Detailed information for compound 136589

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 571.745 | Formula: C33H49NO7
  • H donors: 2 H acceptors: 4 LogP: 6.5 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCC(C(=O)O[C@@H]1C[C@@H](C)[C@H]([C@H]2C1[C@H](CCC1C[C@@H](O)CC(=O)O1)[C@@H](CC2)C)OC(=O)NCc1ccccc1)(C)C
  • InChi: 1S/C33H49NO7/c1-6-33(4,5)31(37)40-27-16-21(3)30(41-32(38)34-19-22-10-8-7-9-11-22)26-14-12-20(2)25(29(26)27)15-13-24-17-23(35)18-28(36)39-24/h7-11,20-21,23-27,29-30,35H,6,12-19H2,1-5H3,(H,34,38)/t20-,21+,23+,24?,25-,26+,27-,29?,30+/m0/s1
  • InChiKey: ZUURLVDIZFDZJT-UQLLKHDVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0143 0.1093 0.1093
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0053 0.0268 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.037 0.3176 0.4567
Trichomonas vaginalis AGC family protein kinase 0.037 0.3176 0.3101
Onchocerca volvulus 0.0041 0.0155 0.0384
Mycobacterium tuberculosis Conserved protein 0.0036 0.0109 0.3324
Schistosoma mansoni growth factor receptor-bound protein 0.0041 0.0155 0.0142
Brugia malayi Egg laying defective protein 4 0.0048 0.0222 0.0222
Brugia malayi Pleckstrin Homology Domain 0.0041 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0041 0.0155 0.4721
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Echinococcus multilocularis Ras associated and pleckstrin y 0.0041 0.0155 0.0147
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0041 0.0155 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Loa Loa (eye worm) CYP4Cod1 0.0143 0.1093 0.1093
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0054 0.0275 0.0275
Entamoeba histolytica hypothetical protein 0.0053 0.0268 0.0268
Toxoplasma gondii cytochrome p450 superfamily protein 0.0041 0.0155 0.0101
Trichomonas vaginalis alpha chimerin, putative 0.0041 0.0155 0.0046
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0058 0.0311 0.0385
Echinococcus granulosus serine/threonine protein kinase 0.0754 0.6713 0.9747
Onchocerca volvulus 0.0036 0.0109 0.027
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0041 0.0155 0.0157
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0041 0.0155 0.0142
Schistosoma mansoni rho gtpase activating protein 0.0041 0.0155 0.0142
Plasmodium falciparum glycogen synthase kinase 3 0.0463 0.4039 0.6314
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0328 0.0396
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0041 0.0155 0.0155
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0165 0.1297 0.1818
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.0311 0.0371
Echinococcus multilocularis protein patched 0.0068 0.0402 0.0509
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0328 0.04
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0222 0.024
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Schistosoma mansoni serine/threonine-protein kinase 0.0754 0.6713 0.9747
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1742 0.1742
Schistosoma mansoni hypothetical protein 0.0041 0.0155 0.0142
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0036 0.0109 0.008
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0325 0.2765 0.2685
Giardia lamblia Kinase, AGC PKA 0.0713 0.6334 1
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1951 0.1951
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0713 0.6334 1
Entamoeba histolytica protein kinase, putative 0.037 0.3176 0.3176
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Trichomonas vaginalis protein transport protein sec7, putative 0.0041 0.0155 0.0046
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.037 0.3176 0.3176
Plasmodium falciparum cGMP-dependent protein kinase 0.0048 0.0222 0.0181
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Brugia malayi TBC domain containing protein 0.0041 0.0155 0.0155
Entamoeba histolytica hypothetical protein 0.0041 0.0155 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0196 0.0217
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0463 0.4039 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0041 0.0155 0.0142
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0053 0.0268 0.0663
Schistosoma mansoni dynamin 0.0041 0.0155 0.0142
Echinococcus multilocularis Niemann Pick C1 protein 0.0068 0.0402 0.0509
Plasmodium falciparum oxysterol-binding protein, putative 0.0041 0.0155 0.0074
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0041 0.0155 0.0147
Brugia malayi probable spectrin beta chain 0.0041 0.0155 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Schistosoma mansoni goodpasture antigen-binding protein 0.0041 0.0155 0.0142
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0328 0.0396
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0053 0.0268 0.024
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0041 0.0155 0.4721
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0041 0.0155 0.0155
Echinococcus multilocularis hyperpolarization activated cyclic 0.0773 0.6886 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0036 0.0109 0.0075
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.037 0.3176 0.3176
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0165 0.1297 0.1297
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0041 0.0155 0.4721
Brugia malayi cytochrome P450 0.0041 0.0155 0.0155
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0041 0.0155 0.0142
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0053 0.0268 0.016
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0048 0.0222 0.0245
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.0155 0.0155
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0041 0.0155 0.0155
Echinococcus granulosus calcium dependent secretion activator 1 0.0041 0.0155 0.0157
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.1297 0.1201
Onchocerca volvulus 0.0041 0.0155 0.0384
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0041 0.0155 0.0142
Brugia malayi Cadps2 protein 0.0041 0.0155 0.0155
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0036 0.0109 0.0075
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0058 0.0005
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0773 0.6886 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0314 0.0379
Schistosoma mansoni hypothetical protein 0.0041 0.0155 0.0142
Echinococcus multilocularis 0.0041 0.0155 0.0147
Echinococcus granulosus Niemann Pick C1 protein 0.0068 0.0402 0.0518
Entamoeba histolytica hypothetical protein 0.0041 0.0155 0.0155
Echinococcus granulosus Pleckstrin y 0.0041 0.0155 0.0157
Leishmania major cytochrome p450-like protein 0.0143 0.1093 0.2705
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0041 0.0155 0.0155
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0036 0.0109 0.008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0328 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0036 0.0109 0.008
Brugia malayi Pre-SET motif family protein 0.0031 0.0058 0.0058
Leishmania major protein kinase A regulatory subunit, putative 0.0036 0.0109 0.027
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0041 0.0155 0.0046
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0155 0.0074
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0463 0.4039 0.5952
Trypanosoma cruzi PH domain containing protein, putative 0.0041 0.0155 0.007
Brugia malayi hypothetical protein 0.0041 0.0155 0.0155
Trypanosoma cruzi PH domain containing protein, putative 0.0041 0.0155 0.007
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0773 0.6886 1
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0041 0.0155 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Entamoeba histolytica PH domain containing protein 0.0041 0.0155 0.0155
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0463 0.4039 0.4039
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Entamoeba histolytica protein kinase, putative 0.1111 1 1
Leishmania major protein kinase, putative 0.0053 0.0268 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Brugia malayi PH domain containing protein 0.0041 0.0155 0.0155
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0463 0.4039 0.5838
Loa Loa (eye worm) rho-GTPase-activating 0.0041 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0041 0.0155 0.4721
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0041 0.0155 0.0147
Echinococcus granulosus Pleckstrin y 0.0041 0.0155 0.0157
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0041 0.0155 0.0157
Echinococcus granulosus Pleckstrin y 0.0041 0.0155 0.0157
Echinococcus multilocularis sterol regulatory element binding protein 0.0068 0.0402 0.0509
Leishmania major protein kinase, putative 0.0048 0.0222 0.0549
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0041 0.0155 0.1195
Echinococcus granulosus calcium activated potassium channel 0.003 0.0055 0.001
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0036 0.0109 0.0053
Schistosoma mansoni hypothetical protein 0.0036 0.0109 0.0075
Echinococcus granulosus cytochrome P450 2K1 0.0041 0.0155 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Schistosoma mansoni serine/threonine-protein kinase 0.0754 0.6713 0.9747
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0048 0.0222 0.0171
Schistosoma mansoni hypothetical protein 0.0041 0.0155 0.0142
Echinococcus multilocularis nervana 2 0.07 0.6221 0.9027
Leishmania major hypothetical protein, conserved 0.0036 0.0109 0.027
Loa Loa (eye worm) AGC/AKT protein kinase 0.1111 1 1
Echinococcus granulosus Rho GTPase activating protein 24 0.0041 0.0155 0.0157
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Brugia malayi Cytochrome P450 family protein 0.0041 0.0155 0.0155
Echinococcus granulosus dynamin 1 0.0041 0.0155 0.0157
Echinococcus multilocularis calcium dependent secretion activator 1 0.0041 0.0155 0.0147
Echinococcus multilocularis oxysterol binding protein 1 0.0041 0.0155 0.0147
Brugia malayi Plekhf2 protein 0.0041 0.0155 0.0155
Echinococcus granulosus Protein kinase C brain isozyme 0.037 0.3176 0.4575
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0036 0.0109 0.0053
Toxoplasma gondii hypothetical protein 0.0041 0.0155 0.0101
Trypanosoma cruzi NIMA-related kinase, putative 0.0053 0.0268 0.024
Trypanosoma cruzi hypothetical protein 0.0041 0.0155 0.007
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0143 0.1093 0.8429
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0053 0.0268 0.024
Echinococcus granulosus microtubule associated protein 2 0.0708 0.6293 0.9134
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0713 0.6334 0.9426
Trypanosoma cruzi hypothetical protein 0.0041 0.0155 0.007
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0041 0.0155 0.1195
Loa Loa (eye worm) hypothetical protein 0.0068 0.0402 0.0402
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0036 0.0109 0.0075
Mycobacterium ulcerans regulatory protein 0.0036 0.0109 0.0841
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0053 0.0268 0.024
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0041 0.0155 0.0155
Schistosoma mansoni oxysterol-binding protein 1 0.0041 0.0155 0.0142
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0068 0.0402 0.0504
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0068 0.0402 0.0402
Brugia malayi Cytochrome P450 family protein 0.0143 0.1093 0.1093
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0036 0.0109 0.0075
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0041 0.0155 0.0069
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0058 0.0311 0.0375
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0036 0.0109 0.5
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0314 0.0389
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0109 0.7041
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0713 0.6334 0.9192
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0041 0.0155 0.4721
Schistosoma mansoni patched 1 0.0068 0.0402 0.0504
Schistosoma mansoni zinc finger protein 0.0041 0.0155 0.0142
Leishmania major folate/biopterin transporter, putative 0.0053 0.0268 0.0663
Loa Loa (eye worm) hypothetical protein 0.0102 0.0714 0.0714
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0036 0.0109 0.0109
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0041 0.0155 0.1195
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0041 0.0155 0.4721
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0041 0.0155 0.0155
Entamoeba histolytica protein kinase domain containing protein 0.0463 0.4039 0.4039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0754 0.6713 0.6713
Echinococcus granulosus voltage gated potassium channel 0.0058 0.0311 0.0385
Leishmania major hypothetical protein, conserved 0.0041 0.0155 0.0384
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.037 0.3176 0.3176
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0041 0.0155 0.1195
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.0155 0.0155
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0041 0.0155 0.1195
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0463 0.4039 0.4163
Trichomonas vaginalis kinesin light chain, putative 0.0041 0.0155 0.0046
Echinococcus granulosus patatin phospholipase domain containing protein 0.0036 0.0109 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0041 0.0155 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0222 0.024
Entamoeba histolytica PH domain containing protein 0.0041 0.0155 0.0155
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.0155 0.0155
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0036 0.0109 0.3324
Leishmania major protein kinase, putative 0.0048 0.0222 0.0549
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0053 0.0268 0.016
Echinococcus granulosus protein kinase shaggy 0.0463 0.4039 0.5838
Trichomonas vaginalis protein transport protein sec7, putative 0.0041 0.0155 0.0046
Leishmania major cytochrome p450-like protein 0.0041 0.0155 0.0383
Brugia malayi Pre-SET motif family protein 0.0214 0.1742 0.1742
Trichomonas vaginalis AGC family protein kinase 0.1111 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0708 0.6293 0.9132
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0078 0.0489 0.0611
Treponema pallidum catabolite gene activator (Crp) 0.0036 0.0109 0.5
Brugia malayi Cyclic-nucleotide gated cation channel 0.0054 0.0275 0.0275
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0041 0.0155 0.0155
Echinococcus multilocularis Oxysterol binding protein 11 0.0041 0.0155 0.0147
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0041 0.0155 0.0155
Echinococcus multilocularis cytohesin 1 0.0041 0.0155 0.0147
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0165 0.1297 0.1826
Mycobacterium leprae putative cytochrome p450 0.0041 0.0155 1
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.1297 0.1798
Leishmania major regulatory subunit of protein kinase a-like protein 0.0036 0.0109 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0041 0.0155 0.4721
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0041 0.0155 0.1195
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0036 0.0109 0.0109
Echinococcus multilocularis Pleckstrin y 0.0041 0.0155 0.0147
Echinococcus multilocularis GRB2 associated binding protein 3 0.0041 0.0155 0.0147
Schistosoma mansoni serine/threonine protein kinase 0.037 0.3176 0.4567
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0268 0.0268
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0196 0.0196
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0036 0.0109 0.009
Trichomonas vaginalis set domain proteins, putative 0.0243 0.2013 0.1925
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Echinococcus multilocularis Glutaredoxin protein 5 0.07 0.6221 0.9027
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0268 0.0268
Leishmania major hypothetical protein, unknown function 0.0036 0.0109 0.027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Brugia malayi Protein kinase domain containing protein 0.037 0.3176 0.3176
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0155 0.0155
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0053 0.0268 0.024
Onchocerca volvulus 0.0041 0.0155 0.0384
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0036 0.0109 0.027
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0489 0.0385
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0041 0.0155 0.0157
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0041 0.0155 0.4721
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0053 0.0268 0.016
Echinococcus multilocularis Pleckstrin y 0.0041 0.0155 0.0147
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0041 0.0155 0.1195
Entamoeba histolytica ARF GTPase activating protein, putative 0.0041 0.0155 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.0311 0.0371
Trypanosoma brucei cytochrome P450, putative 0.0143 0.1093 0.0995
Brugia malayi Dynamin 0.0041 0.0155 0.0155
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0054 0.0275 0.0168
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Brugia malayi intracellular kinase 0.0463 0.4039 0.4039
Schistosoma mansoni cytochrome P450 0.0041 0.0155 0.0142
Trypanosoma cruzi PH domain containing protein, putative 0.0041 0.0155 0.007
Loa Loa (eye worm) uncoordinated protein 104 0.0041 0.0155 0.0155
Entamoeba histolytica protein kinase 2, putative 0.0713 0.6334 0.6334
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0041 0.0155 0.4721
Mycobacterium ulcerans hypothetical protein 0.0036 0.0109 0.0841
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0041 0.0155 0.0384
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0041 0.0155 0.0074
Trichomonas vaginalis centaurin alpha, putative 0.0041 0.0155 0.0046
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0041 0.0155 0.007
Schistosoma mansoni syntrophin 0.0041 0.0155 0.0142
Schistosoma mansoni centaurin alpha 0.0041 0.0155 0.0142
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0036 0.0109 0.3324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0196 0.0202
Echinococcus granulosus NDR protein kinase 0.037 0.3176 0.4575
Brugia malayi p70 ribosomal S6 kinase beta 0.107 0.9621 0.9621
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.1297 0.1798
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0041 0.0155 0.0046
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0036 0.0109 0.0081
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0053 0.0268 0.024
Loa Loa (eye worm) hypothetical protein 0.0052 0.0257 0.0257
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0088 0.0589 0.0589
Echinococcus multilocularis actin binding protein anillin 0.0041 0.0155 0.0147
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Echinococcus multilocularis pdz domain containing protein 0.0041 0.0155 0.0147
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0041 0.0155 0.1195
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Echinococcus multilocularis rac serine:threonine kinase 0.0754 0.6713 0.9747
Brugia malayi Variant SH3 domain containing protein 0.0041 0.0155 0.0155
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0041 0.0155 0.0147
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0328 0.0282
Brugia malayi PH domain containing protein 0.0041 0.0155 0.0155
Brugia malayi Cytochrome P450 family protein 0.0143 0.1093 0.1093
Echinococcus multilocularis serine:threonine protein kinase N2 0.037 0.3176 0.457
Mycobacterium ulcerans hypothetical protein 0.0036 0.0109 0.0841
Trichomonas vaginalis AGC family protein kinase 0.1111 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.0155 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0626 0.0831
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0088 0.0589 0.0589
Echinococcus multilocularis DCC interacting protein 13 beta 0.0041 0.0155 0.0147
Trichomonas vaginalis centaurin/arf, putative 0.0041 0.0155 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0041 0.0155 0.4721
Brugia malayi Cytochrome P450 family protein 0.0041 0.0155 0.0155
Trypanosoma cruzi NIMA-related kinase, putative 0.0053 0.0268 0.024
Echinococcus multilocularis expressed conserved protein 0.0048 0.0222 0.0245
Brugia malayi N-terminal motif family protein 0.0036 0.0109 0.0109
Echinococcus granulosus nervana 2 0.07 0.6221 0.9028
Loa Loa (eye worm) AGC/NDR protein kinase 0.037 0.3176 0.3176
Trichomonas vaginalis AGC family protein kinase 0.0411 0.3555 0.3484
Entamoeba histolytica hypothetical protein 0.0053 0.0268 0.0268
Echinococcus granulosus Glutaredoxin protein 5 0.07 0.6221 0.9028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0041 0.0155 0.0155
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0041 0.0155 0.0069
Plasmodium falciparum PH domain-containing protein, putative 0.0041 0.0155 0.0074
Entamoeba histolytica protein kinase domain containing protein 0.0463 0.4039 0.4039
Plasmodium vivax PH domain containing protein 0.0041 0.0155 0.0155
Toxoplasma gondii Oxysterol-binding protein 0.0041 0.0155 0.0101
Toxoplasma gondii protein kinase domain-containing protein 0.0053 0.0268 0.0219
Trypanosoma brucei PH domain containing protein, putative 0.0041 0.0155 0.0046
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0041 0.0155 0.0046
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0041 0.0155 0.1195
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0041 0.0155 0.4721
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0036 0.0109 0.0053
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0165 0.1297 0.1814
Onchocerca volvulus outspread protein homolog 0.0041 0.0155 0.0384
Brugia malayi protein kinase C II. 0.037 0.3176 0.3176
Schistosoma mansoni hypothetical protein 0.0041 0.0155 0.0142
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0424 0.0318
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0036 0.0109 0.0109
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.037 0.3176 0.457
Treponema pallidum catabolite gene activator 0.0036 0.0109 0.5
Leishmania major cytochrome p450-like protein 0.0041 0.0155 0.0383
Toxoplasma gondii AGC kinase 0.107 0.9621 1
Schistosoma mansoni lipoxygenase 0.0058 0.0314 0.0374
Echinococcus granulosus Ion_trans_N domain containing protein 0.0448 0.3897 0.5629
Trichomonas vaginalis AGC family protein kinase 0.1111 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0058 0.0311 0.0375
Entamoeba histolytica protein kinase, putative 0.0463 0.4039 0.4039
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0489 0.0385
Echinococcus multilocularis hyperpolarization activated cyclic 0.0773 0.6886 1
Brugia malayi Dynamin 0.0041 0.0155 0.0155
Trypanosoma cruzi hypothetical protein 0.0041 0.0155 0.007
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0489 0.0385
Echinococcus multilocularis hypothetical protein 0.0448 0.3897 0.5625
Schistosoma mansoni vav2 0.0041 0.0155 0.0142
Entamoeba histolytica protein kinase, putative 0.1111 1 1
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0036 0.0109 0.3324
Onchocerca volvulus 0.0041 0.0155 0.0384
Schistosoma mansoni serine/threonine protein kinase 0.037 0.3176 0.4567
Trypanosoma cruzi hypothetical protein 0.0041 0.0155 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0402 0.0296
Brugia malayi PH domain containing protein 0.0041 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0041 0.0155 0.4721
Brugia malayi Cytohesin 3 0.0041 0.0155 0.0155
Echinococcus granulosus Protein patched homolog 1 0.0068 0.0402 0.0518
Trichomonas vaginalis AGC family protein kinase 0.1111 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0196 0.0202
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0328 0.2531
Echinococcus granulosus GRB2 associated binding protein 3 0.0041 0.0155 0.0157
Trichomonas vaginalis hypothetical protein 0.0041 0.0155 0.0046
Brugia malayi MH2 domain containing protein 0.0236 0.1951 0.1951
Giardia lamblia Kinase, CMGC GSK 0.0463 0.4039 0.6314
Loa Loa (eye worm) AGC/PKN protein kinase 0.037 0.3176 0.3176
Leishmania major protein kinase, putative 0.0053 0.0268 0.0663
Schistosoma mansoni serine/threonine protein kinase 0.037 0.3176 0.4567
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.0155 0.0155
Trypanosoma brucei protein kinase, putative 0.0053 0.0268 0.016
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0041 0.0155 0.1195
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0041 0.0155 0.0157
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0036 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0165 0.1297 0.1297
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Echinococcus multilocularis oxysterol binding protein 9 0.0041 0.0155 0.0147
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0463 0.4039 0.5834
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.037 0.3176 0.457
Echinococcus granulosus beta 1 syntrophin 0.0041 0.0155 0.0157
Schistosoma mansoni myotubularin-related protein 0.0041 0.0155 0.0142
Echinococcus multilocularis serine:threonine protein kinase N2 0.037 0.3176 0.457
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0036 0.0109 0.0053
Entamoeba histolytica hypothetical protein 0.0041 0.0155 0.0155
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0713 0.6334 1
Brugia malayi PH domain containing protein 0.0041 0.0155 0.0155
Brugia malayi CHE-14 protein 0.0068 0.0402 0.0402
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0268 0.0268
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0053 0.0268 0.016
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0328 0.041
Trypanosoma cruzi hypothetical protein 0.0041 0.0155 0.007
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0041 0.0155 0.007
Trypanosoma cruzi Protein kinase B 0.0754 0.6713 1
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0041 0.0155 0.0147
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0053 0.0268 0.024
Entamoeba histolytica protein kinase, putative 0.0053 0.0268 0.0268
Entamoeba histolytica hypothetical protein 0.0041 0.0155 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Echinococcus multilocularis protein kinase c iota type 0.037 0.3176 0.457
Trichomonas vaginalis AGC family protein kinase 0.1111 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0054 0.0275 0.0318
Loa Loa (eye worm) oxysterol binding protein 0.0041 0.0155 0.0155
Echinococcus granulosus oxysterol binding protein 3 0.0041 0.0155 0.0157
Entamoeba histolytica protein kinase, putative 0.0053 0.0268 0.0268
Onchocerca volvulus 0.0041 0.0155 0.0384
Trichomonas vaginalis centaurin gamma, putative 0.0041 0.0155 0.0046
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0328 0.0812
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0196 0.0207
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.1297 0.321
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0196 0.0207
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0036 0.0109 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Onchocerca volvulus Protein melted homolog 0.0041 0.0155 0.0384
Trichomonas vaginalis AGC family protein kinase 0.037 0.3176 0.3101
Brugia malayi Hr1 repeat family protein 0.037 0.3176 0.3176
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0036 0.0109 0.0075
Entamoeba histolytica PH domain containing protein kinase, putative 0.0754 0.6713 0.6713
Brugia malayi PH domain containing protein 0.0041 0.0155 0.0155
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0041 0.0155 0.0383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0196 0.0217
Treponema pallidum cyclic nucleotide binding protein 0.0036 0.0109 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0054 0.0275 0.0332
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.037 0.3176 0.4567
Schistosoma mansoni goodpasture antigen-binding protein 0.0041 0.0155 0.0142
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0048 0.0222 0.0245
Trypanosoma cruzi PH domain containing protein, putative 0.0041 0.0155 0.007
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0041 0.0155 0.0155
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.107 0.9621 0.9621
Echinococcus granulosus protein kinase C gamma type 0.037 0.3176 0.4575
Schistosoma mansoni dynamin 0.0041 0.0155 0.0142
Loa Loa (eye worm) hypothetical protein 0.0036 0.0109 0.0109
Treponema pallidum cyclic nucleotide binding protein 0.0036 0.0109 0.5
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0165 0.1297 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0054 0.0275 0.0322
Loa Loa (eye worm) hypothetical protein 0.0036 0.0109 0.0109
Echinococcus granulosus nervana 2 0.07 0.6221 0.9028
Loa Loa (eye worm) cytochrome P450 family protein 0.0143 0.1093 0.1093
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0424 0.0318
Echinococcus granulosus cGMP dependent protein kinase 1 0.0048 0.0222 0.0255
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0053 0.0268 0.0334
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0036 0.0109 0.0075
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0036 0.0109 0.0075
Brugia malayi Oxysterol-binding protein 0.0041 0.0155 0.0155
Trichomonas vaginalis AGC family protein kinase 0.1111 1 1
Echinococcus multilocularis Rho GTPase activating protein 24 0.0041 0.0155 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0054 0.0275 0.0318
Entamoeba histolytica PH domain containing protein 0.0041 0.0155 0.0155
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0328 0.2531
Schistosoma mansoni hypothetical protein 0.0448 0.3897 0.5623
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0041 0.0155 0.0155
Echinococcus granulosus protein kinase c epsilon type 0.037 0.3176 0.4575
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0036 0.0109 0.0075
Echinococcus multilocularis dynamin 1 0.0041 0.0155 0.0147
Echinococcus granulosus cytohesin 1 0.0041 0.0155 0.0157
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0088 0.0589 0.0792
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0268 0.0268
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0053 0.0268 0.016
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.037 0.3176 0.457
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.07 0.6221 0.9028
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0054 0.0275 0.0332
Schistosoma mansoni oxysterol-binding protein 1 0.0041 0.0155 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0041 0.0155 0.4721
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0754 0.6713 1
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0036 0.0109 0.0053
Echinococcus granulosus oxysterol binding protein 9 0.0041 0.0155 0.0157
Toxoplasma gondii phosphatidylinositol transfer protein 0.0041 0.0155 0.0101
Echinococcus granulosus pleckstrin y domain containing family A 0.0041 0.0155 0.0157
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0053 0.0268 0.0663
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0041 0.0155 0.4721
Onchocerca volvulus 0.0243 0.2013 0.4984
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0036 0.0109 0.3324
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0109 0.3324
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0041 0.0155 0.1195
Onchocerca volvulus 0.0041 0.0155 0.0384
Leishmania major hypothetical protein, conserved 0.0041 0.0155 0.0384
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0041 0.0155 0.1195
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Onchocerca volvulus 0.0036 0.0109 0.027
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Echinococcus multilocularis Protein kinase C, brain isozyme 0.037 0.3176 0.457
Echinococcus multilocularis Pleckstrin y 0.0041 0.0155 0.0147
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0053 0.0268 0.024
Echinococcus granulosus serine:threonine protein kinase N2 0.037 0.3176 0.4575
Loa Loa (eye worm) hypothetical protein 0.037 0.3176 0.3176
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0053 0.0268 0.016
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.07 0.6221 0.9027
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0155 0.0155
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0463 0.4039 0.4039
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0626 0.0831
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.037 0.3176 0.3176
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0054 0.0275 0.0322
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0036 0.0109 0.008
Echinococcus granulosus protein kinase c iota type 0.037 0.3176 0.4575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0196 0.0202
Brugia malayi Syntrophin-1 0.0041 0.0155 0.0155
Brugia malayi PH domain containing protein 0.0041 0.0155 0.0155
Entamoeba histolytica protein kinase, putative 0.0053 0.0268 0.0268
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0041 0.0155 0.1195
Echinococcus granulosus cGMP dependent protein kinase 0.0048 0.0222 0.0255
Onchocerca volvulus 0.0041 0.0155 0.0384
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0463 0.4039 0.5832
Trypanosoma cruzi hypothetical protein 0.0041 0.0155 0.007
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0041 0.0155 0.0155
Loa Loa (eye worm) Plekhf2 protein 0.0041 0.0155 0.0155
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0036 0.0109 0.0081
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.037 0.3176 0.4575
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0041 0.0155 0.0157
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0041 0.0155 0.1195
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0053 0.0268 0.024
Plasmodium falciparum calcium-dependent protein kinase 7 0.0053 0.0268 0.0255
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0041 0.0155 0.0157
Loa Loa (eye worm) PH domain-containing protein 0.0041 0.0155 0.0155
Echinococcus multilocularis pleckstrin y domain containing family A 0.0041 0.0155 0.0147
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0036 0.0109 0.0075
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.037 0.3176 0.4575
Leishmania major serine/threonine-protein kinase a, putative 0.0053 0.0268 0.0663
Loa Loa (eye worm) cytochrome P450 0.0041 0.0155 0.0155
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0036 0.0109 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0041 0.0155 0.0384
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0058 0.0015
Brugia malayi PH domain containing protein 0.0041 0.0155 0.0155
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0036 0.0109 0.008
Trichomonas vaginalis AGC family protein kinase 0.037 0.3176 0.3101
Toxoplasma gondii hypothetical protein 0.0041 0.0155 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0109 0.3324
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0088 0.0589 0.0783
Leishmania major cyclic nucleotide-binding protein-like protein 0.0036 0.0109 0.027
Entamoeba histolytica p21-activated kinase 0.0053 0.0268 0.0268
Echinococcus multilocularis protein kinase shaggy 0.0463 0.4039 0.5834
Schistosoma mansoni hypothetical protein 0.0041 0.0155 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Echinococcus multilocularis microtubule associated protein 2 0.0708 0.6293 0.9133
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0036 0.0109 0.009
Echinococcus granulosus hyperpolarization activated cyclic 0.0773 0.6886 1
Echinococcus granulosus sterol regulatory element binding protein 0.0068 0.0402 0.0518
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0041 0.0155 0.4721
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0036 0.0109 0.009
Trypanosoma cruzi cytochrome P450, putative 0.0143 0.1093 0.149
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.0155 0.0155
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0773 0.6886 1
Entamoeba histolytica protein kinase, putative 0.107 0.9621 0.9621
Loa Loa (eye worm) hypothetical protein 0.0054 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Brugia malayi PH domain containing protein 0.0041 0.0155 0.0155
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0041 0.0155 0.4721
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0041 0.0155 0.0142
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0054 0.0275 0.0318
Mycobacterium ulcerans transcriptional regulatory protein 0.0036 0.0109 0.0841
Entamoeba histolytica hypothetical protein 0.0041 0.0155 0.0155
Trypanosoma brucei protein kinase, putative 0.0463 0.4039 0.3974
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.0155 0.0155
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0058 0.0311 0.0311
Echinococcus multilocularis serine:threonine protein kinase 38 0.037 0.3176 0.457
Trypanosoma cruzi cytochrome P450, putative 0.0143 0.1093 0.149
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0041 0.0155 0.0147
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0041 0.0155 0.1195
Trypanosoma cruzi hypothetical protein 0.0041 0.0155 0.007
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0041 0.0155 0.0147
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0041 0.0155 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0463 0.4039 0.3974
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.037 0.3176 0.4575
Brugia malayi Oxysterol binding protein 0.0041 0.0155 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Brugia malayi PH domain containing protein 0.0041 0.0155 0.0155
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0041 0.0155 0.1195
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0041 0.0155 0.1195
Echinococcus granulosus serine threonine protein kinase nrc 0.0713 0.6334 0.9193
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0041 0.0155 0.4721
Brugia malayi Protein kinase domain containing protein 0.037 0.3176 0.3176
Echinococcus multilocularis beta 1 syntrophin 0.0041 0.0155 0.0147
Echinococcus multilocularis oxysterol binding protein 3 0.0041 0.0155 0.0147
Onchocerca volvulus Putative zinc finger protein 0.0041 0.0155 0.0384
Brugia malayi MAX-1A 0.0041 0.0155 0.0155
Brugia malayi Uncoordinated protein 104 0.0041 0.0155 0.0155
Leishmania major hypothetical protein, conserved 0.0036 0.0109 0.027
Entamoeba histolytica protein kinase, putative 0.0053 0.0268 0.0268
Echinococcus granulosus oxysterol binding protein 1 0.0041 0.0155 0.0157
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0328 0.2531
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0713 0.6334 0.9193
Echinococcus granulosus hyperpolarization activated cyclic 0.0773 0.6886 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0041 0.0155 0.1195
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0036 0.0109 0.008
Echinococcus multilocularis protein kinase c epsilon type 0.037 0.3176 0.457
Echinococcus multilocularis nervana 2 0.07 0.6221 0.9027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Onchocerca volvulus 0.0463 0.4039 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0041 0.0155 0.4721
Mycobacterium ulcerans hypothetical protein 0.0036 0.0109 0.0841
Trypanosoma brucei rac serine-threonine kinase, putative 0.1111 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0054 0.0275 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.037 0.3176 0.4567
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0041 0.0155 0.0069
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0041 0.0155 0.4721
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0041 0.0155 0.0157
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0041 0.0155 0.0147
Trichomonas vaginalis centaurin beta, putative 0.0041 0.0155 0.0046
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.0155 0.0155
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0155 0.0155
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0041 0.0155 0.0155
Giardia lamblia Kinase, CMGC GSK 0.0463 0.4039 0.6314
Loa Loa (eye worm) syntrophin-1 0.0041 0.0155 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0155 0.0046
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0773 0.6886 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0357 0.3064 0.2987
Echinococcus granulosus DCC interacting protein 13 beta 0.0041 0.0155 0.0157
Schistosoma mansoni voltage-gated potassium channel 0.0054 0.0275 0.0318
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0041 0.0155 0.1195
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Echinococcus granulosus pdz domain containing protein 0.0041 0.0155 0.0157
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0058 0.0005
Trichomonas vaginalis centaurin/arf, putative 0.0041 0.0155 0.0046
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0041 0.0155 0.0046
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.0155 0.0155
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0041 0.0155 0.1195
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0041 0.0155 0.0157
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0041 0.0155 0.0147
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0041 0.0155 0.0155
Mycobacterium ulcerans transmembrane transport protein 0.0036 0.0109 0.0841
Mycobacterium leprae Conserved hypothetical protein 0.0041 0.0155 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0058 0.0311 0.0311
Loa Loa (eye worm) AGC/PKG protein kinase 0.0048 0.0222 0.0222
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0036 0.0109 0.009
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0054 0.0275 0.0332
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0041 0.0155 0.4721
Loa Loa (eye worm) cytohesin 3 0.0041 0.0155 0.0155
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0041 0.0155 0.0155
Trichomonas vaginalis AGC family protein kinase 0.1111 1 1
Echinococcus granulosus myotubularin protein 13 0.0041 0.0155 0.0157
Trichomonas vaginalis CMGC family protein kinase 0.0463 0.4039 0.3974
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Echinococcus multilocularis myotubularin protein 13 0.0041 0.0155 0.0147
Mycobacterium ulcerans hypothetical protein 0.0036 0.0109 0.0841
Plasmodium vivax glycogen synthase kinase 3, putative 0.0463 0.4039 0.6344
Echinococcus multilocularis protein dispatched 1 0.0068 0.0402 0.0509
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0155 0.0074
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1951 0.1951
Schistosoma mansoni serine/threonine kinase 0.037 0.3176 0.4567
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0222 0.024
Brugia malayi Variant SH3 domain containing protein 0.0041 0.0155 0.0155
Toxoplasma gondii AtPH1 family protein 0.0041 0.0155 0.0101
Echinococcus multilocularis serine threonine protein kinase 0.037 0.3176 0.457
Echinococcus granulosus cGMP dependent protein kinase 1 0.0048 0.0222 0.0255
Onchocerca volvulus 0.0031 0.0058 0.0144
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0041 0.0155 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.037 0.3176 0.4567
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0307 0.2599 0.3721
Leishmania major hypothetical protein, conserved 0.0036 0.0109 0.027
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0268 0.016
Schistosoma mansoni zinc finger protein 0.0041 0.0155 0.0142
Schistosoma mansoni atypical protein kinase C 0.037 0.3176 0.4567
Echinococcus granulosus Oxysterol binding protein 11 0.0041 0.0155 0.0157
Entamoeba histolytica protein kinase, putative 0.0053 0.0268 0.0268

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -27 % The compound was evaluated for acute inhibition of cholesterol synthesis in rat; percent change of [14C]-cholesterol ChEMBL. 1875346
IC50 (binding) = 5 nM In vitro ability to inhibit solubilized, partially purified, rat liver HMG-CoA reductase ChEMBL. 1875346
Relative potency (ADMET) = 360 Relative potency of the compound was determined with respect to compactin ChEMBL. 1875346

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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