Detailed information for compound 1369781

Basic information

Technical information
  • TDR Targets ID: 1369781
  • Name: 2-chloro-N-[2-(4-chlorophenyl)ethyl]-5-[(4-me thoxyphenyl)-methylsulfamoyl]benzamide
  • MW: 493.403 | Formula: C23H22Cl2N2O4S
  • H donors: 1 H acceptors: 3 LogP: 5.09 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N(S(=O)(=O)c1ccc(c(c1)C(=O)NCCc1ccc(cc1)Cl)Cl)C
  • InChi: 1S/C23H22Cl2N2O4S/c1-27(18-7-9-19(31-2)10-8-18)32(29,30)20-11-12-22(25)21(15-20)23(28)26-14-13-16-3-5-17(24)6-4-16/h3-12,15H,13-14H2,1-2H3,(H,26,28)
  • InChiKey: BXZCJWYQIBQILZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-[2-(4-chlorophenyl)ethyl]-5-[(4-methoxyphenyl)-methyl-sulfamoyl]benzamide
  • T0517-6320
  • MLS000374650
  • SMR000244265
  • ZINC03319841

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax lysophospholipase, putative 0.0071 0.0544 0.0265
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis dro:myosuppressin receptor 0.0007 0.0012 0.0046
Schistosoma mansoni growth hormone secretagogue receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0007 0.0012 0.0046
Brugia malayi hypothetical protein 0.0006 0.0006 0.0021
Echinococcus multilocularis sex peptide receptor 0.0007 0.0012 0.0046
Echinococcus granulosus cpg binding protein 0.0037 0.0257 0.0944
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus 7tm_1 domain containing protein 0.0007 0.0012 0.0046
Plasmodium falciparum lysophospholipase, putative 0.0071 0.0544 0.0265
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.004 0.0287 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0012 0.0046
Mycobacterium ulcerans hypothetical protein 0.1208 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0054 0.0197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0012 0.0046
Plasmodium falciparum BEM46-like protein, putative 0.0071 0.0544 0.0265
Echinococcus granulosus tachykinin peptides receptor 99D 0.0007 0.0012 0.0046
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0021
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0071 0.0544 0.0528
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0007 0.0012 0.0046
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0012 0.0046
Mycobacterium ulcerans lysophospholipase 0.1208 1 1
Schistosoma mansoni amine GPCR 0.0007 0.0012 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0054 0.0197
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0007 0.0012 0.0046
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis orexin receptor type 2 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus alpha 1A adrenergic receptor 0.0007 0.0012 0.0046
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0562 0.0284
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0012 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Echinococcus granulosus sex peptide receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0012 0.0046
Leishmania major monoglyceride lipase, putative 0.1208 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis serotonin receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2328 0.8545
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0437 0.1603
Onchocerca volvulus 0.0007 0.0012 0.0286
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.1208 1 1
Plasmodium falciparum lysophospholipase, putative 0.1208 1 1
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0071 0.0544 0.7181
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0012 0.0046
Plasmodium falciparum alpha/beta hydrolase, putative 0.0071 0.0544 0.0265
Echinococcus multilocularis neuropeptide receptor A26 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0071 0.0544 0.1998
Echinococcus granulosus fatty acid amide hydrolase 1 0.0333 0.2725 1
Echinococcus granulosus g protein coupled receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0007 0.0012 0.0046
Schistosoma mansoni fatty-acid amide hydrolase 0.004 0.0287 0.1052
Toxoplasma gondii hypothetical protein 0.0071 0.0544 0.7181
Echinococcus granulosus orexin receptor type 2 0.0007 0.0012 0.0046
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0071 0.0544 0.0265
Echinococcus multilocularis cpg binding protein 0.0037 0.0257 0.0944
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0007 0.0012 0.0046
Plasmodium vivax PST-A protein 0.1208 1 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.004 0.0287 0.1052
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0197
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0006 0.0021
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0071 0.0544 0.0265
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0197
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0041 0.0152
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0054 0.0197
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0054 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.1208 1 1
Brugia malayi hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni biogenic amine receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni neuropeptide f receptor 76f 0.0007 0.0012 0.0046
Schistosoma mansoni peptidase 0.0071 0.0544 0.1998
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0054 0.0197
Echinococcus granulosus fatty acid amide hydrolase 1 0.0333 0.2725 1
Echinococcus granulosus Phospholipase carboxylesterase 0.0071 0.0544 0.1998
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Echinococcus granulosus neuropeptide receptor 0.0007 0.0012 0.0046
Echinococcus granulosus dro:myosuppressin receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0007 0.0012 0.0046
Echinococcus multilocularis neuropeptide FF receptor 2 0.0007 0.0012 0.0046
Echinococcus granulosus neuropeptide receptor A26 0.0007 0.0012 0.0046
Brugia malayi nuclear receptor NHR-88 0.0012 0.0054 0.0197
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0111 0.0406
Plasmodium vivax PST-A protein 0.0071 0.0544 0.0265
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni myosin xvIII 0.0007 0.0012 0.0046
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0054 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0054 0.0197
Toxoplasma gondii protein c14orf29, putative 0.0071 0.0544 0.7181
Onchocerca volvulus 0.0007 0.0012 0.0286
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0054 0.0197
Plasmodium vivax lysophospholipase, putative 0.0071 0.0544 0.0265
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0562 0.0284
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0007 0.0012 0.0046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0111 0.0406
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.1208 1 1
Chlamydia trachomatis hydrolase 0.0071 0.0544 1
Echinococcus granulosus abhydrolase domain containing 3 0.0071 0.0544 0.1998
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1208 1 1
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0071 0.0544 0.1998
Schistosoma mansoni hypothetical protein 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0197
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0006 0.0021
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0054 0.0197
Trichomonas vaginalis valacyclovir hydrolase, putative 0.1208 1 1
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0071 0.0544 0.0265
Brugia malayi Dopamine receptor protein 2 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus g protein coupled receptor 0.0007 0.0012 0.0046
Brugia malayi nuclear receptor RXR 0.0006 0.0006 0.0021
Plasmodium falciparum epoxide hydrolase 2 0.0071 0.0544 0.0265
Echinococcus granulosus allatostatin A receptor 0.0007 0.0012 0.0046
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0071 0.0544 0.0265
Onchocerca volvulus 0.0007 0.0012 0.0286
Brugia malayi hypothetical protein 0.0007 0.0012 0.0046
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0012 0.0046
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0054 0.0197
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0071 0.0544 0.0528
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0054 0.0197
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0544 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0054 0.0197
Echinococcus granulosus somatostatin receptor 0.0007 0.0012 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0054 0.0197
Brugia malayi follicle stimulating hormone receptor 0.0007 0.0012 0.0046
Plasmodium falciparum lysophospholipase, putative 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0197
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0007 0.0012 0.0046
Echinococcus granulosus G protein coupled receptor 139 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0333 0.2725 1
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0071 0.0544 0.1998
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni fatty-acid amide hydrolase 0.0333 0.2725 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0024 0.0087
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0111 0.0406
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0562 0.2063
Brugia malayi hypothetical protein 0.0007 0.0012 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0054 0.0197
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0111 0.0406
Leishmania major hypothetical protein, conserved 0.0071 0.0544 0.0265
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.004 0.0287 0.1052
Echinococcus multilocularis neuropeptide s receptor 0.0007 0.0012 0.0046
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0054 0.0197
Plasmodium vivax lysophospholipase, putative 0.0071 0.0544 0.0265
Schistosoma mansoni adenoreceptor 0.0007 0.0012 0.0046
Brugia malayi sulfakinin receptor protein 0.0007 0.0012 0.0046
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0012 0.0046
Echinococcus granulosus serotonin receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0054 0.0197
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0007 0.0012 0.0046
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0012 0.0046
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0562 0.2063
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0012 0.0046
Brugia malayi neuropeptide F receptor 0.0007 0.0012 0.0046
Onchocerca volvulus 0.0007 0.0012 0.0286
Onchocerca volvulus 0.0035 0.0241 0.5511
Brugia malayi ecdysteroid receptor 0.0012 0.0054 0.0197
Echinococcus granulosus neuropeptide FF receptor 2 0.0007 0.0012 0.0046
Brugia malayi AKH receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis serotonin receptor 0.0007 0.0012 0.0046
Plasmodium falciparum alpha/beta hydrolase, putative 0.0071 0.0544 0.0265
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0012 0.0046
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0071 0.0544 0.1998
Onchocerca volvulus Neuropeptide F receptor homolog 0.0007 0.0012 0.0286
Loa Loa (eye worm) TYRA-2 protein 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0054 0.0197
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus 7TM GPCR rhodopsin 0.0007 0.0012 0.0046
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0054 0.0197
Brugia malayi hypothetical protein 0.0007 0.0012 0.0046
Brugia malayi neuropeptide F receptor 0.0007 0.0012 0.0046
Echinococcus granulosus GPCR family 2 0.0019 0.0111 0.0406
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0024 0.0087
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0007 0.0012 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1208 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0054 0.0197
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0295 0.1081
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0012 0.0046
Schistosoma mansoni amine GPCR 0.0007 0.0012 0.0046
Mycobacterium ulcerans hypothetical protein 0.0071 0.0544 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0054 0.0197
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0007 0.0012 0.0046
Brugia malayi hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0012 0.0046
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.004 0.0148
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0054 0.0197
Schistosoma mansoni opsin-like receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0295 0.1081
Plasmodium falciparum esterase, putative 0.0071 0.0544 0.0265
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0071 0.0544 0.1998
Onchocerca volvulus 0.0007 0.0012 0.0286
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0544 0.0528
Plasmodium falciparum alpha/beta hydrolase, putative 0.0071 0.0544 0.0265
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0333 0.2725 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus neuropeptide receptor 0.0007 0.0012 0.0046
Onchocerca volvulus 0.0007 0.0012 0.0286
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0071 0.0544 0.0528
Loa Loa (eye worm) amidase 0.004 0.0287 0.1052
Brugia malayi CXXC zinc finger family protein 0.0035 0.0241 0.0883
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0012 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0054 0.0197
Toxoplasma gondii phospholipase 0.0071 0.0544 0.7181
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0054 0.0197
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0012 0.0046
Schistosoma mansoni cpg binding protein 0.0035 0.0241 0.0883
Loa Loa (eye worm) hypothetical protein 0.006 0.0453 0.1663
Schistosoma mansoni alpha-1 adrenergic receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0012 0.0046
Schistosoma mansoni hypothetical protein 0.0019 0.0111 0.0406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0012 0.0046
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0111 0.0406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0054 0.0197
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0054 0.0197
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0007 0.0012 0.0046
Brugia malayi hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0054 0.0197
Brugia malayi putative neuropeptide receptor NPR1 0.0007 0.0012 0.0046
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0071 0.0544 0.0265
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0111 0.0406
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0021
Brugia malayi MGC79044 protein 0.0071 0.0544 0.1998
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0054 0.1228
Echinococcus multilocularis Phospholipase carboxylesterase 0.0071 0.0544 0.1998
Loa Loa (eye worm) hypothetical protein 0.0286 0.2328 0.8545
Schistosoma mansoni hypothetical protein 0.0007 0.0012 0.0046
Toxoplasma gondii hypothetical protein 0.0071 0.0544 0.7181
Brugia malayi putative amidase 0.004 0.0287 0.1052
Onchocerca volvulus 0.0007 0.0012 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0544 0.0528
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0012 0.0046
Plasmodium vivax unspecified product 0.0071 0.0544 0.0265
Schistosoma mansoni amine GPCR 0.0007 0.0012 0.0046
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0071 0.0544 0.5
Schistosoma mansoni histamine h1 receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0024 0.0087
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0012 0.0046
Mycobacterium tuberculosis Possible lysophospholipase 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0054 0.0197
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2328 0.8545
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0012 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0054 0.0197
Toxoplasma gondii hypothetical protein 0.0071 0.0544 0.7181
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0562 0.2063
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Brugia malayi hypothetical protein 0.0007 0.0012 0.0046
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0071 0.0544 0.0528
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0071 0.0544 0.7181
Brugia malayi hypothetical protein 0.0007 0.0012 0.0046
Trypanosoma brucei monoglyceride lipase, putative 0.1208 1 1
Echinococcus granulosus abhydrolase domain containing protein 13 0.0071 0.0544 0.1998
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0071 0.0544 0.0265
Plasmodium falciparum exported lipase 2 0.0071 0.0544 0.0265
Onchocerca volvulus 0.0058 0.0437 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0024 0.0087
Schistosoma mansoni coup transcription factor 0.0012 0.0054 0.0197
Leishmania major hypothetical protein, conserved 0.0071 0.0544 0.0265
Plasmodium falciparum esterase, putative 0.0071 0.0544 0.0265
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0012 0.0046
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0006 0.0021
Plasmodium vivax unspecified product 0.0071 0.0544 0.0265
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0007 0.0012 0.0046
Schistosoma mansoni opsin-like receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni neuropeptide receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0054 0.0197
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Echinococcus multilocularis G protein coupled receptor 139 0.0007 0.0012 0.0046
Brugia malayi larval opioid receptor 0.0007 0.0012 0.0046
Brugia malayi hypothetical protein 0.0006 0.0006 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0054 0.0197
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0054 0.0197
Echinococcus multilocularis somatostatin receptor 0.0007 0.0012 0.0046
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0071 0.0544 0.7181
Plasmodium vivax PST-A protein 0.0071 0.0544 0.0265
Brugia malayi hypothetical protein 0.0286 0.2328 0.8545
Onchocerca volvulus 0.0007 0.0012 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0054 0.0197
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.004 0.0287 0.5
Brugia malayi ORL1-like opioid receptor 0.0007 0.0012 0.0046
Schistosoma mansoni hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0006 0.0021
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0007 0.0012 0.0046
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0071 0.0544 0.1998
Schistosoma mansoni hypothetical protein 0.0019 0.0111 0.0406
Onchocerca volvulus 0.0012 0.0054 0.1228
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0054 0.1228
Onchocerca volvulus 0.0007 0.0012 0.0286
Brugia malayi Tachykinin-like peptides receptor 99D 0.0007 0.0012 0.0046
Schistosoma mansoni amidase 0.0333 0.2725 1
Brugia malayi steroid hormone receptor 0.0012 0.0054 0.0197
Brugia malayi hypothetical protein 0.0007 0.0012 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0544 0.0265
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0012 0.0046
Mycobacterium ulcerans hydrolase 0.0071 0.0544 0.0265
Mycobacterium ulcerans hypothetical protein 0.0071 0.0544 0.0265
Plasmodium vivax PST-A protein 0.0071 0.0544 0.0265
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0054 0.0197
Echinococcus granulosus peptide allatostatin:somatostatin 0.0007 0.0012 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0544 0.0528
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0197
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0012 0.0046
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0007 0.0012 0.0046
Brugia malayi RE15519p 0.0007 0.0012 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0071 0.0544 0.0265
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0012 0.0046
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0024 0.0087
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0054 0.0197
Brugia malayi Serotonin receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0333 0.2725 1
Loa Loa (eye worm) amidase 0.004 0.0287 0.1052
Plasmodium vivax alpha/beta hydrolase, putative 0.0071 0.0544 0.0265
Onchocerca volvulus 0.0007 0.0012 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0054 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0054 0.0197
Schistosoma mansoni hypothetical protein 0.0019 0.0111 0.0406
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0007 0.0012 0.0046
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0562 0.2063
Echinococcus multilocularis fatty acid amide hydrolase 1 0.004 0.0287 0.1052
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0054 0.0197
Schistosoma mansoni biogenic amine receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0012 0.0046
Brugia malayi nuclear hormone receptor 0.0012 0.0054 0.0197
Brugia malayi amidase 0.0333 0.2725 1
Onchocerca volvulus 0.0007 0.0012 0.0286
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0012 0.0046
Brugia malayi MGC83647 protein 0.0071 0.0544 0.1998
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0012 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0544 0.0528
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1208 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0007 0.0012 0.0046
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0007 0.0012 0.0046
Trypanosoma cruzi monoglyceride lipase, putative 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0197
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0012 0.0046
Onchocerca volvulus 0.0007 0.0012 0.0286
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0054 0.0197
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Plasmodium falciparum alpha/beta hydrolase, putative 0.0071 0.0544 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0544 0.0528
Schistosoma mansoni hypothetical protein 0.0019 0.0111 0.0406
Schistosoma mansoni cpg binding protein 0.0037 0.0257 0.0944
Echinococcus granulosus g protein coupled receptor 0.0007 0.0012 0.0046
Plasmodium falciparum lysophospholipase, putative 0.0071 0.0544 0.0265
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0071 0.0544 0.1998
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0071 0.0544 0.0265
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0453 0.1663
Plasmodium falciparum alpha/beta hydrolase, putative 0.0071 0.0544 0.0265
Brugia malayi Dopamine receptor protein 1 0.0007 0.0012 0.0046
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0054 0.1228
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0054 0.0197
Schistosoma mansoni neuropeptide receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0111 0.0406
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Plasmodium falciparum lysophospholipase, putative 0.1208 1 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0071 0.0544 0.0528
Schistosoma mansoni amine GPCR 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0197
Onchocerca volvulus 0.0007 0.0012 0.0286
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0007 0.0012 0.0046
Brugia malayi G-protein coupled receptor 0.0007 0.0012 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0012 0.0046
Echinococcus multilocularis allatostatin A receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Plasmodium falciparum exported lipase 1 0.0071 0.0544 0.0265
Trypanosoma cruzi serine peptidase, putative 0.0071 0.0544 0.0265
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0012 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0012 0.0046
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0012 0.0046
Echinococcus granulosus fmrfamide receptor 0.0007 0.0012 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0544 0.0528
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0562 0.0284
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0012 0.0046
Plasmodium vivax alpha/beta hydrolase, putative 0.0071 0.0544 0.0265
Onchocerca volvulus 0.0007 0.0012 0.0286
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0007 0.0012 0.0286
Schistosoma mansoni survival motor neuron protein 0.0058 0.0437 0.1603
Schistosoma mansoni hypothetical protein 0.0007 0.0012 0.0046
Brugia malayi G-protein coupled receptor 0.0007 0.0012 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0054 0.0197
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0453 0.1663
Trypanosoma brucei monoglyceride lipase, putative 0.1208 1 1
Brugia malayi Amidase family protein 0.004 0.0287 0.1052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0054 0.0197
Loa Loa (eye worm) hypothetical protein 0.0071 0.0544 0.1998
Plasmodium falciparum prodrug activation and resistance esterase 0.0071 0.0544 0.0265
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1208 1 1
Brugia malayi putative neuropeptide receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Brugia malayi Amidase family protein 0.004 0.0287 0.1052
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0054 0.0197
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0012 0.0046
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0054 0.0197
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0562 0.0284
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0054 0.0197
Chlamydia trachomatis acyltransferase family protein 0.0071 0.0544 1
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0071 0.0544 0.0528
Schistosoma mansoni cpg binding protein 0.0037 0.0257 0.0944
Onchocerca volvulus 0.0007 0.0012 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0054 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.1208 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis GPCR, family 2 0.0019 0.0111 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0544 0.0528
Schistosoma mansoni hypothetical protein 0.0058 0.0437 0.1603
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.004 0.0287 0.1052
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0071 0.0544 0.0528
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.004 0.0287 0.1052
Brugia malayi G protein-coupled receptor F59B2.13 0.0007 0.0012 0.0046
Schistosoma mansoni biogenic amine receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0054 0.0197
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0054 0.0197
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0564 0.2071
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Brugia malayi Dopamine receptor 0.0007 0.0012 0.0046
Toxoplasma gondii phospholipase/carboxylesterase 0.0071 0.0544 0.7181
Echinococcus multilocularis g-protein coupled receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis abhydrolase domain containing 3 0.0071 0.0544 0.1998
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0071 0.0544 0.0528
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0007 0.0012 0.0046
Brugia malayi Serotonin receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0021
Toxoplasma gondii peptidase S15, putative 0.0071 0.0544 0.7181
Schistosoma mansoni amine GPCR 0.0007 0.0012 0.0046
Brugia malayi G protein-coupled receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0007 0.0012 0.0046
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0006 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0012 0.0046
Plasmodium vivax PST-A protein 0.0071 0.0544 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0054 0.0197
Echinococcus granulosus neuropeptide s receptor 0.0007 0.0012 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0054 0.0197
Schistosoma mansoni opsin-like receptor 0.0007 0.0012 0.0046
Plasmodium falciparum esterase, putative 0.1208 1 1
Plasmodium vivax PST-A protein 0.0071 0.0544 0.0265
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0071 0.0544 0.1998
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0562 0.0284
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0007 0.0012 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0012 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0012 0.0046
Onchocerca volvulus 0.0007 0.0012 0.0286
Brugia malayi hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus g-protein coupled receptor 0.0007 0.0012 0.0046
Brugia malayi Melatonin receptor type 1A 0.0007 0.0012 0.0046
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0562 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0041 0.0152
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Schistosoma mansoni hypothetical protein 0.0041 0.0295 0.1081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0054 0.0197
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0544 0.0265
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0071 0.0544 0.0265
Brugia malayi GnHR receptor homolog 0.0007 0.0012 0.0046
Trypanosoma cruzi serine peptidase, putative 0.0071 0.0544 0.0265
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0012 0.0046
Echinococcus granulosus hypothetical protein 0.0007 0.0012 0.0046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0453 0.1663
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0007 0.0012 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0054 0.0197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0054 0.0197
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0071 0.0544 0.0265
Onchocerca volvulus 0.0007 0.0012 0.0286
Echinococcus multilocularis G-protein coupled receptor, putative 0.0007 0.0012 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0544 0.0528
Schistosoma mansoni neuropeptide receptor 0.0007 0.0012 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0544 0.0528
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0012 0.0046
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0012 0.0046
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0041 0.0152
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0007 0.0012 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0054 0.0197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0012 0.0046
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0241 0.0883
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0054 0.0197
Toxoplasma gondii hypothetical protein 0.0071 0.0544 0.7181
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0071 0.0544 0.0265
Brugia malayi Protein C20orf22 0.0071 0.0544 0.1998
Schistosoma mansoni neuropeptide receptor 0.0007 0.0012 0.0046
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0071 0.0544 0.0265
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0071 0.0544 0.0528

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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