Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.8232 | 0.8155 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.1467 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.1467 | 0.1467 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.8232 | 0.8155 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0416 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1467 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.8232 | 0.8155 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1467 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.1467 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.8232 | 0.8155 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.8232 | 0.8232 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1467 | 0.1097 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.1467 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.8232 | 0.8155 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.8232 | 0.8232 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0416 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1467 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.8232 | 0.8155 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0416 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.8232 | 0.8155 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.8232 | 0.8155 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0416 | 0.0416 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0416 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.8232 | 0.8155 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1467 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0416 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0416 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0416 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.1467 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.8232 | 0.8155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0416 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.8232 | 0.8155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 26 uM | PUBCHEM_BIOASSAY: Counterscreen for target specificity Measured in Cell-Free Homogeneous System Using Plate Reader - 2041-02_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2222] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.