Detailed information for compound 1367030

Basic information

Technical information
  • TDR Targets ID: 1367030
  • Name: (4S,6R)-4-cyclopropyl-6-(4-hydroxybutoxy)-N-p henyl-5,6-dihydro-4H-pyran-2-carboxamide
  • MW: 331.406 | Formula: C19H25NO4
  • H donors: 2 H acceptors: 2 LogP: 3.15 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc1ccccc1)C1CC1
  • InChi: 1S/C19H25NO4/c21-10-4-5-11-23-18-13-15(14-8-9-14)12-17(24-18)19(22)20-16-6-2-1-3-7-16/h1-3,6-7,12,14-15,18,21H,4-5,8-11,13H2,(H,20,22)/t15-,18+/m0/s1
  • InChiKey: YIWZZYCPJVORSE-MAUKXSAKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000766568
  • SMR000441983

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis snurportin 1 0.0372 0.0708 0.182
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0028 0.0006
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.5098 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0022 0.0057
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0046 0.0024
Echinococcus multilocularis geminin 0.0205 0.038 0.0976
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0034 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0034 0.0024
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0028 0.0121
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.5098 1 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1991 0.3891 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0033 0.0028
Echinococcus granulosus importin subunit beta 1 0.0035 0.0046 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0122 0.0102
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0022 0.0003
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0046 0.0024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0022 0.0003
Brugia malayi hypothetical protein 0.0026 0.0028 0.0018
Loa Loa (eye worm) hypothetical protein 0.0029 0.0034 0.0207
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0122 0.0102
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0033 0.0028
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0046 0.0118
Schistosoma mansoni ap endonuclease 0.0023 0.0022 0.0022
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.5098 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0022 0.5
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0028 0.0008
Schistosoma mansoni ran 0.0026 0.0028 0.0028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1903 0.489
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0019 0.5
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0034 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0033 0.0028
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.5098 1 1
Plasmodium falciparum importin beta, putative 0.0035 0.0046 0.0026
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0034 0.0014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0034 0.0014
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0122 0.0312
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1991 0.3891 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0121
Schistosoma mansoni hypothetical protein 0.0205 0.038 0.038
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0028 0.0006
Echinococcus granulosus geminin 0.0205 0.038 0.0976
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.5098 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0034 0.0014
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0028 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0034 0.0014
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0122 0.0312
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0034 0.0014
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0046 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0034 0.0017
Brugia malayi RNA, U transporter 1 0.0099 0.0172 0.0162
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0034 0.003
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0028 0.0006
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0034 0.0017
Echinococcus granulosus snurportin 1 0.0372 0.0708 0.182
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0034 0.0012
Brugia malayi Zinc finger, C2H2 type family protein 0.1991 0.3891 0.3885
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0022 0.0057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0019 0.0002
Onchocerca volvulus 0.0029 0.0034 0.5
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0034 0.0024
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1991 0.3891 1
Schistosoma mansoni dihydroorotate dehydrogenase 0.5098 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0034 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0034 0.0012
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.5098 1 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1991 0.3891 1
Entamoeba histolytica Ran family GTPase 0.0026 0.0028 0.0015
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1991 0.3891 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0034 0.003
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0028 0.0071
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0028 1
Schistosoma mansoni hypothetical protein 0.0372 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0029 0.0034 0.0207
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0022 0.0005
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.5098 1 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0034 0.0014
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1991 0.3891 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0028 0.0008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0028 0.0006
Schistosoma mansoni importin beta-1 0.0035 0.0046 0.0046
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1991 0.3891 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0122 0.0122
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0028 0.0006
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.5098 1 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0033 0.0011
Schistosoma mansoni ran 0.0026 0.0028 0.0028
Plasmodium falciparum dihydroorotate dehydrogenase 0.5098 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0122 0.0105
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1991 0.3891 0.3877
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0022 0.0012
Schistosoma mansoni hypothetical protein 0.0205 0.038 0.038
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.1991 0.3891 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0708 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.1991 0.3891 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0046 0.0026
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0028 0.0071
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0033 0.0011
Brugia malayi Importin beta-1 subunit 0.0035 0.0046 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0034 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0034 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0122 0.0122
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0022 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0122 0.0102
Leishmania major hypothetical protein, conserved 0.0026 0.0028 0.0006
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1991 0.3891 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0028 0.0008
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.5098 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1991 0.3891 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0028 0.0006
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0122 0.01
Trichomonas vaginalis ran, putative 0.0026 0.0028 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0028 0.0006
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0122 0.01
Loa Loa (eye worm) hypothetical protein 0.0029 0.0034 0.0207
Entamoeba histolytica hypothetical protein 0.0028 0.0033 0.0028
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0028 0.0008
Leishmania major GTP-binding protein, putative 0.0026 0.0028 0.0006
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.5098 1 1
Schistosoma mansoni ap endonuclease 0.0023 0.0022 0.0022
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0028 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0383
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0022 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0028 0.0008
Leishmania major dihydroorotate dehydrogenase 0.5098 1 1
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.5098 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0032 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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