Detailed information for compound 1366790

Basic information

Technical information
  • TDR Targets ID: 1366790
  • Name: N-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)-( 1,3,5-trimethylpyrazol-4-yl)sulfonylamino]ace tamide
  • MW: 472.557 | Formula: C23H28N4O5S
  • H donors: 1 H acceptors: 4 LogP: 2.95 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)NC(=O)CN(S(=O)(=O)c1c(C)nn(c1C)C)c1ccc(cc1)C
  • InChi: 1S/C23H28N4O5S/c1-15-7-10-19(11-8-15)27(33(29,30)23-16(2)25-26(4)17(23)3)14-22(28)24-18-9-12-20(31-5)21(13-18)32-6/h7-13H,14H2,1-6H3,(H,24,28)
  • InChiKey: HVQOQULHOCGYOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)-(1,3,5-trimethylpyrazol-4-yl)sulfonyl-amino]acetamide
  • N-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)-[(1,3,5-trimethyl-4-pyrazolyl)sulfonyl]amino]acetamide
  • N-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)-(1,3,5-trimethylpyrazol-4-yl)sulfonyl-amino]ethanamide
  • MLS000092315
  • MLS000877070
  • SMR000027392
  • N~1~-(3,4-dimethoxyphenyl)-N~2~-(4-methylphenyl)-N~2~-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]glycinamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Echinococcus granulosus sex peptide receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0029 0.1547 0.1152
Onchocerca volvulus 0.0029 0.1547 0.1152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0866 0.0543
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0866 0.0439
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0866 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0496 0.0053
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0496 0.0053
Brugia malayi Serotonin receptor 0.01 1 1
Brugia malayi G-protein coupled receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0496 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 1 1
Echinococcus granulosus g protein coupled receptor 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0866 0.1186
Brugia malayi putative neuropeptide receptor 0.01 1 1
Onchocerca volvulus 0.01 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 1 1
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0029 0.1547 0.1152
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7296 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.01 1 1
Schistosoma mansoni amine GPCR 0.01 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.01 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0866 0.0543
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus 0.002 0.0496 0.0053
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi prostaglandin transporter 0.0029 0.1547 0.1152
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.01 1 1
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0866 0.0439
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0496 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.01 1 1
Echinococcus granulosus G protein coupled receptor 139 0.01 1 1
Onchocerca volvulus 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.01 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0866 0.5
Onchocerca volvulus 0.002 0.0496 0.0053
Brugia malayi gonadotropin-releasing hormone receptor 2 0.01 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0866 0.5
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0029 0.1547 0.1152
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.01 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.01 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0496 0.0053
Schistosoma mansoni amine GPCR 0.01 1 1
Echinococcus granulosus g-protein coupled receptor 0.01 1 1
Echinococcus multilocularis sex peptide receptor 0.01 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0866 0.0439
Echinococcus multilocularis neuropeptide Y receptor 0.01 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.7296 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0496 0.0053
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Echinococcus granulosus hypothetical protein 0.01 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.01 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.01 1 1
Echinococcus granulosus orexin receptor type 2 0.01 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.01 1 1
Onchocerca volvulus 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Schistosoma mansoni biogenic amine receptor 0.01 1 1
Echinococcus granulosus Solute carrier organic anion transporter family 0.0029 0.1547 0.1152
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Loa Loa (eye worm) ctsf protein 0.002 0.0496 0.0053
Schistosoma mansoni peptide (allatostatin)-like receptor 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.01 1 1
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Echinococcus multilocularis fmrfamide receptor 0.01 1 1
Schistosoma mansoni histamine h1 receptor 0.01 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.4547 0.5957
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Schistosoma mansoni DNA polymerase eta 0.0054 0.4547 0.4292
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0496 0.5
Brugia malayi RE15519p 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Brugia malayi hypothetical protein 0.0029 0.1547 0.1152
Echinococcus multilocularis G-protein coupled receptor, putative 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus neuropeptide s receptor 0.01 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.01 1 1
Schistosoma mansoni opsin-like receptor 0.01 1 1
Loa Loa (eye worm) fibroinase 0.002 0.0496 0.0053
Onchocerca volvulus 0.002 0.0496 0.0053
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.6496 0.8824
Echinococcus granulosus dro:myosuppressin receptor 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Echinococcus multilocularis fmrfamide receptor 0.01 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0866 0.0439
Echinococcus granulosus biogenic amine 5HT receptor 0.01 1 1
Brugia malayi follicle stimulating hormone receptor 0.01 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.01 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0866 0.0543
Schistosoma mansoni biogenic amine receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Schistosoma mansoni organic anion transporter 0.0029 0.1547 0.1152
Onchocerca volvulus 0.01 1 1
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0029 0.1547 0.1152
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.01 1 1
Leishmania major DNA polymerase eta, putative 0.0054 0.4547 0.5957
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.01 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.01 1 1
Plasmodium vivax vivapain-2 0.002 0.0496 0.5
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0866 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.01 1 1
Brugia malayi Melatonin receptor type 1A 0.01 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.4547 0.4292
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus 0.002 0.0496 0.0053
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus 0.0029 0.1547 0.1152
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis g protein coupled receptor 0.01 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Onchocerca volvulus 0.002 0.0496 0.0053
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0496 0.0053
Echinococcus multilocularis neuropeptide s receptor 0.01 1 1
Echinococcus granulosus neuropeptides capa receptor 0.01 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Schistosoma mansoni adenoreceptor 0.01 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.01 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0496 0.0053
Onchocerca volvulus 0.01 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni hypothetical protein 0.01 1 1
Echinococcus granulosus serotonin receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0496 0.0053
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.1547 0.1152
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0866 0.0439
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Toxoplasma gondii cathepsin CPL 0.002 0.0496 0.0231
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0866 0.1186
Brugia malayi putative neuropeptide receptor NPR1 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Leishmania major cathepsin L-like protease 0.0077 0.7296 1
Brugia malayi G protein-coupled receptor F59B2.13 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.01 1 1
Schistosoma mansoni amine GPCR 0.01 1 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.1547 0.1152
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus 0.0029 0.1547 0.1152
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.01 1 1
Onchocerca volvulus 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus neuropeptides capa receptor 0.01 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.01 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Trypanosoma cruzi MFS transporter, putative 0.0029 0.1547 0.1545
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.1547 0.1152
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Schistosoma mansoni hypothetical protein 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Onchocerca volvulus 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Onchocerca volvulus 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus g protein coupled receptor 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni opsin-like receptor 0.01 1 1
Brugia malayi neuropeptide F receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus Putative organic anion transporter 0.0029 0.1547 0.1152
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Onchocerca volvulus 0.002 0.0496 0.0053
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0496 0.0053
Schistosoma mansoni opsin-like receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.01 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.01 1 1
Echinococcus multilocularis cysteine protease 0.002 0.0496 0.0053
Onchocerca volvulus Putative organic anion transporter 0.0029 0.1547 0.1152
Echinococcus multilocularis g protein coupled receptor 0.01 1 1
Brugia malayi ORL1-like opioid receptor 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.01 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.4547 0.6232
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0866 0.0439
Echinococcus multilocularis allatostatin A receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Onchocerca volvulus 0.01 1 1
Onchocerca volvulus 0.0029 0.1547 0.1152
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.01 1 1
Onchocerca volvulus Putative organic anion transporter 0.0029 0.1547 0.1152
Echinococcus multilocularis serotonin receptor 0.01 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.01 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0496 0.0053
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.01 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Brugia malayi neuropeptide F receptor 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.01 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Echinococcus granulosus peptide allatostatin:somatostatin 0.01 1 1
Onchocerca volvulus 0.01 1 1
Plasmodium vivax vivapain-2 0.002 0.0496 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.1547 0.1152
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Schistosoma mansoni biogenic amine receptor 0.01 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.01 1 1
Brugia malayi G-protein coupled receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.01 1 1
Onchocerca volvulus 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0866 0.0439
Leishmania major DNA polymerase eta, putative 0.0038 0.2623 0.3128
Echinococcus multilocularis neuropeptide receptor 0.01 1 1
Brugia malayi G protein-coupled receptor 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Echinococcus granulosus tm gpcr rhodopsin 0.01 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.01 1 1
Echinococcus multilocularis g-protein coupled receptor 0.01 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0866 0.0543
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus dna polymerase eta 0.0054 0.4547 0.4292
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0866 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.4547 0.4292
Echinococcus multilocularis somatostatin receptor 0.01 1 1
Echinococcus multilocularis serotonin receptor 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Leishmania major cathepsin L-like protease 0.0077 0.7296 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0866 1
Echinococcus granulosus neuropeptide Y receptor 0.01 1 1
Brugia malayi hypothetical protein 0.0029 0.1547 0.1152
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus 0.01 1 1
Onchocerca volvulus 0.0029 0.1547 0.1152
Onchocerca volvulus 0.01 1 1
Brugia malayi Dopamine receptor 0.01 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus 0.01 1 1
Echinococcus granulosus g protein coupled receptor 0.01 1 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0496 0.0053
Brugia malayi Dopamine receptor protein 2 0.01 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus neuropeptide receptor 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Loa Loa (eye worm) neuropeptide F receptor 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0496 0.0053
Schistosoma mansoni amine GPCR 0.01 1 1
Echinococcus granulosus neuropeptide receptor 0.01 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.01 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.01 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni organic anion transporter 0.0029 0.1547 0.1152
Onchocerca volvulus Cathepsin F homolog 0.002 0.0496 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Echinococcus multilocularis neuropeptide Y receptor 0.01 1 1
Echinococcus granulosus neuropeptide receptor A26 0.01 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.2623 0.3128
Schistosoma mansoni amine GPCR 0.01 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0866 0.0439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Brugia malayi Serotonin receptor 0.01 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0496 0.0053
Echinococcus multilocularis neuropeptide receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus cathepsin l1 0.002 0.0496 0.0053
Brugia malayi GnHR receptor homolog 0.01 1 1
Echinococcus multilocularis dna polymerase eta 0.0054 0.4547 0.4292
Leishmania major cathepsin L-like protease 0.0077 0.7296 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0866 0.1186
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.01 1 1
Brugia malayi larval opioid receptor 0.01 1 1
Schistosoma mansoni hypothetical protein 0.01 1 1
Brugia malayi AKH receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) cysteine protease 0.002 0.0496 0.0053
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.1547 0.5056
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.01 1 1
Brugia malayi sulfakinin receptor protein 0.01 1 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.0866 0.0543
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.01 1 1
Onchocerca volvulus 0.01 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.01 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7296 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.01 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.01 1 1
Echinococcus granulosus allatostatin A receptor 0.01 1 1
Onchocerca volvulus 0.002 0.0496 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0866 0.1186
Schistosoma mansoni myosin xvIII 0.01 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.01 1 1
Brugia malayi Dopamine receptor protein 1 0.01 1 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.2623 1
Echinococcus multilocularis cysteine protease 0.002 0.0496 0.0053
Brugia malayi hypothetical protein 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Echinococcus multilocularis tachykinin peptides receptor 99D 0.01 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.01 1 1
Onchocerca volvulus 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0496 0.0053
Brugia malayi Tachykinin-like peptides receptor 99D 0.01 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.5322 0.7098
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0866 1
Echinococcus multilocularis orexin receptor type 2 0.01 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7296 1
Echinococcus multilocularis g protein coupled receptor 0.01 1 1
Trypanosoma brucei unspecified product 0.0023 0.0866 0.1186
Echinococcus granulosus somatostatin receptor 0.01 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.01 1 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0496 0.0053
Giardia lamblia DINP protein human, muc B family 0.0023 0.0866 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7296 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.01 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0866 0.0543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Echinococcus granulosus fmrfamide receptor 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0496 0.0053
Schistosoma mansoni hypothetical protein 0.01 1 1
Onchocerca volvulus 0.01 1 1
Loa Loa (eye worm) TYRA-2 protein 0.01 1 1
Echinococcus granulosus neuropeptide Y receptor 0.01 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.