Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0058 | 0.0106 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0729 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1431 | 0.3872 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.3665 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.3665 | 1 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.0729 | 0.0841 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.3665 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1431 | 0.3872 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.3665 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.1431 | 0.3872 | 0.3872 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.3665 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.3665 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.0729 | 0.0841 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0441 | 0.5878 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0441 | 0.5878 |
Brugia malayi | hypothetical protein | 0.003 | 0.003 | 0.003 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.3665 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.0713 | 0.977 |
Brugia malayi | hypothetical protein | 0.0286 | 0.0729 | 0.0729 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1431 | 0.3872 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.3665 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.1431 | 0.3872 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.3665 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.3665 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.3665 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1431 | 0.3872 | 1 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.0441 | 0.0441 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.1431 | 0.3872 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.3665 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1431 | 0.3872 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.0713 | 0.0713 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1431 | 0.3872 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1431 | 0.3872 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1431 | 0.3872 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.3665 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1431 | 0.3872 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0106 | 0.0106 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1431 | 0.3872 | 0.3854 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.3665 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.