Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0402 | 0.1019 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0168 | 0.3904 | 1 |
Treponema pallidum | NADH oxidase | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0402 | 0.1019 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0042 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0365 | 1 | 0.5 | |
Leishmania major | trypanothione reductase | 0.0168 | 0.3904 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0402 | 0.1019 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0402 | 0.1019 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0402 | 0.0402 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0402 | 0.1019 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0402 | 0.1019 |
Trypanosoma brucei | trypanothione reductase | 0.0168 | 0.3904 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.017 | 0.3944 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0168 | 0.3904 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0042 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0168 | 0.3904 | 0.3904 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0042 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0168 | 0.3904 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0168 | 0.3904 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0042 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.0168 | 0.3904 | 0.3904 |
Plasmodium vivax | glutathione reductase, putative | 0.0168 | 0.3904 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0168 | 0.3904 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0168 | 0.3904 | 0.3649 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0168 | 0.3904 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.017 | 0.3944 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0168 | 0.3904 | 0.3649 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0402 | 0.1019 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 75.6863 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.