Detailed information for compound 1367017

Basic information

Technical information
  • TDR Targets ID: 1367017
  • Name: 8-ethyl-3-(morpholine-4-carbonyl)-1H-quinolin -4-one
  • MW: 286.326 | Formula: C16H18N2O3
  • H donors: 1 H acceptors: 3 LogP: 2.27 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc2c1ncc(c2O)C(=O)N1CCOCC1
  • InChi: 1S/C16H18N2O3/c1-2-11-4-3-5-12-14(11)17-10-13(15(12)19)16(20)18-6-8-21-9-7-18/h3-5,10H,2,6-9H2,1H3,(H,17,19)
  • InChiKey: FKTVWNYHCLDGPI-UHFFFAOYSA-N  

Network

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Synonyms

  • 8-ethyl-3-(morpholino-oxomethyl)-1H-quinolin-4-one
  • 8-ethyl-3-(morpholine-4-carbonyl)-4-quinolone
  • 8-ethyl-3-morpholin-4-ylcarbonyl-1H-quinolin-4-one
  • SMR000006211
  • (8-Ethyl-4-hydroxy-quinolin-3-yl)-morpholin-4-yl-methanone
  • MLS000074125
  • ASN 06217871

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0182 0.0607
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0107 0.0712 0.1555
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0189 0.0417
Schistosoma mansoni hypothetical protein 0.0177 0.1226 0.222
Schistosoma mansoni glutamate synthase 0.0107 0.0712 0.1289
Echinococcus multilocularis thioredoxin glutathione reductase 0.0549 0.3988 0.7949
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0104 0.0203
Mycobacterium ulcerans hypothetical protein 0.0043 0.0238 0.0742
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0189 0.0629
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0297 0.212 0.5295
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0284 0.0683
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0107 0.0712 0.1748
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0166
Echinococcus granulosus lamin dm0 0.0028 0.0124 0.0248
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0012
Plasmodium vivax glutathione reductase, putative 0.0549 0.3988 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0549 0.3988 0.8947
Loa Loa (eye worm) hypothetical protein 0.005 0.0284 0.0683
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0107 0.0712 0.1555
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0032 0.0064
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0251 0.0228
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.1473 0.3674
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0023 0.0027
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0183 0.016
Mycobacterium leprae Probable lipase LipE 0.0043 0.0238 0.0485
Schistosoma mansoni cpg binding protein 0.0029 0.0128 0.0232
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0107 0.0712 0.1555
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0107 0.0712 0.2427
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0189 0.0629
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0143 0.0259
Loa Loa (eye worm) glutathione reductase 0.0549 0.3988 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0247 0.0492
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0251 0.06
Echinococcus multilocularis glutamate synthase 0.0107 0.0712 0.142
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0058
Echinococcus granulosus intermediate filament protein 0.0028 0.0124 0.0248
Plasmodium vivax ferrodoxin reductase, putative 0.0107 0.0712 0.1567
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0238 0.0798
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0107 0.0712 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0612 0.4455 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0143 0.0259
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0238 0.0485
Echinococcus granulosus neuropeptide s receptor 0.0468 0.3382 0.6741
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0107 0.0712 0.142
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0032 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0028 0.0077
Mycobacterium tuberculosis Conserved protein 0.0043 0.0238 0.0485
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0405 0.2917 0.2901
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.016 0.0309
Leishmania major hypothetical protein, conserved 0.0043 0.0238 0.0215
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.115 0.8442 0.8438
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0107 0.0712 0.1738
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0107 0.0712 0.1738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0202 0.0674
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1975 0.4404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0312
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0612 0.4455 1
Schistosoma mansoni sulfide quinone reductase 0.0107 0.0712 0.1289
Brugia malayi glutamate synthase 0.0107 0.0712 0.1748
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.3382 0.6741
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0166
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0128 0.029
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0107 0.0712 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0405 0.2917 0.2901
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0116 0.0379
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0405 0.2917 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0405 0.2917 0.528
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0107 0.0712 0.142
Brugia malayi cytochrome P450 0.0015 0.0023 0.0012
Schistosoma mansoni glutamate synthase 0.0107 0.0712 0.1289
Trichomonas vaginalis apoptosis inducing factor, putative 0.0107 0.0712 0.2427
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0238 0.0742
Onchocerca volvulus 0.0239 0.1687 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0104 0.0081
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0247 0.0492
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0238 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0247 0.0828
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0107 0.0712 0.0691
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0247 0.0828
Loa Loa (eye worm) cytochrome P450 0.0015 0.0023 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Leishmania major hypothetical protein, conserved 0.0107 0.0712 0.0691
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0712 0.0691
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0012
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0028 0.0005
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0058
Brugia malayi hypothetical protein 0.0016 0.0037 0.0047
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0165 0.0358
Echinococcus multilocularis musashi 0.0028 0.0124 0.0248
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0247 0.0447
Onchocerca volvulus 0.0029 0.0128 0.0024
Echinococcus granulosus dnaJ subfamily B 0.0408 0.2939 0.5859
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0251 0.0228
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0238 0.0798
Mycobacterium ulcerans monoxygenase 0.0107 0.0712 0.2381
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0247 0.0828
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0247 0.0447
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0405 0.2917 0.7302
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0238 0.0346
Mycobacterium tuberculosis Probable dehydrogenase 0.0315 0.225 0.5025
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.039
Schistosoma mansoni hypothetical protein 0.0408 0.2939 0.5319
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0238 0.0474
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0019 0.0037
Loa Loa (eye worm) hypothetical protein 0.0031 0.0143 0.0328
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0107 0.0712 0.2381
Trichomonas vaginalis glutamate synthase, putative 0.0107 0.0712 0.2427
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.3382 0.6741
Loa Loa (eye worm) glutaminase 2 0.0273 0.1936 0.4839
Loa Loa (eye worm) hypothetical protein 0.0025 0.0104 0.0229
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0247 0.0224
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0028 0.0005
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0107 0.0712 0.1555
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0107 0.0712 0.1919
Echinococcus granulosus lamin 0.0028 0.0124 0.0248
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0107 0.0712 0.142
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.1009 0.7399 0.7393
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0107 0.0712 0.0691
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0107 0.0712 0.2381
Echinococcus multilocularis lamin 0.0028 0.0124 0.0248
Toxoplasma gondii NADPH-glutathione reductase 0.0405 0.2917 0.7299
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0107 0.0712 0.1555
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0107 0.0712 0.0691
Mycobacterium ulcerans beta-lactamase 0.0043 0.0238 0.0742
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0166
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0124 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0251 0.0843
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0107 0.0712 0.2381
Schistosoma mansoni sulfide quinone reductase 0.0107 0.0712 0.1289
Trypanosoma cruzi trypanothione reductase, putative 0.0405 0.2917 0.2901
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0247 0.0224
Brugia malayi hypothetical protein 0.0025 0.0104 0.0214
Echinococcus multilocularis 0.0015 0.0023 0.0046
Schistosoma mansoni hypothetical protein 0.0015 0.0023 0.0042
Schistosoma mansoni lamin 0.0028 0.0124 0.0225
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0019 0.0037
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0107 0.0712 0.2381
Giardia lamblia NADH oxidase lateral transfer candidate 0.0405 0.2917 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0107 0.0712 0.1567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0251 0.0843
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0238 0.0215
Trypanosoma brucei NADH dehydrogenase 0.0107 0.0712 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0251 0.0843
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0107 0.0712 0.142
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.017 0.0566
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0405 0.2917 0.7243
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0166
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0028 0.0005
Echinococcus multilocularis cpg binding protein 0.003 0.014 0.0279
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0251 0.05
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0143 0.0285
Plasmodium falciparum thioredoxin reductase 0.0549 0.3988 1
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0712 0.0691
Brugia malayi beta-lactamase family protein 0.0043 0.0238 0.0553
Plasmodium vivax thioredoxin reductase, putative 0.0549 0.3988 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0238 0.0485
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0104 0.0081
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0238 0.0474
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0247 0.0492
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0405 0.2917 0.7243
Trypanosoma cruzi NADH dehydrogenase, putative 0.0107 0.0712 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0028 0.0077
Entamoeba histolytica disulphide oxidoreductase, putative 0.0107 0.0712 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0143 0.0302
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0028 0.0039
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0238 0.0485
Onchocerca volvulus 0.0031 0.0143 0.012
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0315 0.225 0.5025
Brugia malayi Pre-SET motif family protein 0.0031 0.0143 0.0313
Leishmania major hypothetical protein, conserved 0.0107 0.0712 0.0691
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0107 0.0712 0.1748
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0238 0.0485
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0012
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0107 0.0712 0.1919
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0107 0.0712 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0107 0.0712 0.142
Trichomonas vaginalis mercuric reductase, putative 0.0405 0.2917 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0247 0.0492
Brugia malayi Pre-SET motif family protein 0.021 0.1473 0.3664
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.016 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0116 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0114 0.0372
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0107 0.0712 0.1748
Trichomonas vaginalis glutamate synthase, putative 0.0107 0.0712 0.2427
Brugia malayi glutaminase DH11.1 0.0273 0.1936 0.4831
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0238 0.0485
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0189 0.0376
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0315 0.225 0.5025
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0143 0.0285
Plasmodium falciparum ferrodoxin reductase-like protein 0.0107 0.0712 0.1567
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0251 0.1189
Schistosoma mansoni intermediate filament proteins 0.0028 0.0124 0.0225
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0405 0.2917 0.7243
Brugia malayi follicle stimulating hormone receptor 0.0249 0.176 0.4388
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0183 0.016
Echinococcus granulosus cpg binding protein 0.003 0.014 0.0279
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0315 0.225 0.5025
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.3382 0.6741
Trypanosoma cruzi trypanothione reductase, putative 0.0549 0.3988 0.3974
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0015
Schistosoma mansoni cpg binding protein 0.003 0.014 0.0253
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0247 0.0492
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0107 0.0712 0.0691
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0405 0.2917 0.7243
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0238 0.0798
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.115 0.8442 0.8438
Mycobacterium ulcerans glutaminase 0.0273 0.1936 0.6611
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0189 0.0572
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0107 0.0712 0.1744
Mycobacterium ulcerans lipase LipD 0.0043 0.0238 0.0742
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0238 0.0742
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0251 0.0454
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0019 0.0034
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0107 0.0712 0.1567
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0107 0.0712 0.1555
Schistosoma mansoni hypothetical protein 0.0034 0.0168 0.0303
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0251 0.0228
Onchocerca volvulus 0.0107 0.0712 0.3762
Plasmodium falciparum glutathione reductase 0.0405 0.2917 0.7243
Echinococcus granulosus geminin 0.0177 0.1226 0.2445
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0247 0.0492
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0016 0.0033
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0028 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0284 0.0669
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0238 0.0431
Brugia malayi Inositol-1 0.0037 0.0189 0.0429
Toxoplasma gondii ABC1 family protein 0.0043 0.0238 0.0542
Leishmania major hypothetical protein, conserved 0.0107 0.0712 0.0691
Trypanosoma brucei trypanothione reductase 0.0549 0.3988 0.3974
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0237 0.0429
Echinococcus multilocularis GPCR, family 2 0.0016 0.0032 0.0064
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0023 0.0027
Echinococcus granulosus glutamate synthase 0.0107 0.0712 0.142
Loa Loa (eye worm) inositol-1 0.0037 0.0189 0.0443
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0107 0.0712 0.2381
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0058
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0315 0.225 0.5025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.001
Mycobacterium ulcerans dehydrogenase 0.0107 0.0712 0.2381
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0028 0.0024
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.5017 0.9079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0182 0.0607
Loa Loa (eye worm) programmed cell death 8 0.0107 0.0712 0.176
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0028 0.0056
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0028 0.0005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0238 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0143 0.0259
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0107 0.0712 0.2427
Loa Loa (eye worm) hypothetical protein 0.0107 0.0712 0.176
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0251 0.0228
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0189 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0097 0.0313
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0019 0.0037
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0107 0.0712 0.0691
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0107 0.0712 0.1738
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.2939 0.5859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0097 0.0313
Toxoplasma gondii selenide, water dikinase 0.0107 0.0712 0.1738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0712 0.0691
Echinococcus granulosus tumor protein p63 0.034 0.2437 0.4857
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.013 0.0259
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0612 0.4455 1
Entamoeba histolytica thioredoxin reductase, putative 0.0107 0.0712 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0405 0.2917 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0107 0.0712 0.142
Trichomonas vaginalis esterase, putative 0.0043 0.0238 0.0798
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.5017 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0055 0.0032
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.115 0.8442 0.8438
Leishmania major trypanothione reductase 0.0549 0.3988 0.3974
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0212 0.0423
Schistosoma mansoni disulfide oxidoreductase 0.0107 0.0712 0.1289
Mycobacterium tuberculosis Probable oxidoreductase 0.0612 0.4455 1
Loa Loa (eye worm) thioredoxin reductase 0.0549 0.3988 1
Mycobacterium ulcerans ferredoxin reductase 0.0107 0.0712 0.2381
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0141 0.0463
Toxoplasma gondii thioredoxin reductase 0.0549 0.3988 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0107 0.0712 0.1738
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.136 1 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0107 0.0712 0.176
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0272
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0251 0.05
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0107 0.0712 0.1738
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0189 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0097 0.0313
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0107 0.0712 0.2381
Plasmodium vivax SET domain protein, putative 0.0031 0.0143 0.0101
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0019 0.0034
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0107 0.0712 0.142
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0107 0.0712 0.1555
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0251 0.0228
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0405 0.2917 0.5815
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0238 0.0485
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0405 0.2917 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0032 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Loa Loa (eye worm) hypothetical protein 0.0028 0.0124 0.0281
Treponema pallidum NADH oxidase 0.0405 0.2917 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0107 0.0712 0.142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.136 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.017 0.0566
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0028 0.0005
Echinococcus granulosus thioredoxin glutathione reductase 0.0549 0.3988 0.7949
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0237 0.0429
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0412
Echinococcus granulosus GPCR family 2 0.0016 0.0032 0.0064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.115 0.8442 0.8438
Schistosoma mansoni cpg binding protein 0.003 0.014 0.0253
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0315 0.225 0.5025
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0107 0.0712 0.1555
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0028 0.0056
Mycobacterium tuberculosis Probable reductase 0.0315 0.225 0.5025
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0012
Leishmania major hypothetical protein, conserved 0.0025 0.0104 0.0081
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0212 0.0488
Plasmodium falciparum thioredoxin reductase 0.0405 0.2917 0.7243
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0238 0.0798
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0405 0.2917 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0097 0.0313
Schistosoma mansoni glutaminase 0.0273 0.1936 0.3504
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.005
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0107 0.0712 0.1567
Echinococcus multilocularis tumor protein p63 0.034 0.2437 0.4857
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0107 0.0712 0.142
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0405 0.2917 0.7299
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0405 0.2917 0.5815
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0567
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0058
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0107 0.0712 0.0691
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1009 0.7399 0.7393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0312
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0297 0.212 0.5295
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0238 0.0798
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0023 0.0027
Brugia malayi glutathione reductase 0.0549 0.3988 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0183 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0182 0.0607
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0143 0.0285
Echinococcus multilocularis lamin dm0 0.0028 0.0124 0.0248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0143 0.0259
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0247 0.0224
Loa Loa (eye worm) glutaminase 0.0273 0.1936 0.4839
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0238 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0028 0.0077
Schistosoma mansoni hypothetical protein 0.0177 0.1226 0.222
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0107 0.0712 0.2381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0182 0.0607
Trichomonas vaginalis set domain proteins, putative 0.0239 0.1687 0.5777
Mycobacterium ulcerans hypothetical protein 0.0107 0.0712 0.2381
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0251 0.0228
Brugia malayi beta-lactamase family protein 0.0043 0.0238 0.0553
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0019 0.0037
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0032 0.0034
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0107 0.0712 0.1919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0116 0.0379
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0107 0.0712 0.2427
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0016 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0124 0.0266
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0247 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0133 0.0439
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0326 0.0764
Giardia lamblia Thioredoxin reductase 0.0107 0.0712 0.1744
Brugia malayi Thioredoxin reductase 0.0549 0.3988 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0405 0.2917 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0247 0.0575
Schistosoma mansoni lamin 0.0028 0.0124 0.0225
Trichomonas vaginalis glutathione reductase, putative 0.0405 0.2917 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0238 0.0567
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0405 0.2917 0.2901
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0285 0.0515
Giardia lamblia Glutamate synthase 0.0107 0.0712 0.1744
Mycobacterium tuberculosis Conserved protein 0.0043 0.0238 0.0485
Echinococcus granulosus microtubule associated protein 2 0.0688 0.5017 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0189 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0023 0.0027
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0027 0.0037
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0107 0.0712 0.2427
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0374 0.0677
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0074 0.0051
Trypanosoma cruzi NADH dehydrogenase, putative 0.0107 0.0712 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0165 0.0547
Echinococcus multilocularis geminin 0.0177 0.1226 0.2445
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0405 0.2917 0.2901
Mycobacterium ulcerans NADH dehydrogenase 0.0107 0.0712 0.2381
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0238 0.0485
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0405 0.2917 1
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0023 0.0046
Schistosoma mansoni hypothetical protein 0.0052 0.0302 0.0546
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0212 0.0423
Loa Loa (eye worm) hypothetical protein 0.005 0.0285 0.0684
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0107 0.0712 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0238 0.0485
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0032 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0251 0.0585
Onchocerca volvulus 0.005 0.0285 0.1026
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0107 0.0712 0.2427
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0032 0.0064
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0405 0.2917 0.6531
Onchocerca volvulus 0.0043 0.0238 0.0727
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1009 0.7399 0.7393
Brugia malayi CXXC zinc finger family protein 0.0029 0.0128 0.0276
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0247 0.1108
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0238 0.0567
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0107 0.0712 0.1567
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0104 0.0081
Mycobacterium ulcerans glutamate synthase subunit beta 0.0107 0.0712 0.2381
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0107 0.0712 1
Schistosoma mansoni hypothetical protein 0.0107 0.0712 0.1289
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0107 0.0712 0.142
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0238 0.0431
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.136 1 1
Onchocerca volvulus 0.0043 0.0238 0.0727
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0238 0.0485
Schistosoma mansoni glutamate synthase 0.0107 0.0712 0.1289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0182 0.0607
Schistosoma mansoni inositol monophosphatase 0.0037 0.0189 0.0341
Giardia lamblia GTOR 0.0045 0.0251 0.0016
Leishmania major NADH dehydrogenase, putative 0.0107 0.0712 0.0691
Trichomonas vaginalis glutaminase, putative 0.0273 0.1936 0.6631
Brugia malayi intermediate filament protein 0.0028 0.0124 0.0266
Onchocerca volvulus 0.0043 0.0238 0.0727
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0107 0.0712 0.0691
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0027 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0114 0.0372
Schistosoma mansoni cytochrome P450 0.0015 0.0023 0.0042
Brugia malayi beta-lactamase 0.0043 0.0238 0.0553
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0212 0.0502
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0107 0.0712 0.0691
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0032 0.0064
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0028 0.0051
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0107 0.0712 0.0691
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0107 0.0712 0.1555
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0124 0.0281
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0168 0.0375
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.176 0.4397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0028 0.0077
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0107 0.0712 0.142
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0107 0.0712 0.142
Loa Loa (eye worm) hypothetical protein 0.0045 0.0247 0.0589
Leishmania major acetoin dehydrogenase e3 component-like protein 0.1009 0.7399 0.7393
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0107 0.0712 0.0691
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0251 0.1189
Plasmodium falciparum glutathione reductase 0.0549 0.3988 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0107 0.0712 0.0691
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0284 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0028 0.0077
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0107 0.0712 0.1555

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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