Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium channel, voltage-dependent, T type, alpha 1H subunit | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1283 | 0.1283 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2725 | 0.2521 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2725 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2725 | 0.2521 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0858 | 0.3148 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0858 | 0.0601 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2725 | 0.2725 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1127 | 0.0878 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3469 | 0.3285 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2725 | 0.2725 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2492 | 0.9107 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2725 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0208 | 0.969 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2725 | 0.2725 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2721 | 0.9985 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2725 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2725 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3196 | 0.3196 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2725 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1864 | 0.1636 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0122 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0858 | 0.0858 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0976 | 0.3281 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1864 | 0.1636 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2725 | 0.2521 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1404 | 0.1404 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2725 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1864 | 0.1864 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2492 | 0.9107 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0976 | 0.3281 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1132 | 0.1132 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1864 | 0.1864 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2725 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 8.91 uM | PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channel. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID493021, AID493022, AID493023, AID493041, AID504579, AID504584, AID504619, AID504628] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.8584 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.