococcus multilocularis zinc finger protein 0.008 0.0474 0.0474
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1709 1
Onchocerca volvulus 0.0028 0.0024 0.0088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0104 0.2493
Onchocerca volvulus 0.0053 0.0235 0.1217
Schistosoma mansoni coup transcription factor 0.006 0.0298 0.029
Loa Loa (eye worm) ACC-1 protein 0.0072 0.0405 0.0405
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.026 0.0253
Echinococcus granulosus endoplasmin 0.0051 0.0222 0.0222
Onchocerca volvulus 0.0072 0.0405 0.2126
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0235 0.0228
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0104 0.0104
Onchocerca volvulus 0.0072 0.0405 0.2126
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0157
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0082 0.0407
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0098 0.009
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0087 0.0079
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0072 0.0405 0.0398
Loa Loa (eye worm) hypothetical protein 0.0234 0.1808 0.1808
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0196 0.1478 0.1471
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0284 0.0284
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0024 0.0088
Echinococcus multilocularis snurportin 1 0.03 0.2383 0.2383
Schistosoma mansoni hypothetical protein 0.0124 0.0852 0.0845
Echinococcus granulosus heat shock protein 0.0064 0.0336 0.0336
Echinococcus granulosus nAChR subunit 0.0072 0.0405 0.0405
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.026 0.0253
Onchocerca volvulus 0.0095 0.0603 0.3181
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.006 0.0298 0.1549
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0024 0.0069
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0238 0.1838 0.1838
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0098 0.0442
Entamoeba histolytica hypothetical protein 0.0143 0.1022 0.4293
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0044 0.0157 0.0149
Brugia malayi latrophilin 2 splice variant baaae 0.0134 0.0941 0.0933
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0311 0.195
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0072 0.0405 0.0398
Echinococcus multilocularis nAChR subunit 0.0072 0.0405 0.0405
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0051 0.0222 0.0222
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0034 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0029 0.0021
Echinococcus granulosus Niemann Pick C1 protein 0.0299 0.2371 0.2371
Schistosoma mansoni hypothetical protein 0.0124 0.0852 0.0845
Brugia malayi mbt repeat family protein 0.0046 0.0179 0.0172
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0029 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0078 0.0346
Onchocerca volvulus Huntingtin homolog 0.0124 0.0852 0.4514
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0024 0.0203
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0082 0.1041
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0228 0.0228
Loa Loa (eye worm) MBCTL1 0.0052 0.0235 0.0235
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0072 0.0405 0.0398
Entamoeba histolytica hypothetical protein 0.0143 0.1022 0.4293
Echinococcus granulosus heat shock protein 90 0.0051 0.0222 0.0222
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0098 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0098 0.0442
Trypanosoma brucei ISWI complex protein 0.006 0.03 0.1247
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0029 0.0029 0.0029
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0072 0.0405 0.0398
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.136 0.136
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0022 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.205 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0603 0.2517
Treponema pallidum heat shock protein 90 0.0051 0.0222 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0095 0.0603 0.391
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis transcription factor btf3 0.0034 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0078 0.0346
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0029 0.0029 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.127 0.6178
Onchocerca volvulus 0.0199 0.1507 0.8019
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0592 0.3127
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0022 0.0059
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0098 0.0382
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0072 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0157
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0072 0.0405 0.0405
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0022 0.0059
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0029 0.0029 0.0029
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0072 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0157
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0022 0.0059
Schistosoma mansoni nAChR subunit 0.0029 0.0029 0.0021
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.0235 0.0227
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0072 0.0405 0.0398
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0078 0.1824
Schistosoma mansoni nAChR subunit 0.0072 0.0405 0.0398
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0603 0.2534
Schistosoma mansoni methyl-cpg binding protein mbd 0.0067 0.036 0.0353
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0022 0.0172
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1137 0.6607
Trypanosoma brucei heat shock protein 90, putative 0.0064 0.0336 0.1396
Loa Loa (eye worm) hypothetical protein 0.016 0.1165 0.1165
Schistosoma mansoni hypothetical protein 0.0048 0.0194 0.0186
Echinococcus granulosus snurportin 1 0.03 0.2383 0.2383
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0054 0.0046
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0104 0.0097
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0044 0.0157 0.0149
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0028 0.0024 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0072 0.0405 0.0398
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0104 0.2493
Brugia malayi nuclear hormone receptor 0.0028 0.0024 0.0016
Loa Loa (eye worm) PHD-finger family protein 0.0081 0.0482 0.0482
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0054 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.135 0.6571
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.205 0.205
Onchocerca volvulus 0.0096 0.0609 0.3213
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0311 0.0311
Brugia malayi conserved hypotetical protein 0.0028 0.0024 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0603 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0022 0.0172
Schistosoma mansoni intermediate filament proteins 0.0053 0.0235 0.0228
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0026 0.0008 0.0008
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.025 0.025
Onchocerca volvulus Alhambra homolog 0.0028 0.0024 0.0088
Schistosoma mansoni transcription factor LCR-F1 0.0143 0.1022 0.1015
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0029 0.0021
Brugia malayi hypothetical protein 0.0199 0.1507 0.15
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0182 0.0855
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0072 0.0405 0.0405
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0876 0.0869
Brugia malayi CXXC zinc finger family protein 0.0058 0.028 0.0272
Echinococcus multilocularis para nitrobenzyl esterase 0.0199 0.1507 0.1507
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.006 0.0298 0.0298
Trypanosoma brucei heat shock protein, putative 0.0064 0.0336 0.1396
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0222 0.0911
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0054 0.0054
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0095 0.0603 0.391
Loa Loa (eye worm) endoplasmin 0.0064 0.0336 0.0336
Echinococcus multilocularis acetylcholinesterase 0.118 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0072 0.0405 0.0398
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0182 0.0855
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0054
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0179 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.205 1
Echinococcus multilocularis protein dispatched 1 0.0146 0.1049 0.1049
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0141 0.1002 0.1002
Echinococcus multilocularis glycine receptor subunit beta 0.0072 0.0405 0.0405
Echinococcus granulosus histone lysine methyltransferase setb 0.0099 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0157
Mycobacterium tuberculosis Carboxylesterase LipT 0.0199 0.1507 0.8804
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0311 0.0304
Echinococcus granulosus geminin 0.0836 0.7021 0.7021
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0179 0.0172
Brugia malayi jmjC domain containing protein 0.0045 0.0169 0.0161
Loa Loa (eye worm) hypothetical protein 0.0151 0.1085 0.1085
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0071 0.0395 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.0298 0.029
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0028 0.0024 0.0024
Trypanosoma cruzi heat shock protein 85, putative 0.0064 0.0336 0.1396
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0199 0.1507 0.7341
Schistosoma mansoni heat shock protein 0.0064 0.0336 0.0328
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0072 0.0405 0.0405
Schistosoma mansoni acetylcholine receptor-related 0.0029 0.0029 0.0021
Brugia malayi nuclear receptor RXR 0.0028 0.0024 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0603 0.2517
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.006 0.0298 0.029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0361 0.2012
Plasmodium falciparum endoplasmin, putative 0.0039 0.0121 0.2923
Loa Loa (eye worm) carboxylesterase 0.0199 0.1507 0.1507
Onchocerca volvulus 0.0028 0.0024 0.0088
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0199 0.1507 0.1507
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0298 0.029
Plasmodium falciparum phd finger protein, putative 0.0028 0.0024 0.0425
Brugia malayi Cation transporter family protein 0.0072 0.0405 0.0398
Echinococcus granulosus importin subunit beta 1 0.0028 0.0024 0.0024
Onchocerca volvulus 0.0199 0.1507 0.8019
Schistosoma mansoni nAChR subunit 0.0072 0.0405 0.0398
Leishmania major hypothetical protein, conserved 0.006 0.03 0.1247
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.0298 0.029
Mycobacterium ulcerans hypothetical protein 0.0095 0.0603 0.391
Mycobacterium tuberculosis Conserved protein 0.0035 0.0082 0.0358
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Loa Loa (eye worm) heat shock protein 75 0.0026 0.0008 0.0008
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0022 0.0059
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0179 0.0172
Onchocerca volvulus Huntingtin homolog 0.0124 0.0852 0.4514
Entamoeba histolytica hypothetical protein 0.0143 0.1022 0.4293
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0199 0.1507 0.1507
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0022 0.0068
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0199 0.1507 0.8804
Echinococcus granulosus zinc finger protein 0.008 0.0474 0.0474
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.205 1
Schistosoma mansoni cpg binding protein 0.0068 0.0373 0.0365
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0199 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0081 0.0482 0.0474
Loa Loa (eye worm) hypothetical protein 0.0199 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0082
Brugia malayi tailless protein 0.0028 0.0024 0.0016
Echinococcus multilocularis peregrin 0.0037 0.0105 0.0105
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0024 0.0024
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0076 0.0076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.0603 0.3442
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0592 0.2863
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0179 0.0918
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Brugia malayi Carboxylesterase family protein 0.0199 0.1507 0.15
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Schistosoma mansoni heat shock protein 0.0064 0.0336 0.0328
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0072 0.0405 0.0405
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0072 0.0405 0.0398
Loa Loa (eye worm) hypothetical protein 0.0071 0.0395 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.127 0.6178
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0179 0.0179
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0222 0.1051
Brugia malayi nuclear receptor RXR 0.0032 0.0054 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0298 0.0298
Schistosoma mansoni endoplasmin 0.0064 0.0336 0.0328
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.0235
Brugia malayi jmjC domain containing protein 0.0092 0.0579 0.0572
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0024 0.0024
Giardia lamblia Grp94/Hsp90 0.0051 0.0222 0.3488
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.028 0.028
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0603 1
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0029 0.0029 0.0029
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0029 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0171 0.1259 0.1259
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0104 0.0104
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0072 0.0405 0.0398
Echinococcus granulosus neuroligin 0.0199 0.1507 0.1507
Schistosoma mansoni neuroligin 3 (S09 family) 0.0199 0.1507 0.15
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0199 0.1507 0.15
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0024 0.0203
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0876 0.0869
Echinococcus granulosus glycine receptor subunit beta 0.0072 0.0405 0.0405
Onchocerca volvulus Protein ultraspiracle homolog 0.006 0.0298 0.1549
Trypanosoma brucei heat shock protein, putative 0.0064 0.0336 0.1396
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0078 0.0301
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.006 0.0298 0.0298
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.0298 0.029
Echinococcus multilocularis sterol regulatory element binding protein 0.0128 0.0892 0.0892
Brugia malayi ecdysone receptor 0.0028 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-49 0.006 0.0298 0.029
Echinococcus granulosus acetylcholinesterase 0.118 1 1
Brugia malayi CHE-14 protein 0.0128 0.0892 0.0885
Loa Loa (eye worm) hypothetical protein 0.0048 0.0199 0.0199
Trypanosoma brucei heat shock protein, putative 0.0064 0.0336 0.1396
Loa Loa (eye worm) hypothetical protein 0.0199 0.1507 0.1507
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0082 0.0082
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0141 0.1002 0.1002
Schistosoma mansoni BC026374 protein (S09 family) 0.0199 0.1507 0.15
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0029 0.0029 0.0021
Echinococcus granulosus carboxylesterase 5A 0.118 1 1
Schistosoma mansoni hypothetical protein 0.0062 0.0317 0.031
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0022 0.0172
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0104 0.0408
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0054 0.0054
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0304 0.2411 0.2405
Schistosoma mansoni alpha-glucosidase 0.0142 0.1013 0.1006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.006 0.0298 0.029
Loa Loa (eye worm) hypothetical protein 0.006 0.0298 0.0298
Brugia malayi hypothetical protein 0.0032 0.0054 0.0046
Loa Loa (eye worm) carboxylesterase 0.118 1 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.1507 0.1507
Schistosoma mansoni hypothetical protein 0.0124 0.0852 0.0845
Onchocerca volvulus 0.0035 0.0082 0.0398
Leishmania major basic transcription factor 3a, putative 0.0034 0.0078 0.0301
Trichomonas vaginalis set domain proteins, putative 0.0242 0.1878 0.9155
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0082 0.1923
Schistosoma mansoni hypothetical protein 0.0836 0.7021 0.7019
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0876 0.0869
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0098 0.0384
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0082 0.0364
Onchocerca volvulus 0.0199 0.1507 0.8019
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0169 0.0169
Entamoeba histolytica hypothetical protein 0.0034 0.0078 0.0299
Brugia malayi orphan nuclear receptor NR2E1 0.0028 0.0024 0.0016
Brugia malayi beta-lactamase family protein 0.0035 0.0082 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0317 0.031
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0999 0.4222
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0157
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0072 0.0405 0.0405
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0169 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.127 0.6178
Schistosoma mansoni transcription factor btf3 0.0034 0.0078 0.0071
Brugia malayi mbt repeat family protein 0.0046 0.0179 0.0172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.136 0.1353
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0299 0.2371 1
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0298 0.0298
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0054 0.0046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0072 0.0405 0.0405
Brugia malayi hypothetical protein 0.0032 0.0054 0.0046
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0179 0.0172
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0592 0.0592
Echinococcus granulosus nuclear receptor nhr 48 0.0028 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Brugia malayi Muscleblind-like protein 0.015 0.1082 0.1075
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0072 0.0405 0.0398
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0592 0.2474
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0104 0.0411
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0072 0.0405 0.0405
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0876 0.0869
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0082 0.0358
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0072 0.0405 0.0398
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0104 0.0411
Echinococcus multilocularis musashi 0.0053 0.0235 0.0235
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0082 0.0358
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0592 0.2491
Brugia malayi nuclear receptor NHR-67 0.0028 0.0024 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0592 0.0585
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.026 0.1414
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0072 0.0405 0.0398
Brugia malayi PHD-finger family protein 0.0101 0.0656 0.0648
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.136 0.136
Loa Loa (eye worm) hypothetical protein 0.118 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0064 0.0336 0.1396
Echinococcus granulosus tar DNA binding protein 0.0127 0.0876 0.0876
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.006 0.0298 0.0298
Schistosoma mansoni steroid hormone receptor ad4bp 0.006 0.0298 0.029
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.2383 0.2383
Trypanosoma cruzi heat shock protein 85, putative 0.0064 0.0336 0.1396
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.0603 0.391
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0415 0.0408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.006 0.0298 0.0298
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2355 1
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.0892 0.4329
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0044 0.0157 0.0149
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.006 0.0298 0.0298
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.136 0.136
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0082 0.0358
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0317 0.0317
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.136 0.1353
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0071 0.0395 0.0395
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Trichomonas vaginalis spcc417.12 protein, putative 0.0199 0.1507 0.7341
Entamoeba histolytica hypothetical protein 0.0044 0.0157 0.0632
Loa Loa (eye worm) hypothetical protein 0.0157 0.1142 0.1142
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0072 0.0405 0.0398
Mycobacterium tuberculosis Conserved protein 0.0035 0.0082 0.0358
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Mycobacterium ulcerans lipase LipD 0.0035 0.0082 0.0407
Brugia malayi heat shock protein 90 0.0064 0.0336 0.0328
Echinococcus multilocularis lamin 0.0053 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.006 0.0298 0.0298
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0082 0.0364
Schistosoma mansoni cpg binding protein 0.0058 0.028 0.0272
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0222 0.0914
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0072 0.0405 0.0405
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0029 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0054 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0054 0.0046
Trypanosoma cruzi Heat shock protein 83, putative 0.0064 0.0336 0.1396
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0603 0.2534
Onchocerca volvulus 0.0029 0.0029 0.0111
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0104 0.0472
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.006 0.0298 0.0298
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0104 0.1408
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0849 0.0842
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0054 0.0046
Brugia malayi Pre-SET motif family protein 0.0032 0.0054 0.0046
Echinococcus granulosus Niemann Pick C1 protein 0.0427 0.3482 0.3482
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0098 0.0442
Toxoplasma gondii exonuclease III APE 0.0037 0.0104 0.1193
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.127 0.6749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.006 0.0298 0.0298
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0072 0.0405 0.0405
Brugia malayi Carboxylesterase family protein 0.0199 0.1507 0.15
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0022 0.0014
Entamoeba histolytica heat shock protein 90, putative 0.0064 0.0336 0.1387
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0082 0.0358
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0311 0.0311
Plasmodium vivax acyl-CoA synthetase, putative 0.0071 0.0395 1
Onchocerca volvulus Bile acid receptor homolog 0.006 0.0298 0.1549
Trypanosoma brucei heat shock protein, putative 0.0064 0.0336 0.1396
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0222 0.1051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.006 0.0298 0.029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0634 0.0627
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0199 0.1507 0.15
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.006 0.0298 0.0298
Echinococcus multilocularis acetylcholinesterase 0.118 1 1
Schistosoma mansoni lamin 0.0053 0.0235 0.0228
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0044 0.0157 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.205 1
Brugia malayi Carboxylesterase family protein 0.0199 0.1507 0.15
Echinococcus granulosus cpg binding protein 0.0068 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Brugia malayi hypothetical protein 0.0029 0.0029 0.0021
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Schistosoma mansoni neurotransmitter gated ion channel 0.0044 0.0157 0.0149
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0199 0.1507 0.15
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0029 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0821 0.689 0.6887
Loa Loa (eye worm) hypothetical protein 0.0071 0.0395 0.0395
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0028 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0095 0.0603 0.3442
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.127 0.6178
Schistosoma mansoni kinase 0.0048 0.0193 0.0185
Entamoeba histolytica acyl-coA synthetase, putative 0.0095 0.0603 0.2517
Brugia malayi Calcitonin receptor-like protein seb-1 0.0196 0.1478 0.1471
Echinococcus granulosus intermediate filament protein 0.0053 0.0235 0.0235
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0104 0.0411
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Schistosoma mansoni nAChR subunit 0.0072 0.0405 0.0398
Echinococcus multilocularis BC026374 protein (S09 family) 0.0199 0.1507 0.1507
Onchocerca volvulus 0.0035 0.0082 0.0398
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0022 0.0059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.136 0.1353
Echinococcus granulosus peregrin 0.0037 0.0105 0.0105
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0078 0.0078
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0024 0.0016
Echinococcus granulosus FTZ F1 alpha 0.006 0.0298 0.0298
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.127 0.6178
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Mycobacterium ulcerans carboxylesterase, LipT 0.0199 0.1507 1
Brugia malayi ecdysteroid receptor 0.006 0.0298 0.029
Trypanosoma cruzi heat shock protein 85, putative 0.0064 0.0336 0.1396
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0044 0.0157 0.0149
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0238 0.1838 0.1838
Echinococcus multilocularis protein patched 0.0128 0.0892 0.0892
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0024 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0082 0.0317
Onchocerca volvulus 0.0032 0.0054 0.0247
Echinococcus granulosus methyl CpG binding domain protein 2 0.0067 0.036 0.036
Brugia malayi hypothetical protein 0.0029 0.0029 0.0021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0024 0.0024
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0235 0.0235
Echinococcus multilocularis neuroligin 0.0199 0.1507 0.1507
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0395 0.2511
Onchocerca volvulus 0.0058 0.028 0.1453
Echinococcus multilocularis carboxylesterase 5A 0.118 1 1
Plasmodium vivax endoplasmin, putative 0.0064 0.0336 0.8471
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0078 0.0301
Loa Loa (eye worm) hypothetical protein 0.0099 0.0634 0.0634
Echinococcus multilocularis GPCR, family 2 0.0062 0.0317 0.0317
Onchocerca volvulus 0.0044 0.0157 0.0799
Loa Loa (eye worm) acetylcholine receptor protein 0.0029 0.0029 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0082 0.0317
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0072 0.0405 0.0398
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0876 0.0869
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0142 0.0573
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0104 0.0489
Echinococcus multilocularis heat shock protein 0.0064 0.0336 0.0336
Echinococcus granulosus glycine receptor subunit alpha 1 0.0072 0.0405 0.0405
Loa Loa (eye worm) oxidoreductase 0.0028 0.0022 0.0022
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0072 0.0405 0.0398
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0028 0.0024 0.0024
Loa Loa (eye worm) heat shock protein 90 0.0064 0.0336 0.0336
Echinococcus granulosus dnaJ subfamily B 0.0821 0.689 0.689
Brugia malayi steroid hormone receptor 0.006 0.0298 0.029
Echinococcus granulosus acetylcholinesterase 0.118 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0099 0.0634 0.0634
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0317 0.031
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0026 0.0008 0.0008
Loa Loa (eye worm) GABA receptor subunit 0.0044 0.0157 0.0157
Brugia malayi hypothetical protein 0.015 0.1079 0.1072
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0024 0.0201
Brugia malayi beta-lactamase family protein 0.0035 0.0082 0.0074
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0157
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0022 0.0014
Echinococcus multilocularis geminin 0.0836 0.7021 0.7021
Mycobacterium ulcerans beta-lactamase 0.0035 0.0082 0.0407
Loa Loa (eye worm) hypothetical protein 0.0128 0.0892 0.0892
Plasmodium falciparum importin beta, putative 0.0028 0.0024 0.0421
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0235 0.0235
Toxoplasma gondii heat shock protein 90, putative 0.0064 0.0336 0.4054
Loa Loa (eye worm) hypothetical protein 0.0278 0.2185 0.2185
Brugia malayi hypothetical protein 0.0143 0.1022 0.1015
Brugia malayi hypothetical protein 0.0028 0.0024 0.0016
Toxoplasma gondii hypothetical protein 0.0048 0.0196 0.2323
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0592 0.2863
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0024 0.0024
Echinococcus granulosus BC026374 protein S09 family 0.0199 0.1507 0.1507
Brugia malayi hypothetical protein 0.0029 0.0029 0.0021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.006 0.0298 0.029
Echinococcus granulosus nAChR subunit 0.0044 0.0157 0.0157
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0196 0.1478 0.1478
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Mycobacterium ulcerans heat shock protein 90 0.0051 0.0222 0.1351
Leishmania major heat shock protein 83-1 0.0064 0.0336 0.1396
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0592 0.2863
Onchocerca volvulus Putative nachr subunit 0.0072 0.0405 0.2126
Onchocerca volvulus 0.0029 0.0029 0.0111
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0098 0.0442
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0022 0.0059
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0592 0.2491
Loa Loa (eye worm) hypothetical protein 0.0199 0.1507 0.1507
Trypanosoma brucei Heat shock protein 83, putative 0.0064 0.0336 0.1396
Onchocerca volvulus 0.0044 0.0157 0.0799
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0169 0.0161
Brugia malayi Bromodomain containing protein 0.0037 0.0105 0.0097
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0072 0.0405 0.0398
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0082
Schistosoma mansoni nAChR subunit 0.0072 0.0405 0.0398
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0082 0.0407
Brugia malayi RNA, U transporter 1 0.008 0.0474 0.0466
Brugia malayi hypothetical protein 0.0028 0.0024 0.0016
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.026 0.026
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0579 0.0579
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0104 0.0411
Onchocerca volvulus 0.0053 0.0235 0.1217
Brugia malayi Cation transporter family protein 0.0072 0.0405 0.0398
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0095 0.0603 0.0603
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0052 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Brugia malayi RNA binding protein 0.0127 0.0876 0.0869
Echinococcus multilocularis expressed conserved protein 0.0281 0.2214 0.2214
Loa Loa (eye worm) hypothetical protein 0.006 0.0298 0.0298
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0194 0.0186
Schistosoma mansoni thyroid hormone receptor 0.006 0.0298 0.029
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0078 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0078 0.0346
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0072 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0072 0.0405 0.0398
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0067 0.036 0.036
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0078 0.0873
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0104 0.0104
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.026 0.1606
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.135 0.6571
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0022 0.0059
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.006 0.0298 0.029
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Echinococcus multilocularis glycine receptor subunit beta 0.0072 0.0405 0.0405
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.2355 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0405
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.006 0.0298 0.0298
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0072 0.0405 0.0405
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0199 0.1507 0.1507
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.0298 0.029
Loa Loa (eye worm) hypothetical protein 0.0199 0.1507 0.1507
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0022 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0072 0.0405 0.0398
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0072 0.0405 0.0405
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0311 0.195
Schistosoma mansoni ap endonuclease 0.0037 0.0104 0.0097
Schistosoma mansoni hypothetical protein 0.0124 0.0852 0.0845
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.136 0.136
Brugia malayi Bromodomain containing protein 0.015 0.1082 0.1075
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0082 0.0074
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0298 0.0298
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0603 0.2534
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Echinococcus multilocularis lamin dm0 0.0053 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0142 0.0573
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1624 0.1624
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.006 0.0298 0.0298
Brugia malayi Importin beta-1 subunit 0.0028 0.0024 0.0016
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0592 0.2491
Echinococcus multilocularis cpg binding protein 0.0068 0.0373 0.0373
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0311 0.1717
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0078 0.0299

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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