Detailed information for compound 1369114

Basic information

Technical information
  • TDR Targets ID: 1369114
  • Name: [2-oxo-2-(pyrimidin-2-ylamino)ethyl] 4-(trifl uoromethoxy)benzoate
  • MW: 341.242 | Formula: C14H10F3N3O4
  • H donors: 1 H acceptors: 4 LogP: 2.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ncccn1)COC(=O)c1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C14H10F3N3O4/c15-14(16,17)24-10-4-2-9(3-5-10)12(22)23-8-11(21)20-13-18-6-1-7-19-13/h1-7H,8H2,(H,18,19,20,21)
  • InChiKey: OJAIHCLJJKTHEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(trifluoromethoxy)benzoic acid [2-oxo-2-(2-pyrimidinylamino)ethyl] ester
  • 4-(trifluoromethoxy)benzoic acid [2-keto-2-(pyrimidin-2-ylamino)ethyl] ester
  • T5607463
  • ZINC08316393

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3514 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3514 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3514 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0081 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3514 1
Echinococcus granulosus dna polymerase eta 0.0054 0.3431 0.9729
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.1231 0.262
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0081 0.0355
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0081 0.0355
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.1231 0.3432
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1231 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.1231 0.5
Leishmania major DNA polymerase eta, putative 0.0038 0.2281 0.6568
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.1231 0.3348
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.2281 0.6568
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.042 0.0341
Loa Loa (eye worm) hypothetical protein 0.0012 0.042 0.0341
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Schistosoma mansoni DNA polymerase eta 0.0054 0.3431 0.9762
Echinococcus multilocularis dna polymerase kappa 0.0023 0.1231 0.262
Echinococcus multilocularis dna polymerase eta 0.0054 0.3431 0.9729
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1637 0.3934
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.1231 0.579
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.1231 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.1231 0.579
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1385 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0713 0.1887
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3514 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.1231 0.3501
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Treponema pallidum ATP-dependent DNA helicase 0.0006 0 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.3514 0.3461
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1637 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.184
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1637 1
Loa Loa (eye worm) RecQ helicase 0.0029 0.1637 0.1569
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.1231 0.3501
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.2281 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3514 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.0986
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0671 0.5456
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.1762
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3514 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.0986
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.1762
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.1762
Echinococcus granulosus bloom syndrome protein 0.0029 0.1637 0.3934
Schistosoma mansoni DNA helicase recq1 0.0012 0.042 0.1194
Giardia lamblia DINP protein human, muc B family 0.0023 0.1231 1
Trypanosoma brucei unspecified product 0.0016 0.0713 0.1887
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.3431 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0713 0.1887
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1231 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0966 1
Leishmania major DNA polymerase eta, putative 0.0054 0.3431 1
Trypanosoma brucei unspecified product 0.0023 0.1231 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0713 0.1887
Trypanosoma brucei unspecified product 0.0016 0.0713 0.1887
Loa Loa (eye worm) hypothetical protein 0.0054 0.3431 0.3377
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1231 0.3432
Schistosoma mansoni DNA helicase recq5 0.0012 0.042 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.1231 0.1159
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.3514 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0949 0.416
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.042 0.2945
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.1231 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.184
Echinococcus granulosus dna polymerase kappa 0.0023 0.1231 0.262
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.3431 0.9756
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1637 0.4532
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1231 0.3432
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1231 0.3432
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.1201 0.3417
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.1231 0.262
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.042 0.2596
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.3431 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 59.7279 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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