Detailed information for compound 1367017

Basic information

Technical information
  • TDR Targets ID: 1367017
  • Name: 8-ethyl-3-(morpholine-4-carbonyl)-1H-quinolin -4-one
  • MW: 286.326 | Formula: C16H18N2O3
  • H donors: 1 H acceptors: 3 LogP: 2.27 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc2c1ncc(c2O)C(=O)N1CCOCC1
  • InChi: 1S/C16H18N2O3/c1-2-11-4-3-5-12-14(11)17-10-13(15(12)19)16(20)18-6-8-21-9-7-18/h3-5,10H,2,6-9H2,1H3,(H,17,19)
  • InChiKey: FKTVWNYHCLDGPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-ethyl-3-(morpholino-oxomethyl)-1H-quinolin-4-one
  • 8-ethyl-3-(morpholine-4-carbonyl)-4-quinolone
  • 8-ethyl-3-morpholin-4-ylcarbonyl-1H-quinolin-4-one
  • SMR000006211
  • (8-Ethyl-4-hydroxy-quinolin-3-yl)-morpholin-4-yl-methanone
  • MLS000074125
  • ASN 06217871

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.016 0.0309
Echinococcus granulosus glutamate synthase 0.0107 0.0712 0.142
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0212 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0312
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0251 0.05
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0143 0.0285
Trichomonas vaginalis glutaminase, putative 0.0273 0.1936 0.6631
Trypanosoma cruzi trypanothione reductase, putative 0.0405 0.2917 0.2901
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0285 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0028 0.0077
Loa Loa (eye worm) glutathione reductase 0.0549 0.3988 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0107 0.0712 0.2427
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0183 0.016
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0251 0.0228
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0107 0.0712 0.0691
Brugia malayi Pre-SET motif family protein 0.0031 0.0143 0.0313
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0143 0.0302
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0107 0.0712 0.1555
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0107 0.0712 0.1555
Echinococcus granulosus thioredoxin glutathione reductase 0.0549 0.3988 0.7949
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0238 0.0798
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0019 0.0037
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0107 0.0712 0.2381
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0238 0.0798
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0238 0.0742
Brugia malayi beta-lactamase family protein 0.0043 0.0238 0.0553
Treponema pallidum NADH oxidase 0.0405 0.2917 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0012
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0107 0.0712 0.0691
Schistosoma mansoni sulfide quinone reductase 0.0107 0.0712 0.1289
Plasmodium falciparum ferrodoxin reductase-like protein 0.0107 0.0712 0.1567
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0107 0.0712 0.0691
Echinococcus granulosus microtubule associated protein 2 0.0688 0.5017 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0405 0.2917 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0612 0.4455 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.115 0.8442 0.8438
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Onchocerca volvulus 0.0043 0.0238 0.0727
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0284 0.0669
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0272
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0032 0.0064
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0405 0.2917 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0143 0.0259
Schistosoma mansoni hypothetical protein 0.0107 0.0712 0.1289
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0237 0.0429
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0247 0.0492
Loa Loa (eye worm) hypothetical protein 0.0107 0.0712 0.176
Echinococcus granulosus tumor protein p63 0.034 0.2437 0.4857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0097 0.0313
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0405 0.2917 0.2901
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Brugia malayi beta-lactamase 0.0043 0.0238 0.0553
Brugia malayi glutamate synthase 0.0107 0.0712 0.1748
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0612 0.4455 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0238 0.0474
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0143 0.0259
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0165 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.176 0.4397
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0189 0.0376
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0315 0.225 0.5025
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0251 0.0585
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0107 0.0712 0.1567
Mycobacterium tuberculosis Conserved protein 0.0043 0.0238 0.0485
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0251 0.0228
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0107 0.0712 0.1567
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0028 0.0051
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0124 0.0281
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0107 0.0712 0.1567
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0019 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0374 0.0677
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0405 0.2917 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0166
Schistosoma mansoni intermediate filament proteins 0.0028 0.0124 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0251 0.0843
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0143 0.0285
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0107 0.0712 0.1738
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0107 0.0712 0.142
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0107 0.0712 0.1738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Schistosoma mansoni inositol monophosphatase 0.0037 0.0189 0.0341
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0166
Loa Loa (eye worm) hypothetical protein 0.0045 0.0247 0.0589
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.2939 0.5859
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0107 0.0712 0.2381
Loa Loa (eye worm) programmed cell death 8 0.0107 0.0712 0.176
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0107 0.0712 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0212 0.0488
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.016 0.0309
Plasmodium vivax SET domain protein, putative 0.0031 0.0143 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0251 0.0843
Echinococcus granulosus neuropeptide s receptor 0.0468 0.3382 0.6741
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0247 0.0828
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0405 0.2917 1
Leishmania major NADH dehydrogenase, putative 0.0107 0.0712 0.0691
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0182 0.0607
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0124 0.0266
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0107 0.0712 0.1738
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0251 0.0454
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.136 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0405 0.2917 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0107 0.0712 0.0691
Trichomonas vaginalis set domain proteins, putative 0.0239 0.1687 0.5777
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0019 0.0034
Schistosoma mansoni cpg binding protein 0.003 0.014 0.0253
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0104 0.0081
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.013 0.0259
Schistosoma mansoni cytochrome P450 0.0015 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0251 0.0843
Mycobacterium tuberculosis Probable oxidoreductase 0.0612 0.4455 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0141 0.0463
Onchocerca volvulus 0.0043 0.0238 0.0727
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0297 0.212 0.5295
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0143 0.0259
Giardia lamblia NADH oxidase lateral transfer candidate 0.0405 0.2917 1
Schistosoma mansoni lamin 0.0028 0.0124 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0097 0.0313
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0405 0.2917 0.7302
Schistosoma mansoni glutamate synthase 0.0107 0.0712 0.1289
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0107 0.0712 0.142
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0107 0.0712 0.142
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0251 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0182 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0097 0.0313
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0712 0.0691
Mycobacterium leprae Probable lipase LipE 0.0043 0.0238 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0312
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0284 0.0683
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0212 0.0423
Echinococcus granulosus intermediate filament protein 0.0028 0.0124 0.0248
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0168 0.0375
Giardia lamblia GTOR 0.0045 0.0251 0.0016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0143 0.0285
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0104 0.0203
Trypanosoma cruzi trypanothione reductase, putative 0.0549 0.3988 0.3974
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0019 0.0034
Schistosoma mansoni hypothetical protein 0.0408 0.2939 0.5319
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0189 0.0629
Echinococcus multilocularis tumor protein p63 0.034 0.2437 0.4857
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0058
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0238 0.0485
Onchocerca volvulus 0.0043 0.0238 0.0727
Mycobacterium tuberculosis Conserved protein 0.0043 0.0238 0.0485
Echinococcus multilocularis glutamate synthase 0.0107 0.0712 0.142
Toxoplasma gondii thioredoxin reductase 0.0549 0.3988 1
Echinococcus multilocularis 0.0015 0.0023 0.0046
Entamoeba histolytica thioredoxin reductase, putative 0.0107 0.0712 1
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0058
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0107 0.0712 0.142
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0107 0.0712 0.1748
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.5017 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0238 0.0742
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0074 0.0051
Leishmania major hypothetical protein, conserved 0.0043 0.0238 0.0215
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0405 0.2917 0.5815
Leishmania major acetoin dehydrogenase e3 component-like protein 0.1009 0.7399 0.7393
Mycobacterium tuberculosis Probable reductase 0.0315 0.225 0.5025
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0107 0.0712 0.0691
Schistosoma mansoni cpg binding protein 0.003 0.014 0.0253
Echinococcus granulosus cpg binding protein 0.003 0.014 0.0279
Toxoplasma gondii NADPH-glutathione reductase 0.0405 0.2917 0.7299
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0405 0.2917 0.5815
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0247 0.0224
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0251 0.06
Echinococcus granulosus lamin dm0 0.0028 0.0124 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0247 0.0828
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0028 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0032 0.005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0107 0.0712 0.1748
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0212 0.0423
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0238 0.0346
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0107 0.0712 0.142
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Schistosoma mansoni sulfide quinone reductase 0.0107 0.0712 0.1289
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.017 0.0566
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1009 0.7399 0.7393
Schistosoma mansoni hypothetical protein 0.0177 0.1226 0.222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0182 0.0607
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0107 0.0712 0.0691
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0107 0.0712 0.2381
Trichomonas vaginalis glutamate synthase, putative 0.0107 0.0712 0.2427
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0023 0.0027
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0189 0.0572
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0107 0.0712 0.1738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0028 0.0077
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0247 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0028 0.0077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0238 0.0567
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0143 0.0259
Brugia malayi follicle stimulating hormone receptor 0.0249 0.176 0.4388
Plasmodium vivax ferrodoxin reductase, putative 0.0107 0.0712 0.1567
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0124 0.0281
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0107 0.0712 0.142
Onchocerca volvulus 0.005 0.0285 0.1026
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0107 0.0712 0.1555
Giardia lamblia Glutamate synthase 0.0107 0.0712 0.1744
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0251 0.0228
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0166
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0405 0.2917 0.7243
Mycobacterium ulcerans glutamate synthase subunit beta 0.0107 0.0712 0.2381
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0028 0.0005
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0405 0.2917 0.6531
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0032 0.0064
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0107 0.0712 0.142
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0023 0.0046
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0297 0.212 0.5295
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0238 0.0485
Schistosoma mansoni inositol monophosphatase 0.0037 0.0189 0.0341
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.5017 0.9079
Brugia malayi Inositol-1 0.0037 0.0189 0.0429
Loa Loa (eye worm) hypothetical protein 0.0025 0.0104 0.0229
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0107 0.0712 0.1555
Entamoeba histolytica disulphide oxidoreductase, putative 0.0107 0.0712 1
Leishmania major hypothetical protein, conserved 0.0107 0.0712 0.0691
Mycobacterium tuberculosis Probable dehydrogenase 0.0315 0.225 0.5025
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.115 0.8442 0.8438
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0247 0.0492
Leishmania major hypothetical protein, conserved 0.0107 0.0712 0.0691
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0405 0.2917 0.7299
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0032 0.0064
Plasmodium falciparum glutathione reductase 0.0549 0.3988 1
Mycobacterium ulcerans monoxygenase 0.0107 0.0712 0.2381
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0251 0.05
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0104 0.0081
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0315 0.225 0.5025
Toxoplasma gondii selenide, water dikinase 0.0107 0.0712 0.1738
Trypanosoma cruzi NADH dehydrogenase, putative 0.0107 0.0712 0.0691
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0012
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.1009 0.7399 0.7393
Plasmodium vivax thioredoxin reductase, putative 0.0549 0.3988 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0238 0.0798
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0023 0.0027
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0107 0.0712 0.1555
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0107 0.0712 0.2381
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Brugia malayi Pre-SET motif family protein 0.021 0.1473 0.3664
Giardia lamblia Thioredoxin reductase 0.0107 0.0712 0.1744
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0189 0.0417
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0028 0.0056
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0028 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0238 0.0215
Schistosoma mansoni hypothetical protein 0.0015 0.0023 0.0042
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0107 0.0712 0.142
Trichomonas vaginalis esterase, putative 0.0043 0.0238 0.0798
Brugia malayi glutaminase DH11.1 0.0273 0.1936 0.4831
Mycobacterium ulcerans glutaminase 0.0273 0.1936 0.6611
Loa Loa (eye worm) beta-lactamase 0.0043 0.0238 0.0567
Plasmodium falciparum thioredoxin reductase 0.0405 0.2917 0.7243
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0237 0.0429
Echinococcus multilocularis thioredoxin glutathione reductase 0.0549 0.3988 0.7949
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.017 0.0566
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0107 0.0712 0.1567
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0107 0.0712 0.1555
Brugia malayi Thioredoxin reductase 0.0549 0.3988 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0107 0.0712 1
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.3382 0.6741
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0247 0.0447
Echinococcus multilocularis GPCR, family 2 0.0016 0.0032 0.0064
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0107 0.0712 0.0691
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0251 0.1189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1975 0.4404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Mycobacterium ulcerans hypothetical protein 0.0043 0.0238 0.0742
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0104 0.0081
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0027 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0028 0.0077
Echinococcus multilocularis geminin 0.0177 0.1226 0.2445
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0107 0.0712 0.0691
Schistosoma mansoni cpg binding protein 0.0029 0.0128 0.0232
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0107 0.0712 0.1919
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0405 0.2917 0.7243
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.136 1 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0107 0.0712 0.0691
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0107 0.0712 0.142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0182 0.0607
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0107 0.0712 0.1555
Toxoplasma gondii ABC1 family protein 0.0043 0.0238 0.0542
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0712 0.0691
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0107 0.0712 0.2381
Leishmania major hypothetical protein, conserved 0.0025 0.0104 0.0081
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0107 0.0712 0.1919
Trichomonas vaginalis glutamate synthase, putative 0.0107 0.0712 0.2427
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0107 0.0712 0.2381
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.3382 0.6741
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0016 0.0033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0166
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0238 0.0798
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0247 0.0492
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0107 0.0712 0.2381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0028 0.0077
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0549 0.3988 0.8947
Brugia malayi intermediate filament protein 0.0028 0.0124 0.0266
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0238 0.0485
Trichomonas vaginalis apoptosis inducing factor, putative 0.0107 0.0712 0.2427
Schistosoma mansoni glutamate synthase 0.0107 0.0712 0.1289
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0405 0.2917 0.7243
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0128 0.029
Mycobacterium tuberculosis Conserved protein 0.0043 0.0238 0.0485
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0315 0.225 0.5025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0116 0.0379
Trypanosoma brucei NADH dehydrogenase 0.0107 0.0712 0.0691
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0247 0.1108
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0027 0.0037
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0028 0.0056
Loa Loa (eye worm) cytochrome P450 0.0015 0.0023 0.0027
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0238 0.0485
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0107 0.0712 0.0691
Loa Loa (eye worm) hypothetical protein 0.005 0.0285 0.0684
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0251 0.0228
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.039
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0238 0.0474
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0712 0.0691
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0107 0.0712 0.142
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0028 0.0039
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0107 0.0712 0.142
Brugia malayi glutathione reductase 0.0549 0.3988 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0238 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0116 0.0379
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0032 0.0034
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0023 0.0027
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0107 0.0712 0.1555
Trypanosoma brucei trypanothione reductase 0.0549 0.3988 0.3974
Leishmania major hypothetical protein, conserved 0.0107 0.0712 0.0691
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0107 0.0712 0.1738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.136 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0251 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0182 0.0607
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0247 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0312
Onchocerca volvulus 0.0029 0.0128 0.0024
Plasmodium falciparum thioredoxin reductase 0.0549 0.3988 1
Loa Loa (eye worm) inositol-1 0.0037 0.0189 0.0443
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0247 0.0224
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0189 0.0376
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0012
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0107 0.0712 0.1555
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0238 0.0485
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0107 0.0712 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0247 0.0492
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0028 0.0005
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0238 0.0485
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0412
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0107 0.0712 0.0691
Onchocerca volvulus 0.0107 0.0712 0.3762
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0405 0.2917 0.2901
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0238 0.0431
Mycobacterium ulcerans dehydrogenase 0.0107 0.0712 0.2381
Brugia malayi beta-lactamase family protein 0.0043 0.0238 0.0553
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0405 0.2917 0.2901
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.115 0.8442 0.8438
Brugia malayi cytochrome P450 0.0015 0.0023 0.0012
Loa Loa (eye worm) thioredoxin reductase 0.0549 0.3988 1
Echinococcus granulosus lamin 0.0028 0.0124 0.0248
Mycobacterium ulcerans hypothetical protein 0.0107 0.0712 0.2381
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0326 0.0764
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0114 0.0372
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0028 0.0024
Mycobacterium ulcerans beta-lactamase 0.0043 0.0238 0.0742
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0055 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.1473 0.3674
Brugia malayi CXXC zinc finger family protein 0.0029 0.0128 0.0276
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0107 0.0712 0.1555
Echinococcus multilocularis lamin 0.0028 0.0124 0.0248
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0247 0.0224
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0612 0.4455 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0016 0.0033
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0107 0.0712 0.2427
Mycobacterium ulcerans NADH dehydrogenase 0.0107 0.0712 0.2381
Schistosoma mansoni glutamate synthase 0.0107 0.0712 0.1289
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0284 0.0669
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0405 0.2917 0.528
Loa Loa (eye worm) hypothetical protein 0.0031 0.0143 0.0328
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Trichomonas vaginalis mercuric reductase, putative 0.0405 0.2917 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0238 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0019 0.0037
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Mycobacterium ulcerans ferredoxin reductase 0.0107 0.0712 0.2381
Onchocerca volvulus 0.0031 0.0143 0.012
Plasmodium vivax glutathione reductase, putative 0.0549 0.3988 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0114 0.0372
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0405 0.2917 0.2901
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0058
Schistosoma mansoni hypothetical protein 0.0052 0.0302 0.0546
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0107 0.0712 0.2427
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1009 0.7399 0.7393
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0315 0.225 0.5025
Schistosoma mansoni glutaminase 0.0273 0.1936 0.3504
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0247 0.0224
Schistosoma mansoni hypothetical protein 0.0034 0.0168 0.0303
Brugia malayi hypothetical protein 0.0025 0.0104 0.0214
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0107 0.0712 0.1748
Brugia malayi hypothetical protein 0.0016 0.0037 0.0047
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0032 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.115 0.8442 0.8438
Loa Loa (eye worm) hypothetical protein 0.005 0.0284 0.0683
Loa Loa (eye worm) hypothetical protein 0.0028 0.0124 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0202 0.0674
Onchocerca volvulus 0.0239 0.1687 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0251 0.1189
Loa Loa (eye worm) glutaminase 2 0.0273 0.1936 0.4839
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0238 0.0215
Schistosoma mansoni hypothetical protein 0.0177 0.1226 0.222
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0405 0.2917 0.7243
Echinococcus multilocularis musashi 0.0028 0.0124 0.0248
Trichomonas vaginalis glutathione reductase, putative 0.0405 0.2917 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0238 0.0742
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0012
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0183 0.016
Echinococcus multilocularis cpg binding protein 0.003 0.014 0.0279
Leishmania major trypanothione reductase 0.0549 0.3988 0.3974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0116 0.0379
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0107 0.0712 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0238 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0097 0.0313
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0189 0.0629
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0405 0.2917 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0019 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0238 0.0798
Schistosoma mansoni lamin 0.0028 0.0124 0.0225
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0107 0.0712 0.176
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0238 0.0215
Plasmodium falciparum glutathione reductase 0.0405 0.2917 0.7243
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0189 0.0629
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0107 0.0712 0.0691
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0028 0.0005
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0107 0.0712 0.1919
Echinococcus multilocularis lamin dm0 0.0028 0.0124 0.0248
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0107 0.0712 0.142
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0315 0.225 0.5025
Echinococcus granulosus GPCR family 2 0.0016 0.0032 0.0064
Schistosoma mansoni disulfide oxidoreductase 0.0107 0.0712 0.1289
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0107 0.0712 0.1744
Loa Loa (eye worm) glutaminase 0.0273 0.1936 0.4839
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0183 0.016
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0247 0.0492
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0028 0.0005
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0107 0.0712 0.2427
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0247 0.0575
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0107 0.0712 1
Echinococcus granulosus dnaJ subfamily B 0.0408 0.2939 0.5859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0133 0.0439
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0238 0.0431
Echinococcus granulosus geminin 0.0177 0.1226 0.2445
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0247 0.0828
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0032 0.0064
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.3382 0.6741

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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