Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3155 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.7842 | 0.7823 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0808 | 0.2561 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2284 | 0.724 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0808 | 0.0728 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.719 | 0.7166 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0808 | 0.0728 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3155 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0086 | 0.0271 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3155 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3155 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2284 | 0.724 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0808 | 0.2561 |
Schistosoma mansoni | lamin | 0.0033 | 0.0808 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0776 | 0.246 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0808 | 0.0728 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0808 | 0.2561 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.719 | 0.7166 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0086 | 0.0271 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3155 | 0.3096 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0086 | 0.0271 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0808 | 0.0728 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0808 | 0.2561 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0086 | 0.0271 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0164 | 0.7842 | 0.7823 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.3096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.3096 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2284 | 0.724 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1267 | 0.1191 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2284 | 0.724 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0808 | 0.0728 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0808 | 0.2561 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0808 | 0.0728 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.719 | 0.7166 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1267 | 0.4015 |
Echinococcus granulosus | lamin | 0.0033 | 0.0808 | 0.0728 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.3096 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1267 | 0.4015 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.3096 |
Onchocerca volvulus | 0.0033 | 0.0808 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3155 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.3096 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3155 | 0.3096 |
Onchocerca volvulus | 0.0033 | 0.0808 | 0.5 | |
Schistosoma mansoni | lamin | 0.0033 | 0.0808 | 0.0728 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.7842 | 0.7823 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.02 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 5.1735 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.