Detailed information for compound 1369181

Basic information

Technical information
  • TDR Targets ID: 1369181
  • Name: 2-cyclopentyl-3-oxo-3-(2-tetrahydrofuranylmet hylamino)propanoic acid methyl ester
  • MW: 269.337 | Formula: C14H23NO4
  • H donors: 1 H acceptors: 2 LogP: 2.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C(C(=O)NCC1CCCO1)C1CCCC1
  • InChi: 1S/C14H23NO4/c1-18-14(17)12(10-5-2-3-6-10)13(16)15-9-11-7-4-8-19-11/h10-12H,2-9H2,1H3,(H,15,16)
  • InChiKey: YVUQQXCYHUSPNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-cyclopentyl-3-keto-3-(tetrahydrofurfurylamino)propionic acid methyl ester
  • A2879/0121347
  • ChemDiv2_002366
  • EU-0020063
  • methyl 2-cyclopentyl-3-oxo-3-(oxolan-2-ylmethylamino)propanoate
  • methyl 2-cyclopentyl-3-oxo-3-(tetrahydrofuran-2-ylmethylamino)propanoate
  • methyl 2-cyclopentyl-3-oxo-3-[(tetrahydro-2-furanylmethyl)amino]propanoate
  • MLS000534732
  • Oprea1_050899
  • SMR000142149

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0176 0.0239
Onchocerca volvulus 0.0031 0.0109 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0139 0.0707
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0027 0.0017
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0176 0.0239
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.023 0.1704 0.8837
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0216 0.0915
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0015 0.0011
Entamoeba histolytica deoxycytidyl transferase, putative 0.0161 0.1152 0.8427
Giardia lamblia DNA damage repair protein 0.005 0.026 0.19
Loa Loa (eye worm) hypothetical protein 0.0133 0.0926 0.0916
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0176 0.0239
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0524 0.0741
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0013 0.0002
Echinococcus granulosus regulator of G protein signaling 7 0.0049 0.0254 0.0352
Leishmania major DNA polymerase kappa, putative 0.005 0.026 0.1387
Schistosoma mansoni hypothetical protein 0.0116 0.0787 0.112
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.0846 0.0837
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0027 0.0024
Trypanosoma brucei DNA damage repair protein, putative 0.005 0.026 0.1387
Echinococcus multilocularis expressed protein 0.077 0.6041 0.87
Loa Loa (eye worm) hypothetical protein 0.0174 0.1253 0.1244
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0176 0.0239
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0337 0.2686
Loa Loa (eye worm) hypothetical protein 0.0031 0.0109 0.0099
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0179 0.0227
Plasmodium falciparum phd finger protein, putative 0.006 0.0337 0.2611
Brugia malayi glutathione reductase 0.0101 0.0668 0.0658
Plasmodium vivax ataxin-2 like protein, putative 0.0131 0.0912 0.7274
Brugia malayi regulator of G-protein signaling egl-10 0.0049 0.0254 0.0244
Loa Loa (eye worm) hypothetical protein 0.025 0.1864 0.1855
Trichomonas vaginalis spcc417.12 protein, putative 0.0083 0.0529 0.2422
Treponema pallidum phosphoglycerate kinase 0.0174 0.1253 1
Schistosoma mansoni phosphoglycerate kinase 0.0174 0.1253 0.1793
Onchocerca volvulus 0.0083 0.0529 0.0519
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0524 0.0741
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0065 0.0379 0.0532
Brugia malayi Heterochromatin protein 1 0.0071 0.0429 0.0419
Leishmania major DNA polymerase eta, putative 0.0241 0.1795 1
Giardia lamblia DINP protein human, muc B family 0.0161 0.1152 0.9176
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0013 0.0003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0065 0.0379 0.2056
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0139 0.0707
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0178 0.0242
Trypanosoma cruzi DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0178 0.0168
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0494 0.3826 0.5504
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.026 0.1387
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0256 0.191 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0176 0.0719
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.037 0.2007
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0013 0.0003
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0216 0.0915
Toxoplasma gondii ImpB/MucB/SamB family protein 0.005 0.026 0.2074
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0139 0.1107
Echinococcus multilocularis carboxylesterase 5A 0.0494 0.3826 0.5504
Schistosoma mansoni BC026374 protein (S09 family) 0.0083 0.0529 0.0748
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0262 0.0252
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0437 0.0427
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0429 0.1943
Loa Loa (eye worm) latrophilin receptor protein 2 0.0116 0.0787 0.0777
Trypanosoma brucei polo-like protein kinase 0.0097 0.0641 0.3523
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0641 0.2962
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0139 0.0707
Plasmodium falciparum ataxin-2 like protein, putative 0.0131 0.0912 0.725
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0027 0.0214
Leishmania major trypanothione reductase 0.0101 0.0668 0.3674
Brugia malayi MH1 domain containing protein 0.0042 0.0198 0.0188
Echinococcus multilocularis para nitrobenzyl esterase 0.0083 0.0529 0.0748
Onchocerca volvulus Alhambra homolog 0.006 0.0337 0.0327
Brugia malayi Inositol-1 0.0045 0.0216 0.0206
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0176 0.0719
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.023 0.1704 0.8837
Brugia malayi Carboxylesterase family protein 0.0083 0.0529 0.0519
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0013 0.0003
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0013 0.0003
Brugia malayi hypothetical protein 0.0083 0.0529 0.0519
Trypanosoma cruzi DNA polymerase eta, putative 0.0241 0.1795 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0161 0.1152 0.5431
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Schistosoma mansoni gliotactin 0.0083 0.0529 0.0748
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0116 0.0787 0.112
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0059 0.0331 0.0463
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0015 0.0006
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0013 0.0002
Schistosoma mansoni chromobox protein 0.0071 0.0429 0.0605
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0017
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0216 0.0915
Brugia malayi Carboxylesterase family protein 0.0083 0.0529 0.0519
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0049 0.0254 0.0244
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.006 0.0337 0.0327
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0178 0.0168
Trypanosoma brucei DNA polymerase IV, putative 0.0161 0.1152 0.6393
Trichomonas vaginalis DNA polymerase eta, putative 0.0161 0.1152 0.5431
Brugia malayi Bromodomain containing protein 0.006 0.0337 0.0327
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.0379 0.3026
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0083 0.0529 0.2201
Mycobacterium ulcerans phosphoglycerate kinase 0.0174 0.1253 0.5919
Plasmodium vivax DNA repair protein REV1, putative 0.005 0.026 0.2063
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.0002
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.0379 0.3026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0017
Brugia malayi hypothetical protein 0.0021 0.0027 0.0017
Echinococcus multilocularis isocitrate dehydrogenase 0.0065 0.0379 0.0532
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0013 0.0101
Echinococcus multilocularis regulator of G protein signaling 7 0.0049 0.0254 0.0352
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.023 0.1704 0.8837
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.037 0.2007
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0139 0.0185
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0641 0.4596
Schistosoma mansoni hypothetical protein 0.025 0.1864 0.2674
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0116 0.0787 0.0777
Echinococcus multilocularis geminin 0.0882 0.6942 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0529 0.0519
Schistosoma mansoni smad1 5 8 and 0.0042 0.0198 0.0271
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0017
Brugia malayi PHD-finger family protein 0.006 0.0337 0.0327
Mycobacterium tuberculosis Putative ferredoxin reductase 0.023 0.1704 0.8837
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0429 0.1943
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1152 0.572
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0013 0.0003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0139 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0262 0.0364
Echinococcus granulosus chromobox protein 1 0.0071 0.0429 0.0605
Trypanosoma brucei unspecified product 0.0111 0.0751 0.414
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0178 0.0732
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0101 0.0668 0.2985
Brugia malayi Thioredoxin reductase 0.0101 0.0668 0.0658
Loa Loa (eye worm) glutaminase 2 0.0279 0.2099 0.2091
Brugia malayi PXA domain containing protein 0.004 0.0176 0.0166
Giardia lamblia Kinase, PLK 0.0097 0.0641 0.5005
Loa Loa (eye worm) pax transcription factor protein 2 0.0492 0.3807 0.3801
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0017
Schistosoma mansoni z-protein (S1r protein) 0.0049 0.0254 0.0352
Schistosoma mansoni terminal deoxycytidyl transferase 0.0161 0.1152 0.1647
Leishmania major DNA polymerase eta, putative 0.013 0.0903 0.4994
Mycobacterium tuberculosis Probable dehydrogenase 0.023 0.1704 0.8837
Onchocerca volvulus 0.0083 0.0529 0.0519
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0027 0.0079
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0027 0.0017
Schistosoma mansoni regulator of G protein signaling 0.0049 0.0254 0.0352
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0216 0.0915
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0256 0.191 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0131 0.0912 0.725
Loa Loa (eye worm) hypothetical protein 0.0083 0.0529 0.0519
Mycobacterium ulcerans glutaminase 0.0279 0.2099 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0139 0.0913
Echinococcus granulosus dna polymerase kappa 0.0161 0.1152 0.1647
Trypanosoma brucei DNA damage repair protein, putative 0.005 0.026 0.1387
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0176 0.0239
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0139 0.0707
Echinococcus multilocularis neuroligin 0.0083 0.0529 0.0748
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0176 0.0239
Echinococcus granulosus transcription factor eb 0.0111 0.0752 0.107
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0139 0.0185
Brugia malayi hypothetical protein 0.0131 0.0912 0.0903
Loa Loa (eye worm) hypothetical protein 0.0083 0.0529 0.0519
Echinococcus multilocularis GPCR, family 2 0.0116 0.0787 0.112
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0139 0.1095
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0203 0.0193
Echinococcus multilocularis transcription factor eb 0.0111 0.0752 0.107
Schistosoma mansoni regulator of G protein signaling 0.004 0.0176 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0176 0.0719
Loa Loa (eye worm) hypothetical protein 0.0365 0.2792 0.2785
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0198 0.0188
Loa Loa (eye worm) hypothetical protein 0.0241 0.1795 0.1787
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0176 0.0719
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0379 0.2056
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0064 0.0054
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0013 0.0003
Treponema pallidum NADH oxidase 0.0035 0.0139 0.0913
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0216 0.142
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0036
Schistosoma mansoni hypothetical protein 0.0882 0.6942 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0083 0.0529 0.2201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0139 0.0707
Schistosoma mansoni smad1 5 8 and 0.0042 0.0198 0.0271
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0178 0.0242
Brugia malayi N-terminal motif family protein 0.0199 0.1453 0.1444
Loa Loa (eye worm) transcription factor SMAD2 0.0622 0.4849 0.4844
Schistosoma mansoni hypothetical protein 0.0116 0.0787 0.112
Echinococcus granulosus bloom syndrome protein 0.0026 0.007 0.0087
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.007 0.006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0262 0.0252
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0065 0.0379 0.2954
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0013 0.0003
Echinococcus multilocularis regulator of G protein signaling 7 0.0049 0.0254 0.0352
Schistosoma mansoni DNA polymerase eta 0.0241 0.1795 0.2575
Schistosoma mansoni kinase 0.005 0.0256 0.0354
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0015 0.0104
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0083 0.0529 0.2422
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0216 0.1143
Trypanosoma cruzi PAB1-binding protein , putative 0.0131 0.0912 0.5045
Toxoplasma gondii thioredoxin reductase 0.0101 0.0668 0.5327
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0116 0.0787 0.112
Brugia malayi MH2 domain containing protein 0.0042 0.0198 0.0188
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0015 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0085 0.0281
Brugia malayi topoisomerase 0.0021 0.0027 0.0017
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0139 0.054
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0139 0.1095
Onchocerca volvulus 0.0021 0.0027 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0139 0.0707
Mycobacterium tuberculosis Probable reductase 0.023 0.1704 0.8837
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0027 0.0079
Loa Loa (eye worm) Smad1 0.0042 0.0198 0.0188
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0139 0.1107
Loa Loa (eye worm) hypothetical protein 0.0494 0.3826 0.3819
Plasmodium falciparum DNA repair protein REV1, putative 0.005 0.026 0.1993
Entamoeba histolytica hypothetical protein 0.004 0.0176 0.1116
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0161 0.1152 0.572
Mycobacterium ulcerans DNA polymerase IV 0.0161 0.1152 0.5431
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0176 0.0239
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0139 0.0707
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0216 0.1143
Brugia malayi hypothetical protein 0.0021 0.0027 0.0017
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0083 0.0529 0.0748
Echinococcus granulosus acetylcholinesterase 0.0494 0.3826 0.5504
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0161 0.1152 0.1143
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0027 0.0024
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0139 0.0707
Schistosoma mansoni DNA ligase IV 0.0021 0.0027 0.0024
Echinococcus multilocularis acetylcholinesterase 0.0494 0.3826 0.5504
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0641 0.2962
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0198 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0176 0.0719
Echinococcus granulosus phd:f box containing protein 0.0019 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0178 0.0168
Schistosoma mansoni regulator of G protein signaling 0.004 0.0176 0.0239
Onchocerca volvulus 0.0083 0.0529 0.0519
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0065 0.0379 0.2056
Loa Loa (eye worm) hypothetical protein 0.0083 0.0529 0.0519
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0178 0.0242
Echinococcus granulosus peregrin 0.006 0.0337 0.0471
Echinococcus multilocularis bloom syndrome protein 0.0026 0.007 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.0751 0.414
Schistosoma mansoni regulator of G protein signaling 0.004 0.0176 0.0239
Echinococcus granulosus nibrin 0.0021 0.0027 0.0024
Plasmodium falciparum glutathione reductase 0.0035 0.0139 0.1016
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0195 0.1425 0.2041
Brugia malayi Phosphoglycerate kinase 0.0064 0.037 0.036
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0337 0.0327
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0139 0.0913
Plasmodium falciparum thioredoxin reductase 0.0101 0.0668 0.5279
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0176 0.0239
Plasmodium falciparum glutathione reductase 0.0101 0.0668 0.5279
Loa Loa (eye worm) hypothetical protein 0.0102 0.0678 0.0669
Schistosoma mansoni hypothetical protein 0.0116 0.0787 0.112
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0176 0.0239
Echinococcus granulosus axis inhibition protein axin 0.004 0.0176 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0216 0.1546
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.0751 0.414
Brugia malayi hypothetical protein 0.0187 0.1362 0.1353
Brugia malayi Carboxylesterase family protein 0.0083 0.0529 0.0519
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0161 0.1152 0.1647
Trypanosoma cruzi DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Loa Loa (eye worm) glutaminase 0.0279 0.2099 0.2091
Schistosoma mansoni glutaminase 0.0279 0.2099 0.3013
Schistosoma mansoni DNA polymerase IV / kappa 0.005 0.026 0.036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0065 0.0379 0.0369
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0174 0.1253 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0262 0.0364
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0065 0.0379 0.0532
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0365 0.2792 0.2785
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.037 0.2007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0262 0.0364
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.026 0.1387
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0174 0.1253 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0161 0.1152 0.1647
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0176 0.0166
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0379 0.0532
Echinococcus granulosus axis inhibition protein axin 0.004 0.0176 0.0239
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0437 0.0616
Trypanosoma cruzi DNA polymerase eta, putative 0.013 0.0903 0.4994
Schistosoma mansoni smad 0.0042 0.0198 0.0271
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0166
Loa Loa (eye worm) carboxylesterase 0.0083 0.0529 0.0519
Brugia malayi PHD-finger family protein 0.0019 0.0015 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0365 0.2792 0.2785
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0641 0.0631
Schistosoma mansoni hypothetical protein 0.006 0.0337 0.0471
Brugia malayi MH1 domain containing protein 0.0042 0.0198 0.0188
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.0002
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0337 0.0471
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0641 0.0631
Leishmania major hypothetical protein, conserved 0.0131 0.0912 0.5045
Brugia malayi Carboxylesterase family protein 0.0083 0.0529 0.0519
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0178 0.0242
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0139 0.0913
Plasmodium falciparum phosphoglycerate kinase 0.0174 0.1253 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0065 0.0379 0.0532
Leishmania major DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.007 0.021
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0111 0.0752 0.0743
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.023 0.1704 0.8906
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0015 0.0011
Echinococcus multilocularis dna polymerase kappa 0.0161 0.1152 0.1647
Brugia malayi hypothetical protein 0.0085 0.0539 0.0529
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Schistosoma mansoni acetylcholinesterase 0.0083 0.0529 0.0748
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0161 0.1152 0.6393
Leishmania major phosphoglycerate kinase C, glycosomal 0.0174 0.1253 0.696
Brugia malayi isocitrate dehydrogenase 0.0065 0.0379 0.0369
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0166
Schistosoma mansoni axis inhibition protein axin 0.004 0.0176 0.0239
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0641 0.2962
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0379 0.0532
Brugia malayi PXA domain containing protein 0.004 0.0176 0.0166
Loa Loa (eye worm) thioredoxin reductase 0.0101 0.0668 0.0658
Brugia malayi Isocitrate dehydrogenase 0.0065 0.0379 0.0369
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0246 0.1056
Schistosoma mansoni hypothetical protein 0.0187 0.1362 0.195
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0013 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0203 0.0849
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0178 0.0168
Loa Loa (eye worm) MH2 domain-containing protein 0.0622 0.4849 0.4844
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0027 0.0114
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0045 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Echinococcus granulosus acetylcholinesterase 0.0494 0.3826 0.5504
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0641 0.0909
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0187 0.1362 0.195
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0166
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.037 0.2007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0017
Loa Loa (eye worm) RecQ helicase 0.0026 0.007 0.006
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0013 0.0002
Echinococcus multilocularis Smad4 0.0042 0.0198 0.0271
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0262 0.0364
Echinococcus granulosus Smad4 0.0042 0.0198 0.0271
Loa Loa (eye worm) nuclear factor I 0.0023 0.0046 0.0036
Echinococcus multilocularis BC026374 protein (S09 family) 0.0083 0.0529 0.0748
Brugia malayi Smad1 0.0042 0.0198 0.0188
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0337 0.0471
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0013 0.0003
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0216 0.0297
Schistosoma mansoni transcription factor LCR-F1 0.0187 0.1362 0.195
Echinococcus multilocularis dna polymerase eta 0.0241 0.1795 0.2575
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0013 0.0101
Loa Loa (eye worm) acetylcholinesterase 1 0.0494 0.3826 0.3819
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0216 0.1143
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0174 0.1253 0.696
Trypanosoma brucei hypothetical protein, conserved 0.005 0.026 0.1387
Brugia malayi AF-10 protein 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0017
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0198 0.0271
Brugia malayi MH1 domain containing protein 0.0023 0.0046 0.0036
Loa Loa (eye worm) inositol-1 0.0045 0.0216 0.0206
Entamoeba histolytica hypothetical protein 0.004 0.0176 0.1116
Schistosoma mansoni regulator of G protein signaling 0.004 0.0176 0.0239
Loa Loa (eye worm) RGS-3 protein 0.004 0.0176 0.0166
Loa Loa (eye worm) hypothetical protein 0.1263 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0139 0.054
Echinococcus multilocularis phosphoglycerate kinase 1 0.0174 0.1253 0.1793
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0641 0.3523
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0027 0.0079
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0203 0.0849
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.026 0.1387
Giardia lamblia PHD finger protein 15 0.006 0.0337 0.2526
Brugia malayi glutaminase DH11.1 0.0279 0.2099 0.2091
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0139 0.0707
Echinococcus granulosus regulator of G protein signaling 7 0.0049 0.0254 0.0352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0262 0.0364
Plasmodium vivax glutathione reductase, putative 0.0101 0.0668 0.5321
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0256 0.191 1
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0013 0.0003
Echinococcus granulosus BC026374 protein S09 family 0.0083 0.0529 0.0748
Echinococcus multilocularis peregrin 0.006 0.0337 0.0471
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0139 0.054
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0139 0.0707
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0085 0.0281
Trypanosoma brucei PAB1-binding protein , putative 0.0131 0.0912 0.5045
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0641 0.3523
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0176 0.0719
Loa Loa (eye worm) hypothetical protein 0.0083 0.0529 0.0519
Schistosoma mansoni inositol monophosphatase 0.0045 0.0216 0.0297
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0199 0.1453 0.1444
Echinococcus multilocularis nibrin 0.0021 0.0027 0.0024
Plasmodium vivax JmjC domain containing protein 0.0019 0.0013 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0641 0.2962
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0174 0.1253 1
Entamoeba histolytica hypothetical protein 0.0187 0.1362 1
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.007 0.021
Trypanosoma brucei hypothetical protein, conserved 0.005 0.026 0.1387
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0139 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0178 0.0242
Loa Loa (eye worm) hypothetical protein 0.005 0.026 0.025
Trypanosoma brucei phosphoglycerate kinase, putative 0.0064 0.037 0.2007
Mycobacterium tuberculosis Probable oxidoreductase 0.0256 0.191 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0002
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0198 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.0751 0.414
Echinococcus multilocularis acetylcholinesterase 0.0494 0.3826 0.5504
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0176 0.0239
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.0161 0.1152 0.1143
Plasmodium falciparum thioredoxin reductase 0.0035 0.0139 0.1016
Entamoeba histolytica hypothetical protein 0.0187 0.1362 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0529 0.0519
Loa Loa (eye worm) hypothetical protein 0.0116 0.0787 0.0777
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0641 0.0909
Echinococcus granulosus carboxylesterase 5A 0.0494 0.3826 0.5504
Loa Loa (eye worm) carboxylesterase 0.0494 0.3826 0.3819
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0027 0.0024
Brugia malayi hypothetical protein 0.004 0.0176 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0262 0.0364
Loa Loa (eye worm) hypothetical protein 0.0131 0.0912 0.0903
Schistosoma mansoni axis inhibition protein axin 0.004 0.0176 0.0239
Onchocerca volvulus 0.0083 0.0529 0.0519
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0027 0.0214
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0429 0.0419
Brugia malayi MH1 domain containing protein 0.0023 0.0046 0.0036
Loa Loa (eye worm) hypothetical protein 0.0049 0.0254 0.0244
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0002
Brugia malayi polk-prov protein 0.005 0.026 0.025
Mycobacterium tuberculosis Carboxylesterase LipT 0.0083 0.0529 0.2201
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0337 0.0471
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0262 0.0364
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0083 0.0529 0.0748
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0198 0.0188
Schistosoma mansoni phosphoglycerate kinase 0.0174 0.1253 0.1793
Schistosoma mansoni neuroligin 3 (S09 family) 0.0083 0.0529 0.0748
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0179 0.0807
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0139 0.054
Echinococcus granulosus phosphoglycerate kinase 1 0.0174 0.1253 0.1793
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0139 0.0707
Trypanosoma brucei phosphoglycerate kinase 0.0064 0.037 0.2007
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0174 0.1253 0.696
Toxoplasma gondii ImpB/MucB/SamB family protein 0.013 0.0903 0.7204
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0641 0.0631
Brugia malayi Phosphoglycerate kinase 0.0174 0.1253 0.1244
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0027 0.0079
Schistosoma mansoni inositol monophosphatase 0.0045 0.0216 0.0297
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0379 0.0532
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0139 0.054
Brugia malayi jmjC domain containing protein 0.0195 0.1425 0.1416
Trypanosoma cruzi DNA damage repair protein, putative 0.005 0.026 0.1387
Trypanosoma cruzi DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0246 0.1056
Leishmania major DNA damage repair protein, putative 0.005 0.026 0.1387
Schistosoma mansoni hypothetical protein 0.0059 0.0331 0.0463
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0198 0.0271
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0437 0.0616
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.0006
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0176 0.0166
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0064 0.0054
Entamoeba histolytica phosphoglycerate kinase, putative 0.0174 0.1253 0.9183
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0437 0.0616
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0195 0.1425 0.2041
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0216 0.0297
Brugia malayi latrophilin 2 splice variant baaae 0.025 0.1864 0.1855
Echinococcus granulosus chromobox protein 1 0.0071 0.0429 0.0605
Plasmodium vivax phosphoglycerate kinase, putative 0.0174 0.1253 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0166
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0176 0.0239
Leishmania major phosphoglycerate kinase B, cytosolic 0.0174 0.1253 0.696
Plasmodium vivax hypothetical protein, conserved 0.006 0.0337 0.2676
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0083 0.0529 0.0748
Loa Loa (eye worm) hypothetical protein 0.0083 0.0529 0.0519
Mycobacterium ulcerans hypothetical protein 0.005 0.026 0.1125
Chlamydia trachomatis phosphoglycerate kinase 0.0174 0.1253 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0116 0.0787 0.112
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0015 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0641 0.2962
Echinococcus multilocularis smad 0.0042 0.0198 0.0271
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0013 0.0003
Entamoeba histolytica hypothetical protein 0.0187 0.1362 1
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0027 0.0079
Loa Loa (eye worm) glutathione reductase 0.0101 0.0668 0.0658
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0026 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.026 0.1387
Onchocerca volvulus 0.0492 0.3807 0.3801
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0015 0.0117
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0083 0.0529 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0178 0.0732
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0641 0.0909
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Echinococcus granulosus dna polymerase eta 0.0241 0.1795 0.2575
Brugia malayi jmjC domain containing protein 0.0072 0.0437 0.0427
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0216 0.1727
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0139 0.1016
Schistosoma mansoni jumonji domain containing protein 0.0155 0.1103 0.1576
Brugia malayi Carboxylesterase family protein 0.0494 0.3826 0.3819
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0176 0.0719
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0174 0.1253 0.6291
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0641 0.2962
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0065 0.0379 0.1357
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0176 0.0239
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0176 0.0166
Trypanosoma brucei phosphoglycerate kinase 0.0174 0.1253 0.696
Schistosoma mansoni chromobox protein 0.0071 0.0429 0.0605
Echinococcus granulosus expressed protein 0.077 0.6041 0.87
Brugia malayi chromobox protein homolog 3 0.004 0.0178 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0641 0.2962
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0379 0.2056
Echinococcus granulosus GPCR family 2 0.0116 0.0787 0.112
Toxoplasma gondii LsmAD domain-containing protein 0.0131 0.0912 0.7277
Trypanosoma brucei DNA polymerase eta, putative 0.0241 0.1795 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0379 0.2056
Echinococcus multilocularis thioredoxin glutathione reductase 0.0101 0.0668 0.0948
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0337 0.2686
Mycobacterium ulcerans carboxylesterase, LipT 0.0083 0.0529 0.2422
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0064 0.037 0.2007
Trypanosoma cruzi PAB1-binding protein , putative 0.0131 0.0912 0.5045
Schistosoma mansoni smad1 5 8 and 0.0042 0.0198 0.0271
Onchocerca volvulus 0.1263 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0161 0.1152 0.6393
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0641 0.3523
Trypanosoma cruzi DNA damage repair protein, putative 0.005 0.026 0.1387
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0027 0.0201
Onchocerca volvulus 0.0083 0.0529 0.0519
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0059 0.0331 0.0463
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0083 0.0529 0.0748
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0013 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0139 0.0707
Brugia malayi hypothetical protein 0.004 0.0176 0.0166
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0365 0.2792 0.2785
Mycobacterium ulcerans DNA polymerase IV 0.0161 0.1152 0.5431
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.037 0.2007
Echinococcus granulosus para nitrobenzyl esterase 0.0083 0.0529 0.0748
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.005 0.026 0.2074
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0013 0.0003
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0161 0.1152 0.1647
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0176 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.1152 0.6393
Entamoeba histolytica hypothetical protein 0.0187 0.1362 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0198 0.0271
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0216 0.1143
Echinococcus multilocularis chromobox protein 1 0.0071 0.0429 0.0605
Echinococcus granulosus neuroligin 0.0083 0.0529 0.0748
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0437 0.0616
Brugia malayi Pax transcription factor protein 2 0.0492 0.3807 0.3801
Echinococcus granulosus smad 0.0042 0.0198 0.0271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0139 0.0707
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0139 0.0707
Plasmodium vivax thioredoxin reductase, putative 0.0101 0.0668 0.5321
Schistosoma mansoni topbp1 0.0021 0.0027 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0161 0.1152 0.6393
Trypanosoma brucei unspecified product 0.0111 0.0751 0.414
Entamoeba histolytica hypothetical protein 0.004 0.0176 0.1116
Trichomonas vaginalis glutaminase, putative 0.0279 0.2099 1
Brugia malayi MH2 domain containing protein 0.0042 0.0198 0.0188
Brugia malayi DKFZp564C0469 protein 0.0021 0.0027 0.0017
Trypanosoma brucei trypanothione reductase 0.0101 0.0668 0.3674
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0065 0.0379 0.3016
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0174 0.1253 0.5919
Schistosoma mansoni Smad4 0.0042 0.0198 0.0271
Schistosoma mansoni hypothetical protein 0.0882 0.6942 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0111 0.0748 0.0738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0139 0.0707
Trypanosoma brucei chrX additional, unordered contigs 0.005 0.026 0.1387
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0139 0.0707
Loa Loa (eye worm) hypothetical protein 0.0111 0.0748 0.0738
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0139 0.0913
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0178 0.0168
Loa Loa (eye worm) carboxylesterase 0.0083 0.0529 0.0519
Schistosoma mansoni topbp1 0.0021 0.0027 0.0024
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0015 0.0004
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0174 0.1253 0.6511
Echinococcus multilocularis chromobox protein 1 0.0071 0.0429 0.0605
Giardia lamblia Phosphoglycerate kinase 0.0174 0.1253 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.1453 0.1444
Trypanosoma brucei unspecified product 0.0161 0.1152 0.6393
Trypanosoma brucei phosphoglycerate kinase 0.0174 0.1253 0.696
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0176 0.0166
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0176 0.0239
Brugia malayi Latrophilin receptor protein 2 0.0116 0.0787 0.0777
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0139 0.1016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0139 0.0707
Brugia malayi Carboxylesterase family protein 0.0494 0.3826 0.3819
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0116 0.0787 0.112
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0176 0.0239
Brugia malayi MH2 domain containing protein 0.0622 0.4849 0.4844
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0174 0.1253 0.5919
Schistosoma mansoni hypothetical protein 0.0116 0.0787 0.112
Echinococcus granulosus thioredoxin glutathione reductase 0.0101 0.0668 0.0948
Loa Loa (eye worm) hypothetical protein 0.0494 0.3826 0.3819
Brugia malayi ImpB/MucB/SamB family protein 0.0241 0.1795 0.1787
Trypanosoma cruzi trypanothione reductase, putative 0.0101 0.0668 0.3674
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0187 0.1362 0.195
Echinococcus granulosus geminin 0.0882 0.6942 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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