Detailed information for compound 1369152

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 526.518 | Formula: C24H22N4O8S
  • H donors: 3 H acceptors: 6 LogP: 5.11 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CCOc1ccc(cc1OC)C=NNc1ccc(cc1[N+](=O)[O-])S(=O)(=O)Nc1ccccc1C(=O)O
  • InChi: 1S/C24H22N4O8S/c1-3-12-36-22-11-8-16(13-23(22)35-2)15-25-26-20-10-9-17(14-21(20)28(31)32)37(33,34)27-19-7-5-4-6-18(19)24(29)30/h3-11,13-15,26-27H,1,12H2,2H3,(H,29,30)
  • InChiKey: PKMMWLYTDUYCLW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens small ubiquitin-like modifier 1 Starlite/ChEMBL No references
Homo sapiens DNA (cytosine-5-)-methyltransferase 1 Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens small ubiquitin-like modifier 4 Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis ubiquitin-like protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Neospora caninum hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Small ubiquitin-related modifier 2 precursor, putative Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii small ubiquitin family modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) SMO-1 protein Get druggable targets OG5_127053 All targets in OG5_127053
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis ubiquitin-like protein Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica ubiquitin like protein Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Sentrin Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania infantum small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva ubiquitin, putative Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi Ubiquitin-like protein SMT3 Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium falciparum small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus multilocularis Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium vivax small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium knowlesi small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Plasmodium falciparum small ubiquitin-related modifier small ubiquitin-like modifier 4 95 aa 79 aa 48.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum 6-cysteine protein small ubiquitin-like modifier 1 101 aa 92 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.284 0.284
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0102 0.4312 0.4312
Echinococcus granulosus dna polymerase eta 0.0077 0.2946 0.2946
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.5034 0.5034
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.1283 0.7695
Trypanosoma brucei unspecified product 0.0047 0.1253 0.1253
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.1384 0.1384
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Echinococcus multilocularis dna polymerase kappa 0.0047 0.1253 0.1253
Echinococcus multilocularis geminin 0.0205 0.9951 0.9951
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0639 0.012
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0639 0.0639
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2001 0.1467
Entamoeba histolytica hypothetical protein 0.0039 0.0827 0.0827
Loa Loa (eye worm) phosphofructokinase 0.0131 0.5912 0.564
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1284 0.0703
Loa Loa (eye worm) acetyltransferase 0.0175 0.8321 0.8209
Chlamydia trachomatis phosphoglycerate kinase 0.0206 1 1
Giardia lamblia Phosphoglycerate kinase 0.0206 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.5912 0.5912
Treponema pallidum phosphoglycerate kinase 0.0206 1 1
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0639 0.0639
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.2946 0.2476
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.5912 0.5327
Trypanosoma cruzi small ubiquitin protein, putative 0.0063 0.2153 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.2153 0.1718
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.1253 0.1253
Schistosoma mansoni phosphoglycerate kinase 0.0206 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.1033 0.0435
Brugia malayi Heterochromatin protein 1 0.0084 0.3318 0.2873
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.1177 0.1177
Trichomonas vaginalis chromobox protein, putative 0.0084 0.3318 0.2948
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.1033 0.1033
Brugia malayi chromobox protein homolog 3 0.0047 0.1283 0.0702
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.5912 0.564
Schistosoma mansoni cpg binding protein 0.004 0.0914 0.0914
Loa Loa (eye worm) hypothetical protein 0.0047 0.1283 0.0702
Loa Loa (eye worm) hypothetical protein 0.0041 0.0952 0.0349
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 1 0.5
Schistosoma mansoni hypothetical protein 0.0041 0.0952 0.0952
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.1253 0.1253
Onchocerca volvulus 0.0039 0.0827 0.2365
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 1 1
Leishmania major DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Brugia malayi phosphofructokinase 0.0131 0.5912 0.564
Loa Loa (eye worm) hypothetical protein 0.0037 0.0722 0.0104
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0639 0.0639
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.5912 0.5912
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Echinococcus multilocularis ubiquitin 0.0039 0.0827 0.0827
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.284 0.1885
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0625 0.0625
Echinococcus multilocularis chromobox protein 1 0.0084 0.3318 0.3318
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 1 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 1 1
Echinococcus granulosus ubiquitin 0.0039 0.0827 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0456 0.0456
Trypanosoma brucei phosphoglycerate kinase 0.0206 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.1253 0.1253
Loa Loa (eye worm) hypothetical protein 0.0206 1 1
Echinococcus granulosus geminin 0.0205 0.9951 0.9951
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.2946 0.2005
Brugia malayi Bromodomain containing protein 0.0039 0.0861 0.0252
Leishmania major small ubiquitin protein, putative 0.0063 0.2153 0.2153
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.1253 0.1253
Trichomonas vaginalis ubiquitin, putative 0.0039 0.0827 0.0319
Brugia malayi hypothetical protein 0.0039 0.0827 0.0216
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.1253 0.1253
Echinococcus granulosus disco interacting protein 2 0.0047 0.1248 0.1248
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.8321 0.8209
Entamoeba histolytica ubiquitin like protein 0.0063 0.2153 0.2153
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2001 0.1467
Plasmodium falciparum small ubiquitin-related modifier 0.0063 0.2153 0.2153
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1284 0.1284
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0639 0.012
Brugia malayi 6-phosphofructokinase 0.0131 0.5912 0.564
Brugia malayi CXXC zinc finger family protein 0.004 0.0914 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1283 0.08
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.8321 0.8321
Loa Loa (eye worm) hypothetical protein 0.006 0.201 0.1477
Trypanosoma brucei unspecified product 0.0032 0.0456 0.0456
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.152 0.152
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0827 0.0216
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 1 1
Echinococcus multilocularis disco interacting protein 2 0.0047 0.1248 0.1248
Schistosoma mansoni hypothetical protein 0.0035 0.0625 0.0625
Trichomonas vaginalis chromobox protein, putative 0.0051 0.148 0.1008
Brugia malayi 6-phosphofructokinase 0.0131 0.5912 0.564
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.152 0.105
Giardia lamblia DINP protein human, muc B family 0.0047 0.1253 0.067
Loa Loa (eye worm) CXXC zinc finger family protein 0.004 0.0914 0.0309
Trypanosoma brucei unspecified product 0.0032 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.006 0.2001 0.1467
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.5912 0.5912
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.148 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1284 0.1284
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.152 0.152
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.1033 0.1033
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.8051 0.8051
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.284 0.1885
Schistosoma mansoni chromobox protein 0.0084 0.3318 0.3318
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0639 0.012
Schistosoma mansoni hypothetical protein 0.0205 0.9951 0.9951
Onchocerca volvulus 0.004 0.0914 0.3382
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0952 0.0349
Brugia malayi Ubiquitin-like protein SMT3 0.0063 0.2153 0.163
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Loa Loa (eye worm) hypothetical protein 0.0047 0.1248 0.0664
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.1253 0.067
Trichomonas vaginalis chromobox protein, putative 0.0084 0.3318 0.2948
Toxoplasma gondii hypothetical protein 0.0102 0.4312 0.4312
Echinococcus granulosus chromobox protein 1 0.0084 0.3318 0.3318
Plasmodium falciparum phd finger protein, putative 0.0035 0.0625 0.0625
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2001 0.1467
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Trichomonas vaginalis chromobox protein, putative 0.0051 0.148 0.1008
Leishmania major DNA polymerase eta, putative 0.0045 0.1177 0.1177
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0827 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0456 0.0456
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.5912 0.5686
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0625 0.0625
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1253 0.0086
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0639 0.0639
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.152 0.152
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.5912 0.5633
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0639 0.0015
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0047 0.1248 0.1248
Schistosoma mansoni phosphoglycerate kinase 0.0206 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.9951 0.9951
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0625 0.0625
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.3318 0.2873
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.5034 0.5034
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.5912 0.564
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 1 1
Echinococcus multilocularis dna polymerase eta 0.0077 0.2946 0.2946
Schistosoma mansoni cpg binding protein 0.004 0.0914 0.0914
Echinococcus multilocularis Small ubiquitin modifier 2 0.0063 0.2153 0.2153
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.152 0.152
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.284 0.284
Plasmodium falciparum phosphoglycerate kinase 0.0206 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.1253 0.067
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.1253 0.0768
Onchocerca volvulus 0.0037 0.0722 0.1137
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0639 0.012
Brugia malayi jmjC domain containing protein 0.0115 0.5034 0.4703
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0639 0.0639
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.1253 0.1253
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1253 0.0086
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0639 0.012
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.5912 0.5327
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.284 0.1885
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.5912 0.5912
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 1 1
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 1 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0639 0.0639
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.1253 0.1253
Trypanosoma brucei phosphoglycerate kinase 0.0206 1 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.2946 0.2476
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.2689 0.2201
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0639 0.0639
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Echinococcus multilocularis cpg binding protein 0.004 0.0914 0.0914
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Echinococcus granulosus chromobox protein 1 0.0084 0.3318 0.3318
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.5912 0.5686
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.1253 0.1253
Plasmodium vivax small ubiquitin-related modifier, putative 0.0063 0.2153 0.2153
Echinococcus granulosus cpg binding protein 0.004 0.0914 0.0914
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 1 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.152 0.105
Echinococcus granulosus dna polymerase kappa 0.0047 0.1253 0.1253
Brugia malayi jmjC domain containing protein 0.0043 0.1033 0.0435
Brugia malayi Phosphoglycerate kinase 0.0075 0.284 0.2363
Schistosoma mansoni jumonji domain containing protein 0.0092 0.373 0.373
Trypanosoma cruzi small ubiquitin protein, putative 0.0063 0.2153 0.1107
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0625 0.0625
Echinococcus granulosus jumonji domain containing protein 0.0049 0.1384 0.1384
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.1033 0.1033
Loa Loa (eye worm) SMO-1 protein 0.0063 0.2153 0.163
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0639 0.0639
Leishmania major DNA polymerase eta, putative 0.0077 0.2946 0.2946
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1283 0.08
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.1253 0.1253
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.284 0.284
Trypanosoma brucei small ubiquitin-related modifier 0.0063 0.2153 0.2153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1253 0.0086
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.1033 0.1033
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.5912 0.5686
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.5912 0.5912
Echinococcus granulosus peregrin 0.0039 0.0861 0.0861
Schistosoma mansoni DNA polymerase eta 0.0077 0.2946 0.2946
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.5912 0.5367
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Onchocerca volvulus 0.0047 0.1248 0.728
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0625 0.0625
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.5912 0.5912
Giardia lamblia Sentrin 0.0063 0.2153 0.163
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.284 0.1885
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 1 1
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.5912 0.5912
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0639 0.012
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.5912 0.5686
Echinococcus multilocularis chromobox protein 1 0.0084 0.3318 0.3318
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0625 0.0625
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.2946 0.2946
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.284 0.1885
Toxoplasma gondii small ubiquitin family modifier, putative 0.0063 0.2153 0.2153
Schistosoma mansoni chromobox protein 0.0084 0.3318 0.3318
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.5912 0.5912
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0456 0.0456
Echinococcus granulosus Small ubiquitin modifier 2 0.0063 0.2153 0.2153
Schistosoma mansoni cpg binding protein 0.004 0.0914 0.0914
Echinococcus multilocularis peregrin 0.0039 0.0861 0.0861
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1253 0.1253
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.8321 0.8321
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1253 0.0086
Brugia malayi Disco-interacting protein 2 homolog 0.0047 0.1248 0.0664
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.1253 0.0768
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 1 1
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0063 0.2153 0.2153
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.5912 0.5912
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0639 0.012

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.002 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
IC50 (functional) = 5.32 uM PUBCHEM_BIOASSAY: Dose response confirmation of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 14 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 17.09 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a SUMO2 fluorescence polarization selectivity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 23.1 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule antagonists of the CCR6 receptor: a luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159] ChEMBL. No reference
IC50 (functional) 51.21 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 65.57 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 66 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a SUMO2 fluorescence resonance energy transfer selectivity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66.6 uM PUBCHEM_BIOASSAY: HTS Dose response counterscreen for assays utilizing the enzyme, beta-galactosidase - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159] ChEMBL. No reference
Max_Activity_Concent (functional) 12 uM PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8492 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1682 uM PubChem BioAssay. qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 11.9173 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 67.0158 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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