TDR Targets

Basic information

Technical information

TDR Targets ID: 1369780
Name: 3-(2,1,3-benzoxadiazol-7-ylsulfonyl)-N-(2,3-d imethylphenyl)propanamide
MW: 359.4 | Formula: C17H17N3O4S
H donors: 1 H acceptors: 5 LogP: 1.95 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc(c1C)C)CCS(=O)(=O)c1cccc2c1non2
InChi: 1S/C17H17N3O4S/c1-11-5-3-6-13(12(11)2)18-16(21)9-10-25(22,23)15-8-4-7-14-17(15)20-24-19-14/h3-8H,9-10H2,1-2H3,(H,18,21)
InChiKey: CSJHZDHGIWJBGL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-benzofurazan-4-ylsulfonyl-N-(2,3-dimethylphenyl)propionamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	serine peptidase, putative	0.007	0.0277	0.0277
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0045	0.0184
Trypanosoma brucei	Serine peptidase, Clan SC, Family S09X	0.007	0.0277	0.0277
Plasmodium vivax	PST-A protein	0.007	0.0277	0.0277
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0277	0.0234
Plasmodium vivax	unspecified product	0.007	0.0277	0.0277
Brugia malayi	Muscleblind-like protein	0.018	0.1229	0.5084
Plasmodium falciparum	lysophospholipase, putative	0.1194	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0045	0.0184
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0045	0.0045
Toxoplasma gondii	phospholipase/carboxylesterase	0.007	0.0277	1
Loa Loa (eye worm)	hypothetical protein	0.018	0.1229	0.5084
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0045	0.0045
Plasmodium falciparum	esterase, putative	0.007	0.0277	0.0277
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.007	0.0277	0.0234
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.007	0.0277	0.0234
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.007	0.0277	0.1147
Mycobacterium ulcerans	lipase LipD	0.0043	0.0045	0.0045
Trypanosoma brucei	monoglyceride lipase, putative	0.1194	1	1
Plasmodium vivax	PST-A protein	0.007	0.0277	0.0277
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1194	1	1
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.031	0.0381
Plasmodium vivax	PST-A protein	0.007	0.0277	0.0277
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.1194	1	1
Brugia malayi	Protein C20orf22	0.007	0.0277	0.1147
Plasmodium vivax	lysophospholipase, putative	0.007	0.0277	0.0277
Mycobacterium ulcerans	hypothetical protein	0.007	0.0277	0.0277
Plasmodium falciparum	lysophospholipase, putative	0.1194	1	1
Brugia malayi	beta-lactamase family protein	0.0043	0.0045	0.0184
Echinococcus granulosus	muscleblind protein	0.018	0.1229	0.5084
Loa Loa (eye worm)	hypothetical protein	0.007	0.0277	0.1147
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0045	0.0045
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0045	0.0045
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0318	0.2418	0.297
Echinococcus granulosus	lysine specific demethylase 5A	0.0069	0.0264	0.1093
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0045	0.0184
Echinococcus granulosus	abhydrolase domain containing protein 13	0.007	0.0277	0.1147
Plasmodium vivax	hypothetical protein, conserved	0.007	0.0277	0.0277
Leishmania major	hypothetical protein, conserved	0.007	0.0277	0.0277
Echinococcus granulosus	Phospholipase carboxylesterase	0.007	0.0277	0.1147
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0045	0.0045
Echinococcus multilocularis	Phospholipase carboxylesterase	0.007	0.0277	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0318	0.2418	1
Chlamydia trachomatis	acyltransferase family protein	0.007	0.0277	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0045	0.0045
Plasmodium falciparum	prodrug activation and resistance esterase	0.007	0.0277	0.0277
Onchocerca volvulus		0.0043	0.0045	0.5
Plasmodium vivax	unspecified product	0.007	0.0277	0.0277
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0069	0.0264	0.1093
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.031	0.1283
Mycobacterium ulcerans	hydrolase	0.007	0.0277	0.0277
Leishmania major	monoglyceride lipase, putative	0.1194	1	1
Echinococcus granulosus	geminin	0.0205	0.1439	0.5951
Loa Loa (eye worm)	hypothetical protein	0.018	0.1229	0.5084
Loa Loa (eye worm)	hypothetical protein	0.007	0.0277	0.1147
Plasmodium falciparum	lysophospholipase, putative	0.007	0.0277	0.0277
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.031	0.1283
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.031	0.1283
Plasmodium falciparum	esterase, putative	0.1194	1	1
Plasmodium vivax	alpha/beta hydrolase, putative	0.007	0.0277	0.0277
Plasmodium falciparum	exported lipase 1	0.007	0.0277	0.0277
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0277	0.0234
Loa Loa (eye worm)	hypothetical protein	0.007	0.0277	0.1147
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.007	0.0277	0.5
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.8141	1
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0277	0.0234
Toxoplasma gondii	protein c14orf29, putative	0.007	0.0277	1
Toxoplasma gondii	hypothetical protein	0.007	0.0277	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0318	0.2418	1
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.007	0.0277	0.0277
Mycobacterium ulcerans	lysophospholipase	0.1194	1	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0045	0.0045
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0038	0	0.5
Onchocerca volvulus		0.0043	0.0045	0.5
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.007	0.0277	0.0234
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.007	0.0277	1
Trypanosoma cruzi	serine peptidase, putative	0.007	0.0277	0.0277
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.007	0.0277	0.0234
Toxoplasma gondii	hypothetical protein	0.007	0.0277	1
Brugia malayi	MGC83647 protein	0.007	0.0277	0.1147
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.007	0.0277	1
Toxoplasma gondii	hypothetical protein	0.007	0.0277	1
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0045	0.0045
Schistosoma mansoni	peptidase	0.007	0.0277	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0045	0.0184
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.007	0.0277	0.0277
Chlamydia trachomatis	hydrolase	0.007	0.0277	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1194	1	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0045	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0277	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0045	0.0184
Echinococcus granulosus	abhydrolase domain containing 3	0.007	0.0277	0.1147
Loa Loa (eye worm)	jmjC domain-containing protein	0.0069	0.0264	0.1093
Loa Loa (eye worm)	hypothetical protein	0.007	0.0277	0.1147
Echinococcus multilocularis	geminin	0.0205	0.1439	0.1767
Mycobacterium tuberculosis	Conserved hypothetical protein	0.007	0.0277	0.0277
Plasmodium falciparum	alpha/beta hydrolase, putative	0.007	0.0277	0.0277
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.031	0.1283
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0045	0.0045
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.007	0.0277	0.0277
Plasmodium falciparum	esterase, putative	0.007	0.0277	0.0277
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0045	0.0045
Schistosoma mansoni	hypothetical protein	0.0205	0.1439	0.5951
Echinococcus multilocularis	muscleblind protein 1	0.018	0.1229	0.151
Plasmodium falciparum	lysophospholipase, putative	0.007	0.0277	0.0277
Brugia malayi	RNA binding protein	0.0074	0.031	0.1283
Onchocerca volvulus		0.0043	0.0045	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.007	0.0277	0.0234
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0277	0.0234
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1194	1	1
Brugia malayi	amidase	0.0318	0.2418	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0045	0.0045
Plasmodium vivax	PST-A protein	0.1194	1	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0045	0.0184
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.007	0.0277	0.0234
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0069	0.0264	0.1093
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.2072	0.2072
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0038	0	0.5
Plasmodium vivax	hypothetical protein, conserved	0.007	0.0277	0.0277
Plasmodium vivax	hypothetical protein, conserved	0.007	0.0277	0.0277
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.1194	1	1
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0045	0.0045
Plasmodium vivax	lysophospholipase, putative	0.007	0.0277	0.0277
Plasmodium falciparum	alpha/beta hydrolase, putative	0.007	0.0277	0.0277
Brugia malayi	beta-lactamase family protein	0.0043	0.0045	0.0184
Toxoplasma gondii	peptidase S15, putative	0.007	0.0277	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0045	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0045	0.0184
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0045	0.0045
Plasmodium vivax	PST-A protein	0.007	0.0277	0.0277
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0045	0.0045
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.007	0.0277	0.0234
Plasmodium falciparum	alpha/beta hydrolase, putative	0.007	0.0277	0.0277
Echinococcus multilocularis	muscleblind protein	0.018	0.1229	0.151
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.031	0.1283
Loa Loa (eye worm)	hypothetical protein	0.007	0.0277	0.1147
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.007	0.0277	0.0234
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0277	0.0234
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1194	1	1
Echinococcus multilocularis	abhydrolase domain containing 3	0.007	0.0277	0.0341
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.031	0.1283
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.007	0.0277	0.0277
Toxoplasma gondii	phospholipase	0.007	0.0277	1
Mycobacterium ulcerans	hypothetical protein	0.1194	1	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0069	0.0264	0.1093
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.007	0.0277	0.0341
Mycobacterium tuberculosis	Possible lysophospholipase	0.1194	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.1194	1	1
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.007	0.0277	1
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0045	0.0045
Leishmania major	Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X	0.007	0.0277	0.0277
Trichomonas vaginalis	conserved hypothetical protein	0.1194	1	1
Plasmodium falciparum	alpha/beta hydrolase, putative	0.007	0.0277	0.0277
Leishmania major	hypothetical protein, conserved	0.0043	0.0045	0.0045
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.007	0.0277	0.0277
Plasmodium vivax	PST-A protein	0.007	0.0277	0.0277
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0277	0.0234
Brugia malayi	jmjC domain containing protein	0.0069	0.0264	0.1093
Plasmodium vivax	alpha/beta hydrolase, putative	0.007	0.0277	0.0277
Brugia malayi	MGC79044 protein	0.007	0.0277	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0045	0.0184
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0045	0.0184
Loa Loa (eye worm)	RNA binding protein	0.0074	0.031	0.1283
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1194	1	1
Mycobacterium ulcerans	hypothetical protein	0.007	0.0277	0.0277
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0045	0.0045
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0069	0.0264	0.0325
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0045	0.0184
Brugia malayi	TAR-binding protein	0.0074	0.031	0.1283
Schistosoma mansoni	hypothetical protein	0.0205	0.1439	0.5951
Trypanosoma cruzi	monoglyceride lipase, putative	0.1194	1	1
Plasmodium falciparum	alpha/beta hydrolase, putative	0.007	0.0277	0.0277
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.007	0.0277	0.1147
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.031	0.1283
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.007	0.0277	0.0277
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0277	0.0234
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0045	0.0045
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	0.007	0.0277	0.0277
Schistosoma mansoni	fatty-acid amide hydrolase	0.0318	0.2418	1
Plasmodium falciparum	BEM46-like protein, putative	0.007	0.0277	0.0277
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.007	0.0277	0.0234
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0045	0.0045
Echinococcus granulosus	tar DNA binding protein	0.0074	0.031	0.1283
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0318	0.2418	1
Plasmodium vivax	lysophospholipase, putative	0.007	0.0277	0.0277
Plasmodium falciparum	exported lipase 2	0.007	0.0277	0.0277
Toxoplasma gondii	hypothetical protein	0.007	0.0277	1
Leishmania major	hypothetical protein, conserved	0.007	0.0277	0.0277
Schistosoma mansoni	amidase	0.0318	0.2418	1
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0277	0.0234
Brugia malayi	jmjC domain containing protein	0.0069	0.0264	0.1093
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0045	0.0045
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.007	0.0277	0.0277
Echinococcus multilocularis	lysine specific demethylase 5A	0.0069	0.0264	0.0325
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.007	0.0277	0.0277
Trypanosoma brucei	monoglyceride lipase, putative	0.1194	1	1
Brugia malayi	beta-lactamase	0.0043	0.0045	0.0184
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.031	0.1283
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.007	0.0277	0.1147
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0045	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0045	0.0184
Plasmodium falciparum	epoxide hydrolase 2	0.007	0.0277	0.0277
Plasmodium falciparum	lysophospholipase, putative	0.1194	1	1
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0318	0.2418	0.297
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.1194	1	1
Schistosoma mansoni	jumonji domain containing protein	0.0069	0.0264	0.1093

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0046 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	2.5119 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 2.8184 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	16.3535 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (binding)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	251.1886 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1500652

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1369780