Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0043 | 0.1078 | 0.2936 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0834 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0834 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0834 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0897 | 0.4076 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0834 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1078 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.024 | 0.0739 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0146 | 0.0559 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0834 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0834 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1227 | 0.4709 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.1013 | 0.2673 |
Onchocerca volvulus | 0.0038 | 0.0834 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0834 | 0.5 |
Onchocerca volvulus | 0.0038 | 0.0834 | 0.5 | |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0834 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0834 | 0.3199 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1379 | 0.6521 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0834 | 0.3199 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1078 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0834 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.2064 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0834 | 0.3447 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0834 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0834 | 0.1942 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0834 | 0.1942 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0834 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0834 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0834 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0834 | 0.1942 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1133 | 0.4348 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0834 | 0.3447 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1379 | 0.5987 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1017 | 0.3902 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1379 | 0.6521 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.224 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0897 | 0.4076 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.1379 | 0.5292 |
Onchocerca volvulus | 0.0038 | 0.0834 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0834 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0834 | 0.3199 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0834 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1078 | 0.4586 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1078 | 0.4995 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0834 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0834 | 0.3754 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1078 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.024 | 0.0739 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.2815 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0834 | 0.3199 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0834 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0834 | 0.3199 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1078 | 0.4995 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.024 | 0.0679 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1078 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0834 | 0.3754 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0834 | 0.3199 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1078 | 0.4586 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.1379 | 0.4159 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.2064 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1379 | 0.6521 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1379 | 0.5987 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1379 | 0.5987 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0834 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0834 | 0.3199 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0146 | 0.0242 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0834 | 0.1942 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0834 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0834 | 0.3199 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1379 | 0.6521 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.6626 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.