Detailed information for compound 1367226

Basic information

Technical information
  • TDR Targets ID: 1367226
  • Name: 6-(1,3-thiazol-2-ylcarbamoyl)bicyclo[2.2.1]he pt-2-ene-5-carboxylic acid
  • MW: 264.3 | Formula: C12H12N2O3S
  • H donors: 2 H acceptors: 4 LogP: 1.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1C2C=CC(C1C(=O)O)C2)Nc1nccs1
  • InChi: 1S/C12H12N2O3S/c15-10(14-12-13-3-4-18-12)8-6-1-2-7(5-6)9(8)11(16)17/h1-4,6-9H,5H2,(H,16,17)(H,13,14,15)
  • InChiKey: SUGSIWBFIBIQDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(thiazol-2-ylcarbamoyl)bicyclo[2.2.1]hept-2-ene-5-carboxylic acid
  • 6-[oxo-(2-thiazolylamino)methyl]-5-bicyclo[2.2.1]hept-2-enecarboxylic acid
  • 3-(Thiazol-2-ylcarbamoyl)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
  • BAS 03376006
  • Oprea1_615719
  • ChemDiv2_003893
  • ST5017087
  • MLS000068600
  • SMR000122925
  • IDI1_002608
  • Oprea1_269132

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi folylpolyglutamate synthase, putative 0.0396 0.0443 0.0867
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0017
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.004 0.0039
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0021 0.001 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.001 0.0005
Echinococcus granulosus transcription factor btf3 0.0034 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0018
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0035 0.0034
Toxoplasma gondii thioredoxin reductase 0.0046 0.004 0.0073
Schistosoma mansoni multidrug resistance protein 0.0028 0.0019 0.0016
Treponema pallidum folylpolyglutamate synthetase (folC) 0.0396 0.0443 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0036 0.0522
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0008 0.0007
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.0005
Entamoeba histolytica multidrug resistance protein, putative 0.0028 0.0019 0.1543
Echinococcus multilocularis dihydrofolate reductase 0.8686 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0055 0.01
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0006 0.0005
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0018 0.0089
Onchocerca volvulus 0.0049 0.0043 0.0316
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0009 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0035 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0035 0.0032
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0035 0.0032
Mycobacterium ulcerans thymidylate synthase 0.0994 0.1132 0.1128
Leishmania major DNA polymerase kappa, putative 0.004 0.0032 0.0055
Trypanosoma cruzi metacaspase, putative 0.0043 0.0036 0.0064
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0026 0.0043
Brugia malayi Cell death protein 3 precursor 0.0084 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0034
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0115 0.0119 0.0118
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0022 0.0038
Plasmodium vivax importin-beta 2, putative 0.0028 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Trypanosoma brucei multidrug resistance protein E 0.0028 0.0019 0.0029
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0035 0.0035
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.0102 0.0101
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0055 0.0052
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0021 0.001 0.0728
Loa Loa (eye worm) hypothetical protein 0.0084 0.0083 0.0083
Brugia malayi hypothetical protein 0.0027 0.0018 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0035 0.0035
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0021 0.002
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.0254 0.0253
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0043
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0017 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0055 0.01
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0035 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0043 0.0036 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0552 0.0623 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0031 0.0022 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0062
Brugia malayi jmjC domain containing protein 0.0015 0.0004 0.0004
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0022 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0004 0.0003
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.0768 0.0767
Brugia malayi beta-lactamase family protein 0.0043 0.0036 0.0036
Schistosoma mansoni lozenge 0.0055 0.0049 0.0047
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0018 0.0018
Mycobacterium ulcerans epimerase 0.002 0.0009 0.0004
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.0019 0.1543
Brugia malayi nuclear receptor NHR-88 0.0042 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0058 0.0053 0.0053
Echinococcus granulosus intermediate filament protein 0.0026 0.0017 0.0016
Echinococcus granulosus microtubule associated protein 2 0.0678 0.0768 0.0767
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Schistosoma mansoni loxhd1 0.0019 0.0009 0.0006
Onchocerca volvulus 0.0047 0.0041 0.0294
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0019 0.0029
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0026 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0129 0.0127
Brugia malayi RNA binding protein 0.0124 0.0129 0.0129
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0552 0.0623 0.1221
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0059 0.0054
Schistosoma mansoni hypothetical protein 0.0147 0.0155 0.0153
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0053 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0035 0.0035
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0036 0.0032
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0036 0.0032
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.008 1
Echinococcus multilocularis expressed protein 0.0367 0.0409 0.0408
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0129 0.0127
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0009 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0005 0.0002
Entamoeba histolytica hypothetical protein 0.0049 0.0043 0.495
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0025 0.0022
Brugia malayi beta-lactamase family protein 0.0043 0.0036 0.0036
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0008 0.0008
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0061 0.0113
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0008 0.0007
Toxoplasma gondii hypothetical protein 0.0026 0.0017 0.0028
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0008 0.0008
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0015 0.0021
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0036 0.0521
Schistosoma mansoni zinc finger protein 0.002 0.0009 0.0007
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0061 0.0058
Schistosoma mansoni aryl hydrocarbon receptor 0.0015 0.0004 0.0001
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0036 0.0066
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0002
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0027 0.0018 0.0017
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0073 0.0136
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0025 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0055 0.01
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Onchocerca volvulus 0.0027 0.0018 0.0089
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0036
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0008 0.0007
Trypanosoma brucei unspecified product 0.0023 0.0013 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0008 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0129 0.0127
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0027
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0036 0.0036
Loa Loa (eye worm) thymidylate synthase 0.0994 0.1132 0.1132
Brugia malayi Importin beta-1 subunit 0.0028 0.0019 0.0019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0022 0.0017
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0008 0.001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0013 0.0017
Echinococcus granulosus thymidylate synthase 0.0994 0.1132 0.1131
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0008 0.0007
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0021 0.001 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0035 0.0032
Onchocerca volvulus 0.0043 0.0036 0.0254
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0004
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0034
Brugia malayi folate-like transporter 3 0.0049 0.0043 0.0043
Brugia malayi ecdysteroid receptor 0.0042 0.0035 0.0035
Giardia lamblia MRP-like ABC transporter 0.0028 0.0019 0.3606
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.001 0.0005
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0396 0.0443 0.0442
Onchocerca volvulus 0.0027 0.0018 0.0089
Mycobacterium ulcerans hypothetical protein 0.0043 0.0036 0.0032
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0021 0.001 0.0012
Echinococcus multilocularis aryl hydrocarbon receptor 0.0052 0.0046 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0034
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0053 0.01
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0108 0.0104
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0055 0.0052
Entamoeba histolytica hypothetical protein 0.007 0.0068 0.8302
Trypanosoma cruzi metacaspase, putative 0.0043 0.0036 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0035 0.0034
Onchocerca volvulus 0.0994 0.1132 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0008 0.0006
Trypanosoma brucei pteridine reductase 1 0.0477 0.0536 0.1051
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0043
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0028 0.0019 0.0029
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0021 0.001 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.005 0.0049
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0036 0.0032
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.4408 0.5068 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0008 0.001
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0028 0.0019 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0008 0.0005
Echinococcus multilocularis follistatin 0.0019 0.0008 0.0007
Echinococcus multilocularis GPCR, family 2 0.0015 0.0004 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0062
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0122 0.0117
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0019 0.0018
Brugia malayi hypothetical protein 0.0036 0.0028 0.0028
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.001 0.0005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0004 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0055 0.01
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0025 0.0024
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0038 0.0038
Trypanosoma brucei metacaspase MCA3 0.0043 0.0036 0.0064
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0014 0.0838
Leishmania major DNA polymerase eta, putative 0.0035 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0021 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0043
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0032 0.0055
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0035 0.0063
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0021 0.001 0.0005
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0036 0.0521
Schistosoma mansoni folylpolyglutamate synthase 0.0396 0.0443 0.0441
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0036 0.0522
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0009 0.0007
Schistosoma mansoni multidrug resistance protein 0.0028 0.0019 0.0016
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0021 0.001 0.0005
Leishmania major DNA polymerase eta, putative 0.0058 0.0053 0.0097
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0008 0.0007
Trypanosoma brucei p-glycoprotein 0.0028 0.0019 0.0029
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0006
Schistosoma mansoni lipoxygenase 0.0019 0.0009 0.0006
Onchocerca volvulus 0.0233 0.0255 0.22
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0038 0.0539
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0055 0.01
Brugia malayi jmjC domain containing protein 0.0015 0.0004 0.0004
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0008 0.0007
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0061 0.0061
Echinococcus multilocularis lamin dm0 0.0026 0.0017 0.0016
Brugia malayi hypothetical protein 0.0022 0.0012 0.0012
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0117 0.0121 0.012
Plasmodium falciparum thioredoxin reductase 0.0046 0.004 0.0071
Trichomonas vaginalis glutaminase, putative 0.0267 0.0294 0.4689
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0043
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0108 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0035 0.0034
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0014 0.0019
Echinococcus granulosus folylpolyglutamate synthase mitochondrial 0.0396 0.0443 0.0442
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0008 0.0008
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0004 0.0003
Mycobacterium ulcerans oxidoreductase 0.0021 0.001 0.0005
Brugia malayi hypothetical protein 0.0016 0.0005 0.0005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0008 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0129 0.0127
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0021 0.001 0.0009
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0102 0.01
Toxoplasma gondii endonuclease IV APN 0.0075 0.0073 0.0139
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0035 0.0034
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0018 0.0018
Giardia lamblia Multidrug resistance-associated protein 1 0.0028 0.0019 0.3606
Trypanosoma brucei unspecified product 0.0053 0.0047 0.0085
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0017 0.0017
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0053 0.0052
Schistosoma mansoni transcription factor btf3 0.0034 0.0026 0.0023
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0036 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0007
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.004 0.0039
Mycobacterium leprae PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) 0.0396 0.0443 0.0439
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0028 0.0048
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0008 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0008 0.0007
Brugia malayi Pre-SET motif family protein 0.0205 0.0223 0.0223
Brugia malayi Pre-SET motif family protein 0.003 0.0021 0.0021
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0075 0.007
Loa Loa (eye worm) hypothetical protein 0.0077 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.001 0.001
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0567 0.064 0.064
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0008 0.0006
Toxoplasma gondii redoxin domain-containing protein 0.0084 0.0083 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0035 0.0035
Trypanosoma brucei DNA polymerase eta, putative 0.0058 0.0053 0.0097
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0021 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0018
Onchocerca volvulus 0.0028 0.0019 0.0097
Toxoplasma gondii melibiase subfamily protein 0.0101 0.0102 0.0197
Trypanosoma brucei oxidoreductase-like protein 0.0031 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0026 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0026 0.0352
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0021 0.001 0.0012
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0146 0.0145
Mycobacterium leprae POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN) 0.0021 0.0011 0.0007
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) 0.0396 0.0443 0.0439
Schistosoma mansoni nuclear receptor 0.002 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0147 0.0155 0.0155
Onchocerca volvulus 0.0049 0.0043 0.0316
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0009
Schistosoma mansoni rab6-interacting 0.0019 0.0009 0.0006
Brugia malayi Reduced folate carrier family protein 0.0049 0.0043 0.0043
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.0254 0.0253
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0007
Echinococcus multilocularis multidrug resistance associated protein 7 0.0028 0.0019 0.0018
Loa Loa (eye worm) RNA binding protein 0.0124 0.0129 0.0129
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0022 0.0038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0043 0.0042
Leishmania major metacaspase, putative 0.0043 0.0036 0.0064
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0059 0.0059
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.004 0.0039
Mycobacterium ulcerans thiol peroxidase 0.0021 0.0011 0.0006
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0028 0.0019 0.0029
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0008 0.0008
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0005 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0004 0.0004
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.015 0.015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0009 0.0008
Echinococcus multilocularis expressed protein 0.0019 0.0008 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0047 0.0041 0.0038
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.0019 0.1543
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.0019 0.1543
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0036 0.0064
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0025 0.0024
Plasmodium falciparum enoyl-acyl carrier reductase 0.0021 0.001 0.0012
Entamoeba histolytica hypothetical protein 0.007 0.0068 0.8302
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0031 0.3177
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0075 0.0142
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0035 0.0241
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0022 0.0021
Trichomonas vaginalis peroxiredoxin, putative 0.0021 0.0011 0.011
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0028
Brugia malayi hypothetical protein 0.007 0.0068 0.0068
Trypanosoma brucei folylpolyglutamate synthase, putative 0.0396 0.0443 0.0867
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.005 0.0049
Brugia malayi jmjC domain containing protein 0.0058 0.0053 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0022 0.0021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0022 0.0021
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0004 0.0001
Echinococcus granulosus dna polymerase eta 0.0058 0.0053 0.0052
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0008 0.001
Mycobacterium tuberculosis Conserved protein 0.0043 0.0036 0.0032
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0008 0.0007
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.4408 0.5068 1
Brugia malayi nuclear hormone receptor 0.0042 0.0035 0.0035
Echinococcus multilocularis tar DNA binding protein 0.0124 0.0129 0.0128
Plasmodium vivax SET domain protein, putative 0.003 0.0021 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0022 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0043
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0035 0.0034
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0008 0.0007
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0004 0.0003
Brugia malayi ABC transporter transmembrane region family protein 0.0028 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0043 0.0036 0.0064
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0004 0.0003
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0329 0.0366 0.0715
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0108 0.0104
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0008 0.001
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0005 0.0004
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0022 0.0022
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0521
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0068 0.0067
Echinococcus multilocularis snurportin 1 0.0302 0.0335 0.0334
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0044 0.004
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0022 0.0019
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0059 0.0058
Schistosoma mansoni lamin 0.0026 0.0017 0.0014
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0329 0.0366 0.0715
Schistosoma mansoni dihydropteridine reductase 0.0021 0.001 0.0007
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0055 0.0817
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0009 0.0007
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0005 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0055 0.005
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0396 0.0443 0.0442
Echinococcus granulosus multidrug resistance associated protein 4 0.0022 0.0011 0.001
Onchocerca volvulus 0.0435 0.0488 0.4268
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0034
Entamoeba histolytica hypothetical protein 0.0034 0.0026 0.2533
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0007
Loa Loa (eye worm) RecQ helicase 0.0044 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0043
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0031 0.0022 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0008 0.0005
Brugia malayi TAR-binding protein 0.0124 0.0129 0.0129
Giardia lamblia ABC transporter, putative 0.0028 0.0019 0.3606
Loa Loa (eye worm) FolC protein 0.0396 0.0443 0.0443
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0021 0.001 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0521
Loa Loa (eye worm) hypothetical protein 0.0067 0.0064 0.0063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0025 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0035 0.0032
Schistosoma mansoni caspase-7 (C14 family) 0.0084 0.0083 0.008
Echinococcus multilocularis caspase 2 0.0084 0.0083 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0035 0.0034
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0004 0.0003
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0009 0.0011
Loa Loa (eye worm) runx1 0.0055 0.0049 0.0049
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0075 0.014
Echinococcus multilocularis agrin 0.0019 0.0008 0.0007
Echinococcus granulosus Solute carrier organic anion transporter family 0.0027 0.0018 0.0017
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.4408 0.5068 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0075 0.0071
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0075 0.007
Chlamydia trachomatis dihydrofolate reductase 0.8686 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0012 0.0009
Echinococcus multilocularis geminin 0.0332 0.0369 0.0368
Trypanosoma cruzi folylpolyglutamate synthetase 0.0396 0.0443 0.0867
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0102 0.01
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0035 0.0032
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0005 0.0002
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0329 0.0366 0.0715
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0017
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0043 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.4408 0.5068 1
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0021 0.001 0.0012
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0102 0.01
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0255 0.406
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) beta-lactamase 0.0043 0.0036 0.0036
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Onchocerca volvulus 0.002 0.0009 0.0012
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0021 0.001 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0041 0.0041
Onchocerca volvulus 0.0031 0.0022 0.0122
Brugia malayi Muscleblind-like protein 0.0147 0.0155 0.0155
Loa Loa (eye worm) acetyltransferase 0.0142 0.015 0.015
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0049 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0021 0.0018
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.8686 1 1
Mycobacterium ulcerans endonuclease IV 0.0075 0.0073 0.0068
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0055 0.01
Brugia malayi hypothetical protein 0.0036 0.0028 0.0028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0036 0.0034
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0043
Brugia malayi SPARC precursor 0.0019 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0019 0.0008 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0055 0.01
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0043 0.0043
Brugia malayi hypothetical protein 0.0027 0.0018 0.0018
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0122 0.0117
Trypanosoma cruzi MFS transporter, putative 0.0027 0.0018 0.0027
Schistosoma mansoni lipoxygenase 0.0054 0.0049 0.0046
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0028 0.0019 0.0029
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0031 0.0052
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0008 0.0009
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0008 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0035 0.0035
Brugia malayi hypothetical protein 0.0552 0.0623 0.0623
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0075 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.0904 0.0903
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0035 0.006
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0035 0.0032
Plasmodium falciparum importin beta, putative 0.0028 0.0019 0.0029
Loa Loa (eye worm) TAR-binding protein 0.0124 0.0129 0.0129
Echinococcus granulosus geminin 0.0332 0.0369 0.0368
Brugia malayi beta-lactamase 0.0043 0.0036 0.0036
Mycobacterium ulcerans beta-lactamase 0.0043 0.0036 0.0032
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0008 0.0005
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0008 0.0007
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0008 0.0007
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0061 0.7401
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0036 0.0064
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0044 0.0043
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0017 0.0016
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0036 0.0028 0.0028
Brugia malayi Thioredoxin reductase 0.0046 0.004 0.004
Schistosoma mansoni organic anion transporter 0.0027 0.0018 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0035 0.0034
Schistosoma mansoni polycystin 1-related 0.0019 0.0009 0.0006
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0332 0.0369 0.0366
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0521
Brugia malayi hypothetical protein 0.0052 0.0046 0.0046
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.015 0.0149
Echinococcus granulosus multidrug resistance associated protein 7 0.0028 0.0019 0.0018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0035 0.0034
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Chlamydia trachomatis endonuclease IV 0.0075 0.0073 0.0069
Echinococcus granulosus GPCR family 2 0.0015 0.0004 0.0003
Brugia malayi Dihydrofolate reductase 0.8686 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0035 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0004 0.0004
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0022 0.0035
Brugia malayi prostaglandin transporter 0.0027 0.0018 0.0018
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0036 0.0521
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0009 0.0008
Plasmodium falciparum metacaspase-like protein 0.0043 0.0036 0.0064
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0007
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0329 0.0366 0.0715
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0021 0.001 0.0012
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0004 0.0003
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0026 0.0043
Brugia malayi nuclear hormone receptor 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0036 0.0521
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0053 0.0052
Onchocerca volvulus 0.0027 0.0018 0.0089
Echinococcus granulosus snurportin 1 0.0302 0.0335 0.0334
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0022 0.0022
Brugia malayi follicle stimulating hormone receptor 0.023 0.0251 0.0251
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0027 0.0045
Entamoeba histolytica hypothetical protein 0.007 0.0068 0.8302
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0026 0.0352
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0064 0.0962
Brugia malayi Nuclear hormone receptor E75 0.002 0.0009 0.0009
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0009 0.0008
Onchocerca volvulus Cell death protein 3 homolog 0.0084 0.0083 0.0668
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0002
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.0129 0.0129
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0036 0.0032
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0329 0.0366 0.0715
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0035 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.005 0.0049
Echinococcus granulosus caspase 8 0.0043 0.0036 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0015 0.0021
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.4408 0.5068 1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0031 0.6673
Onchocerca volvulus Protein cycle homolog 0.0036 0.0028 0.0178
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0021 0.001 0.0012
Trypanosoma cruzi hypothetical protein 0.0022 0.0011 0.0014
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0017 0.0013
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0009 0.0009
Leishmania major pentamidine resistance protein 1 0.0028 0.0019 0.0029
Echinococcus multilocularis Protein lozenge 0.0055 0.0049 0.0048
Schistosoma mansoni DNA helicase recq1 0.0018 0.0008 0.0005
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0075 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.005 0.0047
Echinococcus granulosus cpg binding protein 0.003 0.0021 0.002
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0073 0.0068
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus multilocularis caspase 8 0.0043 0.0036 0.0035
Schistosoma mansoni caspase-3 (C14 family) 0.0115 0.0119 0.0116
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0994 0.1132 0.113
Echinococcus granulosus caspase 3 0.0071 0.0069 0.0068
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0021 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0036
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0028 0.0019 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0035 0.0034
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0021 0.001 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0521
Brugia malayi nuclear receptor RXR 0.002 0.0009 0.0009
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.0251 0.0251
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0009 0.0008
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0008 0.0007
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0108 0.0104
Plasmodium vivax metacaspase 1, putative 0.0043 0.0036 0.0064
Loa Loa (eye worm) hypothetical protein 0.0435 0.0488 0.0487
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0021 0.0018
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0008 0.0007
Plasmodium vivax peroxiredoxin, putative 0.0084 0.0083 0.0155
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0017
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.004 0.0071
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0018 0.0089
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0044 0.0043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0021 0.0036
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0021 0.001 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0021 0.002
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0036 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0055 0.01
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0021 0.001 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0059 0.0054
Mycobacterium tuberculosis Soluble secreted antigen Mpt53 precursor 0.0021 0.0011 0.0006
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0009 0.0008
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0019 0.0029
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0036 0.0028 0.0025
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0055 0.0054
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0007
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0014 0.0019
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0008 0.0008
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0035 0.0063
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0061 0.006
Leishmania major biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 0.0436 0.0489 0.0957
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0001
Onchocerca volvulus 0.0019 0.0009 0.0007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0035 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0028 0.0048
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.015 0.0148
Onchocerca volvulus Folate transporter 1 homolog 0.0049 0.0043 0.0316
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Leishmania major hypothetical protein, conserved 0.0025 0.0015 0.0021
Echinococcus granulosus aryl hydrocarbon receptor 0.0052 0.0046 0.0045
Mycobacterium ulcerans hypothetical protein 0.002 0.0009 0.0004
Onchocerca volvulus 0.0049 0.0042 0.0306
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0008 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0035 0.0034
Echinococcus granulosus tumor protein p63 0.0332 0.0369 0.0368
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0021 0.001 0.0006
Leishmania major p-glycoprotein e 0.0028 0.0019 0.0029
Schistosoma mansoni hypothetical protein 0.007 0.0068 0.0065
Leishmania major basic transcription factor 3a, putative 0.0034 0.0026 0.0043
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0009 0.0004
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0031 0.0054
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0017 0.0025
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0033 0.0025 0.0022
Plasmodium falciparum glutathione reductase 0.0046 0.004 0.0071
Plasmodium falciparum 1-cys peroxiredoxin 0.0084 0.0083 0.0155
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0035 0.0034
Schistosoma mansoni DNA polymerase eta 0.0058 0.0053 0.0051
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0009 0.0009
Brugia malayi nuclear receptor NHR-88 0.002 0.0009 0.0009
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0028 0.0019 0.0029
Toxoplasma gondii ABC1 family protein 0.0043 0.0036 0.0067
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0027
Toxoplasma gondii bifunctional protein FolC subfamily protein 0.0396 0.0443 0.087
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Brugia malayi PXA domain containing protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0009 0.0009
Schistosoma mansoni nuclear receptor 0.002 0.0009 0.0007
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0043 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.004 0.0033 0.003
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0005 0.0004
Brugia malayi ecdysone receptor 0.002 0.0009 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0036 0.0064
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0021 0.001 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0055 0.01
Echinococcus granulosus lamin 0.0026 0.0017 0.0016
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0022 0.0035
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0075 0.0071
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0008 0.0007
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0028 0.0019 0.0029
Brugia malayi CXXC zinc finger family protein 0.0028 0.0019 0.0019
Trypanosoma cruzi metacaspase, putative 0.0043 0.0036 0.0064
Onchocerca volvulus 0.0043 0.0036 0.0254
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.008 1
Schistosoma mansoni caspase-7 (C14 family) 0.0115 0.0119 0.0116
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0035 0.0492
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0005 0.0005
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0009 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0036 0.0522
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0028 0.0019 0.0029
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0035 0.0492
Plasmodium falciparum thioredoxin reductase 0.0016 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Trichomonas vaginalis esterase, putative 0.0043 0.0036 0.0522
Treponema pallidum thioredoxin 0.0021 0.0011 0.0138
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0122 0.0117
Brugia malayi hypothetical protein 0.0435 0.0488 0.0488
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0055 0.01
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0019 0.0018
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0005 0.0002
Schistosoma mansoni dihydrofolate reductase 0.8686 1 1
Trypanosoma brucei metacaspase 0.0043 0.0036 0.0064
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0035 0.0241
Brugia malayi jmjC domain containing protein 0.0015 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0062
Schistosoma mansoni agrin 0.0019 0.0008 0.0005
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0009 0.0009
Trypanosoma cruzi multidrug resistance protein E, putative 0.0028 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0035 0.0034
Onchocerca volvulus 0.0021 0.001 0.0019
Onchocerca volvulus 0.0027 0.0018 0.0089
Leishmania major folylpolyglutamate synthetase 0.0396 0.0443 0.0867
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0007
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0052 0.0046 0.0045
Schistosoma mansoni retinoic acid receptor RXR 0.0139 0.0147 0.0144
Mycobacterium tuberculosis Hypothetical protein 0.0552 0.0623 0.0618
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0329 0.0366 0.0715
Onchocerca volvulus 0.0049 0.0043 0.0316
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.004 0.0035
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0008 0.0008
Entamoeba histolytica ABC transporter, putative 0.0028 0.0019 0.1543
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0002
Schistosoma mansoni organic anion transporter 0.0027 0.0018 0.0015
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0008 0.0003
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0075 0.1596
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0081 0.008 0.0079
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.001 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0043 0.0043
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0005 0.0001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0122 0.0118
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0021 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0075 0.0073 0.0073
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0009 0.0008
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0008 0.067
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0022 0.0021
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.0768 0.0765
Echinococcus multilocularis caspase 0.0115 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0008
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0013 0.014
Brugia malayi Nuclear hormone receptor E75 0.002 0.0009 0.0009
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Schistosoma mansoni glutaminase 0.0267 0.0294 0.0291
Echinococcus granulosus muscleblind protein 0.0147 0.0155 0.0154
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0043
Echinococcus multilocularis lamin 0.0026 0.0017 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.005 0.0047
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0008 0.0008
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0004 0.0001
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0017
Entamoeba histolytica hypothetical protein 0.007 0.0068 0.8302
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0019 0.0008 0.0057
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0035 0.0034
Onchocerca volvulus 0.004 0.0033 0.0223
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0008 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0036 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0521
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0025 0.2346
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0035 0.0035
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0075 0.0074
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0036 0.0028 0.0027
Onchocerca volvulus 0.0026 0.0017 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0055 0.01
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0036 0.0032
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0008 0.0005
Entamoeba histolytica hypothetical protein 0.0028 0.0019 0.1543
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0022 0.0017
Toxoplasma gondii hypothetical protein 0.0201 0.0218 0.0425
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0129 0.0127
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0035 0.0035
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0004 0.0001
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0021 0.001 0.0014
Echinococcus multilocularis musashi 0.0026 0.0017 0.0016
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0008 0.0007
Echinococcus granulosus follistatin 0.0019 0.0008 0.0007
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0075 0.014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0032 0.0055
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0034
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0049 0.0048
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0028 0.0019 0.0032
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0017 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0008 0.0005
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0008 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0055 0.01
Brugia malayi hypothetical protein 0.0022 0.0012 0.0012
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0005 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0008 0.0712
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0036 0.0035
Echinococcus granulosus caspase 2 0.0084 0.0083 0.0082
Onchocerca volvulus 0.0049 0.0043 0.0316
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0004 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0012
Trichomonas vaginalis hypothetical protein 0.0021 0.001 0.0094
Onchocerca volvulus Folate transporter 1 homolog 0.0049 0.0043 0.0316
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0059 0.0108
Schistosoma mansoni importin beta-1 0.0028 0.0019 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0052 0.0046 0.0045
Echinococcus multilocularis transcription factor btf3 0.0034 0.0026 0.0025
Echinococcus granulosus lamin dm0 0.0026 0.0017 0.0016
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0027 0.0048
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0022 0.0035
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0035 0.0032
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0008 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0223 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0521
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.0129 0.0129
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0008 0.0007
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0008 0.0005
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0061 0.0113
Echinococcus granulosus folylpolyglutamate synthase, mitochondrial 0.0396 0.0443 0.0442
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0001
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0021 0.001 0.0014
Brugia malayi conserved hypotetical protein 0.002 0.0009 0.0009
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0026 0.0046
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0021 0.001 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0035 0.0035
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0036 0.0032
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0009 0.0012
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0006 0.0005
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0059 0.0058
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0017 0.0025
Loa Loa (eye worm) oxidoreductase 0.0021 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0051 0.0045 0.0042
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0036 0.0035
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0009 0.0008
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0073 0.0071 0.007
Schistosoma mansoni coup transcription factor 0.0042 0.0035 0.0032
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0075 0.0074
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0021 0.001 0.0728
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0008 0.0005
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0008 0.0007
Onchocerca volvulus 0.002 0.0009 0.0012
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0008 0.0008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0036 0.0521
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0008 0.0007
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0021 0.001 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.001 0.0005
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Brugia malayi hypothetical protein 0.012 0.0124 0.0124
Echinococcus multilocularis RUN 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0232 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0034
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0008 0.0392
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0009 0.0009
Brugia malayi hypothetical protein 0.0019 0.0008 0.0008
Echinococcus granulosus RUN 0.0019 0.0009 0.0008
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0008 0.0005
Chlamydia trachomatis oxoacy-ACP reductase 0.0021 0.001 0.0006
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0053 0.005
Echinococcus granulosus dnaJ subfamily B 0.0402 0.0449 0.0448
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0008 0.0007
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0021 0.001 0.0014
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0329 0.0366 0.0715
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0061 0.0061
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.001 0.0005
Schistosoma mansoni hypothetical protein 0.0402 0.0449 0.0447
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0009 0.0009
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0021 0.001 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0004 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0036 0.0522
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0044 0.004
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0008 0.0008
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0075 0.0142
Brugia malayi Doublecortin family protein 0.0019 0.0009 0.0009
Brugia malayi hypothetical protein 0.004 0.0033 0.0033
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.8686 1 1
Echinococcus multilocularis cpg binding protein 0.003 0.0021 0.002
Echinococcus granulosus phd:f box containing protein 0.0015 0.0004 0.0003
Mycobacterium tuberculosis Probable reductase 0.0106 0.0108 0.0104
Brugia malayi steroid hormone receptor 0.0042 0.0035 0.0035
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0042 0.004
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0055 0.005
Echinococcus multilocularis multidrug resistance associated protein 1 0.0028 0.0019 0.0018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0035 0.0034
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0025 0.0025
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0012 0.0011
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0008 0.0006
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0435 0.0488 0.0487
Echinococcus granulosus dihydrofolate reductase 0.8686 1 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0036 0.0028 0.0028
Onchocerca volvulus 0.0052 0.0046 0.0337
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0008 0.0007
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0064 0.0061
Trichomonas vaginalis peroxiredoxin, putative 0.0021 0.0011 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0036 0.0064
Echinococcus granulosus bloom syndrome protein 0.0044 0.0038 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0002
Plasmodium vivax dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0396 0.0443 0.0867
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0021 0.002
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0026 0.0043
Echinococcus granulosus importin subunit beta 1 0.0028 0.0019 0.0018
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0033 0.0032
Echinococcus multilocularis dna polymerase eta 0.0058 0.0053 0.0052
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0008 0.0007
Leishmania major oxidoreductase-like protein 0.0031 0.0022 0.0035
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0108 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.002 0.0032
Schistosoma mansoni multidrug resistance protein 0.0028 0.0019 0.0016
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0003 0.0002
Giardia lamblia DINP protein human, muc B family 0.004 0.0032 0.7055
Brugia malayi Melibiase family protein 0.0067 0.0064 0.0064
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0009 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0036
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0073 0.0069
Echinococcus granulosus folate receptor beta 0.0818 0.0929 0.0928
Brugia malayi polk-prov protein 0.0036 0.0028 0.0028
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.004 0.0071
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.001 0.0005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0013 0.014
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0021 0.001 0.0005
Schistosoma mansoni survival motor neuron protein 0.0047 0.0041 0.0038
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0008 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.0058 0.0053 0.0097
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0008 0.0007
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0027 0.0018 0.0017
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0059 0.0054
Brugia malayi hypothetical protein 0.0025 0.0015 0.0015
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0015 0.0021
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0061 0.006
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0022 0.0017
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0036 0.0521
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.001 0.0005
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0059 0.0056
Schistosoma mansoni cpg binding protein 0.003 0.0021 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0036
Echinococcus granulosus tar DNA binding protein 0.0124 0.0129 0.0128
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0008 0.0007
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0009 0.0009
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0026 0.2533
Leishmania major importin beta-1 subunit, putative 0.0023 0.0013 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0008 0.0056
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0021 0.001 0.0012
Schistosoma mansoni follistatin 0.0019 0.0008 0.0005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0064 0.0061
Brugia malayi beta-NAC-like protein 0.0034 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.0449 0.0448
Brugia malayi nuclear receptor RXR 0.0022 0.0012 0.0012
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0055 0.0817
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0068 0.0065
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0008 0.0008
Echinococcus multilocularis folate receptor beta 0.0818 0.0929 0.0928
Leishmania major ABC-thiol transporter 0.0028 0.0019 0.0029
Brugia malayi tailless protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Onchocerca volvulus 0.0019 0.0009 0.0007
Echinococcus multilocularis tumor protein p63 0.0332 0.0369 0.0368
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0329 0.0366 0.0715
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0001
Onchocerca volvulus Folate transporter 1 homolog 0.0049 0.0043 0.0316
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0008 0.0008
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0108 0.0104
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.002
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0115 0.0119 0.0118
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.0102 0.0101
Schistosoma mansoni single-minded 0.0015 0.0004 0.0001
Trypanosoma brucei unspecified product 0.0023 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) dihydrofolate reductase 0.8686 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0036
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0005 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0062
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0021 0.001 0.0006
Brugia malayi PXA domain containing protein 0.0019 0.0008 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0068 0.0067
Mycobacterium ulcerans lipase LipD 0.0043 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0036 0.0521
Brugia malayi glutaminase DH11.1 0.0267 0.0294 0.0294
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0035 0.0032
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0004 0.0003
Brugia malayi hypothetical protein 0.0232 0.0254 0.0254
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0009 0.0008
Mycobacterium ulcerans folylpolyglutamate synthase protein FolC 0.0396 0.0443 0.0439
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0009 0.0008
Mycobacterium tuberculosis Probable conserved lipoprotein DsbF 0.0021 0.0011 0.0006
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.0005
Echinococcus granulosus transcription factor Dp 1 0.0038 0.003 0.0029
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0009 0.0009
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0312 0.0346 0.0345
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0073 0.0136
Trypanosoma brucei DNA polymerase IV, putative 0.0053 0.0047 0.0085
Loa Loa (eye worm) glutaminase 0.0267 0.0294 0.0294
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0035 0.0034
Schistosoma mansoni lamin 0.0026 0.0017 0.0014
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0036 0.0521
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0061 0.0113
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0034
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0036 0.0522
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0004 0.0003
Echinococcus granulosus multidrug resistance associated protein 1 0.0028 0.0019 0.0018
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0021 0.001 0.0005
Mycobacterium ulcerans glutaminase 0.0267 0.0294 0.0289
Plasmodium falciparum glutathione reductase 0.0016 0.0005 0.0002
Trypanosoma brucei metacaspase 5, putative 0.0043 0.0036 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0004 0.0004
Schistosoma mansoni DNA helicase recq5 0.0018 0.0008 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0001
Loa Loa (eye worm) multidrug resistance-associated protein 0.0022 0.0012 0.0011
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0031 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0135 0.0142 0.0141
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0043 0.0036 0.0034
Loa Loa (eye worm) DR-78 0.002 0.0009 0.0009
Loa Loa (eye worm) retinol dehydrogenase 12 0.0021 0.001 0.0009
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0329 0.0366 0.0717
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.0053 0.0053
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0329 0.0366 0.0715
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0021 0.001 0.0012
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.003 0.0029
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0036 0.0066
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0022 0.0035
Loa Loa (eye worm) glutaminase 2 0.0267 0.0294 0.0294
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0008 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0035 0.0032
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0014 0.0019
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.8686 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0007
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0035 0.0241
Mycobacterium leprae Probable lipase LipE 0.0043 0.0036 0.0032
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0008 0.0005
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0004 0.0001
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0014 0.0154
Onchocerca volvulus 0.0026 0.0017 0.008
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0035 0.0034
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0994 0.1132 0.1128
Schistosoma mansoni multidrug resistance protein 0.0028 0.0019 0.0016
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0036 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0021 0.0018
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0008 0.0008
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0027 0.0018 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0015 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0021 0.0018
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0019 0.0018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0021 0.0035
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0012 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0057 0.0054
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0035 0.0035
Brugia malayi small heat shock protein 0.0567 0.064 0.064
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0155 0.0154
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0043
Schistosoma mansoni intermediate filament proteins 0.0026 0.0017 0.0014
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0075 0.0072
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.005 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0055 0.01
Echinococcus multilocularis muscleblind protein 0.0147 0.0155 0.0154
Brugia malayi intermediate filament protein 0.0026 0.0017 0.0017
Brugia malayi RNA, U transporter 1 0.0081 0.0079 0.0079
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0005 0.0011
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0055 0.0054
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0061 0.0113
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0036 0.0064
Echinococcus granulosus dna polymerase kappa 0.0059 0.0055 0.0054
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0004 0.0003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0036 0.0032
Echinococcus granulosus Major facilitator superfamily general substrate transporter 0.0147 0.0156 0.0155
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0025 0.0025
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0021 0.001 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0012 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0036 0.0034
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0004 0.0003
Brugia malayi multidrug resistance related protein 1 0.0028 0.0019 0.0019
Onchocerca volvulus 0.0042 0.0035 0.0241
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0028 0.0019 0.0018
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0025 0.0022
Echinococcus multilocularis multidrug resistance associated protein 4 0.0022 0.0011 0.001
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0021 0.001 0.0012
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0021 0.001 0.0326
Onchocerca volvulus 0.0027 0.0018 0.0089
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0036 0.0032
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0021 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0027
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0008 0.0006
Echinococcus multilocularis thymidylate synthase 0.0994 0.1132 0.1131
Schistosoma mansoni cpg binding protein 0.0028 0.0019 0.0016
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0009 0.0008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0035 0.0032
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0307 0.0302
Echinococcus multilocularis caspase 3 0.0071 0.0069 0.0068
Plasmodium falciparum metacaspase 1 0.0043 0.0036 0.0064
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0035 0.0035
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0032 0.0027
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0036 0.0066
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0036 0.0521
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0008 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.001 0.001
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0994 0.1132 0.1129
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.002 0.0032
Brugia malayi glutathione reductase 0.0046 0.004 0.004
Trypanosoma brucei Metacaspase-4 0.0043 0.0036 0.0064
Onchocerca volvulus Putative folylpolyglutamate synthase 0.0396 0.0443 0.3872
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase 0.0396 0.0443 0.0867
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0004 0.0001
Mycobacterium tuberculosis Probable thiol peroxidase Tpx 0.0021 0.0011 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.002 0.0032
Giardia lamblia Multidrug resistance-associated protein 1 0.0028 0.0019 0.3538
Loa Loa (eye worm) hypothetical protein 0.0147 0.0155 0.0155
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.0018 0.003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0139 0.0147 0.0146
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0008 0.0008
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0008 0.0005
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0008 0.0007
Brugia malayi FolC bifunctional protein 0.0396 0.0443 0.0443
Onchocerca volvulus 0.003 0.0021 0.0115
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0035 0.0034
Brugia malayi hypothetical protein 0.0019 0.0008 0.0008
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0013 0.014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0008 0.0009
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0008 0.0005
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0008 0.0008
Brugia malayi jmjC domain containing protein 0.0015 0.0004 0.0004
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0038 0.0036
Echinococcus granulosus expressed protein 0.0367 0.0409 0.0408
Brugia malayi PAS domain containing protein 0.0015 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0036 0.0064
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0036
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0018 0.0018
Schistosoma mansoni nuclear hormone receptor 0.002 0.0009 0.0007
Trichomonas vaginalis peroxiredoxin, putative 0.0021 0.0011 0.011
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0005 0.0002
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0027 0.0018 0.0017
Onchocerca volvulus 0.0043 0.0036 0.0254
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0008 0.001
Schistosoma mansoni cpg binding protein 0.003 0.0021 0.0018
Leishmania major dihydrofolate reductase-thymidylate synthase 0.4408 0.5068 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0033 0.0032
Trypanosoma brucei trypanothione reductase 0.0046 0.004 0.0071
Schistosoma mansoni rab6-interacting 0.0019 0.0009 0.0006
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0022 0.0017
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0055 0.01
Schistosoma mansoni nuclear hormone receptor 0.002 0.0009 0.0007
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0022 0.0035
Schistosoma mansoni hypothetical protein 0.0332 0.0369 0.0366
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0005 0.0002
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0027 0.0024
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0009 0.0007
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0009 0.0004
Brugia malayi thymidylate synthase 0.0994 0.1132 0.1132
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0018 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0062
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.0019 0.1543
Schistosoma mansoni hypothetical protein 0.0302 0.0335 0.0332
Entamoeba histolytica hypothetical protein 0.0019 0.0008 0.0057
Loa Loa (eye worm) reduced folate carrier family protein 0.0049 0.0043 0.0043
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0019 0.0032
Loa Loa (eye worm) glutathione reductase 0.0046 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0027
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0035 0.0034
Brugia malayi jmjC domain containing protein 0.0059 0.0055 0.0055
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0009 0.0008
Entamoeba histolytica hypothetical protein 0.0023 0.0013 0.0717
Giardia lamblia Hypothetical protein 0.0049 0.0043 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0008 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0004 0.0004
Brugia malayi isocitrate dehydrogenase 0.0031 0.0022 0.0022
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0035 0.0034
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0026 0.0025
Brugia malayi nuclear receptor NHR-67 0.002 0.0009 0.0009
Brugia malayi Probable ClpP-like protease 0.0077 0.0075 0.0075
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.001 0.0005
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0004 0.0003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0044 0.004
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0038 0.0539
Leishmania major trypanothione reductase 0.0046 0.004 0.0071
Leishmania major pteridine reductase 1 0.0487 0.0548 0.1074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0018
Trypanosoma cruzi metacaspase, putative 0.0043 0.0036 0.0064
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0008 0.0005
Giardia lamblia Multidrug resistance-associated protein 1 0.0028 0.0019 0.3606
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0035 0.0035
Plasmodium vivax glutathione reductase, putative 0.0046 0.004 0.0071
Echinococcus granulosus agrin 0.0019 0.0008 0.0007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.0335 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0035 0.0034
Trypanosoma brucei metacaspase MCA2 0.0043 0.0036 0.0064
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0055 0.01
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0015 0.0021
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0035 0.0035
Mycobacterium leprae conserved hypothetical protein 0.002 0.0009 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0004 0.0003
Trichomonas vaginalis dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0396 0.0443 0.7101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0035 0.0034
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0073 0.0073
Echinococcus granulosus caspase 0.0115 0.0119 0.0118
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0005 0.0002
Echinococcus multilocularis Major facilitator superfamily, general substrate transporter 0.0147 0.0156 0.0155

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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