Detailed information for compound 1366535

Basic information

Technical information
  • TDR Targets ID: 1366535
  • Name: 2-methyl-N-undecylfuran-3-carboxamide
  • MW: 279.418 | Formula: C17H29NO2
  • H donors: 1 H acceptors: 1 LogP: 5.71 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCNC(=O)c1ccoc1C
  • InChi: 1S/C17H29NO2/c1-3-4-5-6-7-8-9-10-11-13-18-17(19)16-12-14-20-15(16)2/h12,14H,3-11,13H2,1-2H3,(H,18,19)
  • InChiKey: HYIIOWZELBDILQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-methyl-N-undecyl-furan-3-carboxamide
  • 2-methyl-N-undecyl-3-furancarboxamide
  • 2-methyl-N-undecyl-3-furamide
  • MLS000550500
  • SMR000114776
  • AK-968/12385351
  • IVK/8121214

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0286 0.8623 0.9472
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0405 0.0355
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.037 0.0371
Mycobacterium tuberculosis Conserved protein 0.0036 0.0604 0.0545
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0486 0.0534
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0188 0.016
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0873 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0584 0.5781
Brugia malayi RNA binding protein 0.0076 0.1899 0.2086
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0723 0.07
Brugia malayi Inositol-1 0.0045 0.0873 0.0959
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0604 0.607
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0723 0.0165
Loa Loa (eye worm) beta-lactamase 0.0036 0.0604 0.0664
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1899 0.2086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0584 0.0645
Trypanosoma brucei trypanothione reductase 0.0103 0.2744 0.4166
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0188 0.016
Trichomonas vaginalis esterase, putative 0.0036 0.0604 0.0601
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0584 0.0645
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0405 0.0355
Loa Loa (eye worm) hypothetical protein 0.003 0.0405 0.0445
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0873 0.0959
Echinococcus granulosus lamin 0.0033 0.0486 0.0507
Mycobacterium ulcerans hypothetical protein 0.0025 0.0232 0.0633
Entamoeba histolytica hypothetical protein 0.0043 0.0836 0.9457
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.6979 0.8898
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0052 0.0057
Schistosoma mansoni DNA polymerase eta 0.0054 0.1178 0.1132
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0584 0.0767
Brugia malayi TAR-binding protein 0.0076 0.1899 0.2086
Schistosoma mansoni inositol monophosphatase 0.0045 0.0873 0.0826
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0584 0.0622
Mycobacterium ulcerans lipase LipD 0.0036 0.0604 0.607
Treponema pallidum NADH oxidase 0.0036 0.0584 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0604 0.0545
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0584 0.0645
Brugia malayi glutathione reductase 0.0103 0.2744 0.3015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.6979 0.8834
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0604 0.607
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.6174 0.6783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1215 0.117
Brugia malayi Pre-SET motif family protein 0.003 0.0405 0.0445
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0584 0.0645
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0584 0.0645
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.2744 0.4166
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0188 0.0207
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0873 0.0959
Plasmodium falciparum thioredoxin reductase 0.0103 0.2744 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.8623 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0584 0.0645
Loa Loa (eye worm) RNA binding protein 0.0076 0.1899 0.2086
Brugia malayi Pre-SET motif family protein 0.0209 0.6174 0.6783
Brugia malayi hypothetical protein 0.0043 0.0836 0.0919
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1215 0.1358
Leishmania major hypothetical protein, conserved 0.0036 0.0604 0.0678
Leishmania major DNA polymerase eta, putative 0.0054 0.1178 0.1612
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.1178 0.1612
Loa Loa (eye worm) hypothetical protein 0.0286 0.8623 0.9472
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0604 0.0556
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0232 0.021
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0584 0.5781
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0604 0.0645
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.782 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0584 0.0645
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0604 0.0601
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0584 0.0572
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1215 0.1358
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.2764 0.3165
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0604 0.0678
Leishmania major hypothetical protein, conserved 0.0214 0.6324 1
Loa Loa (eye worm) glutathione reductase 0.0103 0.2744 0.3015
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0584 0.0767
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.1178 0.1612
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0584 0.0572
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0604 0.0545
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.782 1
Plasmodium vivax glutathione reductase, putative 0.0103 0.2744 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0604 0.0545
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0584 0.0645
Entamoeba histolytica hypothetical protein 0.0043 0.0836 0.9457
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1215 0.1335
Mycobacterium tuberculosis Conserved protein 0.0025 0.0232 0.0057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1375 0.1511
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0604 0.0545
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1899 0.1857
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0188 0.0138
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1899 0.1857
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0584 0.0645
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1215 0.1358
Schistosoma mansoni lamin 0.0033 0.0486 0.0437
Loa Loa (eye worm) hypothetical protein 0.0036 0.0604 0.0664
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.028 0.0308
Echinococcus granulosus tar DNA binding protein 0.0076 0.1899 0.2156
Leishmania major trypanothione reductase 0.0103 0.2744 0.4166
Schistosoma mansoni inositol monophosphatase 0.0045 0.0873 0.0826
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0584 0.0645
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1215 0.1358
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0604 0.0678
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0873 0.2002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0836 0.0915
Loa Loa (eye worm) hypothetical protein 0.0036 0.0604 0.0664
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.2744 0.3015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0873 0.1116
Trypanosoma cruzi hypothetical protein, conserved 0.0214 0.6324 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0604 0.0851
Schistosoma mansoni hypothetical protein 0.0043 0.0836 0.0789
Schistosoma mansoni hypothetical protein 0.0058 0.1312 0.1267
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0836 0.0789
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1899 0.2156
Brugia malayi beta-lactamase family protein 0.0036 0.0604 0.0664
Mycobacterium tuberculosis Conserved protein 0.0036 0.0604 0.0545
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1899 0.2086
Leishmania major DNA polymerase eta, putative 0.0038 0.0661 0.077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0405 0.0355
Echinococcus multilocularis lamin dm0 0.0033 0.0486 0.0507
Onchocerca volvulus 0.0036 0.0604 0.0229
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.6979 0.8898
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0052 0.0057
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0873 1
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0232 0.021
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0584 0.5781
Loa Loa (eye worm) hypothetical protein 0.03 0.9103 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0604 0.0556
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0232 0.0633
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0584 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0604 0.0678
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1899 0.1857
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0604 0.0664
Brugia malayi hypothetical protein 0.03 0.9103 1
Echinococcus multilocularis lamin 0.0033 0.0486 0.0507
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0873 0.099
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.2764 0.3165
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0873 0.099
Mycobacterium tuberculosis Probable reductase 0.0234 0.6979 0.8898
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.782 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0584 0.0645
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0604 0.0601
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0232 0.0633
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0873 0.1116
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1312 0.1441
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0584 0.0645
Schistosoma mansoni intermediate filament proteins 0.0033 0.0486 0.0437
Brugia malayi intermediate filament protein 0.0033 0.0486 0.0534
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0584 0.0645
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0604 0.0545
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0188 0.0138
Loa Loa (eye worm) hypothetical protein 0.006 0.1375 0.1511
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0762 0.0838
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.6979 0.8898
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0604 0.0545
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0232 0.0633
Brugia malayi beta-lactamase 0.0036 0.0604 0.0664
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1375 0.1511
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0405 0.0412
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0486 0.0534
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0405 0.0412
Loa Loa (eye worm) hypothetical protein 0.0033 0.0486 0.0534
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0604 0.0601
Onchocerca volvulus 0.0036 0.0604 0.0229
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.2744 0.3349
Onchocerca volvulus 0.0033 0.0486 0.0093
Onchocerca volvulus 0.0238 0.7105 0.7703
Schistosoma mansoni hypothetical protein 0.0041 0.0762 0.0715
Onchocerca volvulus 0.0033 0.0486 0.0093
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.2744 1
Trypanosoma brucei hypothetical protein, conserved 0.0214 0.6324 1
Entamoeba histolytica hypothetical protein 0.0043 0.0836 0.9457
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0584 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0873 0.1116
Onchocerca volvulus 0.0058 0.1312 0.1043
Onchocerca volvulus 0.03 0.9103 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0057
Mycobacterium tuberculosis Conserved protein 0.0036 0.0604 0.0545
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0873 0.1116
Toxoplasma gondii ABC1 family protein 0.0036 0.0604 0.0851
Trypanosoma cruzi hypothetical protein, conserved 0.0214 0.6324 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0486 0.0507
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.6883 0.8772
Loa Loa (eye worm) hypothetical protein 0.0036 0.0604 0.0664
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0836 0.0915
Loa Loa (eye worm) hypothetical protein 0.0032 0.0467 0.0513
Mycobacterium ulcerans hypothetical protein 0.0025 0.0232 0.0633
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0604 0.0545
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0584 0.0536
Entamoeba histolytica hypothetical protein 0.0043 0.0836 0.9457
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0584 0.0645
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0232 0.0071
Loa Loa (eye worm) hypothetical protein 0.0036 0.0604 0.0664
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0584 0.0519
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0584 0.0767
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0604 0.0645
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.6979 0.8898
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1375 0.1511
Loa Loa (eye worm) hypothetical protein 0.0054 0.1178 0.1294
Schistosoma mansoni lamin 0.0033 0.0486 0.0437
Echinococcus granulosus dna polymerase kappa 0.0023 0.0188 0.016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0762 0.0838
Echinococcus multilocularis dna polymerase eta 0.0054 0.1178 0.1314
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0584 0.0645
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.1178 0.1294
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0661 0.1094
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1215 0.1335
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0873 1
Brugia malayi Thioredoxin reductase 0.0103 0.2744 0.3015
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0584 0.0622
Loa Loa (eye worm) hypothetical protein 0.0036 0.0604 0.0664
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0584 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1899 0.1857
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1215 0.117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0405 0.0355
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0405 0.0412
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.782 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.6979 0.8898
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1215 0.117
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0604 0.0601
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0486 0.0534
Brugia malayi beta-lactamase family protein 0.0036 0.0604 0.0664
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.8623 1
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0188 0.016
Echinococcus granulosus lamin dm0 0.0033 0.0486 0.0507
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0584 0.0767
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0232 0.0071
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0661 0.077
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0873 0.099
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1899 0.2086
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0232 0.0057
Trichomonas vaginalis set domain proteins, putative 0.0238 0.7105 1
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0232 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0584 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1899 0.1857
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.028 0.0308
Loa Loa (eye worm) hypothetical protein 0.0036 0.0604 0.0664
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0584 0.0642
Mycobacterium ulcerans beta-lactamase 0.0036 0.0604 0.607
Echinococcus granulosus dna polymerase eta 0.0054 0.1178 0.1314
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0604 0.0601
Onchocerca volvulus 0.0036 0.0604 0.0229
Schistosoma mansoni survival motor neuron protein 0.0058 0.1312 0.1267
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0188 0.0207
Plasmodium falciparum glutathione reductase 0.0103 0.2744 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0604 0.0664
Toxoplasma gondii thioredoxin reductase 0.0103 0.2744 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0604 0.607
Loa Loa (eye worm) inositol-1 0.0045 0.0873 0.0959
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0232 0.0071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0052 0.0057
Echinococcus multilocularis musashi 0.0033 0.0486 0.0507

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 47.7548 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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