Detailed information for compound 1366790

Basic information

Technical information
  • TDR Targets ID: 1366790
  • Name: N-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)-( 1,3,5-trimethylpyrazol-4-yl)sulfonylamino]ace tamide
  • MW: 472.557 | Formula: C23H28N4O5S
  • H donors: 1 H acceptors: 4 LogP: 2.95 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)NC(=O)CN(S(=O)(=O)c1c(C)nn(c1C)C)c1ccc(cc1)C
  • InChi: 1S/C23H28N4O5S/c1-15-7-10-19(11-8-15)27(33(29,30)23-16(2)25-26(4)17(23)3)14-22(28)24-18-9-12-20(31-5)21(13-18)32-6/h7-13H,14H2,1-6H3,(H,24,28)
  • InChiKey: HVQOQULHOCGYOK-UHFFFAOYSA-N  

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Synonyms

  • N-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)-(1,3,5-trimethylpyrazol-4-yl)sulfonyl-amino]acetamide
  • N-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)-[(1,3,5-trimethyl-4-pyrazolyl)sulfonyl]amino]acetamide
  • N-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)-(1,3,5-trimethylpyrazol-4-yl)sulfonyl-amino]ethanamide
  • MLS000092315
  • MLS000877070
  • SMR000027392
  • N~1~-(3,4-dimethoxyphenyl)-N~2~-(4-methylphenyl)-N~2~-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]glycinamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi G protein-coupled receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus 0.0029 0.1547 0.1152
Onchocerca volvulus Cathepsin L homolog 0.002 0.0496 0.0053
Echinococcus granulosus neuropeptides capa receptor 0.01 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0866 0.0439
Schistosoma mansoni adenoreceptor 0.01 1 1
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0029 0.1547 0.1152
Loa Loa (eye worm) neuropeptide F receptor 0.01 1 1
Echinococcus multilocularis g-protein coupled receptor 0.01 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7296 1
Echinococcus multilocularis sex peptide receptor 0.01 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.01 1 1
Brugia malayi neuropeptide F receptor 0.01 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.01 1 1
Schistosoma mansoni hypothetical protein 0.01 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0496 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0496 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0866 0.0543
Brugia malayi Dopamine receptor 0.01 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7296 1
Onchocerca volvulus 0.01 1 1
Giardia lamblia DINP protein human, muc B family 0.0023 0.0866 0.5
Onchocerca volvulus 0.01 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.01 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0496 0.0053
Echinococcus granulosus g-protein coupled receptor 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Onchocerca volvulus 0.01 1 1
Schistosoma mansoni hypothetical protein 0.01 1 1
Echinococcus multilocularis fmrfamide receptor 0.01 1 1
Plasmodium vivax vivapain-2 0.002 0.0496 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0866 0.5
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.5322 0.7098
Schistosoma mansoni opsin-like receptor 0.01 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Onchocerca volvulus 0.002 0.0496 0.0053
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.01 1 1
Onchocerca volvulus 0.01 1 1
Onchocerca volvulus 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.01 1 1
Plasmodium vivax vivapain-2 0.002 0.0496 0.5
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Echinococcus granulosus G protein coupled receptor 139 0.01 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0866 0.0439
Schistosoma mansoni neuropeptide F-like receptor 0.01 1 1
Onchocerca volvulus 0.01 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0866 0.1186
Onchocerca volvulus Cathepsin L homolog 0.002 0.0496 0.0053
Onchocerca volvulus 0.01 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0866 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.01 1 1
Echinococcus multilocularis g protein coupled receptor 0.01 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0866 0.5
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Schistosoma mansoni amine GPCR 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus dna polymerase eta 0.0054 0.4547 0.4292
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Echinococcus granulosus neuropeptide Y receptor 0.01 1 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0866 0.0439
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis fmrfamide receptor 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0866 0.0543
Brugia malayi Melatonin receptor type 1A 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.01 1 1
Schistosoma mansoni amine GPCR 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 1 1
Onchocerca volvulus 0.01 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.7296 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Echinococcus granulosus somatostatin receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Echinococcus granulosus g protein coupled receptor 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Onchocerca volvulus 0.002 0.0496 0.0053
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.01 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.01 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni organic anion transporter 0.0029 0.1547 0.1152
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0029 0.1547 0.1152
Echinococcus granulosus fmrfamide receptor 0.01 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.6496 0.8824
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0866 0.0439
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.01 1 1
Onchocerca volvulus 0.0029 0.1547 0.1152
Onchocerca volvulus 0.002 0.0496 0.0053
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.01 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 1 1
Toxoplasma gondii cathepsin CPL 0.002 0.0496 0.0231
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.01 1 1
Brugia malayi Dopamine receptor protein 2 0.01 1 1
Echinococcus multilocularis g protein coupled receptor 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Echinococcus granulosus allatostatin A receptor 0.01 1 1
Onchocerca volvulus 0.002 0.0496 0.0053
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.01 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Onchocerca volvulus 0.002 0.0496 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0496 0.0053
Onchocerca volvulus 0.01 1 1
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0866 0.1186
Schistosoma mansoni neuropeptide f receptor 76f 0.01 1 1
Onchocerca volvulus 0.0029 0.1547 0.1152
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Echinococcus granulosus sex peptide receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Schistosoma mansoni biogenic amine receptor 0.01 1 1
Onchocerca volvulus 0.01 1 1
Onchocerca volvulus 0.01 1 1
Echinococcus multilocularis g protein coupled receptor 0.01 1 1
Brugia malayi G-protein coupled receptor 0.01 1 1
Onchocerca volvulus 0.0029 0.1547 0.1152
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.1547 0.5056
Echinococcus multilocularis serotonin receptor 0.01 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.01 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.01 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.01 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.01 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.01 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0866 0.0543
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.01 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Loa Loa (eye worm) G-protein coupled receptor 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Echinococcus multilocularis serotonin receptor 0.01 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.4547 0.6232
Echinococcus granulosus g protein coupled receptor 0.01 1 1
Schistosoma mansoni biogenic amine receptor 0.01 1 1
Onchocerca volvulus 0.0029 0.1547 0.1152
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7296 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0496 0.0053
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.01 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.01 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0866 0.1186
Onchocerca volvulus Cathepsin F homolog 0.002 0.0496 0.0053
Echinococcus granulosus neuropeptide receptor 0.01 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0866 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi Serotonin receptor 0.01 1 1
Echinococcus multilocularis neuropeptide receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.01 1 1
Leishmania major cathepsin L-like protease 0.0077 0.7296 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Echinococcus multilocularis cysteine protease 0.002 0.0496 0.0053
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0866 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Schistosoma mansoni hypothetical protein 0.01 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.01 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.01 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.01 1 1
Leishmania major cathepsin L-like protease 0.0077 0.7296 1
Brugia malayi Serotonin receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Onchocerca volvulus Neuropeptide F receptor homolog 0.01 1 1
Onchocerca volvulus 0.01 1 1
Onchocerca volvulus 0.002 0.0496 0.0053
Schistosoma mansoni opsin-like receptor 0.01 1 1
Trypanosoma brucei unspecified product 0.0023 0.0866 0.1186
Trypanosoma cruzi MFS transporter, putative 0.0029 0.1547 0.1545
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0496 0.0053
Brugia malayi hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) fibroinase 0.002 0.0496 0.0053
Loa Loa (eye worm) TYRA-2 protein 0.01 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.01 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Brugia malayi hypothetical protein 0.0029 0.1547 0.1152
Echinococcus multilocularis G protein coupled receptor 139 0.01 1 1
Echinococcus granulosus hypothetical protein 0.01 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.01 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0866 0.0439
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.01 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Echinococcus granulosus g protein coupled receptor 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Brugia malayi ORL1-like opioid receptor 0.01 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0496 0.5
Onchocerca volvulus 0.01 1 1
Brugia malayi follicle stimulating hormone receptor 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.01 1 1
Leishmania major DNA polymerase eta, putative 0.0038 0.2623 0.3128
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0866 0.0439
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0496 0.0053
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0496 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Leishmania major DNA polymerase kappa, putative 0.0023 0.0866 0.0543
Echinococcus granulosus thyrotropin releasing hormone receptor 0.01 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Echinococcus multilocularis dna polymerase eta 0.0054 0.4547 0.4292
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus neuropeptide s receptor 0.01 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.4547 0.5957
Echinococcus granulosus 7tm_1 domain containing protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.01 1 1
Echinococcus multilocularis somatostatin receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Brugia malayi prostaglandin transporter 0.0029 0.1547 0.1152
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.01 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.01 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.01 1 1
Leishmania major DNA polymerase eta, putative 0.0054 0.4547 0.5957
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi G-protein coupled receptor 0.01 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 1 1
Brugia malayi RE15519p 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0496 0.5
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0866 1
Onchocerca volvulus 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Brugia malayi putative neuropeptide receptor 0.01 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0866 0.0543
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi Dopamine receptor protein 1 0.01 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.01 1 1
Onchocerca volvulus 0.01 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.01 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Brugia malayi hypothetical protein 0.0029 0.1547 0.1152
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0866 0.0439
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) ctsf protein 0.002 0.0496 0.0053
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus neuropeptides capa receptor 0.01 1 1
Schistosoma mansoni biogenic amine receptor 0.01 1 1
Brugia malayi GnHR receptor homolog 0.01 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0496 0.0053
Echinococcus multilocularis orexin receptor type 2 0.01 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.01 1 1
Brugia malayi sulfakinin receptor protein 0.01 1 1
Echinococcus granulosus serotonin receptor 0.01 1 1
Schistosoma mansoni organic anion transporter 0.0029 0.1547 0.1152
Echinococcus multilocularis allatostatin A receptor 0.01 1 1
Echinococcus granulosus neuropeptide receptor A26 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.01 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0866 0.0439
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.4547 0.4292
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 1 1
Schistosoma mansoni amine GPCR 0.01 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0496 0.0053
Echinococcus multilocularis G-protein coupled receptor, putative 0.01 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0496 0.0053
Schistosoma mansoni myosin xvIII 0.01 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Echinococcus granulosus Solute carrier organic anion transporter family 0.0029 0.1547 0.1152
Brugia malayi putative neuropeptide receptor NPR1 0.01 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.01 1 1
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0029 0.1547 0.1152
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.2623 1
Echinococcus granulosus neuropeptide receptor 0.01 1 1
Onchocerca volvulus Putative organic anion transporter 0.0029 0.1547 0.1152
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.1547 0.1152
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.01 1 1
Echinococcus multilocularis cysteine protease 0.002 0.0496 0.0053
Schistosoma mansoni opsin-like receptor 0.01 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.4547 0.4292
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus neuropeptide Y receptor 0.01 1 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.1547 0.1152
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.01 1 1
Echinococcus multilocularis neuropeptide receptor 0.01 1 1
Brugia malayi neuropeptide F receptor 0.01 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.01 1 1
Brugia malayi larval opioid receptor 0.01 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.01 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0496 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Schistosoma mansoni DNA polymerase eta 0.0054 0.4547 0.4292
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0029 0.1547 0.1152
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0866 1
Onchocerca volvulus 0.01 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 1 1
Echinococcus granulosus orexin receptor type 2 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Onchocerca volvulus Putative organic anion transporter 0.0029 0.1547 0.1152
Schistosoma mansoni amine GPCR 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.01 1 1
Leishmania major cathepsin L-like protease 0.0077 0.7296 1
Brugia malayi AKH receptor 0.01 1 1
Echinococcus granulosus cathepsin l1 0.002 0.0496 0.0053
Schistosoma mansoni amine GPCR 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.01 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) cysteine protease 0.002 0.0496 0.0053
Onchocerca volvulus 0.002 0.0496 0.0053
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.01 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0496 0.0053
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus Putative organic anion transporter 0.0029 0.1547 0.1152
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.01 1 1
Schistosoma mansoni hypothetical protein 0.01 1 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.1547 0.1152
Onchocerca volvulus 0.01 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.2623 0.3128
Echinococcus multilocularis neuropeptide s receptor 0.01 1 1
Schistosoma mansoni histamine h1 receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0866 0.0543

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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